Jin Han

Summary

Affiliation: Inje University
Country: Korea

Publications

  1. pmc Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165, Gaegeum dong, Busanjin Gu, Busan 614 735, Korea
    Nutr Res Pract 6:226-31. 2012
  2. pmc Yoga training improves metabolic parameters in obese boys
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 735, Korea
    Korean J Physiol Pharmacol 16:175-80. 2012
  3. pmc Aged garlic extract enhances exercise-mediated improvement of metabolic parameters in high fat diet-induced obese rats
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165, Gaegeum dong, Busanjin Gu, Busan 614 735, Korea
    Nutr Res Pract 6:513-9. 2012
  4. pmc Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis
    Hyoung Kyu Kim
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    Proteome Sci 10:50. 2012
  5. ncbi request reprint Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels
    Won Sun Park
    Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Research Center, Biohealth Products Research Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan, 613 735, South Korea
    Pflugers Arch 454:1023-30. 2007
  6. ncbi request reprint Direct modulation of Ca(2+)-activated K(+) current by H-89 in rabbit coronary arterial smooth muscle cells
    Won Sun Park
    Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Research Center, 633 165 Gaegeum dong, Busanjin Gu, Busan 613 735, Republic of Korea
    Vascul Pharmacol 46:105-13. 2007
  7. doi request reprint HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage
    Seung Hun Jeong
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 614 735, Republic of Korea
    Bioorg Med Chem Lett 23:4225-9. 2013
  8. doi request reprint NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter
    Vu Thi Thu
    Department of Physiology, Inje University, Busan 613 735, Republic of Korea
    Cardiovasc Res 94:342-50. 2012
  9. ncbi request reprint Increased inhibition of inward rectifier K+ channels by angiotensin II in small-diameter coronary artery of isoproterenol-induced hypertrophied model
    Won Sun Park
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Inje University 633 165 Gaegeum Dong, Busanjin Gu, Busan 613 735, Korea
    Arterioscler Thromb Vasc Biol 27:1768-75. 2007
  10. ncbi request reprint Calcium channel inhibitor, verapamil, inhibits the voltage-dependent K+ channels in rabbit coronary smooth muscle cells
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Biomarker Medical Research Center, FIRST Mitochondrial Research Group, Inje University, Busan, Korea
    Biol Pharm Bull 33:47-52. 2010

Collaborators

Detail Information

Publications81

  1. pmc Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165, Gaegeum dong, Busanjin Gu, Busan 614 735, Korea
    Nutr Res Pract 6:226-31. 2012
    ..AGE supplementation reduced homocysteine levels regardless of whether the women also exercised. The present results suggest that AGE supplementation reduces cardiovascular risk factors independently of exercise in postmenopausal women...
  2. pmc Yoga training improves metabolic parameters in obese boys
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 735, Korea
    Korean J Physiol Pharmacol 16:175-80. 2012
    ..Our findings show that an 8-week of yoga training improves body composition and TC levels in obese adolescent boys, suggesting that yoga training may be effective in controlling some metabolic syndrome factors in obese adolescent boys...
  3. pmc Aged garlic extract enhances exercise-mediated improvement of metabolic parameters in high fat diet-induced obese rats
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165, Gaegeum dong, Busanjin Gu, Busan 614 735, Korea
    Nutr Res Pract 6:513-9. 2012
    ....
  4. pmc Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis
    Hyoung Kyu Kim
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    Proteome Sci 10:50. 2012
    ..abstract:..
  5. ncbi request reprint Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels
    Won Sun Park
    Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Research Center, Biohealth Products Research Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan, 613 735, South Korea
    Pflugers Arch 454:1023-30. 2007
    ....
  6. ncbi request reprint Direct modulation of Ca(2+)-activated K(+) current by H-89 in rabbit coronary arterial smooth muscle cells
    Won Sun Park
    Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Research Center, 633 165 Gaegeum dong, Busanjin Gu, Busan 613 735, Republic of Korea
    Vascul Pharmacol 46:105-13. 2007
    ..These findings suggest that H-89 increases the BK(Ca) current independently of PKA...
  7. doi request reprint HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage
    Seung Hun Jeong
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 614 735, Republic of Korea
    Bioorg Med Chem Lett 23:4225-9. 2013
    ..Moreover, HS-1793-treated rat heart showed reduced infarct size. Our data suggest that HS-1793 can protect cardiac against mitochondrial damage following H/R, thereby suppressing injury. ..
