Kwon Soo Ha

Summary

Affiliation: Kangwon National University
Country: Korea

Publications

  1. pmc C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase 2 activation
    Mahendra Prasad Bhatt
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, Korea
    Diabetes 62:243-53. 2013
  2. ncbi request reprint Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation
    Kwon Soo Ha
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, Kangwon National University, School of Medicine, Chunchon, Kangwon Do, Korea
    FASEB J 17:1036-47. 2003
  3. ncbi request reprint [Ca(2+)]-dependent generation of intracellular reactive oxygen species mediates maitotoxin-induced cellular responses in human umbilical vein endothelial cells
    Sun Ju Yi
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chunchon 200 701, Korea
    Mol Cells 21:121-8. 2006
  4. ncbi request reprint High-throughput analysis of GST-fusion protein expression and activity-dependent protein interactions on GST-fusion protein arrays with a spectral surface plasmon resonance biosensor
    Jae Wan Jung
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chuncheon, Kangwon Do, Korea
    Proteomics 6:1110-20. 2006
  5. ncbi request reprint Analysis of protein interactions on protein arrays by a wavelength interrogation-based surface plasmon resonance biosensor
    Jong Seol Yuk
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chunchon, Kangwon Do, South Korea
    Proteomics 4:3468-76. 2004
  6. ncbi request reprint High-throughput analysis of mumps virus and the virus-specific monoclonal antibody on the arrays of a cationic polyelectrolyte with a spectral SPR biosensor
    Hyun Soo Kim
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chuncheon, Kangwon Do, Korea
    Proteomics 6:6426-32. 2006
  7. ncbi request reprint beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation
    Se Kyung Bai
    Vascular System Research Center, Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    Exp Mol Med 37:323-34. 2005
  8. ncbi request reprint Sensitivity enhancement of spectral surface plasmon resonance biosensors for the analysis of protein arrays
    Jong Seol Yuk
    Department of Molecular and Cellular Biochemistry and Nano Bio Sensor Research Center, Kangwon National University School of Medicine, Chunchon, Kangwon Do, 200 701, South Korea
    Eur Biophys J 35:469-76. 2006
  9. ncbi request reprint Inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21(ras)-dependent NF-kappaB activation
    Hee Jun Na
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do, Korea
    J Immunol 173:1276-83. 2004
  10. ncbi request reprint Investigation of selective protein immobilization on charged protein array by wavelength interrogation-based SPR sensor
    Sun Ju Yi
    Department of Molecular and Cellullar Biochemistry, Kangwon National University School of Medicine, Chunchon 200 701, Korea
    Mol Cells 15:333-40. 2003

Collaborators

Detail Information

Publications51

  1. pmc C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase 2 activation
    Mahendra Prasad Bhatt
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, Korea
    Diabetes 62:243-53. 2013
    ..Furthermore, TG2 may be a promising avenue of therapeutic investigation to treat diabetic vasculopathies...
  2. ncbi request reprint Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation
    Kwon Soo Ha
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, Kangwon National University, School of Medicine, Chunchon, Kangwon Do, Korea
    FASEB J 17:1036-47. 2003
    ..Our data suggest that the NO/cGMP pathway suppresses 6-OHDA-induced PC12 cell apoptosis by suppressing the mitochondrial apoptosis signal via PKG/PI3K/Akt-dependent Bad phosphorylation...
  3. ncbi request reprint [Ca(2+)]-dependent generation of intracellular reactive oxygen species mediates maitotoxin-induced cellular responses in human umbilical vein endothelial cells
    Sun Ju Yi
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chunchon 200 701, Korea
    Mol Cells 21:121-8. 2006
    ....
  4. ncbi request reprint High-throughput analysis of GST-fusion protein expression and activity-dependent protein interactions on GST-fusion protein arrays with a spectral surface plasmon resonance biosensor
    Jae Wan Jung
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chuncheon, Kangwon Do, Korea
    Proteomics 6:1110-20. 2006
    ..Thus, protein arrays prepared on the GSH surface provide a useful system for the high-throughput analysis of GST-fusion protein expression and activity-dependent protein interactions with the spectral SPR biosensors...
