Research Topics
Genomes and GenesSpecies | J D JiSummaryCountry: Korea Publications
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Publications
Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2J D Ji
Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, 126 1, Anam Dong 5 Ga, Sungbuk Gu, Seoul 136 705, South Korea
Rheumatology (Oxford) 44:983-8. 2005..The anti-inflammatory effect of IL-10 is mediated via activated STAT3 (signal transducer and activator of transcription 3). In this study, we investigated whether 15d-PGJ2 inhibit IL-10-induced STAT activation...
Polymorphsims of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathiesY H Lee
College of Medicine, Korea University, Seongbuk Ku, Seoul
Clin Rheumatol 20:420-2. 2001..However, further studies are required to discover the possible contribution of the polymorphisms of the CTLA-4 and Fas to the pathogenesis of SpA...
Associations between the p53 codon 72 polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seongbuk gu, Seoul, Korea
Lupus 21:430-7. 2012..The aim of this study was to determine whether the p53 codon 72 polymorphism confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA)...
The functional p53 codon 72 polymorphism is associated with systemic lupus erythematosusY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, College of Medicine, Korea University, Anam Dong, Seongbuk Ku, Seoul, Korea
Lupus 14:842-5. 2005..Further studies for replications are needed to confirm that the p53 polymorphism contributes to SLE...
Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritisY H Lee
Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
Lupus 13:188-91. 2004..In conclusion, our data show that the eNOS ab genotypes may be associated with the development of lupus nephritis, suggesting individuals who carry the 'a' allele are more susceptible to lupus nephritis than those with the 'b' allele...
Functional polymorphisms in matrix metalloproteinase-1 and monocyte chemoattractant protein-1 and rheumatoid arthritisY H Lee
Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
Scand J Rheumatol 32:235-9. 2003..Our data show that the functional promoter polymorphism in the MMP-1 promoter may not play an important role in the susceptibility of RA, but the polymorphism may be related to clinical phenotypes...
Association of programmed cell death 1 polymorphisms and systemic lupus erythematosus: a meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea
Lupus 18:9-15. 2009..031). In conclusion, this meta-analysis demonstrated an association of the PD1.3A allele with LN in European and SLE in Latin-American populations. Furthermore, the PD1.5C allele was associated with SLE susceptibility in Europeans...
Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosusY H Lee
Department of Intemal Medicine, College of Medicine, Korea University, Seoul
Lupus 10:601-5. 2001..05. Clinically, in the lupus patients there was no significant difference according to the CTLA-4 polymorphisms. In conclusion, no correlation was found between CTLA-4 exon 1 (+49) and promoter (-318) polymorphisms and SLE in our study...
p53 codon 72 polymorphism and rheumatoid arthritisY H Lee
Department of Internal Medicine, College of Medicine, Korea University, Seoul
J Rheumatol 28:2392-4. 2001..To investigate whether the p53 codon 72 polymorphism is associated with susceptibility to rheumatoid arthritis (RA) and its clinical features...
The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Lupus 21:60-7. 2012..In conclusion, this meta-analysis demonstrates that the IL-6 -174 G/C polymorphism may confer susceptibility to SLE in Europeans, but that the IL-6 -572 G/C polymorphism is not associated with susceptibility to SLE in Asians...
Fcgamma receptor IIB and IIIB polymorphisms and susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Lupus 18:727-34. 2009..This meta-analysis shows that the FcgammaRIIB T/I232 polymorphism confers susceptibility to SLE, especially in Asian-derived populations...
Genome scan meta-analysis of rheumatoid arthritisS J Choi
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, 126-1 Ka, Anam-dong, Seongbuk-Ku, Seoul 136-705, Korea
Rheumatology (Oxford) 45:166-70. 2006..These data may provide a basis to carry out targeted linkage and candidate gene studies, particularly in the regions...
Tacrolimus for the treatment of active rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trialsY H Lee
Department of Internal Medicine, Division of Rheumatology, Korea University Medical Centre, Korea University College of Medicine, Seoul, Korea
Scand J Rheumatol 39:271-8. 2010..The aim of this study was to assess the efficacy and safety of tacrolimus in patients with active rheumatoid arthritis (RA)...
The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Seoul, Korea
Rheumatology (Oxford) 46:49-56. 2007....
Association between the valine/leucine247 polymorphism of β2-glycoprotein I and susceptibility to anti-phospholipid syndrome: a meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Lupus 21:865-71. 2012....
Induction and maintenance therapy for lupus nephritis: a systematic review and meta-analysisY H Lee
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Lupus 19:703-10. 2010..010), and was associated with a lower infection risk (RR 0.688, 95% CI 0.523-0.905, p-value 0.008). In conclusion, MMF was found to be as effective as CYC and tended to have a better safety profile as an induction therapy for LN than CYC...
Exudative pleural effusion and pleural leukocytoclastic vasculitis in limited sclerodermaY H Lee
Department of Internal Medicine, College of Medicine, Korea University, Seoul
J Rheumatol 25:1006-8. 1998..We describe a 43-year-old woman with limited scleroderma who developed an exudative pleural effusion associated with pleural leukocytoclastic vasculitis...
A case of BOOP developed during bucillamine treatment for rheumatoidY H Lee
Division of Rheumatology, College of Medicine, Korea University, Seoul, Korea
Korean J Intern Med 16:36-9. 2001..Bucillamine was stopped and 50 mg of prednisolone was administered. His symptoms and infiltrations on the chest X-ray resolved. We suggest that bucillamine should be considered as a drug possibly associated with BOOP...
Fas promoter -670 polymorphism is associated with development of anti-RNP antibodies in systemic lupus erythematosusY H Lee
Department of Internal Medicine, College of Medicine, Korea University, Seoul
J Rheumatol 28:2008-11. 2001..To evaluate whether the polymorphism of Fas promoter -670 is associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and their clinical features...
Effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytesJ D Ji
Department of Biochemistry, Korea University College of Medicine, Sungbuk-gu, Seoul, Korea
J Autoimmun 17:215-21. 2001..Furthermore, PPAR-gamma activation induces apoptosis by itself and augments TRAIL/Apo2L-induced apoptosis in THP-1 cells. These results suggest that PPAR-gamma agonists may provide a new therapeutic approach for RA...
Actinomycin D renders cultured synovial fibroblasts susceptible to tumour necrosis factor related apoptosis-inducing ligand (TRAIL)-induced apoptosisY W Park
Division of Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea
Scand J Rheumatol 32:356-63. 2003..ActD, CHX, and MG132 rendered cultured synovial fibroblasts susceptible to TRAIL-induced apoptosis by a caspase-dependent mechanism. However, the exact mechanism of sensitization by these metabolic inhibitors remains to be determined...
