Bokyung Kim

Summary

Affiliation: Konkuk University
Country: Korea

Publications

  1. pmc Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension
    Bokyung Kim
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong 322, Choongju 380 701, Korea
    Br J Pharmacol 139:408-14. 2003
  2. ncbi request reprint Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats
    Chang Kwon Lee
    Department of Physiology, College of Medicine, Konkuk University, Chungju 380 701, Korea
    Arch Pharm Res 29:1024-31. 2006
  3. ncbi request reprint Endothelin-1 induces contraction via a Syk-mediated p38 mitogen-activated protein kinase pathway in rat aortic smooth muscle
    Hwan Myung Lee
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong, Chungju, Korea
    J Pharmacol Sci 103:427-33. 2007
  4. ncbi request reprint p38 mitogen-activated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, Danwol dong 322, Chungju 380 701, Korea
    J Pharmacol Sci 105:74-81. 2007
  5. pmc DJ-1 regulates mast cell activation and IgE-mediated allergic responses
    Do Kyun Kim
    Department of Immunology and Physiology, Functional Genomics Institute, College of Medicine, Konkuk University, Chungju, Korea
    J Allergy Clin Immunol 131:1653-62. 2013
  6. ncbi request reprint Cofilin phosphorylation mediates proliferation in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells
    Kyung Jong Won
    Institute of Medical Sciences, School of Medicine, Konkuk University, Chungju, Korea
    J Pharmacol Sci 108:372-9. 2008
  7. ncbi request reprint Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways
    Chang Kwon Lee
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong 322, Chungju 380 701, Republic of Korea
    Cardiovasc Res 74:159-68. 2007
  8. ncbi request reprint Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats
    Junghwan Kim
    Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Danwol dong 322, Choongju 380 701, Korea
    Eur J Pharmacol 514:209-15. 2005
  9. ncbi request reprint Spleen tyrosine kinase participates in Src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, Chungju 380 701, Korea
    Arch Pharm Res 30:761-9. 2007
  10. ncbi request reprint Contribution of soluble intercellular adhesion molecule-1 to the migration of vascular smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, 322 Danwol dong, Chungju City, Chungbuk 380 701, South Korea
    Eur J Pharmacol 579:260-8. 2008

Collaborators

Detail Information

Publications57

  1. pmc Conventional-type protein kinase C contributes to phorbol ester-induced inhibition of rat myometrial tension
    Bokyung Kim
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong 322, Choongju 380 701, Korea
    Br J Pharmacol 139:408-14. 2003
    ..4 These results suggest that cPKC may be at least partly involved in the PKC-mediated inhibition of muscle tension in the rat myometrium...
  2. ncbi request reprint Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats
    Chang Kwon Lee
    Department of Physiology, College of Medicine, Konkuk University, Chungju 380 701, Korea
    Arch Pharm Res 29:1024-31. 2006
    ....
  3. ncbi request reprint Endothelin-1 induces contraction via a Syk-mediated p38 mitogen-activated protein kinase pathway in rat aortic smooth muscle
    Hwan Myung Lee
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong, Chungju, Korea
    J Pharmacol Sci 103:427-33. 2007
    ..These results suggest that Syk may play an important role in the regulation of aortic smooth muscle contraction induced by ET-1, which may be mediated by the p38 MAPK/HSP27 signaling pathway...
  4. ncbi request reprint p38 mitogen-activated protein kinase contributes to angiotensin II-stimulated migration of rat aortic smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, Danwol dong 322, Chungju 380 701, Korea
    J Pharmacol Sci 105:74-81. 2007
    ..These results suggest that p38 MAPK contributes to the regulation of the Ang II-induced chemotactic migration of vascular smooth muscle cells, which is mediated by Hsp27 phosphorylation...
