Eunjoon Kim

Summary

Affiliation: Korea Advanced Institute of Science and Technology
Country: Korea

Publications

  1. ncbi request reprint PDZ domain proteins of synapses
    Eunjoon Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yuseong Gu, Daejeon 305 701, Korea
    Nat Rev Neurosci 5:771-81. 2004
  2. ncbi request reprint NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation
    Seho Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Nat Neurosci 9:1294-301. 2006
  3. pmc Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase
    Hyejin Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    Philos Trans R Soc Lond B Biol Sci 369:20130158. 2014
  4. pmc The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development
    Jooyeon Woo
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 305 701, South Korea
    J Cell Biol 201:929-44. 2013
  5. ncbi request reprint Molecular organization and assembly of the postsynaptic density of excitatory brain synapses
    Eunjoon Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    Results Probl Cell Differ 43:1-23. 2006
  6. ncbi request reprint Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 23:1667-77. 2003
  7. doi request reprint Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis
    Hyun Woo Lee
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 28:14546-56. 2008
  8. ncbi request reprint Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:42377-85. 2003
  9. ncbi request reprint The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42
    Eunhye Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:19220-9. 2003
  10. doi request reprint Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
    Jooyeon Woo
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea
    Nat Neurosci 12:428-37. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint PDZ domain proteins of synapses
    Eunjoon Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong Dong, Yuseong Gu, Daejeon 305 701, Korea
    Nat Rev Neurosci 5:771-81. 2004
    ..As key organizers that control synaptic protein composition and structure, PDZ scaffolds are themselves highly regulated by synthesis and degradation, subcellular distribution and post-translational modification...
  2. ncbi request reprint NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation
    Seho Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Nat Neurosci 9:1294-301. 2006
    ..NGL-2 knockdown reduced excitatory, but not inhibitory, synapse numbers and currents. These results suggest that NGL regulates the formation of excitatory synapses...
  3. pmc Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase
    Hyejin Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    Philos Trans R Soc Lond B Biol Sci 369:20130158. 2014
    ..These results suggest that NGL-3 is a novel substrate of MMPs and γ-secretase and that NGL-3 cleavage may regulate synaptic adhesion during LTD. ..
  4. pmc The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development
    Jooyeon Woo
    Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon 305 701, South Korea
    J Cell Biol 201:929-44. 2013
    ....
  5. ncbi request reprint Molecular organization and assembly of the postsynaptic density of excitatory brain synapses
    Eunjoon Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    Results Probl Cell Differ 43:1-23. 2006
    ..PSD proteins associate with diverse motor proteins, suggesting that they function as adaptors linking motors to their specific cargoes...
  6. ncbi request reprint Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 23:1667-77. 2003
    ..These results suggest that the GIT1-liprin-alpha interaction is required for AMPA receptor targeting and that GIT1 may play an important role in the organization of presynaptic and postsynaptic multiprotein complexes...
  7. doi request reprint Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis
    Hyun Woo Lee
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 28:14546-56. 2008
    ..These results suggest that Preso positively regulates spine density through its interaction with the synaptic plasma membrane, actin filaments, PSD-95, and the betaPix-based Rac1 signaling pathway...
  8. ncbi request reprint Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:42377-85. 2003
    ..These results suggest that the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones...
  9. ncbi request reprint The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42
    Eunhye Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:19220-9. 2003
    ..Considering the involvement of Rac1 and PAK in spine dynamics, these results suggest that Shank recruits beta PIX and PAK to spines for the regulation of postsynaptic structure...
  10. doi request reprint Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
    Jooyeon Woo
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea
    Nat Neurosci 12:428-37. 2009
    ..Competitive inhibition by soluble LAR reduced NGL-3-induced presynaptic differentiation. These results suggest that the trans-synaptic adhesion between NGL-3 and LAR regulates excitatory synapse formation in a bidirectional manner...
  11. ncbi request reprint ARF6 and EFA6A regulate the development and maintenance of dendritic spines
    Seungwon Choi
    National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 26:4811-9. 2006
    ..ARF6 and EFA6A protect mature spines from inactivity-induced destabilization. These results suggest that ARF6 and EFA6A may regulate the conversion of filopodia to spines and the stability of both early and mature spines...
  12. doi request reprint Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins
    Daeyoung Oh
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 30:14134-44. 2010
    ..These results suggest that BCR and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions...
