Affiliation: Korea Advanced Institute of Science and Technology
Kim Y, Kim S, Kim K, Chae S, Kim C, Kim J, et al
. Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Hum Mol Genet. 2015;24:7196-206 pubmed publisher
..These results suggest that the loss of Rnf170 gene function mediates ADSA-associated phenotypes and this gives insights on the cure of patients with ADSA and other age-dependent walking abnormalities. ..
Kim D, Cheong E, Shin H. Overcoming Depression by Inhibition of Neural Burst Firing. Neuron. 2018;98:878-879 pubmed publisher
..Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression. ..
Park Y, Choi J, Lee C, Kim S, Kim Y, Chang K, et al
. Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice. Mol Brain. 2015;8:3 pubmed publisher
..However, harmaline-induced tremor, which is known to be abolished by Î±1G(-/-), showed no TRCP. Our results demonstrate that the Î±1(-/-);Î±1G(-/-) double-knockout tremor model is useful for studying cortical mechanisms of tremor. ..
Shin A, Woo J, Kim J, Kim D. Nodding behavior couples to vigilance fluctuation in a high-calorie diet model of drowsiness. Mol Brain. 2018;11:33 pubmed publisher
..Our findings indicate that delta oscillations play a dominant role in controlling vigilance dynamics during sleep/wake competition and that our novel mouse model may be useful for studying drowsiness and related neurological disorders. ..
Park S, Jeong Y, Kim D, Lee M, Shin A, Park G, et al
. Medial preoptic circuit induces hunting-like actions to target objects and prey. Nat Neurosci. 2018;21:364-372 pubmed publisher
..Using this device, we successfully guided mice to navigate specified routes. Our study explains how the brain yields a strong motivation to acquire a target object along the continuum of hunting behavior. ..
Hong J, Kim D. Freezing response-independent facilitation of fear extinction memory in the prefrontal cortex. Sci Rep. 2017;7:5363 pubmed publisher
..These results provide in vivo evidence for IL-dependent facilitation of extinction memory without post-synaptic modulation of freezing circuits. ..
Kim J, Kim Y, Nakajima R, Shin A, Jeong M, Park A, et al
. Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in the Thalamus. Neuron. 2017;95:1181-1196.e8 pubmed publisher
..Thus, BG inhibitory input generates excitatory motor signals in the thalamus and, in excess, promotes PD-like motor abnormalities. VIDEO ABSTRACT. ..