  5. pmc DJ-1 regulates mast cell activation and IgE-mediated allergic responses
    Do Kyun Kim
    Department of Immunology and Physiology, Functional Genomics Institute, College of Medicine, Konkuk University, Chungju, Korea
    J Allergy Clin Immunol 131:1653-62. 2013
    ..DJ-1 is an antioxidant protein known to reduce levels of reactive oxygen species (ROS), but its presence or function in mast cells and allergic diseases is unknown...
  6. ncbi request reprint Cofilin phosphorylation mediates proliferation in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells
    Kyung Jong Won
    Institute of Medical Sciences, School of Medicine, Konkuk University, Chungju, Korea
    J Pharmacol Sci 108:372-9. 2008
    ....
  7. ncbi request reprint Syk contributes to PDGF-BB-mediated migration of rat aortic smooth muscle cells via MAPK pathways
    Chang Kwon Lee
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong 322, Chungju 380 701, Republic of Korea
    Cardiovasc Res 74:159-68. 2007
    ..Here we investigated the role of spleen tyrosine kinase (Syk) in the migration induced by platelet-derived growth factor (PDGF) in rat aortic smooth muscle cells (RASMC)...
  8. ncbi request reprint Mitogen-activated protein kinase contributes to elevated basal tone in aortic smooth muscle from hypertensive rats
    Junghwan Kim
    Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Danwol dong 322, Choongju 380 701, Korea
    Eur J Pharmacol 514:209-15. 2005
    ..Thus, basal vascular tone is elevated by the altered activation of MAPK in DOCA-salt hypertensive rats, and this is regulated by PKC, but not by Rho or intracellular Ca2+...
  9. ncbi request reprint Spleen tyrosine kinase participates in Src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, Chungju 380 701, Korea
    Arch Pharm Res 30:761-9. 2007
    ..These results imply that Syk is regulated by Src kinase, which participates in migration and proliferation in response to PDGF-BB in RASMCs...
  10. ncbi request reprint Contribution of soluble intercellular adhesion molecule-1 to the migration of vascular smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, 322 Danwol dong, Chungju City, Chungbuk 380 701, South Korea
    Eur J Pharmacol 579:260-8. 2008
    ..The results suggest that sICAM-1 play crucial roles in vascular cell function through Syk pathways, and that the altered responses of sICAM-1 in RASMCs from SHRs may be mediated by the increased expression of the CD18 receptor...
  11. doi request reprint Soluble form of vascular cell adhesion molecule 1 induces migration and proliferation of vascular smooth muscle cells
    Hwan Myung Lee
    Department of Medicine, College of Medicine, Konkuk University, Chungju, South Korea
    J Vasc Res 45:259-68. 2008
    ..This study clarified the effects of sVCAM-1 on vascular responses in rat aortic smooth muscle cells (RASMCs)...
  12. doi request reprint The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells
    Do Kyun Kim
    1Department of Immunology and Physiology and Functional Genomics Institute, College of Medicine, Konkuk University, Chungju 380 701, Korea
    Sci Signal 6:ra80. 2013
    ..Together, these results suggest that PHB is essential for FcεRI-mediated mast cell activation and allergic responses in vivo, raising the possibility that PHB might serve as a therapeutic target for the treatment of allergic diseases. ..
  13. pmc Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
    Dong Jun Sung
    1 Department of Physiology and the Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea 2 Division of Sport Science, College of Science and Technology, Konkuk University, Choongju, Korea
    Exp Mol Med 45:e67. 2013
    ..Our data suggest that 4-AP-sensitive Kv channels are the primary regulator of the resting tone in rat mesenteric arteries. 5-HT constricts the arteries by inhibiting Kv channels via the 5-HT2A receptor and Src tyrosine kinase pathway. ..
  14. ncbi request reprint Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle cells of deoxycorticosterone acetate-salt hypertensive rats
    Young Min Bae
    Artificial Muscle Research Center, Departments of Physiology, College of Medicine, Konkuk University, Choongju, Korea
    J Hypertens 25:809-17. 2007
    ..The aims of the present study were to investigate whether the ROC current is increased in DOCA-hypertensive rats and determine whether aldosterone directly enhances the expression of TRPC...