  8. doi request reprint NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter
    Vu Thi Thu
    Department of Physiology, Inje University, Busan 613 735, Republic of Korea
    Cardiovasc Res 94:342-50. 2012
    ..We examined the protective effects and mechanism of a new compound, NecroX-5, on rat heart mitochondria in a hypoxia/reoxygenation (HR) model...
  9. ncbi request reprint Increased inhibition of inward rectifier K+ channels by angiotensin II in small-diameter coronary artery of isoproterenol-induced hypertrophied model
    Won Sun Park
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Inje University 633 165 Gaegeum Dong, Busanjin Gu, Busan 613 735, Korea
    Arterioscler Thromb Vasc Biol 27:1768-75. 2007
    ..We investigated the effects of angiotensin II (Ang II) on inward rectifier K+ (Kir) channels in small-diameter coronary arterial smooth muscle cells (SCASMCs) of control and isoproterenol (Iso)-induced hypertrophied rabbits...
  10. ncbi request reprint Calcium channel inhibitor, verapamil, inhibits the voltage-dependent K+ channels in rabbit coronary smooth muscle cells
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Biomarker Medical Research Center, FIRST Mitochondrial Research Group, Inje University, Busan, Korea
    Biol Pharm Bull 33:47-52. 2010
    ..Based on these results, we concluded that verapamil inhibited Kv current in a state-, time-, and use-dependent manner, independent of Ca(2+) channel inhibition...
  11. doi request reprint Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts
    Vu Thi Thu
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, FIRST Mitochondrial Research Group, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan, 613 735, Korea
    Pflugers Arch 460:55-68. 2010
    ..These findings will help clarify the mechanisms of HR injury and will aid in the development of antioxidant therapies to prevent cardiac mitochondrial dysfunction associated with reoxygenation...
  12. ncbi request reprint Potential biomarkers for ischemic heart damage identified in mitochondrial proteins by comparative proteomics
    Nari Kim
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Diseases Research Center, Biohealth Products Research Center, Inje University, Busanjin Gu, Busan, Korea
    Proteomics 6:1237-49. 2006
    ....
  13. ncbi request reprint Mitochondrial Ca2+-activated K+ channels more efficiently reduce mitochondrial Ca2+ overload in rat ventricular myocytes
    Sung Hyun Kang
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 613 735, Korea
    Am J Physiol Heart Circ Physiol 293:H307-13. 2007
    ....
  14. ncbi request reprint The guanylyl cyclase activator YC-1 directly inhibits the voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
    Won Sun Park
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, FIRST Mitochondrial Research Group, Biomarker Medical Research Center, Inje University, Korea
    J Pharmacol Sci 112:64-72. 2010
    ..From these results, we suggest that YC-1 directly inhibits the Kv current independently of sGC activation and in a state-, time-, and use-dependent fashion...
  15. ncbi request reprint Angiotensin II inhibits inward rectifier K+ channels in rabbit coronary arterial smooth muscle cells through protein kinase Calpha
    Won Sun Park
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
    Biochem Biophys Res Commun 341:728-35. 2006
    ..The Ang II type 1 (AT(1))-receptor antagonist CV-11974 prevented the Ang II-induced inhibition of the Kir current. From these results, we conclude that Ang II inhibits Kir channels through AT(1) receptors by the activation of PKCalpha...
  16. ncbi request reprint Site specific differential activation of ras/raf/ERK signaling in rabbit isoproterenol-induced left ventricular hypertrophy
    Nari Kim
    Department of Physiology and Biophysics, Mitochondrial Signaling Laboratory, Mitochondria Research Group, College of Medicine, Cardiovascular and Metabolic Diseases Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 614 735, Korea
    Biochim Biophys Acta 1763:1067-75. 2006
    ..This varied response may account for underlying mechanisms of development of cardiac hypertrophy and cerebrovascular events in heart and cerebral arteries, respectively...
  17. pmc Beta adrenergic overstimulation impaired vascular contractility via actin-cytoskeleton disorganization in rabbit cerebral artery
    Hyoung Kyu Kim
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    PLoS ONE 7:e43884. 2012
    ..We investigated the possible cerebrovascular dysfunction response to isoproterenol induced beta-adrenergic overstimulation (ISO) in rabbit cerebral arteries (CAs)...
