Yong Kee Kim

Summary

Affiliation: Kwandong University
Country: Korea

Publications

  1. ncbi request reprint Reversal of multidrug resistance by 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide through the reversible inhibition of P-glycoprotein
    Yong Kee Kim
    College of Medicine, Kwandong University, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 355:136-42. 2007
  2. ncbi request reprint Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 347:1088-93. 2006
  3. ncbi request reprint Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1
    Yong Kee Kim
    College of Medicine, Kwandong University, Gangneung 210 701, Republic of Korea
    Cell Signal 18:236-43. 2006
  4. ncbi request reprint TGF-beta1 induction of p21WAF1/cip1 requires smad-independent protein kinase C signaling pathway
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Korea
    Arch Pharm Res 30:739-42. 2007
  5. ncbi request reprint Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, 522 Naegok dong, Gangneung, Gangwon Do, Republic of Korea
    Biochem Biophys Res Commun 358:553-8. 2007
  6. doi request reprint Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin
    Ji Hye Seo
    Myunggok Medical Research Institute, College of Medicine, Konyang Univeristy, Daejeon 302 718, Republic of Korea
    Cancer Lett 288:50-6. 2010
  7. doi request reprint Histone deacetylase inhibitor induction of P-glycoprotein transcription requires both histone deacetylase 1 dissociation and recruitment of CAAT/enhancer binding protein beta and pCAF to the promoter region
    Su Nam Kim
    KIST Gangneung Institute, Gangneung, Korea
    Mol Cancer Res 7:735-44. 2009
  8. pmc Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
    Kang Jin Jeong
    Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 302 718, Korea
    Exp Mol Med 40:607-16. 2008
  9. ncbi request reprint Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol
    Soon Young Park
    College of Medicine, Konyang University, Seo Gu, Daejeon, Republic of Korea
    Cancer Lett 258:63-9. 2007
  10. doi request reprint Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 368:959-64. 2008

Collaborators

  • Seokjoon Lee
  • Eun Young Shin
  • Hyun Cheol Chung
  • Qian Wang
  • Su Nam Kim
  • Jeung Whan Han
  • Hoi Young Lee
  • Nam Hyun Kim
  • Dong Wan Seo
  • Hyang Woo Lee
  • Chang Gyo Park
  • Jangsoon Lee
  • Soon Young Park
  • Kang Jin Jeong
  • Gyu Un Bae
  • Wahn Soo Choi
  • Hanna Kim
  • Jae Ku Kang
  • In Duk Jung
  • Woojung Lee
  • Ji Hye Seo
  • Eun Jung Cho
  • Jong Woo Yoon
  • Seong Hoon Ahn
  • Hyoung Keun Kwon
  • Yumi Um
  • Hye Young Choi
  • Do Yeun Cho
  • Jae Kwang Chun
  • Bum Kyeong Kim
  • Jueng Soo You
  • Jae Cheol Lee
  • Chang Hee Lee
  • Min Jeong Joe
  • Soyoung Kim
  • Kyung Bok Lee
  • Dong Won Kang
  • Eun Kyung Lee
  • Yong Jin Song
  • Kang Ro Lee
  • Dong Keun Jung
  • Sungyoul Hong
  • So Hee Kwon
  • Goo Yoon
  • Joa Sub Oh
  • Ye Ran Hwang
  • Yeon Suk Park
  • Jeong Whan Han
  • Jaeku Kang
  • Joo Hee Kang
  • Jang Sihn Sohn
  • Hae Jeong Sul
  • Woo Jin Oh
  • Yeon Sook Park
  • Jungyeob Ham
  • Chan Mug Ahn
  • Sungsik Cho
  • Ho Bum Woo
  • Dae Sung Yoon
  • Jae Hyun Park
  • Woon Seob Shin
  • Gab Man Park
  • Sun Young Rha
  • Dae Young Lee
  • Won Keun Chang
  • Se Jin Paek
  • Jong Woo Park
  • Dongeun Park
  • Hyeog Kang
  • Seung Hee Han
  • Mary L Stracke
  • Sung Hoon Noh
  • Jang Soon Lee
  • Yin Won Lee

