Hyunggee Kim

Summary

Affiliation: Korea University
Country: Korea

Publications

  1. Jin X, Jin X, Kim L, Dixit D, Jeon H, Kim E, et al. Inhibition of ID1-BMPR2 Intrinsic Signaling Sensitizes Glioma Stem Cells to Differentiation Therapy. Clin Cancer Res. 2018;24:383-394 pubmed publisher
    ..i>Clin Cancer Res; 24(2); 383-94. ©2017 AACR. ..
  2. Jeon H, Ham S, Kim J, Jin X, Lee S, Shin Y, et al. Ly6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model. Cell Death Differ. 2019;: pubmed publisher
    ..Together, our results illustrate important roles for Ly6G+ inflammatory cells recruited by radiation-induced SASP in cancer cell dedifferentiation and tumor recurrence. ..
  3. Ham S, Kim J, Jeon H, Kim E, Jin X, Eun K, et al. Korean Red ginseng extract inhibits glioblastoma propagation by blocking the Wnt signaling pathway. J Ethnopharmacol. 2019;236:393-400 pubmed publisher
    ..Therefore, our observations imply that RG could be applied to the GBM patients in parallel with CCRT to enhance therapeutic efficacy. ..
  4. Eun K, Park M, Jeong Y, Jeong Y, Hyun S, Hwang W, et al. Establishment of TP53-knockout canine cells using optimized CRIPSR/Cas9 vector system for canine cancer research. BMC Biotechnol. 2019;19:1 pubmed publisher
    ..Thus, we suggest our CRISPR/Cas9-derived canine TP53 knockout cells as a useful platform to reveal novel oncogenic functions and effects of developing anti-cancer therapeutics. ..
  5. Ham S, Jeon H, Jin X, Kim E, Kim J, Shin Y, et al. TP53 gain-of-function mutation promotes inflammation in glioblastoma. Cell Death Differ. 2019;26:409-425 pubmed publisher
    ..Taken together, our findings suggest that the TP53 GOF mutation plays a crucial role in inflammatory responses, thereby deteriorating prognostic outcomes in patients with GBM. ..
  6. Jeon H, Kim S, Jin X, Park J, Kim S, Joshi K, et al. Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression. Cancer Res. 2014;74:4482-92 pubmed publisher
    ..Thus, targeting the PDGF-NOS-ID4-miR129 axis and NOTCH activity in the perivascular microenvironment might serve as an efficacious therapeutic modality for glioblastoma. ..
  7. Park C, Sohn Y, Kim E, Kim S, Kim S, Kim H. LIM domain only 2 induces glioma invasion via cytosolic p27(KIP1). Tumour Biol. 2016;37:2473-80 pubmed publisher
    ..Taken together, our findings indicate that LMO2 promotes glioma cell migration and invasion by increasing the levels of cytosolic p27(Kip1). ..
  8. Jeon H, Kim J, Ham S, Oh S, Kim J, Park J, et al. Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype. Tumour Biol. 2016;37:5857-67 pubmed publisher
    ..Taken together, our findings suggest that the increases in senescent cells and SASP in GBM cells after irradiation is likely one of main reasons for tumor recurrence in post-radiotherapy GBM patients. ..
  9. Jin X, Jeon H, Jin X, Kim E, Yin J, Jeon H, et al. The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells. Cell Rep. 2016;16:1629-1641 pubmed publisher
    ..Taken together, a loss of CULLIN3 represents a common signaling node for controlling the activity of intracellular WNT and SHH signaling pathways mediated by ID1. ..

More Information

Publications12

  1. Kim J, Jeon H, Jeon H, Oh S, Kim E, Jin X, et al. Conversion of glioma cells to glioma stem-like cells by angiocrine factors. Biochem Biophys Res Commun. 2018;496:1013-1018 pubmed publisher
    ..Taken together, our results reveal the molecular mechanism underlying GSCs generation by cancer cell dedifferentiation. ..
  2. Eun K, Jeon H, Kim S, Choi S, Lee S, Jin X, et al. A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells. Biochem Biophys Res Commun. 2017;486:564-570 pubmed publisher
  3. Oh H, Jin X, Kim J, Oh M, Pian X, Kim J, et al. Characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs. BMC Cell Biol. 2007;8:20 pubmed
    ..These results suggest that p53 signaling might be a major determinant for the replicative senescence in the MPF cells that have the shorter lifespan and slower growth rate compared to PF cells in vitro. ..