  5. ncbi request reprint Analysis of protein interactions on protein arrays by a wavelength interrogation-based surface plasmon resonance biosensor
    Jong Seol Yuk
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chunchon, Kangwon Do, South Korea
    Proteomics 4:3468-76. 2004
    ..These results suggest that the wavelength interrogation-based SPR sensor can be used as the biosensor for the high-throughput analysis of protein interactions on protein arrays...
  6. ncbi request reprint High-throughput analysis of mumps virus and the virus-specific monoclonal antibody on the arrays of a cationic polyelectrolyte with a spectral SPR biosensor
    Hyun Soo Kim
    Department of Molecular and Cellular Biochemistry, Kangwon National University College of Medicine, Chuncheon, Kangwon Do, Korea
    Proteomics 6:6426-32. 2006
    ..Thus, it is likely that the spectral SPR biosensor based on the cationic polyelectrolyte surface may provide an efficient system for a high-throughput analysis of intact virus and serodiagnosis of infectious diseases...
  7. ncbi request reprint beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation
    Se Kyung Bai
    Vascular System Research Center, Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    Exp Mol Med 37:323-34. 2005
    ..These results suggest that beta-carotene possesses anti-inflammatory activity by functioning as a potential inhibitor for redox-based NF-kappaB activation, probably due to its antioxidant activity...
  8. ncbi request reprint Sensitivity enhancement of spectral surface plasmon resonance biosensors for the analysis of protein arrays
    Jong Seol Yuk
    Department of Molecular and Cellular Biochemistry and Nano Bio Sensor Research Center, Kangwon National University School of Medicine, Chunchon, Kangwon Do, 200 701, South Korea
    Eur Biophys J 35:469-76. 2006
    ..Therefore, it is suggested that sensitivity enhancement is readily achieved by reducing the refractive index of the sensing prism of spectral SPR biosensors to be operated at long wavelength ranges for the analysis of protein arrays...
  9. ncbi request reprint Inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21(ras)-dependent NF-kappaB activation
    Hee Jun Na
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do, Korea
    J Immunol 173:1276-83. 2004
    ..Together, these findings reveal that the inhibitory effect of LB42708 on p21(ras)-dependent NF-kappaB activation may have potential therapeutic value for arthritis and other inflammatory diseases...
  10. ncbi request reprint Investigation of selective protein immobilization on charged protein array by wavelength interrogation-based SPR sensor
    Sun Ju Yi
    Department of Molecular and Cellullar Biochemistry, Kangwon National University School of Medicine, Chunchon 200 701, Korea
    Mol Cells 15:333-40. 2003
    ..The arrays could be reutilized at least 5 times. Thus, it is likely that charged surfaces, assembled by the layer-by-layer method using polyelectrolytes, will prove useful for preparing selective protein arrays...
  11. doi request reprint Cellular responses to chlorin-based photosensitizer DH-II-24 under darkness in human gastric adenocarcinoma AGS cells
    Young Cheol Lim
    Department of Molecular and Cellular Biochemistry and Institute of Medical Scicence, Kangwon National University School of Medicine, Kangwon Do, Korea
    Cancer Sci 102:549-56. 2011
    ..DH-II-24-mediated PDT decreased cell viability and induced cell detachment. These results demonstrate that DH-II-24 treatment alone under darkness induced different cellular responses to DH-II-24-mediated PDT...
  12. pmc Transglutaminase 2 promotes both caspase-dependent and caspase-independent apoptotic cell death via the calpain/Bax protein signaling pathway
    Je Ok Yoo
    Department of Molecular and Cellular Biochemistry and Institute of Medical Science, Kangwon National University School of Medicine, Kangwon Do 200 701, Korea
    J Biol Chem 287:14377-88. 2012
    ..Moreover, these results indicate that TG2 may be a possible therapeutic target for PDT treatment of cancer...