  15. pmc The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice
    Jun Ho Lee
    Institute of Biomedical Sciences and Technology, College of Medicine, Konkuk University, Chungju 380 701, Korea
    J Immunol 187:1807-15. 2011
    ..In conclusion, Fgr positively regulates mast cell through activation of Syk. These findings help clarify the interplay among Src family kinases and identify Fgr as a potential therapeutic target for allergic diseases...
  16. doi request reprint Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels
    Chang Kwon Lee
    Institute of Functional Genomics, School of Medicine, Konkuk University, Danwol dong, Choonju, Korea
    Proteomics 9:4851-8. 2009
    ..These results suggest that the deficiency in BH4 regeneration produced by diminished dihydrobiopterin reductase expression is involved in vascular disorders in hypertensive rats...
  17. ncbi request reprint Cdc42 contributes to phorbol ester-induced Ca2+-independent contraction of pulmonary artery smooth muscle
    Won Ho Choi
    Department of Physiology and Anesthesiology, College of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Choongju, Korea
    J Vet Med Sci 67:787-93. 2005
    ..These results indicate that phorbol ester evokes PKC-mediated Ca2+-independent contraction via a Rho GTPase pathway, especially Cdc42, in smooth muscle from swine pulmonary arteries...
  18. doi request reprint DJ-1/park7 protects against neointimal formation via the inhibition of vascular smooth muscle cell growth
    Kyung Jong Won
    Department of Medicine, Institute of Functional Genomics, School of Medicine, Konkuk University, 322 Danwol dong, Chungju 380 701, Korea
    Cardiovasc Res 97:553-61. 2013
    ..However, its function in the vascular system has not been determined. We investigated the protective roles of DJ-1/park7 in vascular disorders, especially in neointimal hyperplasia...
  19. ncbi request reprint c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle
    Youn Ri Lee
    Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, Choong Buk, Korea
    J Pharmacol Sci 100:119-25. 2006
    ..These results show that JNK contributes to NE-mediated contraction through phosphorylation of caldesmon in rat aortic smooth muscle, and that this effect is regulated by the PKC pathway, especially cPKC...
  20. ncbi request reprint p38 Mitogen-activated protein kinase regulates vasoconstriction in spontaneously hypertensive rats
    Seongchun Kwon
    Department of Physiology, College of Medicine, Kwandong University, Kangnung, Korea
    J Pharmacol Sci 95:267-72. 2004
    ..However, p38 MAPK, rather than p42/p44 MAPK, activation plays an important role for the maintenance of ET-1-induced vasoconstriction in SHR through a MLC phosphorylation-independent pathway...
  21. ncbi request reprint Protein tyrosine phosphatase SHP-2 is positively involved in platelet-derived growth factor-signaling in vascular neointima formation via the reactive oxygen species-related pathway
    Kyung Jong Won
    Institute of Functional Genomics, School of Medicine, Konkuk University, 322 Danwol dong, Choongju 380 701, Korea
    J Pharmacol Sci 115:164-75. 2011
    ..These results suggest that the activity of SHP-2 is controlled by ROS and is positively involved in the regulation of PDGF-BB-induced RASMC migration and neointima formation...
  22. ncbi request reprint Serotonin-induced ion channel modulations in mesenteric artery myocytes from normotensive and DOCA-salt hypertensive rats
    Young Min Bae
    Artificial Muscle Research Center, Department of Physiology, Konkuk University, 322 Danwol dong, Choongju 380 701, Korea
    J Smooth Muscle Res 43:85-97. 2007
    ..In this brief review, we compared the electrophysiological properties of mesenteric artery myocytes and their modulation by 5-HT between sham-operated control and deoxycorticosterone acetate (DOCA)-salt hypertensive rats...
