Sung Joon Lee
Affiliation: Korea University
Wu C, Thach T, Kim Y, Lee S. Olfactory receptor 43 reduces hepatic lipid accumulation and adiposity in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:489-499 pubmed publisher
..The knockdown of Olfr43 gene expression in cultured hepatocytes negated these effects of (-)-carvone. In conclusion, an ectopic olfactory receptor, hepatic Olfr43, regulates energy metabolism via the CREB-HES1-PPARγ signaling axis. ..
Lee S, Depoortere I, Hatt H. Therapeutic potential of ectopic olfactory and taste receptors. Nat Rev Drug Discov. 2018;: pubmed publisher
..This Review outlines current understanding of the diverse functions of ectopic olfactory and taste receptors and assesses their potential to be therapeutically exploited. ..
Jo D, Lee J, Jun H, Kim J, Wen Q, Hoang M, et al
. Gene expression profiles of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. Genet Mol Res. 2015;14:1855-67 pubmed publisher
..These results suggest that specific genes associated with lipid metabolism and angiogenesis are involved in the pathogenesis and progression of AMD. ..
Seo W, Lee J, Jia Y, Wu C, Lee S. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. Bioorg Med Chem Lett. 2015;25:5237-42 pubmed publisher
..Collectively, these results suggest that saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake. ..
Jia Y, Wu C, Kim J, Kim B, Lee S. Astaxanthin reduces hepatic lipid accumulations in high-fat-fed C57BL/6J mice via activation of peroxisome proliferator-activated receptor (PPAR) alpha and inhibition of PPAR gamma and Akt. J Nutr Biochem. 2016;28:9-18 pubmed publisher
..In addition to the previously reported differential regulation of PPARÎ± and PPARÎ³, inhibition of Akt activity and activation of hepatic autophagy reduced hepatic steatosis in mouse livers. ..
Thach T, Lee C, Park H, Lee S, Lee S. Syringaresinol induces mitochondrial biogenesis through activation of PPAR? pathway in skeletal muscle cells. Bioorg Med Chem Lett. 2016;26:3978-83 pubmed publisher
..Taken together, our results indicate that syringaresinol induces mitochondrial biogenesis by activating PPAR? pathway. ..
Yang M, Lee G, Si J, Lee S, You H, Ko G. Curcumin Shows Antiviral Properties against Norovirus. Molecules. 2016;21: pubmed
..Our results demonstrated that CCM may be a promising candidate for development as an anti-noroviral agent to prevent outbreaks of foodborne illness. ..
Wu C, Jia Y, Lee J, Kim Y, Sekharan S, Batista V, et al
. Activation of OR1A1 suppresses PPAR-Î³ expression by inducing HES-1 in cultured hepatocytes. Int J Biochem Cell Biol. 2015;64:75-80 pubmed publisher
..These results indicate that OR1A1 may function as a non-redundant receptor in hepatocytes that regulates the PKA-CREB-HES-1 signaling axis and thereby modulates hepatic triglyceride metabolism. ..
Hoang M, Jia Y, Mok B, Jun H, Hwang K, Lee S. Kaempferol ameliorates symptoms of metabolic syndrome by regulating activities of liver X receptor-Î². J Nutr Biochem. 2015;26:868-75 pubmed publisher
..They also suggest that kaempferol activates LXR-Î² and suppresses SREBP-1 to enhance symptoms in metabolic syndrome. ..