  13. ncbi request reprint Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB
    Kwang Chang
    Department of Molecular and Cellular Biochemistry, School of Medicine Kangwon National University, Chuncheon, Gangwon Do, Korea
    Exp Mol Med 36:311-24. 2004
    ..These results identify a novel negative feedback mechanism whereby NO down-regulates iNOS gene expression...
  14. doi request reprint Differential cytotoxic responses to low- and high-dose photodynamic therapy in human gastric and bladder cancer cells
    Je Ok Yoo
    Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Kangwon Do 200 701, Korea
    J Cell Biochem 112:3061-71. 2011
    ..Thus, these results demonstrate that LDP and HDP induced apoptotic and necrotic cell death by differential signaling mechanisms involving intracellular Ca(2+) , ROS, and TG2...
  15. doi request reprint Rapid determination of blood coagulation factor XIII activity using protein arrays for serodiagnosis of human plasma
    Mi Hye Kwon
    Department of Molecular and Cellular Biochemistry and Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, South Korea
    Anal Chem 83:2317-23. 2011
    ..Moreover, it has a strong potential to be applied toward FXIII-related personalized medicines...
  16. doi request reprint Normalization using a tagged-internal standard assay for analysis of antibody arrays and the evaluation of serological biomarkers for liver disease
    Deok Hoon Kong
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, Republic of Korea
    Anal Chim Acta 718:92-8. 2012
    ..Thus, median-centered/IgM-TIS assay normalization is a useful approach for analyzing antibody array data and evaluating serological biomarkers for the diagnosis of liver disease or cancers...
  17. pmc Integrative proteomic profiling of protein activity and interactions using protein arrays
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Kangwon Do, Korea
    Mol Cell Proteomics 11:1167-76. 2012
    ..This integrative proteomic profiling method can be applied to quantitative validation of previously known protein interactions, and in understanding the functions and regulation of target proteins in biological processes of interest...
  18. doi request reprint Quantitative and rapid analysis of transglutaminase activity using protein arrays in mammalian cells
    Mi Hye Kwon
    Department of Molecular and Cellular Biochemistry and Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon 200 701, Korea
    Mol Cells 27:337-43. 2009
    ....
  19. ncbi request reprint Identification and ultrastructural imaging of photodynamic therapy-induced microfilaments by atomic force microscopy
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry and Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, Korea
    Ultramicroscopy 109:1428-34. 2009
    ....
  20. doi request reprint Comparative characterization of direct and indirect substrate probes for on-chip transamidating activity assay of transglutaminases
    Kangseung Lee
    Department of Molecular and Cellular Biochemistry and Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, South Korea
    J Biotechnol 168:324-30. 2013
    ..Furthermore, this study provides a helpful guide for development of new probes, which is necessary for the identification of potential biomarkers and therapeutic targets for treating enzyme-related diseases. ..
  21. ncbi request reprint Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways
    Seon Jin Lee
    Dept of Molecular and Cellular Biochemistry, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    Am J Physiol Heart Circ Physiol 291:H2836-46. 2006
    ..This study suggests that FKN may play an important role in the pathophysiological process of inflammatory angiogenesis...
  22. ncbi request reprint Functional role of NF-κB in expression of human endothelial nitric oxide synthase
    Kyu Sun Lee
    Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon do 200 702, South Korea
    Biochem Biophys Res Commun 448:101-7. 2014
    ..These results suggest that NF-κB is a potential therapeutic target for preventing vascular inflammation and endothelial dysfunction induced by suppression of miR-155-mediated eNOS expression...
