Research Topics

Nam In Baek


Affiliation: Kyung Hee University
Country: Korea


  1. Kim H, Oh H, Ko J, Song H, Lee Y, Kang S, et al. Lanceoleins A-G, hydroxychalcones, from the flowers of Coreopsis lanceolata and their chemopreventive effects against human colon cancer cells. Bioorg Chem. 2019;85:274-281 pubmed publisher
    ..9 ± 1.18 μM, respectively. In the Tali assay, compounds 2 and 5 increased the numeral of apoptotic cells. These compounds also significantly promoted the expression of apoptotic proteins including PARP and caspase-3. ..
  2. Lim D, Kim Y, Park J, Baek N, Han D. Antidepressant-like effects of the ethyl acetate soluble fraction of the root bark of Morus alba on the immobility behavior of rats in the forced swim test. Molecules. 2014;19:7981-9 pubmed publisher
    ..These findings demonstrated that M. alba EtOAc fraction have beneficial effects on depressive behaviors and restore both altered c-fos expression and HPA activity. ..
  3. Lee D, Kim J, Shrestha S, Seo K, Lee Y, Noh H, et al. Quality evaluation of Panax ginseng roots using a rapid resolution LC-QTOF/MS-based metabolomics approach. Molecules. 2013;18:14849-61 pubmed publisher
    ..The classification result can be used to identify P. ginseng origin. ..
  4. Lee J, Ji S, Choi B, Choi D, Lee Y, Kim H, et al. UPLC-QTOF/MS-Based Metabolomics Applied for the Quality Evaluation of Four Processed Panax ginseng Products. Molecules. 2018;23: pubmed publisher
    ..Finally, it was indicated that the proposed metabolomics approach was useful for the quality evaluation and control of processed ginseng products. ..
  5. Joo S, Park H, Park J, Cho J, Kang J, Jeong T, et al. Flavonoids from Machilus japonica stems and their inhibitory effects on LDL oxidation. Int J Mol Sci. 2014;15:16418-29 pubmed publisher
    ..9 µM, while compounds 3 and 5 showed little activity. Compounds 1, 3, and 5 exhibited LDL antioxidant activity with IC50 values of 2.8, 7.1, and 4.6 µM, respectively. ..
  6. Jung J, Ko W, Park J, Seo K, Oh E, Lee D, et al. Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities. Arch Pharm Res. 2015;38:2066-75 pubmed publisher
    ..54 ± 0.86, 34.03 ± 7.71, 19.71 ± 0.71, 16.50 ± 7.82, and 1.02 ± 0.13 μM, respectively. ..
  7. Cho J, Cha B, Min Lee S, Shrestha S, Jeong R, Sung Lee D, et al. Diterpenes from the roots of Oryza sativa L. and their inhibition activity on NO production in LPS-stimulated RAW264.7 macrophages. Chem Biodivers. 2015;12:1356-64 pubmed publisher
    ..7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels. ..
  8. Seo K, Nam Y, Lee D, Ahn E, Kang T, Baek N. Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio). Carbohydr Res. 2015;416:70-4 pubmed publisher
    ..All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3-5 significantly increased glucose absorption in zebrafish. ..
  9. Jung J, Baek N, Hwang Bo J, Lee S, Park J, Seo K, et al. Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito. Molecules. 2015;20:20823-31 pubmed publisher
    ..Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3). ..