  13. ncbi request reprint Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases
    Jeonghoon Choi
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 25:869-79. 2005
    ..These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis...
  14. ncbi request reprint Association of the kinesin motor KIF1A with the multimodular protein liprin-alpha
    Hyewon Shin
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:11393-401. 2003
    ..These results suggest that liprin-alpha functions as a KIF1A receptor, linking KIF1A to various liprin-alpha-associated proteins for their transport in neurons...
  15. pmc Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD
    Kihoon Han
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    PLoS Biol 7:e1000187. 2009
    ..This suggests that scaffolding proteins at specialized cellular junctions can switch their function from maintenance to endocytosis of interacting membrane proteins in a regulated manner...
  16. ncbi request reprint Characterization of the movement of the kinesin motor KIF1A in living cultured neurons
    Jae Ran Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:2624-9. 2003
    ..These results suggest that KIF1A mediates neuronal transport at a high velocity and processivity in vivo...
  17. ncbi request reprint SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    Neuron 50:233-45. 2006
    ..These results suggest that SALM2 is an important regulator of the differentiation of excitatory synapses...
  18. doi request reprint Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins
    Seungnam Han
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 30:15102-12. 2010
    ..TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development...
  19. pmc DGKι regulates presynaptic release during mGluR-dependent LTD
    Jinhee Yang
    Department of Biological Sciences, National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Korea
    EMBO J 30:165-80. 2011
    ..These results suggest that DGKι requires PSD-95 family proteins for synaptic localization and regulates presynaptic DAG signalling and neurotransmitter release during mGluR-LTD...
  20. pmc Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance
    Karam Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Yuseong Gu, Daejeon, Republic of Korea
    EMBO J 28:1170-9. 2009
    ..We propose that PSD-95 targets DGKzeta to synaptic DAG-producing receptors to tightly couple synaptic DAG production to its conversion to PA for the maintenance of spine density...
  21. doi request reprint Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation
    Won Mah
    National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
    J Neurosci 30:5559-68. 2010
    ..These results suggest that selected SALM family proteins regulate synapse formation, and that SALM3 and SALM5 may promote synapse formation through distinct mechanisms...
  22. pmc An intramolecular interaction between the FHA domain and a coiled coil negatively regulates the kinesin motor KIF1A
    Jae Ran Lee
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    EMBO J 23:1506-15. 2004
    ..These results suggest that the intramolecular FHA-CC2 interaction negatively regulates KIF1A activity by inhibiting MT binding and dimerization of KIF1A, and point to a novel role of the FHA domain in the regulation of kinesin motors...
  23. ncbi request reprint Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins
    Hyejung Mok
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 22:5253-8. 2002
    ..These results suggest that the PSD-95 family proteins and S-SCAM have a novel function as KIF1Balpha receptors, linking KIF1Balpha to its specific cargos, and are involved in peripheral neuropathies...
  24. doi request reprint The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic
    Hyun Woo Lee
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 30:5508-18. 2010
    ..These results suggest that PSD-95-interacting MTMR2 contributes to the maintenance of excitatory synapses by inhibiting excessive endosome formation and destructive endosomal traffic to lysosomes...
  25. ncbi request reprint The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo
    Seho Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 278:6291-300. 2003
    ..These results suggest that, through their multimerization and interaction with Piccolo, the GIT family proteins are involved in the organization of the CAZ...
  26. doi request reprint The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules
    Jungyong Nam
    National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea
    Semin Cell Dev Biol 22:492-8. 2011
    ..In addition to these functional diversities, the fifth member of the SALM family, SALM5/Lrfn5, has recently been implicated in severe progressive autism and familial schizophrenia, pointing to the clinical importance of SALMs...
  27. pmc Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation
    Seok Kyu Kwon
    National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701
    J Biol Chem 285:13966-78. 2010
    ..These results suggest that trans-synaptic adhesion between NGL-3 and the three LAR family proteins regulates excitatory synapse formation in shared and distinct neural circuits...
  28. ncbi request reprint Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 26:963-70. 2006
    ....
  29. doi request reprint PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility
    Jae Ick Kim
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    Nat Neurosci 14:1447-54. 2011
    ..Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior...
  30. doi request reprint Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53
    Myoung Hwan Kim
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 29:1586-95. 2009
    ..These results suggest that IRSp53 is involved in the regulation of NMDA receptor-mediated excitatory synaptic transmission, LTP, and learning and memory behaviors...