  18. pmc Functional expression of smooth muscle-specific ion channels in TGF-β(1)-treated human adipose-derived mesenchymal stem cells
    Won Sun Park
    Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea
    Am J Physiol Cell Physiol 305:C377-91. 2013
    ..Our results suggest that TGF-β1 induces the increased expression of vascular SMC-like ion channels and the differentiation of hASCs into contractile vascular SMCs. ..
  19. ncbi request reprint Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts
    Dang Van Cuong
    Department of Physiology and Biophysics, Mitochondrial Signaling Laboratory, College of Medicine, Biohealth Products Research Center, Inje University, 633 165 Gaegeum dong, Busanjin Ku, Busan 614 735, South Korea
    Mitochondrion 5:121-33. 2005
    ..By contrast, SUR1 was not present in mitochondria. These results suggest that mitoKATP channels in rat hearts might comprise a combination of Kir6.1, Kir6.2, and SUR2 subunits...
  20. ncbi request reprint The protein kinase A inhibitor, H-89, directly inhibits KATP and Kir channels in rabbit coronary arterial smooth muscle cells
    Won Sun Park
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
    Biochem Biophys Res Commun 340:1104-10. 2006
    ..These results suggest that H-89 directly inhibits the KATP and Kir currents of rabbit coronary arterial smooth muscle cells independently of PKA inhibition...
  21. pmc Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
    In Sung Song
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    Exp Mol Med 45:e50. 2013
    ..Therefore, combination therapy with specific mitochondrial-targeting drugs may prove useful to the development of novel strategies for the treatment of bortezomib-resistant MM patients. ..
  22. doi request reprint The angiotensin receptor blocker and PPAR-γ agonist, telmisartan, delays inactivation of voltage-gated sodium channel in rat heart: novel mechanism of drug action
    Hyoung Kyu Kim
    National Research Laboratory for Mitochondrial Signaling Laboratory, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    Pflugers Arch 464:631-43. 2012
    ..Above 30 μM, telmisartan may potentially cause cardiac cell death and MI...
  23. doi request reprint APE1/Ref-1 promotes the effect of angiotensin II on Ca2+ -activated K+ channel in human endothelial cells via suppression of NADPH oxidase
    Won Sun Park
    National Research Laboratory for Mitochondrial Signaling Laboratory, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Medical Research Center, Inje University, Busan, Korea
    Arch Pharm Res 31:1291-301. 2008
    ..From these results, we conclude that the inhibitory effect of Ang II on BK(Ca) channel function is NADPH oxidase-dependent and may be promoted by APE1/Ref-1...
  24. ncbi request reprint Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts
    Dang Van Cuong
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Biohealth Products Research Center, Inje University, Busan, Korea
    Am J Physiol Heart Circ Physiol 290:H1808-17. 2006
    ..Moreover, the PKG shows priority over NO as the upstream regulator of NO-cGMP-PKG signal-induced KATP channel opening that leads to cardioprotection during APC treatment...
  25. ncbi request reprint Ketamine blocks Ca2+-activated K+ channels in rabbit cerebral arterial smooth muscle cells
    Jin Han
    Department of Physiology and Biophysics, Molecular Cell Physiology Research Group, College of Medicine, Inje University, 633 165 Gaegum Dong, Busanjin Gu, Busan 614 735, Korea
    Am J Physiol Heart Circ Physiol 285:H1347-55. 2003
    ..This inhibition of KCa channels may represent a mechanism for ketamine-induced cerebral vasoconstriction...
  26. doi request reprint Glucocorticoids and their receptors: insights into specific roles in mitochondria
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, 613 735 Busan, Republic of Korea
    Prog Biophys Mol Biol 112:44-54. 2013
    ..In this review, we outline possible mechanisms of regulation of mitochondrial genes in response to GCs in view of translocation of the GR into mitochondria and the possible regulation of OXPHOS genes by GREs in the mitochondrial genome...
  27. ncbi request reprint Patho-, physiological roles of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells
    Won Sun Park
    Department of Physiology, Kangwon National University School of Medicine, Korea
    J Smooth Muscle Res 46:89-105. 2010
    ..Kv channels play a central role in the maintenance of cellular homeostasis and ion channels, and consequential signaling cascades. Therefore, Kv channels are potential therapeutic targets for the treatment of pulmonary vascular disease...
