Yongkeun Park

Summary

Affiliation: Korea Advanced Institute of Science and Technology
Country: Korea

Publications

  1. pmc Anisotropic light scattering of individual sickle red blood cells
    Youngchan Kim
    Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 305 701, Republic of Korea
    J Biomed Opt 17:040501. 2012
  2. pmc Light scattering of human red blood cells during metabolic remodeling of the membrane
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 16:011013. 2011
  3. pmc Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient
    Heesu Byun
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Acta Biomater 8:4130-8. 2012
  4. pmc Measurement of the nonlinear elasticity of red blood cell membranes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051925. 2011
  5. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
  6. pmc Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing
    Zahid Yaqoob
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:10681-7. 2009
  7. pmc High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography
    Kyoohyun Kim
    Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 305 701, Republic of Korea
    J Biomed Opt 19:011005. 2014
  8. pmc Digital optical phase conjugation for delivering two-dimensional images through turbid media
    Timothy R Hillman
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 3:1909. 2013
  9. pmc Metabolic remodeling of the human red blood cell membrane
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1289-94. 2010
  10. pmc Measurement of red blood cell mechanics during morphological changes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:6731-6. 2010

Collaborators

Detail Information

Publications29

  1. pmc Anisotropic light scattering of individual sickle red blood cells
    Youngchan Kim
    Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 305 701, Republic of Korea
    J Biomed Opt 17:040501. 2012
    ..These results provide evidence that effective viscosity and elasticity of sickle RBCs are significantly different from those of the healthy RBCs...
  2. pmc Light scattering of human red blood cells during metabolic remodeling of the membrane
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 16:011013. 2011
    ..RBC cytosolic ATPs are both chemically and metabolically depleted, and the corresponding scattering signals are compared with the light scattering signal of normal RBCs having physiologic levels of ATP...
  3. pmc Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient
    Heesu Byun
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Acta Biomater 8:4130-8. 2012
    ....
  4. pmc Measurement of the nonlinear elasticity of red blood cell membranes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:051925. 2011
    ..As the cell swells, the elastic contribution from the now tensed lipid membrane becomes dominant...
  5. pmc Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
    Yongkeun Park
    Massachusetts Institute of Technology, G R Harrison Spectroscopy Laboratory, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    J Biomed Opt 15:020506. 2010
    ..Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering...
  6. pmc Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing
    Zahid Yaqoob
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Express 17:10681-7. 2009
    ..We present the detection of natural motions of cell surface and two-dimensional surface profiling of a HeLa cell...
  7. pmc High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography
    Kyoohyun Kim
    Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon 305 701, Republic of Korea
    J Biomed Opt 19:011005. 2014
    ..The in situ structural evolution and chemical characteristics of subcellular hemozoin crystals are also elucidated...
  8. pmc Digital optical phase conjugation for delivering two-dimensional images through turbid media
    Timothy R Hillman
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 3:1909. 2013
    ..By measuring the output response to digital distortion of the SLM write pattern, we validate the sub-wavelength sensitivity of the system...
  9. pmc Metabolic remodeling of the human red blood cell membrane
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1289-94. 2010
    ....
  10. pmc Measurement of red blood cell mechanics during morphological changes
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:6731-6. 2010
    ..This mechanical transition can alter cell circulation and impede oxygen delivery...
  11. pmc Measuring large optical transmission matrices of disordered media
    HyeonSeung Yu
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Phys Rev Lett 111:153902. 2013
    ..Our results comport with theoretical expectations, given the experimental limitations of the system. We consider the impact of these limitations on the usefulness of transmission matrices in optical measurements. ..
  12. pmc Label-free imaging of membrane potential using membrane electromotility
    Seungeun Oh
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biophys J 103:11-8. 2012
    ..We demonstrate wide-field imaging of the propagation of electrical stimuli in gap-junction-coupled cell networks. Membrane electromotility-induced cell deformation may be useful as a reporter of electrical activity...
  13. pmc Speckle-field digital holographic microscopy
    Yongkeun Park
    George R Harrison Spectroscopy Laboratory, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Opt Express 17:12285-92. 2009