Detail Information

Publications34

  1. ncbi request reprint Reversal of multidrug resistance by 4-chloro-N-(3-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide through the reversible inhibition of P-glycoprotein
    Yong Kee Kim
    College of Medicine, Kwandong University, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 355:136-42. 2007
    ..Collectively, our results describe the potential of C-4 to reverse the P-gp-mediated MDR phenotype through reversible inhibition of P-gp function, which may make it an attractive new agent for the chemosensitization of cancer cells...
  2. ncbi request reprint Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 347:1088-93. 2006
    ..Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin...
  3. ncbi request reprint Cooperation of H2O2-mediated ERK activation with Smad pathway in TGF-beta1 induction of p21WAF1/Cip1
    Yong Kee Kim
    College of Medicine, Kwandong University, Gangneung 210 701, Republic of Korea
    Cell Signal 18:236-43. 2006
    ....
  4. ncbi request reprint TGF-beta1 induction of p21WAF1/cip1 requires smad-independent protein kinase C signaling pathway
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Korea
    Arch Pharm Res 30:739-42. 2007
    ..Taken together, our data suggest that PKC signaling pathway is required for p21WAF1/Cip1 expression by TGF-beta1, which is independent of Smad signaling pathway...
  5. ncbi request reprint Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, 522 Naegok dong, Gangneung, Gangwon Do, Republic of Korea
    Biochem Biophys Res Commun 358:553-8. 2007
    ..Taken together, our data clearly demonstrate the ability of reversine to stimulate adipocyte differentiation, which is independent of the Akt and p70(s6k) signaling pathways...
  6. doi request reprint Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin
    Ji Hye Seo
    Myunggok Medical Research Institute, College of Medicine, Konyang Univeristy, Daejeon 302 718, Republic of Korea
    Cancer Lett 288:50-6. 2010
    ..Collectively, the present study shows the critical role of STAT3 in ovarian cancer cell motility and that this process can be prevented by curcumin...
  7. doi request reprint Histone deacetylase inhibitor induction of P-glycoprotein transcription requires both histone deacetylase 1 dissociation and recruitment of CAAT/enhancer binding protein beta and pCAF to the promoter region
    Su Nam Kim
    KIST Gangneung Institute, Gangneung, Korea
    Mol Cancer Res 7:735-44. 2009
    ..Taken together, our findings show that HDAC inhibitor treatment leads to an increase in P-gp expression through dynamic changes in chromatin structure and transcription factor association within the promoter region...
  8. pmc Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
    Kang Jin Jeong
    Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 302 718, Korea
    Exp Mol Med 40:607-16. 2008
    ..Collectively, our results clearly show the significance of LPA2 and Gi/Src pathway for LPA-induced COX-2 expression and cell migration that could be a promising drug target for ovarian cancer cell metastasis...
  9. ncbi request reprint Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol
    Soon Young Park
    College of Medicine, Konyang University, Seo Gu, Daejeon, Republic of Korea
    Cancer Lett 258:63-9. 2007
    ..Collectively, these results show that LPA under hypoxic condition enhances cell migration through the sequential induction of HIF-1alpha and VEGF, and that this enhancement is efficiently blocked by resveratrol...
  10. doi request reprint Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein
    Yong Kee Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 368:959-64. 2008
    ....
  11. ncbi request reprint p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase
    Jangsoon Lee
    Department of Pharmacology, College of Medicine, Konyang University, Nonsan, 320 711, Republic of Korea
    Exp Cell Res 307:315-28. 2005
    ..Taken together, the present data suggest that p85 beta-PIX, located downstream of Rac1, is a key regulator for the activations of FAK or p38 MAP kinase and plays a pivotal role in focal complex formation and cell motility induced by LPA...