  28. doi request reprint Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca²⁺ reuptake
    Hyoung Kyu Kim
    Cardiovascular and Metabolic Disease Center CMDC, National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Inje University, Busan, South Korea
    Pflugers Arch 467:2151-63. 2015
    ..Taken together, our data show that Ech A negatively regulates cardiac contractility by inhibiting SERCA2A activity, which leads to a reduction in internal Ca(2+) stores...
  29. ncbi request reprint The mitochondrial Ca2+-activated K+ channel activator, NS 1619 inhibits L-type Ca2+ channels in rat ventricular myocytes
    Won Sun Park
    National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondrial Research Group, Department of Physiology and Biophysics, College of Medicine, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 613 735, Republic of Korea
    Biochem Biophys Res Commun 362:31-6. 2007
    ..Since NS 1619 is widely used to study mitoBK(Ca) channel function, it is essential to verify these unexpected effects of NS 1619 before experimental data can be interpreted accurately...
  30. doi request reprint Alteration of ATP-sensitive K+ channels in rabbit aortic smooth muscle during left ventricular hypertrophy
    Won Sun Park
    Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea
    Am J Physiol Cell Physiol 303:C170-8. 2012
    ....
  31. ncbi request reprint ATP-sensitive K(+) channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes
    Jin Han
    Department of Physiology and Biophysics, College of Medicine, Inje University, Busan 614 735, Korea
    Am J Physiol Heart Circ Physiol 283:H1545-54. 2002
    ..With the use of 5 nM okadaic acid (a PP2A inhibitor), PP2A had no effect on the channel activity. These results suggest that the NO-cGMP-PKG pathway contributes to phosphorylation of K(ATP) channels in rabbit ventricular myocytes...
  32. ncbi request reprint Role of stretch-activated channels on the stretch-induced changes of rat atrial myocytes
    Jae Boum Youm
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Biohealth Products Research Center, Inje University, Busan 614 735, Republic of Korea
    Prog Biophys Mol Biol 90:186-206. 2006
    ....
  33. ncbi request reprint Endothelin-1 inhibits inward rectifier K+ channels in rabbit coronary arterial smooth muscle cells through protein kinase C
    Won Sun Park
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    J Cardiovasc Pharmacol 46:681-9. 2005
    ..From these results, we conclude that Kir channels are expressed at a higher density in SCASMC than in larger arteries and that the Kir channel activity is negatively regulated by the stimulation of ETA-receptors via the PKC pathway...
  34. ncbi request reprint The T-type Ca²⁺ channel inhibitor mibefradil inhibits voltage-dependent K⁺ channels in rabbit coronary arterial smooth muscle cells
    Da Hye Hong
    Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Korea
    J Pharmacol Sci 120:196-205. 2012
    ..Moreover, the absence of ATP inside the pipette did not alter the blocking effect of mibefradil. Therefore, we suggest that mibefradil directly inhibited the Kv current, independently of Ca²⁺ channel inhibition...
  35. doi request reprint Identification of potential target genes of cardioprotection against ischemia-reperfusion injury by express sequence tags analysis in rat hearts
    Hyoung Kyu Kim
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
    J Cardiol 60:98-110. 2012
    ..However, effective target genes and proteins for IPC are unknown. We characterized global changes in gene expression in the heart during IR, and identified effective target genes for IPC...
  36. doi request reprint Low abundance of mitochondrial DNA changes mitochondrial status and renders cells resistant to serum starvation and sodium nitroprusside insult
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Bokji ro 75, Busanjin Gu, Busan, 614 735, Republic of Korea
    Cell Biol Int 39:865-72. 2015
    ..Taken together, we conclude that the low abundance of mtDNA cause changes in cellular status, such as changes in reactive oxygen species, calcium, and zinc ion levels inducing resistance to stress. ..
  37. doi request reprint Increased sensitivity of serotonin on the voltage-dependent K+ channels in mesenteric arterial smooth muscle cells of OLETF rats
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, FIRST Mitochondrial Research Group, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 614 735, Republic of Korea
    Prog Biophys Mol Biol 103:88-94. 2010
    ..The enhanced expression of 5-HT(2A) receptor together with PKCbeta may promote mesenteric vasoconstriction and increase vascular resistance in OLETF rats...
