Hee Kang

Summary

Affiliation: Kyung Hee University
Country: Korea

Publications

  1. ncbi Suppression of tumour necrosis factor-alpha by Schizonepeta tenuifolia water extract via inhibition of IkappaBalpha degradation and Jun N-terminal kinase/stress-activated protein kinase activation
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Gyeonggi Do, South Korea
    J Pharm Pharmacol 62:1069-76. 2010
  2. ncbi Leuconostoc citreum HJ-P4 (KACC 91035) regulates immunoglobulin E in an ovalbumin-induced allergy model and induces interleukin-12 through nuclear factor-kappa B and p38/c-Jun N-terminal kinases signaling in macrophages
    Hee Kang
    Department of Oriental Medical Science, Graduate School of East West Medical Science, Kyunghee University, Yongin 446 701, South Korea
    Microbiol Immunol 53:331-9. 2009
  3. ncbi Upregulation of interferon-gamma and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 T cells
    Hee Kang
    Department of Oriental Medical Science, Graduate School of East West Medical Science, Kyunghee University, 1 Seochungdong, Yongin, South Korea
    J Ethnopharmacol 123:6-14. 2009
  4. ncbi Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro
    Hee Kang
    Department of Pathology, College of Oriental Medicine, Kyunghee University, Seoul, 130 710, South Korea
    J Pharm Pharmacol 60:901-7. 2008
  5. ncbi Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyunghee University, Yongin, South Korea
    Cytokine 46:283-9. 2009
  6. ncbi Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation
    Beom Joon Lee
    Department of Internal Medicine, Kangnam Korean Hospital, Kyung Hee University, Seoul, South Korea
    Immunopharmacol Immunotoxicol 33:714-22. 2011
  7. ncbi Immunomodulatory effect of Astragali Radix extract on murine TH1/TH2 cell lineage development
    Hee Kang
    Department of Pathology, College of Oriental Medicine, Kyunghee University, Seoul, South Korea
    Biol Pharm Bull 27:1946-50. 2004
  8. ncbi Regulation of interferon-gamma, interleukin-4 and interleukin-2 by Schizonepeta tenuifolia through differential effects on nuclear factor-kappaB, NFATc2 and STAT4/6
    Hee Kang
    Department of Oriental Medical Science, Graduate School of East West Medicine, Kyunghee University, Yongin, South Korea
    Exp Biol Med (Maywood) 235:230-6. 2010
  9. ncbi Suppression of autophagy exacerbates Mefloquine-mediated cell death
    Ji Hyun Shin
    Graduate School of East West Medical Science, Kyung Hee University, Gyeoggi Do, Republic of Korea
    Neurosci Lett 515:162-7. 2012
  10. ncbi The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Gyeonggi Do, South Korea
    Am J Chin Med 39:1261-73. 2011

Collaborators

  • Ji Hyun Shin
  • Joung Woo Hong
  • Dong Hyung Cho
  • So Jung Park
  • Eunjoo H Lee
  • Hoon Ji Jung
  • Beom Joon Lee
  • Jee Hun Park
  • Kyoo-Seok Ahn
  • Kyoo Seok Ahn
  • Eu Soo Lim
  • Chang Keun Kim
  • Ji Ho Park
  • Eun Sung Kim
  • Yoon Kyung Jo
  • Seok Hyun Eom
  • Yoon Bum Kim
  • Ga Eun Yang
  • Jae Hwan Lew
  • Jong Woo Kim
  • Kyong Nyon Nam
  • Min Sook Son
  • Youn Jung Kim
  • Jung Jin Hwang
  • Nak Won Sohn
  • Jeong-Min Lee
  • Jae Hoon You
  • Jee-Hun Park
  • Se-Na Kim
  • Sung Hoon Jun
  • Seung Ha Lee
  • Jae-Hoon You
  • Jeong Min Lee
  • Seung-Ha Lee
  • Se Na Kim
  • Sung-Hoon Jun
  • Min Kyu Park
  • Sung Hoon Kim
  • Yun Hee Rhee
  • Eu-Soo Lim
  • Sung-Hoon Kim
  • Beom Sang Shim
  • Hwa-seung Yoo
  • Beom-Sang Shim
  • Min-Kyu Park
  • Hwa Seung Yoo
  • Yun-Hee Rhee
  • Young Yull Koh
  • Beyong Il Kim
  • Choon Sik Park
  • Sang Woo Kim

