Jae Young Um


Affiliation: Kyung Hee University
Country: Korea


  1. request reprint
    Han Y, Kee J, Kim D, Park J, Jeong M, Mun J, et al. Anti-obesity effects of Arctii Fructus (Arctium lappa) in white/brown adipocytes and high-fat diet-induced obese mice. Food Funct. 2016;7:5025-5033 pubmed
  2. Lee J, Kim C, Um J, Sethi G, Ahn K. Casticin-Induced Inhibition of Cell Growth and Survival Are Mediated through the Dual Modulation of Akt/mTOR Signaling Cascade. Cancers (Basel). 2019;11: pubmed publisher
    ..Overall, the findings suggest that CTC can interfere with Akt/mTOR signaling cascade involved in tumorigenesis and can be used together with pharmacological agents targeting Akt/mTOR pathway. ..
  3. Kim H, Park J, Jung Y, Ahn K, Um J. Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis. Phytomedicine. 2019;52:254-263 pubmed publisher
    ..AMPK inhibition nullified the effects of PD, suggesting its anti-adipogenic and thermogenic actions were dependent on AMPK pathway activation. ..
  4. Kim S, Lee G, Jung J, Oh S, Ahn E, Kim S, et al. The ameliorative effect of sophoricoside on mast cell-mediated allergic inflammation in vivo and in vitro. Molecules. 2013;18:6113-27 pubmed publisher
    ..Collectively, the findings of this study provide us with novel insights into the pharmacological actions of sophoricoside as a potential molecule for use in the treatment of allergic inflammation diseases. ..
  5. Kim H, Sim J, Choi H, Choi I, Jeong M, Park J, et al. The AMPK pathway mediates an anti-adipogenic effect of fruits of Hovenia dulcis Thunb. Food Funct. 2014;5:2961-8 pubmed publisher
    ..52%, 38.25%, and 20.39%, respectively. These results indicate that FHD has a significant anti-obesity effect through the modulation of the AMPK pathway, suggesting that FHD has a potential benefit in preventing obesity. ..
  6. Ko J, Nam D, Um J, Jung S, Sethi G, Ahn K. Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition. Molecules. 2018;23: pubmed publisher
    ..BGM treatment also inhibited multiple oncogenic cascades such as PI3K/Akt/mTOR. Overall, the results demonstrate the potential antimetastatic activity of BGM against lung cancer cells. ..
  7. Han Y, Kee J, Kim D, Mun J, Jeong M, Park S, et al. Arctigenin Inhibits Lung Metastasis of Colorectal Cancer by Regulating Cell Viability and Metastatic Phenotypes. Molecules. 2016;21: pubmed publisher
    ..In an experimental metastasis model, ARC significantly inhibited lung metastasis of CT26 cells. Taken together, our study demonstrates the inhibitory effects of ARC on colorectal metastasis. ..
  8. Kee J, Han Y, Kim D, Mun J, Park J, Jeong M, et al. Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability. Phytomedicine. 2016;23:1680-1690 pubmed publisher
    ..These results indicate that quercetin may be a potent therapeutic agent for the treatment of metastatic colorectal cancer. ..
  9. Ko J, Lee S, Yang W, Um J, Sethi G, Mishra S, et al. The Application of Embelin for Cancer Prevention and Therapy. Molecules. 2018;23: pubmed publisher
    ..Therefore, embelin could be used as a potential agent for cancer therapy. ..

More Information


  1. Kang J, Park J, Kim H, Jung Y, Youn D, Lim S, et al. Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway. Eur J Pharmacol. 2018;820:235-244 pubmed publisher
    ..These results suggest that SDG inhibits adipogenesis by activating AMPK?, suggesting it could be an attractive therapeutic candidate for the treatment of obesity. ..
  2. Lee H, Baek S, Lee J, Kim C, Ko J, Lee S, et al. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades. Int J Mol Sci. 2017;18: pubmed publisher
    ..Overall, our results indicate, for the first time, that Rhy could exert anticancer and anti-metastatic effects through regulation of multiple signaling cascades in hepatocellular carcinoma cells. ..
  3. Ko J, Sethi G, Um J, Shanmugam M, Arfuso F, Kumar A, et al. The Role of Resveratrol in Cancer Therapy. Int J Mol Sci. 2017;18: pubmed publisher
    ..This is also accompanied by a comprehensive update of the various clinical trials that have demonstrated it to be a promising therapeutic and chemopreventive agent. ..
  4. Jung Y, Park J, Kim H, Sim J, Youn D, Kang J, et al. Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro. FASEB J. 2017;: pubmed publisher
    ..E., Youn, D.-H., Kang, J., Lim, S., Jeong, M.-Y., Yang, W. M., Lee, S.-G., Ahn, K. S., Um, J.-Y. Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro...
  5. Jeong M, Park J, Youn D, Jung Y, Kang J, Lim S, et al. Albiflorin ameliorates obesity by inducing thermogenic genes via AMPK and PI3K/AKT in vivo and in vitro. Metabolism. 2017;73:85-99 pubmed publisher
  6. Ko J, Lee J, Jung S, Lee S, Chinnathambi A, Alharbi S, et al. 2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway. Molecules. 2017;22: pubmed publisher
    ..DHAP also potentiated the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. Our results suggest that DHAP can be an effective therapeutic agent to target multiple myeloma. ..
  7. Um J, Rim H, Kim S, Kim H, Hong S. Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice. PLoS ONE. 2011;6:e29524 pubmed publisher
    ..Taken together, IL-1? treatment regulated the differentiation of preadipocytes. IL-1? C-889T (rs1800587) is a functional polymorphism of IL-1? associated with obesity. IL-1? may have a critical function in the development of obesity. ..
  8. Baek S, Lee J, Kim C, Ko J, Ryu S, Lee S, et al. Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase. Molecules. 2017;22: pubmed publisher
    ..Overall, GAC 17:1 was found to abrogate STAT3 signaling pathway and thus exert its anticancer effects against multiple myeloma cells. ..
  9. Kim C, Baek S, Um J, Shim B, Ahn K. Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma. BMC Nephrol. 2016;17:19 pubmed publisher
    ..Overall, our results suggest that RES is a blocker of both STAT3 and STAT5 activation and thus may exert potential growth inhibitory effects against RCC cells. ..
  10. Jeon Y, Kee J, Kim D, Han Y, Kim S, Kim S, et al. Effects of Ixeris dentata water extract and caffeic acid on allergic inflammation in vivo and in vitro. BMC Complement Altern Med. 2015;15:196 pubmed publisher
    ..These results suggest that ID is a potential therapeutic agent for allergic inflammatory diseases, including dermatitis. ..
  11. Um J, Jang C, Kim H, Cho Y, Park J, Lee S, et al. Proinflammatory cytokine IL-1 ? polymorphisms in sudden sensorineural hearing loss. Immunopharmacol Immunotoxicol. 2013;35:52-6 pubmed publisher
    ..This suggests that the IL-1? -511 and +3953 loci may play an important role in the etiopathogenesis of SSNHL. ..