Hyung Min Kim


Affiliation: Kyung Hee University
Country: Korea


  1. Han N, Park C, Kim N, Kim H, Yoou M, Nam S, et al. Protective effect of porcine placenta in a menopausal ovariectomized mouse. Reproduction. 2015;150:173-81 pubmed publisher
    ..Free Korean abstract: A Korean translation of this abstract is freely available at http://www.reproduction-online.org/content/150/3/173/suppl/DC1. ..
  2. Kim H, Jee H, Yeom J, Jeong H, Kim H. The ameliorative effect of AST2017-01 in an ovalbumin-induced allergic rhinitis animal model. Inflamm Res. 2019;: pubmed publisher
    ..Taken together, these findings indicate that AST2017-01 has an anti-allergic effect as a therapeutic agent or functional food for treating and preventing AR. ..
  3. Moon P, Han N, Lee J, Kim H, Hong S, Kim H, et al. ?-eudesmol inhibits thymic stromal lymphopoietin through blockade of caspase-1/NF-?B signal cascade in allergic rhinitis murine model. Chem Biol Interact. 2018;294:101-106 pubmed publisher
    ..Taken together, these results indicate that ?-eudesmol would be effective for the treatment of allergic and inflammatory diseases, such as AR. ..
  4. Nam S, Chung C, Seo J, Rah S, Kim H, Jeong H. The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitis. Int Immunopharmacol. 2014;23:273-82 pubmed publisher
    ..Taken together, we suggest that α-PN is a promising anti-allergic agent and may be useful in the clinical management of AR. ..
  5. Han N, Park J, Jang J, Jeong H, Kim H. A natural dye, Niram improves atopic dermatitis through down-regulation of TSLP. Environ Toxicol Pharmacol. 2014;38:982-90 pubmed publisher
    ..These results establish Niram as a functional dye embracing the aspects of not only a traditional use but also a pharmacological effect. ..
  6. Yoou M, Kim H, Jeong H. Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2. Int Immunopharmacol. 2015;26:23-9 pubmed publisher
    ..In conclusion, these results indicate that acteoside is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases. ..
  7. Rim H, Kim K, Ryu J, Song Y, Kim H, Han J, et al. Alcohol-fermented soybean increases the expression of receptor-interacting protein 2 and I?B kinase ? in mouse peritoneal macrophages. J Med Food. 2011;14:1181-9 pubmed publisher
    ..Our results indicate that AFS increases the production of NO and TNF-? through the activation of Rip2/IKK-? in rIFN-?-primed macrophages. ..
  8. Han N, Kim H, Yang W, Jeong H, Kim H. Glutamic acid ameliorates estrogen deficiency-induced menopausal-like symptoms in ovariectomized mice. Nutr Res. 2015;35:774-83 pubmed publisher
    ..Estrogen response element activity increased by GA was inhibited by an estrogen antagonist. Taken together, our data demonstrated that GA has estrogenic and osteogenic activities in OVX mice, MG-63 cells, and MCF-7 cells. ..
  9. Han N, Moon P, Yoo M, Ryu K, Kim H, Jeong H. Regulatory effects of chrysophanol, a bioactive compound of AST2017-01 in a mouse model of 2,4-dinitrofluorobenzene-induced atopic dermatitis. Int Immunopharmacol. 2018;62:220-226 pubmed publisher
    ..Taken together, these results suggest that AST2017-01 has beneficial effects on AD and may be used as a health functional food in AD. ..

More Information


  1. Moon P, Han N, Lee J, Kim H, Jeong H. Effects of Linalyl Acetate on Thymic Stromal Lymphopoietin Production in Mast Cells. Molecules. 2018;23: pubmed publisher
    ..Taken together, these results suggest that LA would be beneficial to treatment of atopic and inflammatory diseases by reducing TSLP. ..
  2. Kim H, Han N, Kim H, Jeong H. The Iron Chelator and Anticancer Agent Dp44mT Relieves Allergic Inflammation in Mice With Allergic Rhinitis. Inflammation. 2018;41:1744-1754 pubmed publisher
    ..In conclusion, these results indicate that Dp44mT also has potential antiinflammatory effects in vivo as well as in vitro. ..