  23. doi request reprint Prevention of VEGF-mediated microvascular permeability by C-peptide in diabetic mice
    Young Cheol Lim
    Department of Molecular and Cellular Biochemistry, Institute of Medical Scicence, Kangwon National University School of Medicine, Kangwon Do 200 701, Korea
    Cardiovasc Res 101:155-64. 2014
    ..Our purpose was to explore the potential protective role of C-peptide against microvascular permeability mediated by vascular endothelial growth factor (VEGF)-induced reactive oxygen species (ROS) generation in diabetes...
  24. doi request reprint Simultaneous activity assay of two transglutaminase isozymes, blood coagulation factor XIII and transglutaminase 2, by use of fibrinogen arrays
    Mi Hye Kwon
    Department of Molecular and Cellular Biochemistry and Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, South Korea
    Anal Chem 83:8718-24. 2011
    ....
  25. pmc Propofol and aminophylline antagonize each other during the mobilization of intracellular calcium in human umbilical vein endothelial cells
    Hee Jeong Son
    Department of Anesthesiology and Pain Medicine, Kangwon National University Medical School, Chuncheon, Korea
    J Korean Med Sci 25:1222-7. 2010
    ..Serious consideration should be given to how this interaction affects mobilization of intracellular calcium when these two drugs are used together...
  26. ncbi request reprint Arachidonic acid activates tissue transglutaminase and stress fiber formation via intracellular reactive oxygen species
    Sun Ju Yi
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chunchon, Kangwon Do 200 701, Republic of Korea
    Biochem Biophys Res Commun 325:819-26. 2004
    ..These results suggested that the activation of in situ tTGase and stress fiber formation by arachidonic acid was mediated by intracellular ROS in NIH3T3 cells...
  27. doi request reprint Quantitative kinetics of proteolytic enzymes determined by a surface concentration-based assay using peptide arrays
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry and Institute of Medical Science, Chuncheon, Kangwon Do 200 701, Korea
    Analyst 137:3814-20. 2012
    ..Thus, this new assay has a strong potential for use in the quantitative evaluation of proteases, and for drug discovery through kinetics studies including the determination of K(m) and V(max)...
  28. doi request reprint Rapid analysis of matrix metalloproteinase-3 activity by gelatin arrays using a spectral surface plasmon resonance biosensor
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry and Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, Korea
    Analyst 135:1050-7. 2010
    ..Therefore, this new assay system using a spectral SPR biosensor is simple, label-free, and high-throughput, and is likely to have a strong potential for inhibitor screening...
  29. doi request reprint Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA
    Ji Hee Kim
    Vascular Homeostasis Laboratory and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do, Korea
    Free Radic Biol Med 53:629-40. 2012
    ..Thus, siRNA targeting Keap1 may provide a new therapeutic approach for inflammation-associated vascular diseases and sepsis...
  30. doi request reprint Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization
    Kyu Sun Lee
    Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon Do, South Korea
    Biochem Biophys Res Commun 418:49-55. 2012
    ..Our results indicate that l-NMA can inhibit iNOS-dependent NO production by preventing iNOS dimerization and destabilizing its dimeric form...
  31. doi request reprint Extracellular ultrathin fibers sensitive to intracellular reactive oxygen species: formation of intercellular membrane bridges
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry and Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, Republic of Korea
    Exp Cell Res 317:1763-73. 2011
    ..Furthermore, ultrastructural imaging of ultrathin fibers may contribute to understanding the diverse mechanisms of cell-to-cell communication and the intercellular transfer of biomolecules, including proteins and cell organelles...
  32. pmc C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes
    Mahendra Prasad Bhatt
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Korea
    Diabetes 62:3851-62. 2013
    ..These findings highlight a novel mechanism by which C-peptide activates AMPKα and protects against hyperglycemia-induced vasculopathy. ..
  33. ncbi request reprint Analysis of C-reactive protein on amide-linked N-hydroxysuccinimide-dextran arrays with a spectral surface plasmon resonance biosensor for serodiagnosis
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, South Korea
    Anal Chem 79:5703-10. 2007
    ..945, p < 0.0001). Thus, the array-based spectral SPR biosensor based on the AL NHS-dextran surface is a potential system for rapid and label-free serodiagnosis of human diseases...
