Research Topics
Genomes and Genes
| Eunjoon KimSummaryAffiliation: Korea Advanced Institute of Science and Technology Country: Korea Publications
| Collaborators
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Detail Information
Publications
PDZ domain proteins of synapsesEunjoon Kim
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yuseong Gu, Daejeon 305 701, Korea
Nat Rev Neurosci 5:771-81. 2004..As key organizers that control synaptic protein composition and structure, PDZ scaffolds are themselves highly regulated by synthesis and degradation, subcellular distribution and post-translational modification...- Molecular organization and assembly of the postsynaptic density of excitatory brain synapsesEunjoon Kim
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
Results Probl Cell Differ 43:1-23. 2006..PSD proteins associate with diverse motor proteins, suggesting that they function as adaptors linking motors to their specific cargoes... - Interaction between liprin-alpha and GIT1 is required for AMPA receptor targetingJaewon Ko
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 23:1667-77. 2003..These results suggest that the GIT1-liprin-alpha interaction is required for AMPA receptor targeting and that GIT1 may play an important role in the organization of presynaptic and postsynaptic multiprotein complexes... - Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteinsJaewon Ko
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 278:42377-85. 2003..These results suggest that the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones... 
Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesisHyun Woo Lee
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 28:14546-56. 2008..These results suggest that Preso positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, PSD-95, and the betaPix-based Rac1 signaling pathway...- NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formationSeho Kim
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
Nat Neurosci 9:1294-301. 2006..NGL-2 knockdown reduced excitatory, but not inhibitory, synapse numbers and currents. These results suggest that NGL regulates the formation of excitatory synapses... - The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42Eunhye Park
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 278:19220-9. 2003..Considering the involvement of Rac1 and PAK in spine dynamics, these results suggest that Shank recruits beta PIX and PAK to spines for the regulation of postsynaptic structure... - Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapsesJooyeon Woo
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea
Nat Neurosci 12:428-37. 2009..Competitive inhibition by soluble LAR reduced NGL-3-induced presynaptic differentiation. These results suggest that the trans-synaptic adhesion between NGL-3 and LAR regulates excitatory synapse formation in a bidirectional manner... - ARF6 and EFA6A regulate the development and maintenance of dendritic spinesSeungwon Choi
National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 26:4811-9. 2006..ARF6 and EFA6A protect mature spines from inactivity-induced destabilization. These results suggest that ARF6 and EFA6A may regulate the conversion of filopodia to spines and the stability of both early and mature spines... - Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPasesJeonghoon Choi
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 25:869-79. 2005..These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis... - Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteinsDaeyoung Oh
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 30:14134-44. 2010..These results suggest that BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions... - Association of the kinesin motor KIF1A with the multimodular protein liprin-alphaHyewon Shin
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 278:11393-401. 2003..These results suggest that liprin-alpha functions as a KIF1A receptor, linking KIF1A to various liprin-alpha-associated proteins for their transport in neurons... 
Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTDKihoon Han
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PLoS Biol 7:e1000187. 2009..This suggests that scaffolding proteins at specialized cellular junctions can switch their function from maintenance to endocytosis of interacting membrane proteins in a regulated manner...- SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapsesJaewon Ko
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST, Daejeon 305-701, Korea
Neuron 50:233-45. 2006..These results suggest that SALM2 is an important regulator of the differentiation of excitatory synapses... - Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteinsSeungnam Han
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 30:15102-12. 2010..TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development... - DGKι regulates presynaptic release during mGluR-dependent LTDJinhee Yang
Department of Biological Sciences, National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Korea
EMBO J 30:165-80. 2011..These results suggest that DGKι requires PSD-95 family proteins for synaptic localization and regulates presynaptic DAG signalling and neurotransmitter release during mGluR-LTD... - Characterization of the movement of the kinesin motor KIF1A in living cultured neuronsJae Ran Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 278:2624-9. 2003..These results suggest that KIF1A mediates neuronal transport at a high velocity and processivity in vivo... - Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteinsHyejung Mok
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 22:5253-8. 2002..These results suggest that the PSD-95 family proteins and S-SCAM have a novel function as KIF1Balpha receptors, linking KIF1Balpha to its specific cargos, and are involved in peripheral neuropathies... - Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenanceKaram Kim
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Yuseong Gu, Daejeon, Republic of Korea
EMBO J 28:1170-9. 2009..We propose that PSD-95 targets DGKzeta to synaptic DAG-producing receptors to tightly couple synaptic DAG production to its conversion to PA for the maintenance of spine density... - An intramolecular interaction between the FHA domain and a coiled coil negatively regulates the kinesin motor KIF1AJae Ran Lee
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
EMBO J 23:1506-15. 2004..These results suggest that the intramolecular FHA-CC2 interaction negatively regulates KIF1A activity by inhibiting MT binding and dimerization of KIF1A, and point to a novel role of the FHA domain in the regulation of kinesin motors... - The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein PiccoloSeho Kim
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 278:6291-300. 2003..These results suggest that, through their multimerization and interaction with Piccolo, the GIT family proteins are involved in the organization of the CAZ... - Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formationWon Mah
National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
J Neurosci 30:5559-68. 2010..These results suggest that selected SALM family proteins regulate synapse formation, and that SALM3 and SALM5 may promote synapse formation through distinct mechanisms... - The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion moleculesJungyong Nam
National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
Semin Cell Dev Biol 22:492-8. 2011..In addition to these functional diversities, the fifth member of the SALM family, SALM5/Lrfn5, has recently been implicated in severe progressive autism and familial schizophrenia, pointing to the clinical importance of SALMs... - Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1Jaewon Ko
National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 26:963-70. 2006.... - Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formationSeok Kyu Kwon
National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701
J Biol Chem 285:13966-78. 2010..These results suggest that trans-synaptic adhesion between NGL-3 and the three LAR family proteins regulates excitatory synapse formation in shared and distinct neural circuits... - The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal trafficHyun Woo Lee
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 30:5508-18. 2010..These results suggest that PSD-95-interacting MTMR2 contributes to the maintenance of excitatory synapses by inhibiting excessive endosome formation and destructive endosomal traffic to lysosomes... - Clustering assay for studying the interaction of membrane proteins with PDZ domain proteinsJaewon Ko
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
Methods Mol Biol 332:245-53. 2006..This chapter describes the experimental details of the clustering assay, using the interaction between potassium channels and PSD-95, an abundant PDZ domain protein in neuronal synapses, as a model... - GIT1 is associated with ADHD in humans and ADHD-like behaviors in miceHyejung Won
Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Korea
Nat Med 17:566-72. 2011..Our study identifies a previously unknown involvement of GIT1 in human ADHD and shows that GIT1 deficiency in mice causes psychostimulant-responsive ADHD-like phenotypes... - The NGL family of leucine-rich repeat-containing synaptic adhesion moleculesJooyeon Woo
National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
Mol Cell Neurosci 42:1-10. 2009.... - Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53Myoung Hwan Kim
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 29:1586-95. 2009..These results suggest that IRSp53 is involved in the regulation of NMDA receptor-mediated excitatory synaptic transmission, LTP, and learning and memory behaviors... - Analysis of PDZ domain interactions using yeast two-hybrid and coimmunoprecipitation assaysHyun Woo Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
Methods Mol Biol 332:233-44. 2006..In addition, we discuss the features that must be considered for an efficient analysis of PDZ interactions... - Diacylglycerol kinases in the regulation of dendritic spinesKaram Kim