  31. pmc Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway
    Ki Jun Yoon
    Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, South Korea
    Mol Brain 5:40. 2012
    ..Therefore, genetic ablation of Mib1 in mature neuron would give valuable insight to understand the cell-to-cell interaction between neurons via Notch signaling for their proper function...
  32. ncbi request reprint Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses
    Yoo Sung Song
    Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    J Cell Sci 126:4926-38. 2013
    ..We propose that trans-synaptic adhesions at early neuronal synapses trigger recruitment of neighboring adhesion molecules in a cis manner in order to couple initial axo-dendritic adhesion with synaptic differentiation...
  33. doi request reprint GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
    Hyejung Won
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Korea
    Nat Med 17:566-72. 2011
    ..Our study identifies a previously unknown involvement of GIT1 in human ADHD and shows that GIT1 deficiency in mice causes psychostimulant-responsive ADHD-like phenotypes...
  34. ncbi request reprint Clustering assay for studying the interaction of membrane proteins with PDZ domain proteins
    Jaewon Ko
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    Methods Mol Biol 332:245-53. 2006
    ..This chapter describes the experimental details of the clustering assay, using the interaction between potassium channels and PSD-95, an abundant PDZ domain protein in neuronal synapses, as a model...
  35. ncbi request reprint The NGL family of leucine-rich repeat-containing synaptic adhesion molecules
    Jooyeon Woo
    National Creative Research Initiative Center for Synaptogenesis, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    Mol Cell Neurosci 42:1-10. 2009
    ....
  36. doi request reprint Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
    Hyejung Won
    Department of Biological Sciences, KAIST, Daejeon 305 701, Korea
    Nature 486:261-5. 2012
    ..These results suggest that reduced NMDAR function may contribute to the development of ASD-like phenotypes in Shank2(-/-) mice, and mGluR modulation of NMDARs offers a potential strategy to treat ASD...
  37. doi request reprint Presynaptic proteoglycans: sweet organizers of synapse development
    Yoo Sung Song
    Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, Daejeon, 305 701, Korea
    Neuron 79:609-11. 2013
    ..2013) and de Wit et al. (2013) demonstrate that LRRTM4, a postsynaptic adhesion molecule, trans-synaptically interacts with presynaptic heparan sulfate proteoglycans (HSPGs) to promote synapse development. ..
  38. ncbi request reprint Analysis of PDZ domain interactions using yeast two-hybrid and coimmunoprecipitation assays
    Hyun Woo Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon
    Methods Mol Biol 332:233-44. 2006
    ..In addition, we discuss the features that must be considered for an efficient analysis of PDZ interactions...
  39. doi request reprint Diacylglycerol kinases in the regulation of dendritic spines
    Karam Kim
    Department of Biological Sciences and National Creative Research Initiative Center for Synaptogenesis, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    J Neurochem 112:577-87. 2010
    ..In addition, DGKzeta appears to form a multi-protein complex with functionally related proteins to organize efficient DAG and PA signaling pathways at excitatory synapses...
  40. doi request reprint Synaptic adhesion molecules and PSD-95
    Kihoon Han
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Kuseong dong, Yuseong Ku, Daejeon, Republic of Korea
    Prog Neurobiol 84:263-83. 2008
    ..PSD-95 may be one of the central organizers of synaptic adhesion that recruits diverse proteins to sites of synaptic adhesion, promotes trans-synaptic signaling, and couples neuronal activity with changes in synaptic adhesion...
  41. ncbi request reprint Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95
    Jeonghoon Choi
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Biol Chem 277:12359-63. 2002
    ..These results suggest that phosphorylation of the stargazin C terminus by PKA regulates its interaction with PSD-95 and synaptic targeting of AMPARs...
  42. ncbi request reprint Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia
    Seung Hee Lee
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, Rio, College of Natural Sciences, Seoul National University, San 56 1 Silim dong Gwanak gu, Seoul 151 747, Korea
    Cell 129:801-12. 2007
    ..Combined, our data suggest that CAMAP is a retrograde signaling component that translocates from activated synapses to the nucleus during synapse-specific LTF...
  43. pmc Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila
    Saera Song
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    J Biol Chem 288:5660-72. 2013
    ..We believe that this study provides the basis for understanding the molecular and physiological functions of various PINK1 mutations and provides insights into the pathogenic mechanisms of PINK1-linked PD...