  23. ncbi request reprint Blockade of K+ and Ca2+ channels by azole antifungal agents in neonatal rat ventricular myocytes
    Dong Jun Sung
    Department of Physiology, Institute of Functional Genomics, Research Institute of Medical Science, School of Medicine, Konkuk University, Choongju, Korea
    Biol Pharm Bull 35:1469-75. 2012
    ..We suggest that it is necessary to consider this inhibition of ion channels by azole agents when assessing cardiovascular side effects...
  24. ncbi request reprint Ketamine blocks voltage-gated K(+) channels and causes membrane depolarization in rat mesenteric artery myocytes
    Seong Hyop Kim
    Department of Anesthesiology, College of Medicine, Konkuk University, Seoul, South Korea
    Pflugers Arch 454:891-902. 2007
    ....
  25. doi request reprint The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle
    Hyun J Noh
    Artificial Muscle Research Center, Konkuk University, Seoul, Korea
    Eur J Anaesthesiol 26:676-82. 2009
    ..Therefore, we examined whether the NMDAr is functional in vascular smooth muscle and whether the vasodilatory effect of ketamine is associated with the NMDAr...
  26. ncbi request reprint Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle
    Chang Kwon Lee
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong 322, Choongju 380 701, Korea
    Biochim Biophys Acta 1774:848-55. 2007
    ..These results suggest that Prxs play a crucial role against oxidative stress in vascular smooth muscles during hypertension...
  27. doi request reprint Ketoconazole induces apoptosis in rat cardiomyocytes through reactive oxygen species-mediated parkin overexpression
    Kyung Jong Won
    Department of Physiology, School of Medicine, Konkuk University, 120 Neungdong ro, Gwangjin gu, Seoul, 143 701, Korea
    Arch Toxicol 89:1871-80. 2015
    ..From the present findings, we concluded that ketoconazole may increase the expression of parkin via the ROS-mediated pathway, which consequently results in the apoptosis and decreased viability of cardiomyocytes. ..
  28. doi request reprint DJ-1 regulates the expression of renal (pro)renin receptor via reactive oxygen species-mediated epigenetic modification
    Dong Youb Lee
    Department of Physiology, Functional Genomics Institute, School of Medicine, Konkuk University, 322 Danwol dong, Choongju 380 701, Republic of Korea
    Biochim Biophys Acta 1850:426-34. 2015
    ..We investigated whether DJ-1 protein regulates the expression of (pro)renin receptor (PRR), a newly identified member of renin-angiotensin system...
  29. doi request reprint Monoclonal antibody against α-actinin 4 from human umbilical vein endothelial cells inhibits endothelium-dependent vasorelaxation
    Kyung Jong Won
    Department of Physiology, School of Medicine, Konkuk University, Chungju, Korea
    J Vasc Res 50:210-20. 2013
    ....
  30. ncbi request reprint Epidermal growth factor induces vasoconstriction through the phosphatidylinositol 3-kinase-mediated mitogen-activated protein kinase pathway in hypertensive rats
    Junghwan Kim
    Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Choongju, Korea
    J Pharmacol Sci 101:135-43. 2006
    ..These results strongly suggest that EGF induces contraction by the activation of ERK1/2, which is regulated by the PI3K pathway in the aortic smooth muscle of DOCA-salt hypertensive rats...
  31. doi request reprint A mixture of Trachelospermi caulis and Moutan cortex radicis extracts suppresses collagen-induced arthritis in mice by inhibiting NF-κB and AP-1
    Hyuk Soon Kim
    College of Medicine and Institute of Biomedical Science and Technology, Konkuk University, Chungju, Korea
    J Pharm Pharmacol 64:420-9. 2012
    ..We aimed to determine the anti-arthritis effect and its mechanism of a combination of herbal extracts from Trachelospermi caulis (TC) and Moutan cortex radicis (MC) (TCMC)...
