Kyung Mi Lee

Summary

Affiliation: Korea University
Country: Korea

Publications

  1. ncbi request reprint Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells
    Kyung Mi Lee
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:4881-5. 2003
  2. pmc 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells
    Kyung Mi Lee
    Department of Biochemistry, Korea University College of Medicine, Sungbuk Gu, Anam Dong, Seoul 136 705, Korea
    J Exp Med 199:1245-54. 2004
  3. ncbi request reprint Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
    Kyung Mi Lee
    Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea Seoul 136 705, Korea
    Exp Mol Med 38:703-17. 2006
  4. pmc Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions
    Kyung Mi Lee
    Department of Pathology, University of Chicago, IL, USA
    Blood 107:3181-8. 2006
  5. doi request reprint Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells
    Eun Ok Kim
    Global Research Lab, Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Graduate School of Medicine, Korea University College of Medicine, Seoul, Korea
    J Leukoc Biol 88:707-14. 2010
  6. doi request reprint Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy
    Seon Ah Lim
    Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea
    Cancer Res 73:2598-607. 2013
  7. ncbi request reprint 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells
    Megan E McNerney
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Mol Immunol 42:489-94. 2005
  8. pmc Suppression of human anti-porcine natural killer cell xenogeneic responses by combinations of monoclonal antibodies specific to CD2 and NKG2D and extracellular signal-regulated kinase kinase inhibitor
    Tae Jin Kim
    Global Research Lab, Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Seoul, Korea
    Immunology 130:545-55. 2010
  9. doi request reprint FK506 causes cellular and functional defects in human natural killer cells
    Tae Jin Kim
    Global Research Lab, Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Seoul, Korea
    J Leukoc Biol 88:1089-97. 2010
  10. pmc Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2
    Chung Hee Sonn
    Global Research Lab, BAERI Institute, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136 705, Korea
    J Radiat Res 53:823-9. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells
    Kyung Mi Lee
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:4881-5. 2003
    ..Therefore, 2B4 functions as a costimulator of CD8(+) T cells in MHC-restricted cytotoxicity. We conclude that 2B4/CD48 interactions among T cells themselves can augment CTL lysis of their specific targets...
  2. pmc 2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells
    Kyung Mi Lee
    Department of Biochemistry, Korea University College of Medicine, Sungbuk Gu, Anam Dong, Seoul 136 705, Korea
    J Exp Med 199:1245-54. 2004
    ..This indicates that 2B4 inhibitory signaling occurs regardless of the presence of SH2D1A. These findings reveal a novel role for 2B4 as a non-major histocompatibility complex binding negative regulator of NK cells...
  3. ncbi request reprint Tyrosine phosphatase and cytochrome P450 activity are critical in regulating store-operated calcium channels in human fibroblasts
    Kyung Mi Lee
    Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Korea Seoul 136 705, Korea
    Exp Mol Med 38:703-17. 2006
    ..Thus, multiple pathways do operate in a single cell type leading to the activation of Ca2+ entry and some of these signaling pathways are more prominently involved in regulating calcium entry in different cell types...
  4. pmc Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions
    Kyung Mi Lee
    Department of Pathology, University of Chicago, IL, USA
    Blood 107:3181-8. 2006
    ..Thus, these data identify a novel mechanism whereby NK effector function is regulated via homotypic 2B4/CD48 interactions...
  5. doi request reprint Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells
    Eun Ok Kim
    Global Research Lab, Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Graduate School of Medicine, Korea University College of Medicine, Seoul, Korea
    J Leukoc Biol 88:707-14. 2010
    ..Therefore, our results demonstrate unequivocally that CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice...
  6. doi request reprint Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy
    Seon Ah Lim
    Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea
    Cancer Res 73:2598-607. 2013
    ....
  7. ncbi request reprint 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells
    Megan E McNerney
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Mol Immunol 42:489-94. 2005
    ..In this review we will discuss the significance of these multiple functions and the events that may regulate differential 2B4 signaling outcome...
  8. pmc Suppression of human anti-porcine natural killer cell xenogeneic responses by combinations of monoclonal antibodies specific to CD2 and NKG2D and extracellular signal-regulated kinase kinase inhibitor
    Tae Jin Kim
    Global Research Lab, Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Seoul, Korea
    Immunology 130:545-55. 2010
    ....
  9. doi request reprint FK506 causes cellular and functional defects in human natural killer cells
    Tae Jin Kim
    Global Research Lab, Department of Biochemistry and Division of Brain Korea 21 Program for Biomedical Science, Korea University College of Medicine, Seoul, Korea
    J Leukoc Biol 88:1089-97. 2010
    ..Thus, our data provide a new insight into the mechanism of immunosuppression by FK506, which should be considered to interpret the outcome of graft transplantation...
  10. pmc Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2
    Chung Hee Sonn
    Global Research Lab, BAERI Institute, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136 705, Korea
    J Radiat Res 53:823-9. 2012
    ....
  11. doi request reprint Clusterin synergizes with IL-2 for the expansion and IFN-γ production of natural killer cells
    Chung Hee Sonn
    Korea University College of Medicine, 126 1 Anam dong 5 ga, Seongbuk gu, Seoul, Korea
    J Leukoc Biol 88:955-63. 2010
    ..Therefore, the role of CLU on NK cells should be taken into consideration for the previously observed, diverse functions of CLU in chronic inflammatory and autoimmune conditions...
  12. ncbi request reprint Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis
    Nitin J Karandikar
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390 9072, USA
    Blood 104:2007-9. 2004