  44. ncbi request reprint Leucine-rich repeat proteins of synapses
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Yuseong Ku, Kuseong dong, Daejeon, Korea
    J Neurosci Res 85:2824-32. 2007
    ..These proteins have been implicated in the formation, differentiation, maintenance, and plasticity of neuronal synapses...
  45. ncbi request reprint Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization
    Young Jun Im
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    J Biol Chem 278:48099-104. 2003
    ..This configuration may provide a means of facilitating dimeric organization of PDZ-target assemblies...
  46. ncbi request reprint Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting
    Michael Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:39-52. 2002
    ..Thus, by mediating the targeting of liprin/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation...
  47. ncbi request reprint The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal
    Jong Ik Hwang
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790 784, Korea
    J Biol Chem 280:12467-73. 2005
    ..These results demonstrate that Shank2 brings PLC-beta3 closer to Homer 1b and constitutes an efficient mGluR-coupled signaling pathway in the PSD region of neuronal synapses...
  48. ncbi request reprint Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2
    Joo Young Kim
    Department of Pharmacology and Brain Korea 21 Project fo Medical Science, Yonsei University College of Medicine, Seoul 120 752
    J Biol Chem 279:10389-96. 2004
    ..Our results indicate that Shank2 negatively regulates CFTR and that this may play a significant role in maintaining epithelial homeostasis under normal and diseased conditions such as those presented by secretory diarrhea...
  49. ncbi request reprint Crystal structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain-mediated multimerization
    Young Jun Im
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    J Biol Chem 278:8501-7. 2003
    ..This configuration may enable formation of GRIP multimers and efficient clustering of GRIP-binding proteins...
  50. ncbi request reprint Crystallization and preliminary X-ray crystallographic studies of the sixth PDZ domain of glutamate-receptor interacting protein 1 (GRIP1) from Rattus norvegicus
    Seong Ho Park
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Acta Crystallogr D Biol Crystallogr 58:1063-5. 2002
    ..9 A. The complex crystal belongs to space group R32, with unit-cell parameters a = b = 117.8, c = 102.0 A. Native and peptide-complex diffraction data were collected to resolutions of 1.5 and 1.8 A, respectively, using synchrotron X-rays...
  51. ncbi request reprint Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells
    Ryan R McWilliams
    Department of Medicine, University of Colorado Health Sciences Center, 4200 E 9th St, Denver, Colorado 80262, USA
    Am J Physiol Cell Physiol 289:C1042-51. 2005
    ..In sum, Shank2E is concentrated in the apical domain of renal PT cells, specifically binds NaP(i)-IIa via PDZ interactions, and undergoes P(i)-induced internalization...
  52. ncbi request reprint Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus
    Seong Ho Park
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Acta Crystallogr D Biol Crystallogr 58:1353-5. 2002
    ..0, b = 50.3, c = 51.8 A, beta = 106.3 degrees. The complex crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 89.4, b = 97.5, c = 108.3 A...
  53. ncbi request reprint Shank2 associates with and regulates Na+/H+ exchanger 3
    Wonsun Han
    Department of Pharmacology, Brain Korea 21 Project for Medical Science, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 281:1461-9. 2006
    ..These results indicate that Shank2 is a novel NHE3 interacting protein that is involved in the fine regulation of transepithelial salt and water transport through affecting NHE3 expression and activity...
  54. ncbi request reprint Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
    Ji Hyun Lee
    Department of Pharmacology, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 282:10414-22. 2007
    ....
  55. pmc Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory
    Daejong Jeon
    Center for Neural Science, Korea Institute of Science and Technology, Seoul 136 791, Korea
    J Biol Chem 283:12093-101. 2008
    ..Our results suggest a possibility that, unrelated to VDCCs regulation, Ca(v)beta3 negatively regulates the NMDAR activity in the hippocampus and thus activity-dependent synaptic plasticity and cognitive behaviors in the mouse...
  56. ncbi request reprint Regulation of neuritogenesis and synaptic transmission by msec7-1, a guanine nucleotide exchange factor, in cultured Aplysia neurons
    Minjung Huh
    National Research Laboratory of Neurobiology, Institute of Molecular Biology and Genetics, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
    J Neurochem 85:282-5. 2003
    ..Our results demonstrate that msec7-1 regulates neuritogenesis and synaptic transmission...