Won Sun Park

Summary

Affiliation: Kangwon National University
Country: Korea

Publications

  1. Li H, Kang H, An J, Seo M, Jung W, Lee D, et al. Inhibitory Effect of Tricyclic Antidepressant Doxepin on Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells. Cardiovasc Toxicol. 2019;: pubmed publisher
    ..Therefore, our present study suggests that doxepin inhibits Kv channels in a concentration-dependent, but not use-, and state-dependent manners, irrespective of its own function. ..
  2. Li H, An J, Seo M, Ha K, Han E, Hong S, et al. Inhibitory effect of immunosuppressive drug tacrolimus on voltage-gated K+ current in rabbit coronary arterial smooth muscle cells. Eur J Pharmacol. 2019;849:59-66 pubmed publisher
    ..From these results, we concluded that tacrolimus inhibited the vascular Kv currents in a dose, state (open and closed)-dependent manner. ..
  3. Seo M, Li H, An J, Jang J, Jung H, Kim T, et al. The vasodilatory effect of the antidiabetic drug linagliptin via inhibition of Rho-associated protein kinase in aortic smooth muscle. Life Sci. 2019;219:1-10 pubmed publisher
  4. Seo M, Li H, An J, Jung I, Jung W, Ha K, et al. Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle. Cardiovasc Toxicol. 2018;: pubmed publisher
    ..However, other K+ channels, PKA/PKG-related signaling cascades associated with vascular dilation, and the endothelium were not involved in vildagliptin-induced vasodilation. ..
  5. Jung H, Lee D, Park S, Choi J, Jung W, Park W, et al. Fucoxanthin Inhibits Myofibroblast Differentiation and Extracellular Matrix Production in Nasal Polyp-Derived Fibroblasts via Modulation of Smad-Dependent and Smad-Independent Signaling Pathways. Mar Drugs. 2018;16: pubmed publisher
    ..The results from the present study suggest that Fx may be a novel anti-fibrotic agent for the treatment of NP formation. ..
  6. Li H, Choi I, Hong D, Son Y, Na S, Jung W, et al. W-7 inhibits voltage-dependent K(+) channels independent of calmodulin activity in rabbit coronary arterial smooth muscle cells. Eur J Pharmacol. 2015;750:14-9 pubmed publisher
    ..From these results, we conclude that W-7 inhibited the Kv current in a dose-dependent manner, but this inhibition occurred independent of calmodulin activity and in a closed (inactivated) state of the Kv channels. ..
  7. Li H, Shin S, Seo M, An J, Ha K, Han E, et al. Alterations of ATP-sensitive K+ channels in human umbilical arterial smooth muscle during gestational diabetes mellitus. Pflugers Arch. 2018;470:1325-1333 pubmed publisher
  8. Li H, Hong D, Son Y, Na S, Jung W, Bae Y, et al. Cilostazol induces vasodilation through the activation of Ca(2+)-activated K(+) channels in aortic smooth muscle. Vascul Pharmacol. 2015;70:15-22 pubmed publisher
    ..We conclude that cilostazol induced vasorelaxation of the aorta through activation of BK(Ca) channel via a PKA-dependent signaling mechanism independent of endothelium. ..
  9. Li H, Shin S, An J, Seo M, Ha K, Han E, et al. Blockade of voltage-dependent K+ current in rabbit coronary arterial smooth muscle cells by the tricyclic antidepressant clomipramine. J Pharmacol Sci. 2018;137:61-66 pubmed publisher
    ..Therefore, we concluded that clomipramine inhibited vascular Kv channels in a concentration-dependent, but state (use)-independent manner, regardless of its own function. ..

More Information

Publications19

  1. Li H, Hong D, Kim H, Kim H, Jung W, Na S, et al. The calmodulin inhibitor CGS 9343B inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Toxicol Appl Pharmacol. 2015;285:207-13 pubmed publisher
    ..Our results demonstrated that CGS 9343B inhibited Kv currents in a state-, time-, and use-dependent manner, independent of calmodulin inhibition. ..
  2. Li H, Shin S, Seo M, An J, Choi I, Jung W, et al. The anti-diabetic drug dapagliflozin induces vasodilation via activation of PKG and Kv channels. Life Sci. 2018;197:46-55 pubmed publisher
    ..We concluded that dapagliflozin induced vasodilation via the activation of Kv channels and PKG, and was independent of other K+ channels, Ca2+ channels, intracellular Ca2+, and the endothelium. ..
  3. Kim H, Li H, Kim H, Shin S, Jung W, Ha K, et al. The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle. Vascul Pharmacol. 2016;84:38-46 pubmed publisher
  4. Li H, Kim H, Kim H, Shin S, Jung W, Ha K, et al. The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:713-21 pubmed publisher
    ..Therefore, these results strongly suggest that amiodarone inhibits Kv currents in a concentration- and state-dependent manner. ..
  5. Lee H, Park S, Park S, Park W, Ryu S, Yang J, et al. Multiple mini-interviews as a predictor of academic achievements during the first 2 years of medical school. BMC Res Notes. 2016;9:93 pubmed publisher
    ..In particular, critical thinking, professionalism, and presentation and communication skills may be meaningful topics for predicting academic achievements, especially in performance-based subjects. ..
  6. Li H, Shin S, Seo M, An J, Jung W, Ha K, et al. The PPAR? activator fenofibrate inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Eur J Pharmacol. 2017;812:155-162 pubmed publisher
    ..From these results, we suggest that fenofibrate inhibited Kv current in a state-, time-, and use-dependent manner, completely independent of PPAR? activation. ..
  7. Kim H, Yoon J, Li H, Jeong G, Park J, Shin S, et al. Functional expression and pharmaceutical efficacy of cardiac-specific ion channels in human embryonic stem cell-derived cardiomyocytes. Sci Rep. 2017;7:13821 pubmed publisher
    ..These results suggest that hESC-CMs can be useful for evaluation of pharmaceutical efficacy and safety of novel drug candidate in cardiac research. ..
  8. Shin S, Li H, An J, Seo M, Na S, Jung W, et al. Inhibition of the Voltage-Dependent K+ Current by the Tricyclic Antidepressant Desipramine in Rabbit Coronary Arterial Smooth Muscle Cells. Cardiovasc Toxicol. 2018;18:252-260 pubmed publisher
    ..Based on these results, we concluded that desipramine directly inhibited the Kv channels in a dose- and state-dependent manner, but the effect was independent of norepinephrine/serotonin reuptake inhibition. ..
  9. Li H, Kim H, Shin S, Seo M, An J, Ha K, et al. The vasorelaxant effect of mitiglinide via activation of voltage-dependent K+ channels and SERCA pump in aortic smooth muscle. Life Sci. 2017;188:1-9 pubmed publisher
    ..However, the vasorelaxant effects of mitiglinide did not involve other K+ channels, Ca2+ channels, PKA/PKG signaling pathways, or the endothelium. ..
  10. Kim H, Li H, Kim H, Shin S, Jung W, Ha K, et al. Cisapride, a selective serotonin 5-HT4-receptor agonist, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells. Biochem Biophys Res Commun. 2016;478:1423-8 pubmed publisher