  34. doi request reprint Monitoring of proteolytic enzyme activity using phase transition-based peptide arrays
    Deok Hoon Kong
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, Republic of Korea
    Biosens Bioelectron 36:147-53. 2012
    ..Therefore, this new assay has potential for the quantitative analysis of enzyme kinetics of protease and informs research developments in drug discovery utilizing kinetic studies...
  35. ncbi request reprint Proteomic applications of surface plasmon resonance biosensors: analysis of protein arrays
    Jong Seol Yuk
    Department of Molecular and Cellular Biochemistry, Nano bio Sensor Research Center, Kangwon National University School of Medicine, Chuncheon, Gangwon do 200 701, South Korea
    Exp Mol Med 37:1-10. 2005
    ..SPR biosensors have a strong potential for analyzing proteomes by SPR imaging and SPR spectroscopic imaging, even though the challenge is to produce proteins on a proteomic scale...
  36. doi request reprint Label-free and quantitative analysis of C-reactive protein in human sera by tagged-internal standard assay on antibody arrays
    Jae Wan Jung
    Department of Molecular and Cellular Biochemistry and Vascular System Research Center, Chuncheon, Kangwon Do 200 701, South Korea
    Biosens Bioelectron 24:1469-73. 2009
    ..967, CV=0.32%). Thus, the antibody array-based TIS assay system is high-throughput, quantitative, and label-free and may be useful in the rapid serodiagnosis of human disease...
  37. pmc Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein
    Yoon Kyung Choi
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Kangwon Do 200 701, Republic of Korea
    J Biol Chem 285:32116-25. 2010
    ..These results suggest that CO stimulates VEGF production by increasing HIF-1α protein level via two distinct mechanisms, translational stimulation and protein stabilization of HIF-1α...
  38. doi request reprint TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions
    Hee Jun Na
    Vascular Homeostasis Laboratory and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon Do, 200 701, Korea
    Angiogenesis 17:179-94. 2014
    ..These data indicate that caspase-8 may be used as an anti-angiogenic drug for solid tumors resistant to TRAIL and anti-tumor drugs. ..
  39. doi request reprint New insights into the mechanisms for photodynamic therapy-induced cancer cell death
    Je Ok Yoo
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, South Korea
    Int Rev Cell Mol Biol 295:139-74. 2012
    ..Understanding the complex cross talk between these pathways may improve the effectiveness of PDT. Here, we discuss the interplay between these mechanisms based on recent evidence and suggest prospects with regard to advances in PDT...
  40. pmc Serological responses to a soluble recombinant chimeric Plasmodium vivax circumsporozoite protein in VK210 and VK247 population
    Yang Cheng
    Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, Gangwon do 200 701, Republic of Korea
    Malar J 12:323. 2013
    ..Naturally acquired humoral immune responses study show that antigenicity of rPvCSP-c was much higher than that of native strain. However, the serologic reactivity of rPvCSP-c was still unclear in detail...
  41. doi request reprint Array-based spectral SPR biosensor: analysis of mumps virus infection
    Jong Seol Yuk
    Department of Molecular and Cellular Biochemistry and Nanobio Sensor Research Center, Kangwon National University College of Medicine, Chuncheon, Kangwon Do, Korea
    Methods Mol Biol 503:37-47. 2009
    ..The array-based spectral SPR biosensor has a strong potential for a high-throughput serodiagnosis of infectious diseases...
  42. doi request reprint Antitumor effect of photodynamic therapy with chlorin-based photosensitizer DH-II-24 in colorectal carcinoma
    Young Cheol Lim
    Department of Molecular and Cellular Biochemistry and Vascular System Research Center, Kangwon National University School of Medicine, Kangwon Do, Korea
    Cancer Sci 100:2431-6. 2009
    ..Histological examination revealed necrotic damage in PDT-treated tumors, concomitantly with severe damage of tumor vasculature. These results suggest that DH-II-24 is a potential photosensitizer of photodynamic therapy for cancer...