More Information


  1. Ko J, Nam Y, Joo S, Kim H, Lee Y, Kang T, et al. Flavonoid 8-O-Glucuronides from the Aerial Parts of Malva verticillata and Their Recovery Effects on Alloxan-Induced Pancreatic Islets in Zebrafish. Molecules. 2018;23: pubmed publisher
    ..This is the first report of the isolation of compounds 1-6 from M. verticillata as well evaluated for anti-diabetic and anti-oxidant ativities. ..
  2. Ko J, Cho S, Joo S, Kim H, Lee Y, Kang S, et al. Glycosyl glycerides from the aerial parts of Malva verticillata and their chemopreventive effects. Bioorg Chem. 2018;78:381-392 pubmed publisher
    ..The n-BuOH fraction and compounds 1, 2, and 11 increased the number of apoptotic cells in the Tali assay and had a significant effect on the levels of proteins related to apoptosis including PARP, caspase-3, Bcl-2, Bax, and β-actin. ..
  3. Lee D, Cha B, Lee Y, Kim G, Noh H, Kim S, et al. The potential of minor ginsenosides isolated from the leaves of Panax ginseng as inhibitors of melanogenesis. Int J Mol Sci. 2015;16:1677-90 pubmed publisher
    ..These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds. ..
  4. Park J, Mohamed M, Jung Y, Shrestha S, Lee T, Lee C, et al. Germacrane sesquiterpenes isolated from the rhizome of Curcuma xanthorrhiza Roxb. inhibit UVB-induced upregulation of MMP-1, -2, and -3 expression in human keratinocytes. Arch Pharm Res. 2015;38:1752-60 pubmed publisher
    ..Moreover, this upregulation occurred in a dose-dependent manner over the range of 1-10 μM for each compound. ..
  5. Jung J, Park J, Lee Y, Seo K, Oh E, Lee D, et al. Three New Isoprenylated Flavonoids from the Root Bark of Morus alba. Molecules. 2016;21: pubmed publisher
    ..In addition, compounds 1-4 were isolated for the first time from the root bark of M. alba in this study. ..
  6. Seo K, Lee D, Lee Y, Baek N. Dineolignans of 3-O-4' diphenyl ether-type from fruits of Magnolia obovata. Phytochemistry. 2017;136:133-140 pubmed publisher
    ..Especially, compounds 1-5 include the relatively rare 1,4-benzodioxane ring moiety in the molecular structure. ..
  7. Lee H, Lee S, Bae G, Baek N, Ryu J. Canadine from Corydalis turtschaninovii Stimulates Myoblast Differentiation and Protects against Myotube Atrophy. Int J Mol Sci. 2017;18: pubmed publisher
    ..In this study, we found that canadine from C. turtschaninovii stimulates myogenesis and also inhibits muscle protein degradation. Therefore, we suggest canadine as a protective agent against muscle atrophy. ..
  8. Lee D, Kim H, Lee Y, Kim J, Lee J, Choi B, et al. Isolation and Quantification of Ginsenoside Rh23, a New Anti-Melanogenic Compound from the Leaves of Panax ginseng. Molecules. 2018;23: pubmed publisher
    ..Furthermore, this study demonstrated the utility of MS-based compound 1 for the quantitative analysis. Ginsenoside Rh23 (1) was found at a level of 0.31 mg/g in leaves of hydroponic P. ginseng. ..
  9. Lee J, Kim Y, Park J, Ha S, Kim Y, Baek N, et al. Mulberry fruit extract protects pancreatic β-cells against hydrogen peroxide-induced apoptosis via antioxidative activity. Molecules. 2014;19:8904-15 pubmed publisher
    ..In addition, ME inhibited DNA condensation and/or fragmentation induced by H2O2. These results suggest that ME protects pancreatic β-cells against hydrogen peroxide-induced oxidative stress. ..
  10. Lee J, Ji S, Lee Y, Choi D, Choi B, Kim G, et al. Mass Spectrometry Based Profiling and Imaging of Various Ginsenosides from Panax ginseng Roots at Different Ages. Int J Mol Sci. 2017;18: pubmed publisher
    ..ginseng roots. Furthermore, this study demonstrated the utility of MS-based profiling and imaging of ginsenosides for the quality control of ginseng roots. ..
  11. Lee J, Choi B, Kim Y, Choi D, Lee Y, Kim G, et al. Comprehensive Profiling and Quantification of Ginsenosides in the Root, Stem, Leaf, and Berry of Panax ginseng by UPLC-QTOF/MS. Molecules. 2017;22: pubmed publisher
    ..The results of this study indicate that the UPLC-QTOF/MS method can be an effective tool to characterize various ginsenosides from the different parts of P. ginseng. ..