Department of Biological Sciences and National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
J Neurochem 112:577-87. 2010..In addition, DGKzeta appears to form a multi-protein complex with functionally related proteins to organize efficient DAG and PA signaling pathways at excitatory synapses... - Synaptic adhesion molecules and PSD-95Kihoon Han
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Kuseong dong, Yuseong Ku, Daejeon, Republic of Korea
Prog Neurobiol 84:263-83. 2008..PSD-95 may be one of the central organizers of synaptic adhesion that recruits diverse proteins to sites of synaptic adhesion, promotes trans-synaptic signaling, and couples neuronal activity with changes in synaptic adhesion... - Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionHyejung Won
Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
Nature 486:261-5. 2012..These results suggest that reduced NMDAR function may contribute to the development of ASD-like phenotypes in Shank2(-/-) mice, and mGluR modulation of NMDARs offers a potential strategy to treat ASD... - Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95Jeonghoon Choi
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Biol Chem 277:12359-63. 2002..These results suggest that phosphorylation of the stargazin C terminus by PKA regulates its interaction with PSD-95 and synaptic targeting of AMPARs... - Leucine-rich repeat proteins of synapsesJaewon Ko
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Yuseong Ku, Kuseong dong, Daejeon, Korea
J Neurosci Res 85:2824-32. 2007..These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses... - Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targetingMichael Wyszynski
Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Neuron 34:39-52. 2002..Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation... - The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signalJong Ik Hwang
Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, Korea
J Biol Chem 280:12467-73. 2005..These results demonstrate that Shank2 brings PLC-beta3 closer to Homer 1b and constitutes an efficient mGluR-coupled signaling pathway in the PSD region of neuronal synapses... - Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2Joo Young Kim
Department of Pharmacology and Brain Korea 21 Project fo Medical Science, Yonsei University College of Medicine, Seoul 120 752
J Biol Chem 279:10389-96. 2004..Our results indicate that Shank2 negatively regulates CFTR and that this may play a significant role in maintaining epithelial homeostasis under normal and diseased conditions such as those presented by secretory diarrhea... - Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerizationYoung Jun Im
Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
J Biol Chem 278:48099-104. 2003..This configuration may provide a means of facilitating dimeric organization of PDZ-target assemblies... - Shank2 associates with and regulates Na+/H+ exchanger 3Wonsun Han
Department of Pharmacology, Brain Korea 21 Project for Medical Science, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
J Biol Chem 281:1461-9. 2006..These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity... - Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cellsRyan R McWilliams
Department of Medicine, University of Colorado Health Sciences Center, 4200 E 9th St, Denver, Colorado 80262, USA
Am J Physiol Cell Physiol 289:C1042-51. 2005..In sum, Shank2E is concentrated in the apical domain of renal PT cells, specifically binds NaP(i)-IIa via PDZ interactions, and undergoes P(i)-induced internalization... - Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memoryDaejong Jeon
Center for Neural Science, Korea Institute of Science and Technology, Seoul 136 791, Korea
J Biol Chem 283:12093-101. 2008..Our results suggest a possibility that, unrelated to VDCCs regulation, Ca(v)beta3 negatively regulates the NMDAR activity in the hippocampus and thus activity-dependent synaptic plasticity and cognitive behaviors in the mouse... - Crystallization and preliminary X-ray crystallographic studies of the sixth PDZ domain of glutamate-receptor interacting protein 1 (GRIP1) from Rattus norvegicusSeong Ho Park
Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500-712, South Korea
Acta Crystallogr D Biol Crystallogr 58:1063-5. 2002..9 A. The complex crystal belongs to space group R32, with unit-cell parameters a = b = 117.8, c = 102.0 A. Native and peptide-complex diffraction data were collected to resolutions of 1.5 and 1.8 A, respectively, using synchrotron X-rays... - Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicusSeong Ho Park
Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
Acta Crystallogr D Biol Crystallogr 58:1353-5. 2002..0, b = 50.3, c = 51.8 A, beta = 106.3 degrees. The complex crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 89.4, b = 97.5, c = 108.3 A... - Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neuronsMinjung Huh
National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
J Neurochem 85:282-5. 2003..Our results demonstrate that msec7-1 regulates neuritogenesis and synaptic transmission... - Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in AplysiaSeung Hee Lee
Department of Biological Sciences, Institute of Molecular Biology and Genetics, Rio, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, Korea
Cell 129:801-12. 2007..Combined, our data suggest that CAMAP is a retrograde signaling component that translocates from activated synapses to the nucleus during synapse-specific LTF... - Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptorsJi Hyun Lee
Department of Pharmacology, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
J Biol Chem 282:10414-22. 2007.... - Crystal structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain-mediated multimerizationYoung Jun Im
Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500-712, South Korea
J Biol Chem 278:8501-7. 2003..This configuration may enable formation of GRIP multimers and efficient clustering of GRIP-binding proteins...