  12. ncbi request reprint Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression
    Jangsoon Lee
    College of Medicine, Konyang University, Daejeon, Korea
    Clin Cancer Res 12:6351-8. 2006
    ..In the present study, we investigated whether LPA activates hypoxia inducible factor-1 (HIF-1), a key transcriptional complex in tumor progression and metastasis, thereby increasing the expression of VEGF...
  13. doi request reprint HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: implication for chemosensitization
    Hanna Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Int J Oncol 38:807-12. 2011
    ..Collectively, our data provide a molecular rationale for the application of HDAC inhibitors to overcome MDR in cancer cells...
  14. ncbi request reprint Apoptotic potential of sesquiterpene lactone ergolide through the inhibition of NF-kappaB signaling pathway
    Yong Jin Song
    College of Medicine, Kwandong University, Gangneung 210 701, Korea
    J Pharm Pharmacol 57:1591-7. 2005
    ....
  15. doi request reprint PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion
    Nam Hyun Kim
    Department of Pharmacology, Kwandong University College of Medicine, 522 Naegok dong, Gangneung si 210 701, Republic of Korea
    Biochem Biophys Res Commun 432:60-5. 2013
    ..Taken together, our data demonstrate that PRMT6 overexpression is associated with regulation of motility and invasion through up-regulation of TSP-1 and down-regulation of MMPs in human cancer cells...
  16. doi request reprint Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible factor-1α protein-dependent mechanism
    Soon Young Park
    Department of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Republic of Korea
    Int J Cancer 128:2306-16. 2011
    ..These findings will help to understand the mechanism of cancer progression by stress-induced catecholamines and design therapeutic strategies for cancer angiogenesis...
  17. doi request reprint 7-Diethylamino-3(2'-benzoxazolyl)-coumarin is a novel microtubule inhibitor with antimitotic activity in multidrug resistant cancer cells
    Su Nam Kim
    KIST Gangneung Institute, Gangneung, Republic of Korea
    Biochem Pharmacol 77:1773-9. 2009
    ..Taken together, these results describe a novel pharmacological property of DBC as a microtubule inhibitor, which may make it an attractive new agent for treatment of MDR cancer...
  18. doi request reprint Involvement of HDAC1 in E-cadherin expression in prostate cancer cells; its implication for cell motility and invasion
    Nam Hyun Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 404:915-21. 2011
    ..Collectively, our data demonstrate that HDAC1 is a major repressive enzyme for E-cadherin expression as well as HDAC inhibitor-mediated anti-invasiveness...
  19. doi request reprint Regulation of adipocyte differentiation by histone deacetylase inhibitors
    Su Nam Kim
    KIST Gangneung Institute, Gangneung, 210 340, Korea
    Arch Pharm Res 32:535-41. 2009
    ..Collectively, our results suggest that adipocyte differentiation and dedifferentiation may be regulated by HDAC inhibitors...
  20. doi request reprint Synthesis of curcumin mimics with multidrug resistance reversal activities
    Yumi Um
    College of Medicine, Kwandong University, Gangneung 210 701, Republic of Korea
    Bioorg Med Chem 16:3608-15. 2008
    ....
  21. doi request reprint Anti-mitotic potential of 7-diethylamino-3(2'-benzoxazolyl)-coumarin in 5-fluorouracil-resistant human gastric cancer cell line SNU620/5-FU
    Nam Hyun Kim
    Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210 701, Republic of Korea
    Biochem Biophys Res Commun 418:616-21. 2012
    ....
  22. ncbi request reprint Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells
    In Duk Jung
    College of Medicine, Konyang University, Nonsan 320 711, Korea
    Eur J Biochem 271:1557-65. 2004
    ..Taken together, these findings strongly indicated that PAK1 activation was necessary for LPA-induced cell motility and FAK phosphorylation that might be mediated by sequential activation of Gi protein, PI3Kgamma and Rac1/Cdc42...