  32. ncbi request reprint Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle
    Chang Kwon Lee
    Department of Physiology, Konkuk University, Danwol dong, Chungju City, Chungbuk, Korea
    Proteomics 6:6455-75. 2006
    ..These results suggest that cofilin is one of the proteins regulated by H2O2 treatment in vascular smooth muscle, and has an important role in the induction of vascular apoptosis through PTP-dependent mechanisms...
  33. ncbi request reprint Serotonin depolarizes the membrane potential in rat mesenteric artery myocytes by decreasing voltage-gated K+ currents
    Young Min Bae
    Artificial Muscle Research Center, College of Medicine, Konkuk University 322 Danwol dong, Choongju 380 701, Republic of Korea
    Biochem Biophys Res Commun 347:468-76. 2006
    ..These results indicate that the resting Em is largely under the regulation of Kv currents in rat MASMCs, and that 5-HT depolarizes Em by reducing Kv currents in a [Ca2+]i-dependent manner...
  34. doi request reprint Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin E-mediated allergic responses
    Hyuk Soon Kim
    School of Medicine, Konkuk University, Chungju 380 701, Korea
    Sci Signal 8:ra28. 2015
    ..Together, these findings suggest that an important function of IL-10-producing CD5(+) B cells is inhibiting mast cells and IgE-mediated allergic responses. ..
  35. doi request reprint The serum protein fetuin-B is involved in the development of acute myocardial infarction
    Seung Hyo Jung
    Department of Physiology, School of Medicine, Konkuk University, Chungju, Korea
    Clin Sci (Lond) 129:27-38. 2015
    ..From these results, we suggest that fetuin-B may act as a modulator in the development of AMI. This study may provide a therapeutic advantage for patients at high risk of AMI...
  36. doi request reprint DJ-1/park7 modulates vasorelaxation and blood pressure via epigenetic modification of endothelial nitric oxide synthase
    Kyung Jong Won
    Department of Physiology, Institute of Functional Genomics, School of Medicine, Konkuk University, 322 Danwol dong, Chungju 380 701, South Korea
    Cardiovasc Res 101:473-81. 2014
    ..The present study was designed to investigate whether the DJ-1/park7 is involved in the regulation of vascular contractility and systolic blood pressure (SBP)...
  37. doi request reprint 3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration
    Kyung Jong Won
    Department of Physiology, School of Medicine, Konkuk University, Danwol dong, Chungju, Korea
    Proteomics 11:193-201. 2011
    ..These results demonstrate that SIN-1 may attenuate vascular neointima formation by inhibiting annexin A2-mediated migration. Therefore, annexin A2 may be a potential target for therapeutic strategies for atherosclerosis...
  38. ncbi request reprint Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway
    Se Hwan Mun
    College of Medicine, Konkuk University, Korea
    J Pharmacol Sci 111:13-21. 2009
    ..This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway...
  39. doi request reprint Morus bombycis Koidzumi extract suppresses collagen-induced arthritis by inhibiting the activation of nuclear factor-κB and activator protein-1 in mice
    Hyuk Soon Kim
    Department of Immunology and Physiology, College of Medicine, Konkuk University, Chungju, Republic of Korea
    J Ethnopharmacol 136:392-8. 2011
    ..Morus bombycis Koidzumi is widely distributed in Asia. In Korea, it has been used in traditional medicine because of its apparent anti-inflammatory, antioxidant, and hepatoprotective properties...
  40. ncbi request reprint p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats
    Bokyung Kim
    Department of Physiology, College of Medicine, Konkuk University, Choongju, Korea
    Hypertension 43:1086-91. 2004
    ....
  41. pmc Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow's milk casein-induced allergic responses in mice
    A Ram Kim
    School of Medicine, Konkuk University, Chungju 380 701, Korea
    Sci Rep 6:19685. 2016
    ..Taken together, mesenteric IL-10-producing regulatory B cells control food allergy via Foxp3(+) regulatory T cells and could potentially act as a therapeutic regulator for food allergy. ..
