Affiliation: Korea University
Kim C, Kim M. Differences in ?-? transmembrane domain interactions among integrins enable diverging integrin signaling. Biochem Biophys Res Commun. 2013;436:406-12 pubmed publisher
..We suggest, therefore, that the degree of TMD interaction is designed to accommodate the specific, desired function of each integrin. ..
Lee H, Oh S, Lee K, Lee Y, Ko E, Kim K, et al
. Gln-362 of angiopoietin-2 mediates migration of tumor and endothelial cells through association with Î±5Î²1 integrin. J Biol Chem. 2014;289:31330-40 pubmed publisher
..Taken together, these results provide a novel insight into the mechanism of integrin regulation by Ang-2, which contributes to tumor invasion and endothelial cell migration in a Tie2-independent manner. ..
Kim J, Jang J, Yang C, Kim E, Jung H, Kim C. Vimentin filament controls integrin ?5?1-mediated cell adhesion by binding to integrin through its Ser38 residue. FEBS Lett. 2016;590:3517-3525 pubmed publisher
..Our results suggest that phosphorylation of vimentin at Ser38 may regulate the integrin-ligand interaction, thus providing a molecular basis for antivimentin therapeutic strategies. ..
Ye F, Yang C, Kim J, MacNevin C, Hahn K, Park D, et al
. Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. J Biol Chem. 2017;292:9858-9864 pubmed publisher
..Thus, this widely ingested polyphenol exhibits pleiotropic effects on transmembrane signaling by modifying the topology of TMDs. ..
Lim I, Joo H, Jeong M, Kim J, Choi S, Kim C, et al
. Talin Modulation by a Synthetic N-Acylurea Derivative Reduces Angiogenesis in Human Endothelial Cells. Int J Mol Sci. 2017;18: pubmed publisher
..By further optimization and in vivo studies of KCH-1521, a novel drug of talin modulation could be used to achieve therapeutic anti-angiogenesis for vascular diseases and cancers. ..