Genomes and Genes


Chul Ho Lee


Affiliation: Korea Research Institute of Bioscience and Biotechnology
Country: Korea


  1. Cho S, Noh J, Cho M, Go M, Kim Y, Kang E, et al. An injectable collagen/poly(?-glutamic acid) hydrogel as a scaffold of stem cells and ?-lipoic acid for enhanced protection against renal dysfunction. Biomater Sci. 2017;5:285-294 pubmed publisher
    ..These findings suggested that this novel type of hydrogel could be applied as an injectable scaffold for use in regenerative medicine. ..
  2. Lee H, Dhodary B, Lee J, An J, Ryu Y, Kim K, et al. Dereplication of Components Coupled with HPLC-qTOF-MS in the Active Fraction of Humulus japonicus and It's Protective Effects against Parkinson's Disease Mouse Model. Molecules. 2019;24: pubmed publisher
    ..HJF, including active components leads to an improvement of motor behavior in a Parkinson's disease mouse model. ..
  3. Noh J, Kim Y, Kim D, Hwang J, Kim K, Choi D, et al. Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation. Sci Rep. 2018;8:15222 pubmed publisher
    ..Collectively, SHP regulates Cxcl2 transcription in hepatocytes, playing a pivotal role in the recruitment of neutrophils. SHP-targeting strategies may represent alternative approaches to control fulminant hepatitis. ..
  4. Kim Y, Hwang J, Kim K, Noh J, Choi D, Kim D, et al. Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. J Hepatol. 2015;63:75-82 pubmed publisher
    ..Metformin would be a promising therapeutic strategy for treatment of APAP overdose. ..
  5. Noh J, Kim Y, Hwang J, Choi D, Kim K, Oh W, et al. Sulforaphane protects against acetaminophen-induced hepatotoxicity. Food Chem Toxicol. 2015;80:193-200 pubmed publisher
    ..These results suggest that SFN plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. SFN has preventive action in oxidative stress-mediated liver injury. ..
  6. Kim Y, Noh J, Hwang J, Kim K, Choi D, Kim J, et al. Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45?-dependent manner. Arch Toxicol. 2018;92:2563-2572 pubmed publisher
    ..SHP is suggested to be a novel therapeutic target for APAP overdose treatment. ..
  7. Ryu Y, Park H, Go J, Kim Y, Hwang J, Choi D, et al. Effects of histone acetyltransferase inhibitors on L-DOPA-induced dyskinesia in a murine model of Parkinson's disease. J Neural Transm (Vienna). 2018;125:1319-1331 pubmed publisher
    ..Our findings indicate that HAT inhibitor co-treatment with L-DOPA may have therapeutic potential for management of L-DOPA-induced dyskinesia in patients with PD. ..
  8. Gang G, Hwang J, Kim Y, Noh J, Kim K, Jeong J, et al. Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice. Free Radic Biol Med. 2014;67:139-49 pubmed publisher
    ..These results provide convincing evidence that NQO1 activation might be beneficial for ameliorating renal injury induced by I/R. ..
  9. Hwang J, Kim Y, Noh J, Gang G, Kim K, Chung H, et al. The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction. Arch Toxicol. 2015;89:2159-66 pubmed publisher

More Information


  1. Park H, Ryu Y, Kim Y, Park T, Go J, Hwang J, et al. Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model. Neurobiol Dis. 2016;89:169-79 pubmed publisher
    ..These data suggest that the increased expression of Gadd45β induced by repeated administration of L-DOPA may be beneficial in patients with PD. ..
  2. Han J, Li H, Cho M, Baek S, Lee C, Park H, et al. Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-Like Factor 2 and Adhesion Molecules. Int J Mol Sci. 2017;18: pubmed publisher
    ..These results suggest that ESL supplementation has potential for preventing HCD-induced atherosclerosis effectively. ..
  3. Ryu Y, Park H, Go J, Choi D, Kim Y, Hwang J, et al. Metformin Inhibits the Development of L-DOPA-Induced Dyskinesia in a Murine Model of Parkinson's Disease. Mol Neurobiol. 2018;55:5715-5726 pubmed publisher
    ..These findings suggest that metformin may have therapeutic potential for the suppression or management of L-DOPA-induced motor complications in patients with PD. ..