  42. doi request reprint DJ-1 protein regulates CD3+ T cell migration via overexpression of CXCR4 receptor
    Seung Hyo Jung
    Department of Physiology, School of Medicine, Konkuk University, Chungju 380 701, Republic of Korea
    Atherosclerosis 235:503-9. 2014
    ..Here we investigated the hypothesis that DJ-1 protein might participate in CD3+ T cell functions in response to SDF-1 and contribute to the pathogenesis of atherosclerosis...
  43. pmc Hydrogen peroxide induces vasorelaxation by enhancing 4-aminopyridine-sensitive Kv currents through S-glutathionylation
    Sang Woong Park
    Department of Physiology, Institute of Functional Genomics, Research Institute of Medical Science, School of Medicine, Konkuk University, Choongju, 380 701, Korea
    Pflugers Arch 467:285-97. 2015
    ..Furthermore, our results support the idea that the basal redox status of MASMCs determines the response of Kv currents to H2O2. ..
  44. ncbi request reprint Ligusticum wallichi-induced vasorelaxation mediated by mitogen-activated protein kinase in rat aortic smooth muscle
    Bokyung Kim
    Department of Physiology, College of Medicine, Konkuk University, Danwol dong 322, Chungju, Choong Buk 380 701, South Korea
    J Ethnopharmacol 90:397-401. 2004
    ..These results suggest that Ch1LW induces vasorelaxation in rat aortic smooth muscle, which may be mediated by the inhibition of ERK1/2 pathway, but not p38 MAPK...
  45. doi request reprint Antifungal miconazole induces cardiotoxicity via inhibition of APE/Ref-1-related pathway in rat neonatal cardiomyocytes
    Kyung Jong Won
    Department of Medical Science, Institute of Functional Genomics, School of Medicine, Konkuk University, Choongju 380 701, Korea
    Toxicol Sci 126:298-305. 2012
    ..This possible new adverse event in cardiomyocyte function caused by miconazole may provide a basis for the development of novel antifungal agents...
  46. doi request reprint Carvacrol inhibits atherosclerotic neointima formation by downregulating reactive oxygen species production in vascular smooth muscle cells
    Kang Pa Lee
    Department of Physiology, School of Medicine, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, South Korea
    Atherosclerosis 240:367-73. 2015
    ..We investigated the effects of carvacrol on the migration and proliferation of rat aortic smooth muscle cells (RASMCs) and on vascular neointima formation...
  47. pmc Tetrahydrobiopterin Inhibits PDGF-stimulated Migration and Proliferation in Rat Aortic Smooth Muscle Cells via the Nitric Oxide Synthase-independent Pathway
    Xiaowen Jiang
    Departments of Physiology and Biotechnology, Konkuk University, Chungju 380 701, Korea
    Korean J Physiol Pharmacol 14:177-83. 2010
    ..Therefore, BH4 and its derivative could be useful for the development of a candidate molecule with an NO-independent anti-atherosclerotic function...
  48. doi request reprint Immunogenicity of Japanese encephalitis virus envelope protein by Hyphantria cunea nuclear polyhedrosis virus vector in guinea pig
    Hyung Hoan Lee
    Department of Biotechnology, Konkuk University, Chungju 380 701, Korea
    Appl Biochem Biotechnol 167:259-69. 2012
    ..The survival rates of guinea pig immunized with HcE protein was significantly increased over that of JE vaccine. This result indicates helpful information for developing a subunit vaccine against JEV...
  49. ncbi request reprint Tamoxifen induces vasorelaxation via inhibition of mitogen-activated protein kinase in rat aortic smooth muscle
    Sohyun Park
    Department of Veterinary Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Korea
    J Vet Med Sci 65:1155-60. 2003
    ..These results suggest that tamoxifen induces relaxation of rat vascular smooth muscle, and that this is, at least in part, mediated by the inhibition of the Ca(2+)-independent MAPK pathway...