  3. Kim H, Jeong H, Kim H. Anti-allergic and anti-inflammatory effects of the Bcl-2 inhibitor ABT-737 on experimental allergic rhinitis models. Eur J Pharmacol. 2018;833:34-43 pubmed publisher
    ..In conclusion, we identified new anti-allergic and anti-inflammatory effects of ABT-737. These results imply that ABT-737 can ameliorate allergic inflammatory diseases such as AR. ..
  4. Han N, Nam S, Hong S, Kim H, Moon P, Kim H, et al. Improvement effects of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich on postmenopausal symptoms of ovariectomized mice. Biomed Pharmacother. 2018;103:524-530 pubmed publisher
    ..Finally, PCE17, PE, CE, Tec, or Hes significantly increased norepinephrine and dopamine levels in the hypothalamus of OVX mice. Thus, these results imply that PCE17 has protective effects against hot flushes. ..
  5. Han N, Moon P, Kim H, Jeong H. Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP. Arch Biochem Biophys. 2014;542:14-20 pubmed publisher
    ..Finally, TR significantly inhibited the production of IL-4, IFN-?, and TNF-? from the stimulated splenocytes. Taken together, TR exhibits the potential to be a therapeutic agent for AD through down-regulation of TSLP. ..
  6. Nam S, Kim H, Jeong H. Attenuation of IL-32-induced caspase-1 and nuclear factor-κB activations by acteoside. Int Immunopharmacol. 2015;29:574-582 pubmed publisher
    ..Our data suggest that acteoside exhibits an anti-inflammatory activity by suppressing IL-32 signaling pathway. Collectively, the results indicate that acteoside may act as a regulator of the IL-32 induced immune responses. ..
  7. Nam S, Kim H, Jeong H. Cysteine ameliorates allergic inflammatory reactions by suppressing thymic stromal lymphopoietin production in activated human mast cells. Nutr Res. 2018;49:79-87 pubmed publisher
  8. request reprint
    Kim H, Nam S, Jang J, Choi Y, Kang I, Kim H, et al. 2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide as a new lead compound for management of allergic rhinitis. Inflamm Res. 2016;65:963-973 pubmed
    ..PA showed the possibility to regulate AR in OVA-induced AR models, suggesting that it has therapeutic potential for the management of AR as a lead compound. ..
  9. Nam S, Kim H, Jeong H. Anti-fatigue effect by active dipeptides of fermented porcine placenta through inhibiting the inflammatory and oxidative reactions. Biomed Pharmacother. 2016;84:51-59 pubmed publisher
    ..Taken together, our results indicated that GL and LG dipeptides, active components of FPP, should be considered as candidate of anti-fatigue agents. ..
  10. Yoou M, Park C, Kim M, Kim H, Jeong H. Inhibition of MDM2 expression by rosmarinic acid in TSLP-stimulated mast cell. Eur J Pharmacol. 2016;771:191-8 pubmed publisher
    ..In conclusion, the results of the study suggest that RA has a significant anti-inflammatory effect on TSLP-induced inflammatory reactions. These effects of RA are likely to be mediated through inhibiting the MDM2 increased by TSLP. ..
  11. Nam S, Yoou M, Kim H, Jeong H. Efficacy of proline in the treatment of menopause. Exp Biol Med (Maywood). 2016;241:611-9 pubmed publisher
    ..Those findings implied that proline can be a promising candidate for the treatment of menopause. ..
  12. Yoou M, Nam S, Wan Yoon K, Jeong H, Kim H. Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis. Chin J Nat Med. 2018;16:97-104 pubmed publisher
    ..Furthermore, the activation of caspase-1 was reduced by BS in the AD skin lesions. Our results suggested that BS should be considered as a candidate treatment for allergic inflammatory diseases including AD. ..
  13. Moon P, Han N, Ryu K, Kang S, Go J, Jang J, et al. A novel compound 2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide downregulates TSLP through blocking of caspase-1/NF-?B pathways. Int Immunopharmacol. 2016;38:420-5 pubmed publisher
    ..Finally, PA inhibited ear swelling response induced by phorbol myristate acetate in mice. These results indicate that PA would be effective to treat inflammatory and atopic disorders through the down-regulations of TSLP. ..
  14. Han N, Kim N, Kim H, Jeong H. Cysteine Prevents Menopausal Syndromes in Ovariectomized Mouse. Reprod Sci. 2016;23:670-9 pubmed publisher
    ..The novel insights gained here strongly imply the potential use of Cys as a new agent for postmenopausal women. ..
