Affiliation: Korea Institute of Science and Technology
Lim S, Haque M, Nam G, Ryoo N, Rhim H, Kim Y. Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors. Int J Mol Sci. 2015;16:20212-24 pubmed publisher
..Our results demonstrated the protective role of OGT in tau aggregation and also suggest the counter-regulatory mechanism of OGA and OGT in tau pathology. ..
Kim J, Keum G, Chung H, Nam G. Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment. Eur J Med Chem. 2016;123:665-672 pubmed publisher
..Compounds 9a and 9b displayed better efficacy than mibefradil and gabapentin against cold allodynia. In particular, compound 9a seemed to be valuable as shown fast acting performance in mechanical neuropathic pain model. ..
Kim J, Nam G. Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain. Bioorg Med Chem. 2016;24:5028-5035 pubmed publisher
..Compounds 10d and 10e contained hydrophobic substituents at the 3N-position and exhibited potent in vitro efficacy, as well as neuropathic pain alleviation in rats. ..
Hong J, Choi Y, Keum G, Nam G. Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives. Bioorg Med Chem. 2017;25:4677-4685 pubmed publisher
..The maximum efficacy of compound 10, which was 3-fold more potent than gabapentin, was observed at 1h after administration, and co-administration of compound 10 with gabapentin showed a considerable synergic effect. ..
Hong J, Choo H, Nam G. Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2017;27:4146-4149 pubmed publisher
..Among them, selected compounds, 12 and 13, having 8-quinoylsulfonamino groups, showed potent neuropathic pain-alleviating effects in the rat model. ..