  38. doi request reprint The effect of tyrosine kinase inhibitor genistein on voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
    Vascul Pharmacol 50:51-6. 2009
    ..Moreover, the absence of ATP inside the pipette did not influence the blocking effect of genistein. We suggest that genistein directly inhibited the Kv current, independently of PTK inhibition...
  39. ncbi request reprint Simulated hyperglycemia in rat cardiomyocytes: a proteomics approach for improved analysis of cellular alterations
    Mohamad Warda
    Department of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Cardiovascular and Metabolic Disease Center, FIRST Mitochondrial Research Group, Inje University, Busan, Korea
    Proteomics 7:2570-90. 2007
    ..This effect was apparently mediated via alterations in multiple biochemical pathways that collectively increased apoptotic susceptibility...
  40. pmc Echinochrome a increases mitochondrial mass and function by modulating mitochondrial biogenesis regulatory genes
    Seung Hun Jeong
    Cardiovascular and Metabolic Disease Center CMDC, National Research Laboratory for Mitochondrial Signaling, Inje University, Busan 614 735, Korea
    Mar Drugs 12:4602-15. 2014
    ..In conclusion, these data suggest that Ech A is a potentiated marine drug which enhances mitochondrial biogenesis. ..
  41. ncbi request reprint Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts
    Jin Han
    Department of Physiology and Biophysics, College of Medicine, Inje University, Busan 614 735, Korea
    Am J Physiol Heart Circ Physiol 283:H13-21. 2002
    ..These data are consistent with the notion that inhibition of sarcolemmal or mitochondrial K(ATP) channels may contribute, at least in part, to the mechanism of the blockade of ischemic preconditioning by ketamine...
  42. ncbi request reprint Effects of prostaglandin F2alpha on membrane currents in rabbit middle cerebral arterial smooth muscle cells
    Nari Kim
    Department of Physiology and Biophysics, College of Medicine, Inje University, Busanjin Gu, Busan, 614 735, Korea
    Am J Physiol Heart Circ Physiol 284:H1018-27. 2003
    ..This study provides the first finding that the direct effects of PGF(2alpha) on middle cerebral arterial SMCs, at least in part, could attenuate vasoconstriction...
  43. doi request reprint Non-genomic effect of glucocorticoids on cardiovascular system
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan, Korea
    Pflugers Arch 464:549-59. 2012
    ..We suggest that manipulation of GC action based on both GC and GR metabolism, mitochondrial impact, and the action of serum- and glucocorticoid-dependent kinase 1 may provide new information with which to treat cardiovascular diseases...
  44. doi request reprint Modeling of stochastic behavior of pacemaker potential in interstitial cells of Cajal
    Jae Boum Youm
    Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea Electronic address
    Prog Biophys Mol Biol 116:56-69. 2014
    ..In conclusion, our updated mathematical model could now reproduce stochastic features of pacemaker activity in ICCs. ..
  45. ncbi request reprint KSP inhibitor SB743921 induces death of multiple myeloma cells via inhibition of the NF-κB signaling pathway
    In Sung Song
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    BMB Rep 48:571-6. 2015
    ..Altogether, these data suggest that treatment with SB743921 alone or in combination with bortezomib offers excellent translational potential and promises to be a novel MM therapy...
  46. ncbi request reprint Modulation by melatonin of the cardiotoxic and antitumor activities of adriamycin
    Chunghui Kim
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Biohealth Products Research Center, Inje University, Busan, Korea
    J Cardiovasc Pharmacol 46:200-10. 2005
    ....
  47. ncbi request reprint Changes in the Ca2+-activated K+ channels of the coronary artery during left ventricular hypertrophy
    Nari Kim
    Department of Physiology and Biophysics, College of Medicine, Inje University, Busanjin Gu, Busan, Korea
    Circ Res 93:541-7. 2003
    ..The effect of TEA on the resting tension of the LVH coronary artery was reduced compared with the effect on the control. Our findings imply a novel mechanism for reduced coronary reserve during LVH...
  48. pmc Mitochondrial peroxiredoxin III is a potential target for cancer therapy
    In Sung Song
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 7 5, Korea E Mails I S S H K K S H J S R L N K B D R K S K
    Int J Mol Sci 12:7163-85. 2011
    ..We hope that this review will provide the basis for new strategic approaches in the development of effective cancer treatments...
