Ho Min Kim
Affiliation: Korea Advanced Institute of Science and Technology
Lee J, Kim C, Yang H, Park I, Oh N, Hua S, et al
. Novel glycosylated VEGF decoy receptor fusion protein, VEGF-Grab, efficiently suppresses tumor angiogenesis and progression. Mol Cancer Ther. 2015;14:470-9 pubmed publisher
..Collectively, our results highlight VEGF-Grab as a promising therapeutic candidate for further clinical drug development. ..
Won S, Lee P, Kim H. Synaptic organizer: Slitrks and type IIa receptor protein tyrosine phosphatases. Curr Opin Struct Biol. 2019;54:95-103 pubmed publisher
..Here, we will discuss key structural aspects of Slitrk interactions with type IIa RPTP family members, the biological roles of Slitrks in neurons, and our current knowledge of SLITRK mutations in human diseases. ..
Kang J, Choi Y, Cui C, Lee D, Kim S, Kim H. Pro-angiogenic Ginsenosides F1 and Rh1 Inhibit Vascular Leakage by Modulating NR4A1. Sci Rep. 2019;9:4502 pubmed publisher
..These findings demonstrate that ginsenosides F1 and Rh1 can be a promising herbal remedy for vessel normalization in ischemic disease and cancer and that NR4A1 is the key target. ..
Kim H, Kim Y. HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis. Immunity. 2018;49:582-584 pubmed publisher
..In this issue of Immunity, Deng et al. (2018) report that high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into the cytoplasm and mediates pyroptosis. ..
Lee D, Lee M, Seo Y, Hong H, An H, Kang J, et al
. Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities. Biomaterials. 2018;171:34-45 pubmed publisher
..These results indicate that multi-paratopic VEGF decoy receptor can be a promising agent, combining tumor-targeted anti-angiogenic therapy with efficient blockade of proliferative signals mediated by EGFR family. ..
Ryu J, Kim S, Rah S, Kang J, Jung H, Lee D, et al
. Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer. Immunity. 2017;46:38-50 pubmed publisher
..The definition of the structural determinants of the LPS transfer cascade to TLR4 may enable the development of targeted therapeutics for intervention in LPS-induced sepsis. ..
Kim J, Kim D, Won S, Han K, Park D, Cho E, et al
. Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex. Neuron. 2017;94:1121-1131.e6 pubmed publisher
..However, MDGA1 selectively associated with NL2, but not NL1, in vivo. These findings collectively provide structural insights into the mechanism by which MDGAs negatively modulate synapse development governed by NLs/neurexins. ..
Seo B, Lee J, Kim H, Kang M. Neuronal calcium channel Î±1 subunit interacts with AMPA receptor, increasing its cell surface localisation. Biochem Biophys Res Commun. 2018;498:402-408 pubmed publisher
..The Î±1 subunit increased the cell-surface localisation of the AMPA-R, which could be a post-synaptic function of the Cav2. ..