Su Hyun Jo
Affiliation: Kangwon National University
Vu T, Jeong B, Yu J, Koo B, Jo S, Robinson R, et al
. Soluble prokaryotic expression and purification of crotamine using an N-terminal maltose-binding protein tag. Toxicon. 2014;92:157-65 pubmed publisher
..The crotamine product fused with MBP at its N-terminus also inhibited the hKv1.3 channel, suggesting that the N-terminus is not involved in the channel binding of the toxin. ..
Yu J, Park M, Jo S. Inhibitory effects of cortisone and hydrocortisone on human Kv1.5 channel currents. Eur J Pharmacol. 2015;746:158-66 pubmed publisher
..These results show that cortisone and hydrocortisone inhibited Kv1.5 channel currents differently, and that Kv1.5 channels were more sensitive to hydrocortisone than to cortisone. ..
Kim S, Lee E, Lee K, Jo S, Seo S. PKA regulates calcineurin function through the phosphorylation of RCAN1: identification of a novel phosphorylation site. Biochem Biophys Res Commun. 2015;459:604-9 pubmed publisher
..Our results suggest the presence of a novel phosphorylation site in RCAN1 and that its phosphorylation influences calcineurin-dependent inflammatory target gene expression. ..
Jo S, Hong H, Chong S, Choe H. Protriptyline block of the human ether-à-go-go-related gene (HERG) K+ channel. Life Sci. 2008;82:331-40 pubmed publisher
..Our findings suggest that inhibition of HERG currents may contribute to the arrhythmogenic side effects of protriptyline. ..
Jo S, Hong H, Chong S, Lee H, Choe H. H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res. 2009;60:429-37 pubmed publisher
..These results suggest that promethazine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects during the clinical administration of promethazine...
Lee K, Kim Y, Cho Y, Chung S, Jo S, Choi S. Polychlorinated biphenyl 19 blocks the most common form of store-operated Ca2+ entry through Orai. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:1221-1228 pubmed publisher
..These results imply that PCB19 inhibits not only TRPC-mediated SOCE as in PC12 cells but also Orai-mediated SOCE as in many other cells including HEK293, Jurkat T and HL-60 cells. ..