    ..This technique has great potential in studying biological samples with improved sensitivity, resolution and optical sectioning capability...
  14. pmc Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells
    Yongkeun Park
    George R Harrison Spectroscopy Laboratory, MIT, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Opt Lett 34:3668-70. 2009
    ..The end point of this study is noninvasive monitoring of physiological states of intact living cells...
  15. pmc Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells
    Monica Diez-Silva
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Rep 2:614. 2012
    ....
  16. pmc Ultraviolet refractometry using field-based light scattering spectroscopy
    Dan Fu
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Opt Express 17:18878-86. 2009
    ..Typical accuracy of the present refractive index technique is <or=0.003. The precision of refractive index measurements is <or=0.002 and that of specific refractive index increment determination is <or=0.01 mL/g...
  17. pmc Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
    Yongkeun Park
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:13730-5. 2008
    ..These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases...
  18. doi request reprint Dynamic spectroscopic phase microscopy for quantifying hemoglobin concentration and dynamic membrane fluctuation in red blood cells
    Yunhun Jang
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon, 305 701 South Korea
    Opt Express 20:9673-81. 2012
    ..Using molecular specific dispersion, we demonstrate the extraction of Hb concentration and the dynamic membrane fluctuation from individual RBCs...
  19. doi request reprint Fourier-transform light scattering of individual colloidal clusters
    HyeonSeung Yu
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Opt Lett 37:2577-9. 2012
    ..The measured scattering patterns are consistent with simulated patterns calculated from the generalized multiparticle Mie solution...
  20. doi request reprint Polarization holographic microscopy for extracting spatio-temporally resolved Jones matrix
    Youngchan Kim
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Opt Express 20:9948-55. 2012
    ..We demonstrate the features of PHM with imaging the dynamics of liquid crystal droplets at a video-rate...
  21. pmc Angle-resolved light scattering of individual rod-shaped bacteria based on Fourier transform light scattering
    YoungJu Jo
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Sci Rep 4:5090. 2014
    ..In addition, the cellular dry mass of individual bacteria is calculated and used to demonstrate that the cell-to-cell variations in light scattering within bacterial species is related to the cellular dry mass and growth. ..
  22. pmc Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications
    Kyeoreh Lee
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Sensors (Basel) 13:4170-91. 2013
    ....
  23. ncbi request reprint Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy
    Christopher Fang-Yen
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Opt Lett 32:1572-4. 2007
    ..We use the microscope to image cultured neurons and measure nanometer-scale voltage-dependent motions in cells expressing the membrane motor protein prestin...
  24. ncbi request reprint Fresnel particle tracing in three dimensions using diffraction phase microscopy
    Yongkeun Park
    GR Harrison Spectroscopy Laboratory, Massachusettes Institute of Technology, Cambridge, Massachusettes 02139, USA
    Opt Lett 32:811-3. 2007
    ..The particles are localized in space within an error cube of 20 nm x 20 nm x 20 nm for a 33 Hz acquisition rate and 20s recording time...
  25. doi request reprint Active spectral filtering through turbid media
    Jung Hoon Park
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Opt Lett 37:3261-3. 2012
    ..Given the linearity of the transmission matrix, multiple foci with different wavelengths can also be simultaneously constructed...
  26. pmc Simple super-resolution live-cell imaging based on diffusion-assisted Förster resonance energy transfer
    Sangyeon Cho
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Sci Rep 3:1208. 2013
    ..Due to the simplicity of this approach, we expect that the proposed method will prove an attractive option for super-resolution imaging...
  27. doi request reprint Optical imaging techniques for the study of malaria
    Sangyeon Cho
    Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, 305 701, Republic of Korea
    Trends Biotechnol 30:71-9. 2012
    ....
  28. doi request reprint Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging
    Jae Hwang Jung
    Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Anal Chem 85:10519-25. 2013
    ..With unprecedented precision and sensitivity, we demonstrate the quantitative spectroscopic microrefractometry of individual polystyrene beads, 30% bovine serum albumin solution, and healthy human red blood cells. ..
  29. doi request reprint Fourier transform light scattering angular spectroscopy using digital inline holography
    Kyoohyun Kim
    Department of Physics, Korea Advanced Institutes of Science and Technology KAIST, Daejeon 305701, Korea
    Opt Lett 37:4161-3. 2012
    ..Using the present method, an existing microscope can be directly transformed into a precise instrument for ARLS measurements...