  43. ncbi request reprint Regulation of programmed cell death in neuronal cells by nitric oxide
    Yun Chul Kang
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, College of Medicine, Kangwon National University, Chunchon, Kangwon Do, Korea
    In Vivo 18:367-76. 2004
    ..We review the molecular mechanism by which NO exerts both pro- and anti-apoptotic actions in neuronal cells and the clinical implications for regulating neuronal apoptosis...
  44. ncbi request reprint Transglutaminase 2: a multi-functional protein in multiple subcellular compartments
    Donghyun Park
    Department of Molecular and Cellular Biochemistry, Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon, Kangwon Do, 200 701, Republic of Korea
    Amino Acids 39:619-31. 2010
    ..In this review, the biological functions and molecular interactions of TG2 will be discussed in the context of the unique environments of the subcellular compartments to which TG2 localizes...
  45. ncbi request reprint The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signal pathways
    Chun Ki Kim
    Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Kangwon Do 200 701, South Korea
    Mol Pharmacol 78:142-50. 2010
    ..These data indicate that the antitumor effect of LB42708 can be associated with direct inhibition of VEGF-induced tumor angiogenesis by blocking Ras-dependent MAPK and PI3K/Akt signal pathways in tumor-associated endothelial cells...
  46. pmc Molecular imaging of membrane proteins and microfilaments using atomic force microscopy
    Se Hui Jung
    Department of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon 200 701, Korea
    Exp Mol Med 42:597-605. 2010
    ..These approaches can contribute to many applications of AFM in cell imaging...
  47. pmc Cyclic AMP prolongs graft survival by suppressing apoptosis and inflammatory gene expression in acute cardiac allograft rejection
    Jie Young Lee
    Vascular System Research Center, School of Medicine, Kangwon National University, Chuncheon, Korea
    Exp Mol Med 42:69-79. 2010
    ..These results suggest that db-cAMP exerts a beneficial effect on murine cardiac allograft survival by modulating allogeneic immune response and cytotoxicity...
  48. doi request reprint Measurement of naturally acquired humoral immune responses against the C-terminal region of the Plasmodium vivax MSP1 protein using protein arrays
    Jun Hu Chen
    Department of Parasitology and Institute of Medical Science, Kangwon National University School of Medicine, Hyoja2 dong, Chunchon, 200 701, Kangwon Do, Republic of Korea
    Parasitol Res 109:1259-66. 2011
    ..05). The novel protein array platform may be used for profiling naturally acquired humoral immune responses to P. vivax infection...
  49. ncbi request reprint Water extract of Korean red ginseng stimulates angiogenesis by activating the PI3K/Akt-dependent ERK1/2 and eNOS pathways in human umbilical vein endothelial cells
    Young Mi Kim
    Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon Do 200 701, Korea
    Biol Pharm Bull 30:1674-9. 2007
    ..This study demonstrated that KRGE stimulates in vitro and in vivo angiogenesis through the activation of the PI3K/Akt-dependent ERK1/2 and eNOS signal pathways and their cross talk...
  50. doi request reprint Co-localization of inducible nitric oxide synthase and phosphorylated Akt in the lesional skins of patients with melasma
    Ho Youn Jo
    Department of Dermatology, Kangwon National University, Chunchon, Kangwon Do, Korea
    J Dermatol 36:10-6. 2009
    ....
  51. doi request reprint A novel array-based assay of in situ tissue transglutaminase activity in human umbilical vein endothelial cells
    Jin Young Park
    Department of Molecular and Cellular Biochemistry and Vascular System Research Center, Kangwon National University School of Medicine, Chuncheon, Kangwon Do 200 701, South Korea
    Anal Biochem 394:217-22. 2009
    ..Thus, the array-based in situ TG activity assay constitutes a rapid and high-throughput approach to investigating the roles of TGs in cell signaling...