Detail Information

Publications19

  1. ncbi Suppression of tumour necrosis factor-alpha by Schizonepeta tenuifolia water extract via inhibition of IkappaBalpha degradation and Jun N-terminal kinase/stress-activated protein kinase activation
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Gyeonggi Do, South Korea
    J Pharm Pharmacol 62:1069-76. 2010
    ..The anti-inflammatory effects of an aqueous extract of Schizonepeta tenuifolia on lipopolysaccharide (LPS)-induced tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in vivo and in vitro have been investigated...
  2. ncbi Leuconostoc citreum HJ-P4 (KACC 91035) regulates immunoglobulin E in an ovalbumin-induced allergy model and induces interleukin-12 through nuclear factor-kappa B and p38/c-Jun N-terminal kinases signaling in macrophages
    Hee Kang
    Department of Oriental Medical Science, Graduate School of East West Medical Science, Kyunghee University, Yongin 446 701, South Korea
    Microbiol Immunol 53:331-9. 2009
    ..Taken together, the use of L. citreum can be useful in preventing the development and progression of IgE production...
  3. ncbi Upregulation of interferon-gamma and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 T cells
    Hee Kang
    Department of Oriental Medical Science, Graduate School of East West Medical Science, Kyunghee University, 1 Seochungdong, Yongin, South Korea
    J Ethnopharmacol 123:6-14. 2009
    ..So-Shi-Ho-Tang (SSHT) or known as Sho-Saiko-To in Japanese and Xiao-Chai-Hu-Tang in Chinese has been used to treat chronic liver disease and other infections, and its hepatoprotective effects have been widely studied...
  4. ncbi Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro
    Hee Kang
    Department of Pathology, College of Oriental Medicine, Kyunghee University, Seoul, 130 710, South Korea
    J Pharm Pharmacol 60:901-7. 2008
    ..Our study demonstrates that ST regulates inflammatory responses by reducing the release of Th1 and Th2 cytokines from T cells and prevents unprimed CD4 T cells from differentiating into Th1 and Th2 cells...
  5. ncbi Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyunghee University, Yongin, South Korea
    Cytokine 46:283-9. 2009
    ..These observations suggest that this microorganism can be a useful Th1-inducing agent in modulating the Th1/Th2 imbalance...
  6. ncbi Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation
    Beom Joon Lee
    Department of Internal Medicine, Kangnam Korean Hospital, Kyung Hee University, Seoul, South Korea
    Immunopharmacol Immunotoxicol 33:714-22. 2011
    ..Cinnamon bark is a very popular herb used in traditional medicine to treat various disorders such as chronic gastric symptoms, arthritis, and the common cold...
  7. ncbi Immunomodulatory effect of Astragali Radix extract on murine TH1/TH2 cell lineage development
    Hee Kang
    Department of Pathology, College of Oriental Medicine, Kyunghee University, Seoul, South Korea
    Biol Pharm Bull 27:1946-50. 2004
    ..Our data clearly indicates that AR selectively alters Th1/Th2 cytokine secretion patterns and provides the pharmacological basis for AR's clinical applications...
  8. ncbi Regulation of interferon-gamma, interleukin-4 and interleukin-2 by Schizonepeta tenuifolia through differential effects on nuclear factor-kappaB, NFATc2 and STAT4/6
    Hee Kang
    Department of Oriental Medical Science, Graduate School of East West Medicine, Kyunghee University, Yongin, South Korea
    Exp Biol Med (Maywood) 235:230-6. 2010
    ..Further mechanistic work is required to investigate the role of STE on its modulation of anti-CD3-induced cytokines...
  9. ncbi Suppression of autophagy exacerbates Mefloquine-mediated cell death
    Ji Hyun Shin
    Graduate School of East West Medical Science, Kyung Hee University, Gyeoggi Do, Republic of Korea
    Neurosci Lett 515:162-7. 2012
    ..Moreover, suppression of autophagy significantly intensified Mefloquine-mediated cytotoxicity in SH-SY5Y cells. Our findings suggest that suppression of autophagy may exacerbate Mefloquine toxicity in neuroblastoma cells...
  10. ncbi The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Gyeonggi Do, South Korea