    ..This case provides an instructive example of uncontrolled reactive proliferation of CD8+ T cells in FHL, resulting in atypical morphology and unusual immunophenotypic features that might suggest malignancy in other clinical settings...
  13. doi request reprint Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages
    Young Jun Shim
    Department of Pharmacology and Biochemistry, College of Medicine, Korea
    J Leukoc Biol 90:761-9. 2011
    ..Collectively, these data highlight a novel role of clusterin as a stimulator for MMP-9 expression in macrophages, which may contribute to the tissue reorganization by serving as a modulator for ECM degradation...
  14. ncbi request reprint The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat
    Kyounghwa Lee
    Department of Biochemistry, College of Medicine, Korea University, Seoul, Korea
    Exp Mol Med 36:563-71. 2004
    ..Taken together, we have identified the proliferation event associated-methylation of the nuclear p16 protein in the hepatocytes undergoing liver regeneration...
  15. ncbi request reprint Mutations of the immunoglobulin heavy chain variable region gene in CD99-deficient BJAB cell line
    Young Ho Suh
    Department of Pathology, Seoul National University College of Medicine, Korea
    Mol Cells 13:237-44. 2002
    ..We expect that the analysis of the mutation pattern of the CD99-deficient BJAB cell line might be the basis for the understanding of the molecular and cellular mechanism that regulate somatic mutation and B cell selection...
  16. doi request reprint Single step isolation and activation of primary CD3+ T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers
    Kwanghee Kim
    Global Research Lab, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136 713, Korea
    Nano Lett 12:4018-24. 2012
    ....
  17. doi request reprint Isolation and expansion of synovial CD34(-)CD44(+)CD90(+) mesenchymal stem cells: comparison of an enzymatic method and a direct explant technique
    Dae Hee Lee
    Department of Orthopaedic Surgery, Korea University College of Medicine, Seoul, Korea
    Connect Tissue Res 52:226-34. 2011
    ..Because the explant technique is simpler and less invasive, it may be preferred over enzymatic techniques for isolating MSCs from the synovium of osteoarthritic patients for cartilage regeneration...
  18. pmc Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2
    Eun Ok Kim
    Department of Biochemistry, Division of Brain Korea 21 Program for Biomedical Science, Global Research Lab, Korea University College of Medicine, Seoul, Korea
    J Biol Chem 285:41755-64. 2010
    ..Collectively, these results reveal the importance of homotypic NK-to-NK cell cross-talk through 2B4/CD48 and CD2/CD58 pairs and further present their differential and overlapping roles in human NK cells...
  19. doi request reprint Novel streptavidin-functionalized silicon nanowire arrays for CD4+ T lymphocyte separation
    Sung Tae Kim
    Global Research Laboratory, Department of Biochemistry, Division of Brain Korea, College of Medicine, Korea University, Seoul 136 701, Korea
    Nano Lett 10:2877-83. 2010
    ..Thus, our STR-SiNW arrays provide a potential tool for specific cell separation and further present a possibility to be applied to the other area of biomedical applications...
  20. doi request reprint The effect of radiation on the immune response to cancers
    Bonggoo Park
    Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, 126 1 Anam dong 5 ga, Seongbuk gu, Seoul 136 713, Korea
    Int J Mol Sci 15:927-43. 2014
    ....
  21. doi request reprint Partial role of TLR4 as a receptor responding to damage-associated molecular pattern
    Kyung Mi Lee
    Department of Biochemistry, Korea University College of Medicine, Seoul, Republic of Korea
    Immunol Lett 125:31-9. 2009
    ..Therefore, endogenous DAMP ligands themselves, not contaminated LPS, activate TLR4 signaling leading to activation of professional antigen-presenting cells...
  22. doi request reprint Synthesis of streptavidin-FITC-conjugated core-shell Fe3O4-Au nanocrystals and their application for the purification of CD4+ lymphocytes
    Hong Ling Liu
    Research Institute of Engineering and Technology, Korea University, Seoul 136 713, Republic of Korea
    Biomaterials 29:4003-11. 2008
    ....
  23. ncbi request reprint Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells
    Swapnil V Vaidya
    Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Immunol 174:800-7. 2005
    ..In vitro and in vivo experiments reveal a complex role of NK cells in gender specificity...
  24. ncbi request reprint Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients
    June Chul Lee
    Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 744, Korea
    J Immunol 172:7335-40. 2004
    ..Taken together, our data suggest that impaired NK function in cancer patients can be attributed to down-modulation of activating receptors, such as NKG2D, via secretion of TGF-beta1...
  25. ncbi request reprint Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation
    Ji Hye Seong
    National Research Laboratory for Drug and Gene Delivery, College of Pharmacy, Seoul National University, Seoul, Korea 151 742
    J Gene Med 8:314-23. 2006
    ....
  26. ncbi request reprint Molecular mechanisms underlying calcium current modulation by nociceptin
    Kyu Young Yeon
    Department of Physiology, College of Dentistry and Dental Research Institute, Seoul National University, Seoul 110 749, Korea
    Neuroreport 15:2205-9. 2004
    ..Thus, our results strongly demonstrate that heterologous cross-talk between ORL1 and muOR is not involved in the ICa inhibition by nociceptin...
  27. ncbi request reprint Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia
    Seung Hoon Lee
    Department of Neurology, National University, Seoul, Republic of Korea
    Stroke 35:2195-9. 2004
    ..1 protein after cerebral ischemia. To evaluate the role of HSP70.1 protein in ischemia, we analyzed the mitochondrial apoptotic pathway using hsp70.1 knockout (KO) mice and their wild-type (WT) mice...
  28. ncbi request reprint Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: in vitro characterization and in vivo factors affecting biodistribution
    Chung Gyu Park
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    Pharm Res 20:1239-48. 2003
    ..We hypothesized that by conjugating CTLA4Ig to liposomes the efficacy of CTLA4Ig could be enhanced through multivalent ligand effect, superior targetability, and modification of the fate of ligated costimulatory molecules...