  15. Kim N, Kim H, Kim M, Kim H, Jeong H. Improvement of depressive behavior by Sweetme Sweet Pumpkin™ and its active compound, β-carotene. Life Sci. 2016;147:39-45 pubmed publisher
    ..In conclusion, these findings suggest the potential of SSP and β-carotene as a novel therapeutic agent for the treatment of depression. ..
  16. Kim H, Han N, Kim N, Lee M, Kim J, Kim C, et al. Effect of fermented porcine placenta on physical fatigue in mice. Exp Biol Med (Maywood). 2016;241:1985-1996 pubmed
    ..In addition, FPP, Lys, and Leu significantly promoted proliferation of splenocytes. In conclusion, these findings suggest the potential of FPP as a novel functional food for the regulation of fatigue. ..
  17. Nam S, Kim H, Jeong H. The potential protective role of taurine against experimental allergic inflammation. Life Sci. 2017;184:18-24 pubmed publisher
    ..In summary, taurine could serve as potential novel remedy of allergic inflammatory disorders. ..
  18. Nam S, Han N, Yoon K, Kim H, Jeong H. Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), an anticancer agent, exerts an anti-inflammatory effect in activated human mast cells. Inflamm Res. 2017;66:871-879 pubmed publisher
    ..Overall, our results indicate that the anticancer agent Dp44mT has an anti-inflammatory effect and may be of therapeutic importance for the treatment of mast cell-mediated inflammatory diseases. ..
  19. Yoou M, Nam S, Jin M, Lee S, Kim M, Roh S, et al. Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP. Food Chem Toxicol. 2017;106:78-85 pubmed publisher
    ..Taken together, these findings suggest that ATL-III plays a useful role as an anti-inflammatory agent and should be viewed as a potential anti-cancer agent. ..
  20. Nam S, Kim H, Kim H, Jeong H. Î’eta-eudesmol reduces stem cell factor-induced mast cell migration. Int Immunopharmacol. 2017;48:1-7 pubmed publisher
    ..These results demonstrate that β-eudesmol has an anti-allergic inflammatory effect through the inhibition of mast cell migration and inflammatory cytokine production. ..
  21. Han N, Moon P, Nam S, Ryu K, Yoou M, Choi J, et al. Inhibitory effects of atractylone on mast cell-mediated allergic reactions. Chem Biol Interact. 2016;258:59-68 pubmed publisher
    ..Taken together, these results of this study indicate that Atr regulates the degranulation of mast cell, proving its potential in the treatment of mast cell-mediated allergic reactions. ..
  22. Nam S, Jeong H, Kim H. Kaempferol impedes IL-32-induced monocyte-macrophage differentiation. Chem Biol Interact. 2017;274:107-115 pubmed publisher
    ..In brief, our findings may provide new mechanistic insights into the anti-inflammatory effects of kaempferol. ..
  23. Jeong H, Kim H, Kim H. Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models. Int Immunopharmacol. 2018;54:238-244 pubmed publisher
    ..In conclusion, these findings indicate that chrysophanol is an active component of AST2017-01 and AST2017-01 acts as a novel potent anti-inflammatory herbal medicine or functional food. ..
  24. Jeong H, Yang S, Kim H, Kim N, Jang J, Kim H. Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test. Exp Biol Med (Maywood). 2016;241:1559-67 pubmed publisher
    ..These results suggest that chelidonic acid might serve as a new therapeutic strategy for the regulation of depression associated with inflammation...
  25. Han N, Moon P, Jeong H, Kim H. Hydrogen sulfide diminishes the levels of thymic stromal lymphopoietin in activated mast cells. Arch Dermatol Res. 2016;308:103-13 pubmed publisher
    ..In conclusion, these findings show that H2S, as an active compound of BS is a potential agent to cure allergic inflammation. ..
  26. Yoou M, Yoon K, Choi Y, Kim H, Jeong H. Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production. Eur J Pharmacol. 2017;802:1-6 pubmed publisher
    ..In conclusion, our study shows that cordycepin has potential effect for the treatment of allergic inflammatory diseases through the blockade of IL-13 and MDM2 exacerbated by TSLP. ..
  27. Kim H, Nam S, Hwang S, Kim H, Jeong H. Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models. Mol Immunol. 2016;78:121-132 pubmed publisher
    ..These results indicate that Atr is an active constituent of KMP6 and a potential therapeutic agent for AR. ..