    Am J Chin Med 39:1261-73. 2011
    ..The inhibition of iNOS, TNF-α and IL-6 by the chloroform fraction may be partly due to the suppression of p38, JNK and ERK1/2. Further study is required to identify the active compounds of S. nigrum...
  11. ncbi Inhibitory effect of Physalis alkekengi L. var. franchetii extract and its chloroform fraction on LPS or LPS/IFN-γ-stimulated inflammatory response in peritoneal macrophages
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyunghee University, Yongin si, Gyeonggi Do 446 701, South Korea
    J Ethnopharmacol 135:95-101. 2011
    ..franchetii (PA) are traditionally used in folk medicine to treat cough, middle ear infection, sore throat, abscesses, and urinary problems. However, the cellular mechanisms underlying PA's possible anti-inflammatory effects are unknown...
  12. ncbi Protective effect of the methanol extract from Cryptotaenia japonica Hassk. against lipopolysaccharide-induced inflammation in vitro and in vivo
    Hee Kang
    Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Gyeonggi Do 446 701, South Korea
    BMC Complement Altern Med 12:199. 2012
    ..In this paper, the in vitro and in vivo anti-inflammatory activity of CJ methanol extract was tested using lipopolysaccharide (LPS)-induced inflammatory models...
  13. ncbi Exopolysaccharide-overproducing Lactobacillus paracasei KB28 induces cytokines in mouse peritoneal macrophages via modulation of NF-κβ and MAPKs
    Hee Kang
    Department of East West Medical Science, Graduate School of East West Medical Science, Kyung Hee University, Yongin 446 701, Korea
    J Microbiol Biotechnol 21:1174-8. 2011
    ..paracasei KB28. Our results provide information for a better understanding of molecular mechanisms of the immunomodulatory effect of food-derived EPS-producing lactic acid bacteria...
  14. ncbi Indirubin-3'-oxime inhibits inflammatory activation of rat brain microglia
    Hoon Ji Jung
    Graduate School of East West Medical Science, Kyung Hee University, Yongin si 446 701, Republic of Korea
    Neurosci Lett 487:139-43. 2011
    ..These results suggest that indirubin-3'-oxime provides neuroprotection by reducing the productions of various neurotoxic molecules in activated microglia...
  15. ncbi Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models
    Joung Woo Hong
    Graduate School of East West Medical Science, Kyung Hee University, Yongin, Gyeonggi, 446 701, South Korea
    BMC Complement Altern Med 12:237. 2012
    ..The goal of this study is to investigate the in vivo and in vitro inhibitory effect of cinnamon water extract (CWE) on lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α and its underlying intracellular mechanisms...
  16. ncbi DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells
    Eu Soo Lim
    O Lab of Angiogenesis and Chemoprevention, College of Oriental Medicine, Kyunghee University, 1 Hoegi dong, Dongdaemun ku, Seoul 131 701, South Korea
    Ann N Y Acad Sci 1095:7-18. 2007
    ..Taken together, DMNQ S-64 may exhibit cytotoxicity against A549 cells via caspase activation and COX-2 inhibition...
  17. ncbi Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death
    So Jung Park
    Graduate School of East West Medical Science, Kyung Hee University, Yongin, Korea
    BMB Rep 44:517-22. 2011
    ..Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death...
  18. ncbi Treatment with SI000413, a new herbal formula, ameliorates murine collagen-induced arthritis
    Jee Hun Park
    Life Science RD Center, Sinil Pharmaceutical Co Ltd, Chungju, Republic of Korea
    Biol Pharm Bull 31:1337-42. 2008
    ..These findings suggest that SI000413 is a potential new therapeutic herbal formula for the treatment of RA...
  19. ncbi Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis
    Chang Keun Kim
    Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea
    J Allergy Clin Immunol 112:64-71. 2003
    ..CONCLUSIONS: These findings suggest that a subgroup of the RSV-induced bronchiolitis group results in a T(H)2-type response, and this could provide a valuable framework to explain the link between RSV-induced bronchiolitis and asthma...