  49. pmc A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K Channels in Rabbit Ventricular Myocytes
    Won Sun Park
    Department of Physiology, Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon 200 701, Korea
    Korean J Physiol Pharmacol 14:119-25. 2010
    ..In summary, AIP1 reduces APD by activating I(Kr) but not I(Ks). These results suggest that the natural product AIP1 may provide an adjunctive therapy of long QT syndrome...
  50. doi request reprint Toward a better understanding of preeclampsia: Comparative proteomic analysis of preeclamptic placentas
    Young Nam Kim
    Department of Obstetrics and Gynecology, College of Medicine, Inje University, Busan, Korea Paik Institute for Clinical Research, College of Medicine, Inje University, Busan, Korea
    Proteomics Clin Appl 1:1625-36. 2007
    ..These results provide a better understanding of proteomic alterations and may help in clarification of stress-related changes in preeclamptic placentas...
  51. doi request reprint Influence of starvation on heart contractility and corticosterone level in rats
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Bokji Ro 57, Busanjin Gu, Busan, 614 735, Republic of Korea
    Pflugers Arch 467:2351-60. 2015
    ..05). In summary, prolonged starvation, which leads to a deficiency of available nutrition, increases the stress-related corticosterone level, impairs the cardiac output, and is associated with changes in cardiac morphogeometry. ..
  52. doi request reprint Occurrence and fate of fetal lumbar rib induced by Scutellariae radix in rats
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, South Korea
    Birth Defects Res B Dev Reprod Toxicol 89:201-6. 2010
    ..This study was conducted to evaluate the occurrence and fate of fetal lumbar rib induced by Scutellariae radix (SR) in rats...
  53. doi request reprint Cloning of large-conductance Ca(2+)-activated K(+) channel alpha-subunits in mouse cardiomyocytes
    Jae Hong Ko
    Department of Physiology, College of Medicine, Chung Ang University, Seoul, South Korea
    Biochem Biophys Res Commun 389:74-9. 2009
    ..These findings suggest that a unique BK(Ca) channel alpha-subunit is expressed in mouse cardiomyocytes...
  54. doi request reprint Cardiac proteomic responses to ischemia-reperfusion injury and ischemic preconditioning
    Hyoung Kyu Kim
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University 633 165 Gaegeum Dong, Busanjin Gu, Busan 613 735, Korea
    Expert Rev Proteomics 8:241-61. 2011
    ..Further developments in the proteomic field that target specialized proteins will yield new insights for optimizing therapeutic targets and developing a wide range of therapeutic agents against ischemic heart disease...
  55. pmc Echinochrome A protects mitochondrial function in cardiomyocytes against cardiotoxic drugs
    Seung Hun Jeong
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center CMDC, Inje University, Busan 614 735, Korea
    Mar Drugs 12:2922-36. 2014
    ..These findings indicate the therapeutic potential of Ech A for reducing cardiotoxic agent-induced damage. ..
  56. ncbi request reprint Kobophenol A inhibits sodium nitroprusside-induced cardiac H9c2 cell death through suppressing activation of JNK and preserving mitochondrial anti-apoptotic Bcl-2 and Mcl-1
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Department of Health Sciences and Technology, Inje University
    Chem Pharm Bull (Tokyo) 62:713-8. 2014
    ..These biological properties of Kob A might provide insights into developing new cardioprotectant against SNP-induced cardiac cell death. ..
  57. pmc Acetylcholinesterase inhibitory activity of pigment echinochrome A from sea urchin Scaphechinus mirabilis
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 735, Korea
    Mar Drugs 12:3560-73. 2014
    ..These findings indicate new therapeutic potential for EchA in treating reduced acetylcholine-related diseases including AD and provide an insight into developing new AChE inhibitors. ..
  58. pmc An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression
    Seung Hun Jeong
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, 614 735, Korea
    Mol Cells 34:357-65. 2012
    ..We therefore propose that HS-1793 can be a useful chemosensitization agent, which together with other such agents can efficiently target cancer cells...
  59. doi request reprint NecroX-5 suppresses sodium nitroprusside-induced cardiac cell death through inhibition of JNK and caspase-3 activation
    Sung Ryul Lee
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 633 165 Gaegeum Dong Busanjin Gu, Busan, 614 735, Republic of Korea
    Cell Biol Int 38:702-7. 2014
    ..These findings will provide insights and facilitate development of antidotes to SNP toxicity in cardiac cells...