  23. ncbi request reprint The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts
    Min Jeong Joe
    Marine Biomedical Research Center, Kwandong University College of Medicine, Korea
    Biol Pharm Bull 29:1735-9. 2006
    ....
  24. doi request reprint Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition
    Woojung Lee
    Natural Medicine Center, KIST Gangneung Institute, Gangneung, Korea
    BMB Rep 45:141-6. 2012
    ..Altogether, our findings strongly suggest that 2 compounds are novel PTP1B inhibitors and might be considered as anti-obesity agents that are effective for suppressing body weight gain and improving lipid homeostasis...
  25. ncbi request reprint Suppression of the NF-kappaB signalling pathway by ergolide, sesquiterpene lactone, in HeLa cells
    Jae Kwang Chun
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    J Pharm Pharmacol 59:561-6. 2007
    ..Taken together, our results suggest that ergolide suppresses NF-kappaB activation through the inhibition of PKCalpha-IKK activity, providing insight for PKCalpha as a molecular target for anti-inflammatory drugs...
  26. ncbi request reprint Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells
    Hoi Young Lee
    College of Medicine, Konyang University, 320 711, Nonsan, South Korea
    FEBS Lett 515:137-40. 2002
    ..Furthermore, stimulation of tumor cell motility by ATX was inhibited by catalytically inactive form of PI3Kgamma, strongly indicating the crucial role of PI3Kgamma for ATX-mediated motility in human melanoma cells..
  27. ncbi request reprint Oligosaccharide-linked acyl carrier protein, a novel transmethylase inhibitor, from porcine liver inhibits cell growth
    Dong Wan Seo
    Arch Pharm Res 25:463-8. 2002
    ..Therefore, O-ACP, a novel transmethylase inhibitor, could be a useful tool for elucidating the novel role of methylation in cell proliferation and cell cycle progression...
  28. ncbi request reprint Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway
    Yong Kee Kim
    Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    Oncogene 22:6023-31. 2003
    ..Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin...
  29. ncbi request reprint Hydrogen peroxide mediates arsenite activation of p70(s6k) and extracellular signal-regulated kinase
    Dong Keun Jung
    Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Korea
    Exp Cell Res 290:144-54. 2003
    ....
  30. ncbi request reprint Hydrogen peroxide mediates Rac1 activation of S6K1
    Gyu Un Bae
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, South Korea
    Exp Cell Res 300:476-84. 2004
    ..Taken together, these results suggest that H2O2 plays a pivotal role as a mediator in Rac1 activation of S6K1...
  31. ncbi request reprint Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites
    Soyoung Kim
    College of Pharmacy, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Biochem Biophys Res Commun 342:1168-73. 2006
    ..Our results demonstrate that regulation of histone modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent...
  32. ncbi request reprint Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells
    So Hee Kwon
    Department of Biochemistry and Molecular Biology, College of Pharmacy and Department of Genetic Engineering, College of Life Science and Natural Resources, Sungkyunkwan University, Suwon 440 746, Korea
    J Biol Chem 277:2073-80. 2002
    ....
  33. ncbi request reprint Constitutive activation of p70S6k in cancer cells
    Hyoung Keun Kwon
    Department of Biochemistry and Molecular Biology, College of Pharmacy, Sungkyunkwan University, Suwon, Korea
    Arch Pharm Res 25:685-90. 2002
    ....
  34. ncbi request reprint beta-Carboline alkaloid suppresses NF-kappaB transcriptional activity through inhibition of IKK signaling pathway
    Jong Woo Yoon
    College of Pharmacy, Sungkyunkwan University, Changan gu, Suwon, Korea
    J Toxicol Environ Health A 68:2005-17. 2005
    ..7 cells. Taken together, these results indicate that beta-carboline alkaloid has the capability to suppress NF-kappaB signaling pathway through inhibition of IKK activity in LPS-stimulated RAW 264.7 cells...