Research Topics
| S ChoSummaryAffiliation: Korea Research Institute of Bioscience and Biotechnology Country: Korea Publications
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Detail Information
Publications
Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7S Cho
Center for Cellular Switch Protein Structure, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, South Korea
FEBS Lett 498:62-6. 2001..PSMA7 inhibited the transactivation function of HIF-1alpha under both normoxic and hypoxia-mimicking conditions. In addition, we show that the PSMA7-mediated regulation of HIF-1alpha activity is associated with the proteasome pathway...
Structural basis of the redox switch in the OxyR transcription factorH Choi
Center for Cellular Switch Protein Structure, Korea Research Institute of Bioscience and, Biotechnology, P O Box 115, Yusong, 305 600, Taejon, South Korea
Cell 105:103-13. 2001....
Sex-specific and non-sex-specific oligomerization domains in both of the doublesex transcription factors from Drosophila melanogasterW An
Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254 9110, USA
Mol Cell Biol 16:3106-11. 1996..We speculate that the common function of OD1 and OD2 is to oligomerize the full-length proteins, whereas their specialized functions are to form a dimeric DNA binding unit and a sex-specific transcriptional activation or repression unit...
Purification and physical properties of the male and female double sex proteins of DrosophilaS Cho
Department of Biochemistry and The Rosenstiel Center, Brandeis University, Waltham, MA 02254 9110, USA
Proc Natl Acad Sci U S A 93:2043-7. 1996..These oligomerization and DNA binding properties are indistinguishable between the male and female proteins...
Binding of p300/CBP co-activators by polyoma large T antigenS Cho
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 276:33533-9. 2001....
Linkage between oligomerization and DNA binding in Drosophila doublesex proteinsS Cho
The Rosenstiel Center, The Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254 9110, USA
Biochemistry 37:11301-8. 1998..6; DSXM, k12 = 5.4). This suggests that the sex-specific domains may have a second effect on DNA binding, namely, an effect on binding cooperativity that depends on the number and arrangement of DNA sites...
Specification of germ cell fates by FOG-3 has been conserved during nematode evolutionP J Chen
Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 158:1513-25. 2001..elegans hermaphrodites, we propose that alterations in the upstream sex-determination pathway, perhaps acting through TRA-1A, allow spermatogenesis in C. elegans and C. briggsae XX larvae but not in C. remanei...
9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response elementS Cho
School of Biological Sciences and Research Center for Cell Differentiation, Seoul National University, Seoul, 151-742, South Korea
Brain Res Mol Brain Res 87:214-22. 2001..In conclusion, the present study clearly demonstrates that 9-cis-RA is a negative regulator of GnRH gene expression in immortalized GnRH neurons...
A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) geneS Cho
School of Biological Sciences and Research Center for Cell Differentiation, Seoul National University, Seoul, 151-742, South Korea
Brain Res Mol Brain Res 87:204-13. 2001..Taken together, these data indicate that all-trans-RA enhances GnRH transcription via functional RARE present in the distal region of the GnRH promoter...
Evidence for direct involvement of beta-catenin in phorbol ester-induced neurite outgrowth in GT1-1 hypothalamic neuronesW Sun
School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-742, Korea
J Neuroendocrinol 13:249-60. 2001..Moreover, TPA was found to increase the transcription-activational roles of beta-catenin. Together, these data provide evidence that beta-catenin is involved in the TPA-induced functional differentiation of immortalized GnRH neurones...
Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cellsS Cho
Departments of Pediatrics, Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA
J Neurosci Res 62:234-40. 2000..Drugs that raise the level of protein palmitoylation are pro-apoptotic and PPT1 inhibition may enhance the killing efficacy of chemotherapeutic agents used to kill neuroblastoma-derived cells...
Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3K M Chung
Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Korea
J Virol 74:5233-41. 2000..This indicates that NS5A may inhibit karyopherin beta3 function via protein-protein interaction. The role of NS5A in HCV replication is discussed...
Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cellsS Cho
Department of Pediatrics, University of Chicago, Illinois, USA
J Neurochem 74:1478-88. 2000..PPT overexpression also led to reduced membrane association of another palmitoylated protein, GAP-43, a neuron-specific protein. Our studies suggest that protein palmitoylation could be a physiological regulator of apoptosis...
Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null miceT J McDonnell
Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Pathol 188:322-8. 1999..These data raise the possibility that heterozygosity at the mdm2 locus in the absence of p53 affects the development of tumours of mesenchymal origin...
The crystal structure of an Fe-superoxide dismutase from the hyperthermophile Aquifex pyrophilus at 1.9 A resolution: structural basis for thermostabilityJ H Lim
Structural Biology Center, Korea Institute of Science and Technology, Seoul, South Korea
J Mol Biol 270:259-74. 1997..Comparisons of the Ap SOD structure with that of other known enzymes from hyperthermophiles reveal that the increased number of intrasubunit ion-pairs is a common feature...
DNA binding by the male and female doublesex proteins of Drosophila melanogasterS Cho
Rosenstiel Center and the Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254 9110, USA
J Biol Chem 272:3185-9. 1997..We infer that the sex-specific oligomerization domains play roles in binding cooperativity to multiple DNA sites or in other protein:protein interactions...
Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosisS Cho
Departments of Pediatrics, Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
Eur J Paediatr Neurol 5:53-5. 2001..In contrast, overexpression of PPT1 led to increased resistance to cell death induced by these drugs...