  60. doi request reprint FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function
    In Sung Song
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
    Gastroenterology 149:1006-16.e9. 2015
    ..Reagents designed to target cancer stem cells (CSCs) could reduce tumor growth, recurrence, and metastasis. We investigated the mitochondrial features of CSCs...
  61. pmc Echinochrome A Improves Exercise Capacity during Short-Term Endurance Training in Rats
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Bokji ro 75, Busanjin, Busan 633 165, Korea
    Mar Drugs 13:5722-31. 2015
    ..These findings show that Echi A administration after short-term endurance training enhances exercise capacity, which was associated with an increase in skeletal muscle mitochondrial content. ..
  62. doi request reprint Humanized animal exercise model for clinical implication
    Dae Yun Seo
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Department of Health Sciences and Technology, Cardiovascular and Metabolic Disease Center, Inje University, Bok Ji Ro 75, Busanjin Gu, Busan, 613 735, Republic of Korea
    Pflugers Arch 466:1673-87. 2014
    ..Finally, we provide suggestions and/or considerations for developing a new regime for an exercise model. ..
  63. doi request reprint Effects of the novel angiotensin II receptor type I antagonist, fimasartan on myocardial ischemia/reperfusion injury
    Jin Han
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Republic of Korea
    Int J Cardiol 168:2851-9. 2013
    ....
  64. doi request reprint Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, FIRST Mitochondrial Research Group, Inje University, 633 165 Gaegeum dong, Busanjin Gu, Busan 614 735, Republic of Korea
    Prog Biophys Mol Biol 103:95-101. 2010
    ....
  65. pmc Increased Expression of ATP-sensitive K Channels Improves the Right Ventricular Tolerance to Hypoxia in Rabbit Hearts
    Seong Woo Choi
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 735, Korea
    Korean J Physiol Pharmacol 15:189-94. 2011
    ..2 was higher in RV. Therefore, we suggest that different K(ATP) expression between LV and RV is responsible for the different response to hypoxia and hypoxic preconditioning of rabbit hearts...
  66. pmc A computational model of cytosolic and mitochondrial [ca] in paced rat ventricular myocytes
    Jae Boum Youm
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 735, Korea
    Korean J Physiol Pharmacol 15:217-39. 2011
    ..The present study also suggests that cytosolic Ca(2+) affects mitochondrial Ca(2+) in a beat-to-beat manner, however, removal of Ca(2+) influx mechanism into mitochondria does not affect the amplitude of cytosolic Ca(2+) transients...
  67. doi request reprint Glucagon-like peptide-1 enhances glucokinase activity in pancreatic β-cells through the association of Epac2 with Rim2 and Rab3A
    Jae Hyung Park
    Department of Physiology, Keimyung University School of Medicine, Daegu 704 701, Korea
    Endocrinology 153:574-82. 2012
    ..The present finding may also be an important mechanism of GLP-1 for recovery of GSIS in T2D...
  68. ncbi request reprint Dynamic changes in nitric oxide and mitochondrial oxidative stress with site-dependent differential tissue response during anoxic preconditioning in rat heart
    Dang Van Cuong
    Mitochondrial Signaling Laboratory, Department of Physiology and Biophysics, College of Medicine, Mitochondrial Research Group Frontier Inje Research Science and Technology Project, Inje University, Busanjin Ku, Busan 614 735, Korea
    Am J Physiol Heart Circ Physiol 293:H1457-65. 2007
    ..The results afford a better understanding of cardiac-adapting mechanism during AP and the role of inducible NO synthase in this important phenomenon...
  69. ncbi request reprint Physiological roles of K+ channels in vascular smooth muscle cells
    Eun A Ko
    National Research Laboratory for Mitochondrial Signaling, FIRST Mitochondria Research Group, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University
    J Smooth Muscle Res 44:65-81. 2008
    ..Impaired Kv, KATP, and Kir channel functions has been linked to a number of pathological conditions, which may lead to vasoconstriction...
  70. doi request reprint Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock
    In Duk Jung
    Department of Microbiology and Immunology and National Research Laboratory of Dendritic Cell Differentiation and Regulation, Medical Research Institute, Pusan National University, College of Medicine, Busan, South Korea
    J Immunol 182:3146-54. 2009
    ..Our findings demonstrate that the detrimental immune response to endotoxin shock may occur via IDO modulation. Restoring the IL-12 and IL-10 balance by blocking IDO represents a potential strategy for sepsis treatment...