  50. ncbi request reprint Direct block by bisindolylmaleimide of the voltage-dependent K+ currents of rat mesenteric arterial smooth muscle
    Aeran Kim
    Department of Physiology, College of Medicine, Konkuk University, 322 Danwol dong, Choongju 380 701, South Korea
    Eur J Pharmacol 483:117-26. 2004
    ..These results suggest that bisindolylmaleimide (I) directly inhibits the Kv currents of rat mesenteric arterial smooth muscle cells independently of PKC inhibition, in a state-, voltage-, time- and use-dependent manner...
  51. doi request reprint Morin inhibits Fyn kinase in mast cells and IgE-mediated type I hypersensitivity response in vivo
    Jie Wan Kim
    Department of Immunology and Physiology, College of Medicine, Konkuk University, 322 Danwol dong, Chungju, Republic of Korea
    Biochem Pharmacol 77:1506-12. 2009
    ..7 microM). In conclusion, the results suggest that morin suppresses the IgE-mediated allergic response by primarily inhibiting Fyn kinase in mast cells...
  52. ncbi request reprint Mitogen-activated protein kinases partially regulate endothelin-1-induced contractions through a myosin light chain phosphorylation-independent pathway
    Seongchun Kwon
    Department of Physiology, Kwandong University College of Medicine, Korea
    J Vet Med Sci 65:225-30. 2003
    ..These results indicate that p38 MAPK, as well as p42/p44 MAPK, may partially regulate the ET-1-induced contraction through a MLC phosphorylation-independent pathway...
  53. ncbi request reprint Cardioprotective effects of BMS-180448, a prototype mitoK(ATP) channel opener, and the role of salvage kinases, in the rat model of global ischemia and reperfusion heart injury
    Ju Han Lee
    Department of Applied Biochemistry, Division of Life Science, College of Biomedical and Health Science, Konkuk University, Chungju 380 701, Korea
    Arch Pharm Res 30:634-40. 2007
    ....
  54. pmc Proteomic analysis of colonic mucosal tissue from tuberculous and ulcerative colitis patients
    Seong Chun Kwon
    Department of Physiology, Kwandong University College of Medicine, Gangneung 210 701, Korea
    Korean J Physiol Pharmacol 16:193-8. 2012
    ..This study therefore provides a valuable resource for the molecular and diagnostic analysis of human colitis...
  55. ncbi request reprint Up-regulation of Rnd1 during pregnancy serves as a negative-feedback control for Ca2+ sensitization of contractile elements in rat myometrium
    Yoon Sun Kim
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, 113 8657, Tokyo, Japan
    Biochem Biophys Res Commun 311:972-8. 2003
    ..These results suggest that Rnd1 may have an important role as a negative-feedback control of uterine contraction during gestation through the inhibition of RhoA-mediated increase in the Ca(2+) sensitivity of contractile elements...
  56. ncbi request reprint Effects of fluid flow on voltage-dependent calcium channels in rat vascular myocytes: fluid flow as a shear stress and a source of artifacts during patch-clamp studies
    Sang Woong Park
    Artificial Muscle Research Center, Konkuk University, Choongju, Republic of Korea
    Biochem Biophys Res Commun 358:1021-7. 2007
    ..The facilitation of VDCC(L) currents by fluid flow in vascular myocytes may contribute to the myogenic contraction of blood vessels. The mechanism by which fluid flow causes the voltage shift is vigorously discussed...
  57. ncbi request reprint Antihypertensive activity of chitin derivatives
    Jae Young Je
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Biopolymers 83:250-4. 2006
    ..021 microM. In addition, the antihypertensive effect of AEC50 on spontaneously hypertensive rats (SHR) was evaluated, and the result showed that it effectively decreased systolic blood pressure (SBP) in a dose-dependent manner...