Geum Sook Hwang


Affiliation: Korea Basic Science Institute
Country: Korea


  1. Khan I, Nam M, Kwon M, Seo S, Jung S, Han J, et al. LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics. Cancers (Basel). 2019;11: pubmed publisher
    ..These results demonstrated that metabolomics profiling is capable of distinguishing CINs and cervical cancers from normal and highlighted potential biomarkers for the early detection of cervical carcinogenesis. ..
  2. Lee J, Jung Y, Shin J, Kim H, Moon B, Ryu D, et al. Secondary metabolite profiling of Curcuma species grown at different locations using GC/TOF and UPLC/Q-TOF MS. Molecules. 2014;19:9535-51 pubmed publisher
  3. Han J, Kim K, Jung Y, Lee J, Namgung J, Lee H, et al. Metabolic Alterations Associated with Atorvastatin/Fenofibric Acid Combination in Patients with Atherogenic Dyslipidaemia: A Randomized Trial for Comparison with Escalated-Dose Atorvastatin. Sci Rep. 2018;8:14642 pubmed publisher
    ..Our results provide comprehensive information regarding metabolic changes beyond conventional lipid profiles for this combination therapy. ..
  4. Lee S, Kim K, Hwang G, Ryu D. Highly enantioselective catalytic 1,3-dipolar cycloadditions of α-alkyl diazoacetates: efficient synthesis of functionalized 2-pyrazolines. Org Biomol Chem. 2015;13:2745-9 pubmed publisher
    ..The synthetic utility of 2-pyrazoline was expanded via preparation of 2,4-diamino ester compounds bearing a chiral quaternary carbon center. ..
  5. Lee J, Jung Y, Park J, Lee S, Ryu D, Hwang G. LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction. J Pharm Biomed Anal. 2015;115:475-86 pubmed publisher
    ..This approach could be utilized to observe gender-specific metabolic pattern differences between healthy controls and patients with MI. ..
  6. Kim N, Hyeon J, Kim N, Cho A, Lee G, Jang S, et al. Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model. Arch Biochem Biophys. 2018;646:90-97 pubmed publisher
    ..We demonstrated phase-specific alterations in metabolites during progression of DKD. This study provides insights into perturbed mechanisms during evolution of the disease and identifies potential novel biomarkers for DKD. ..
  7. Nam M, Huh J, Kim M, Ryu D, Park J, Kim H, et al. Metabolic alterations in the bone tissues of aged osteoporotic mice. Sci Rep. 2018;8:8127 pubmed publisher
    ..This study demonstrates that LC-MS-based global profiling of lipid and polar metabolites can elucidate metabolic changes that occur during age-related bone loss and identify potential biomarkers of osteoporosis. ..
  8. Kim O, Jung Y, Cho Y, Chung J, Hwang G, Shin M. Altered heart and kidney phospholipid fatty acid composition are associated with cardiac hypertrophy in hypertensive rats. Clin Biochem. 2013;46:1111-1117 pubmed publisher
    ..05) and negatively with kidney EPA (r=-0.575, p<0.05). Tissue FA compositions were associated with cardiac hypertrophy in a hypertensive setting, implicating the pathogenic role of tissue FAs in hypertension and related complications. ..
  9. Jung J, Ha T, Lee J, Lho Y, Nam M, Lee D, et al. Changes in one-carbon metabolism after duodenal-jejunal bypass surgery. Am J Physiol Endocrinol Metab. 2016;310:E624-E632 pubmed publisher
    ..This study shows that bariatric surgery altered trans-sulfuration and purine metabolism in the liver. Characterization of these mechanisms increases our understanding of the benefits of bariatric surgery. ..

More Information


  1. Lee J, Choi J, Kwon Y, Lee D, Jung H, Ryu H, et al. Changes in serum metabolites with the stage of chronic kidney disease: Comparison of diabetes and non-diabetes. Clin Chim Acta. 2016;459:123-131 pubmed publisher
    ..Metabolomics is useful clinically for providing a metabolic signature that is associated with the CKD phenotype and diabetes more seriously affects patients with early stage CKD compared to those with advanced CKD. ..
  2. Jung Y, Hyeon J, Hwang G. Software-assisted serum metabolite quantification using NMR. Anal Chim Acta. 2016;934:194-202 pubmed publisher
    ..The SASMeQ method will advance NMR-based serum metabolic profiling by providing an accurate and reliable method for absolute quantification that is superior to bin-based quantification. ..
  3. Jung S, Song S, Lee S, Kim S, Ann S, Cheon E, et al. Metabolic phenotyping of human atherosclerotic plaques: Metabolic alterations and their biological relevance in plaque-containing aorta. Atherosclerosis. 2018;269:21-28 pubmed publisher
    ..Our study provides insight into the disease mechanism and potential markers of atherosclerosis through comprehensive metabolic profiling of human aortic tissue samples containing plaque. ..
  4. Nam M, Jung Y, Ryu D, Hwang G. A metabolomics-driven approach reveals metabolic responses and mechanisms in the rat heart following myocardial infarction. Int J Cardiol. 2017;227:239-246 pubmed publisher
    ..The comprehensive integration of various omics data provides a novel means of understanding the underlying pathophysiological mechanisms of MI. ..
  5. Kim N, Jung Y, Nam M, Sun Kang M, Lee M, Cho Y, et al. Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes. Sci Rep. 2017;7:10328 pubmed publisher
    ..Our results provide new molecular targets for the development of therapeutics for inflammation-related conditions, such as atrial fibrillation. ..
  6. Cho S, Kwon Y, Nam M, Vaidya B, Kim S, Lee S, et al. Integrated profiling of global metabolomic and transcriptomic responses to viral hemorrhagic septicemia virus infection in olive flounder. Fish Shellfish Immunol. 2017;71:220-229 pubmed publisher
  7. Lee J, Jung S, Kim N, Shin M, Ryu D, Hwang G. Myocardial metabolic alterations in mice with diet-induced atherosclerosis: linking sulfur amino acid and lipid metabolism. Sci Rep. 2017;7:13597 pubmed publisher
    ..These findings demonstrate that the SAA metabolic pathway is a promising therapeutic target for CVD treatment and that metabolomics can be used to investigate the metabolic signature of atherosclerosis. ..
  8. Nam M, Choi M, Choi J, Kim N, Kim M, Jung S, et al. Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet. J Nutr Biochem. 2018;51:1-7 pubmed publisher
    ..This study showed abnormal changes in lipid species associated with obesity, and these levels were attenuated by GT intake, suggesting a relationship between the reduction of hepatic LPL levels and inflammation in obesity. ..