  71. pmc Modeling of arrhythmogenic automaticity induced by stretch in rat atrial myocytes
    Jae Boum Youm
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology and Biophysics, College of Medicine, Inje University, Busan 614 735, Korea
    Korean J Physiol Pharmacol 12:267-74. 2008
    ....
  72. doi request reprint Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells
    Won Sun Park
    National Research Laboratory for Mitochondrial Signalling, Department of Physiology and Biophysics, College of Medicine, Cardiovascular and Metabolic Disease Center, 613 735, South Korea
    Pflugers Arch 457:137-47. 2008
    ....
  73. ncbi request reprint Mitochondrial metabolism in cancer stem cells: a therapeutic target for colon cancer
    In Sung Song
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    BMB Rep 48:539-40. 2015
    ..Together, our findings indicate that FOXM1, PRDX3, and CD133 are potential therapeutic targets for the elimination of CSCs in colon cancer...
  74. doi request reprint Heart rate reduction with ivabradine prevents thyroid hormone-induced cardiac remodeling in rat
    Bo Hyun Kim
    Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea
    Heart Vessels 28:524-35. 2013
    ..In conclusion, selective HR reduction by ivabradine attenuates thyroid hormone-induced reduction of myocardial deformation and altered intracellular Ca(2+) handling without modification of the myocyte hypertrophy with fibrosis in rats...
  75. doi request reprint Potential therapeutic applications of tetrahydrobiopterin: from inherited hyperphenylalaninemia to mitochondrial diseases
    Hyoung K Kim
    National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Cardiovascular and Metabolic Disease Center, FIRST Mitochondrial Research Group, Inje University, Busan, Korea
    Ann N Y Acad Sci 1201:177-82. 2010
    ..BH(4) supplementation successfully prevents the development or progression of these diseases and thus has valuable clinical potential...
  76. doi request reprint CD40 stimulation induces vincristine resistance via AKT activation and MRP1 expression in a human multiple myeloma cell line
    Soo Woong Lee
    Advanced Research Center for Multiple Myeloma, College of Medicine, Inje University, Busan, Republic of Korea
    Immunol Lett 144:41-8. 2012
    ..Therefore, blocking CD40 and inhibiting MRP1 are potential targets to treat CD40-induced drug resistance in multiple myeloma...
  77. doi request reprint Characterization of basic amino acids-conjugated PAMAM dendrimers as gene carriers for human adipose-derived mesenchymal stem cells
    Yoonhee Bae
    Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 614 735, Republic of Korea
    Int J Pharm 501:75-86. 2016
    ..Also, treatment of human AD-MSCs to polyplex formation in conjugated PAMAM derivatives, their cellular uptake and localization were analyzed by flow cytometry and confocal microscopy. ..
  78. ncbi request reprint Mitochondrial alterations in human gastric carcinoma cell line
    Hyoung Kyu Kim
    Mitochondrial Signaling Laboratory, Mitochondria Research Group, Dept of Physiology and Biophysics, College of Medicine, Biohealth Products Research Center, Cardiovascular and Metabolic Disease Center, Inje University, Busanjin Gu, Busan, Korea
    Am J Physiol Cell Physiol 293:C761-71. 2007
    ..The results provide clues as to the mechanism of the mitochondrial changes in cancer at the protein level and may serve as potential cancer biomarkers in mitochondria...
  79. pmc Proteomic changes in rat gastrocnemius muscle after botulinum toxin a injection
    Nami Han
    Department of Physical Medicine and Rehabilitation, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
    Ann Rehabil Med 37:157-66. 2013
    ..To observe the changes in protein expression induced by botulinum toxin A (BoNT-A) injection and to characterize the molecular and cellular action of mechanisms of BoNT-A injection on skeletal muscles using proteomic elements as biomarkers...
  80. pmc Plasma proteomic analysis of patients with squamous cell carcinoma of the uterine cervix
    Dae Hoon Jeong
    Department of Obstetrics and Gynecology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea
    J Gynecol Oncol 19:173-80. 2008
    ..To compare plasma protein expression between patients with squamous cell carcinoma (SCC) of the cervix and normal controls...