Hyeon Son

Summary

Affiliation: Hanyang University
Country: Korea

Publications

  1. pmc Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress
    Hyeon Son
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 109:11378-83. 2012
  2. pmc Effects of serotonin on erythropoietin expression in mouse hippocampus
    Miyeon Choi
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul 133 791, Korea
    Exp Neurobiol 22:45-50. 2013
  3. pmc Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells
    Dong Hoon Oh
    Department of Psychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul 133 791, Korea
    Korean J Physiol Pharmacol 16:281-5. 2012
  4. pmc Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul, Korea
    Mol Pain 3:16. 2007
  5. pmc Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul, 151 747, Korea
    Mol Brain 2:1. 2009
  6. ncbi request reprint Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus
    Hyeon Son
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, South Korea
    J Neurochem 85:872-81. 2003
  7. ncbi request reprint Retrovirally transduced NCAM140 facilitates neuronal fate choice of hippocampal progenitor cells
    Ju Hee Kim
    Department of Bicohemistry, Hanyang University College of Medicine, Seoul, Korea
    J Neurochem 94:417-24. 2005
  8. ncbi request reprint In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neurons
    Chang Hwan Park
    Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea
    J Neurochem 92:1265-76. 2005
  9. ncbi request reprint Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo
    Jin Seuk Kim
    Department of Biochemistry, Hanyang University College of Medicine, Seoul, Korea
    J Neurochem 89:324-36. 2004
  10. ncbi request reprint Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL
    Jae Won Shim
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, Korea
    J Neurosci 24:843-52. 2004

Collaborators

Detail Information

Publications37

  1. pmc Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress
    Hyeon Son
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 109:11378-83. 2012
    ..Our results reveal a unique action of neuritin in models of stress and depression, and demonstrate a role for neuroplasticity in antidepressant treatment response and related behaviors...
  2. pmc Effects of serotonin on erythropoietin expression in mouse hippocampus
    Miyeon Choi
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul 133 791, Korea
    Exp Neurobiol 22:45-50. 2013
    ..In conclusion, actions of antidepressants might involve EPO induction in the brain...
  3. pmc Comparison of Neurite Outgrowth Induced by Erythropoietin (EPO) and Carbamylated Erythropoietin (CEPO) in Hippocampal Neural Progenitor Cells
    Dong Hoon Oh
    Department of Psychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul 133 791, Korea
    Korean J Physiol Pharmacol 16:281-5. 2012
    ..These suggest that EPO and CEPO could be a good candidate for treating neuropsychiatric disorders such as depression and anxiety associated with neuronal atrophy and reduced hippocampal neurogenesis...
  4. pmc Null effect of antidepressants on the astrocytes-mediated proliferation of hippocampal progenitor cells in vitro
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory and Institute of Molecular Biology and Genetics, Department of Biological Sciences, College of Natural Sciences, Seoul National University, Gwanak Gu, Seoul, Korea
    Mol Pain 3:16. 2007
    ..It has been recently reported that astroglia induce the neurogenesis of the hippocampal neural progenitor cells (NPCs). Therefore, we hypothesized that antidepressants may act on astrocytes, and this in turn induces neurogenesis of NPCs...
  5. pmc Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory
    Hyoung Gon Ko
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul, 151 747, Korea
    Mol Brain 2:1. 2009
    ..These results suggest that although adult newborn neurons contribute to contextual fear memory, they may not be involved in the extinction or erasure of hippocampus-dependent contextual fear memory...
  6. ncbi request reprint Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus
    Hyeon Son
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, South Korea
    J Neurochem 85:872-81. 2003
    ..Our results suggest that the enhancement of LTP is independent of the increased number of neurons per se and it is more closely associated with key molecules, which are probably involved in neurogenesis...
  7. ncbi request reprint Retrovirally transduced NCAM140 facilitates neuronal fate choice of hippocampal progenitor cells
    Ju Hee Kim
    Department of Bicohemistry, Hanyang University College of Medicine, Seoul, Korea
    J Neurochem 94:417-24. 2005
    ..Overall, these findings suggest that NCAM140 may facilitate hippocampal neurogenesis via regulation of proneurogenic transcription factors in an extracellular signal-regulated kinase (ERK)-dependent manner...
  8. ncbi request reprint In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neurons
    Chang Hwan Park
    Department of Microbiology, College of Medicine, Hanyang University, Seoul, Korea
    J Neurochem 92:1265-76. 2005
    ..Therefore, unlike those from mouse ES cells, hES cell-derived DA neurons either do not survive or their DA phenotype is unstable when grafted into rodent brains...
  9. ncbi request reprint Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo
    Jin Seuk Kim
    Department of Biochemistry, Hanyang University College of Medicine, Seoul, Korea
    J Neurochem 89:324-36. 2004
    ..These findings suggest that lithium in therapeutic amounts may elicit its beneficial effects via facilitation of neural progenitor differentiation toward a calbindin(D28k)-positive neuronal cell type...
  10. ncbi request reprint Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL
    Jae Won Shim
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, Korea
    J Neurosci 24:843-52. 2004
    ..These data suggest a role for Bcl-XL during in vitro midbrain DA neuron differentiation and provide an improved system for cell transplantation in a preclinical animal model of Parkinson's disease...
  11. doi request reprint Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation
    In Tag Yu
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Neuropharmacology 56:473-80. 2009
    ..The discovery of an association between HDACi and the Ngn1, Math1 and p15 promoters extends the importance of HDAC inhibition as a key regulator of neuronal differentiation at the transcriptional level...
  12. doi request reprint Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
    Byung Woo Kim
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Cell Signal 20:714-25. 2008
    ..Our findings suggest that VEGF released from neuronal cells plays a local role in Ca2+ influx and synaptic transmission that may influence the generation of long-term changes in synaptic efficacy...
  13. ncbi request reprint Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro
    Jong Bin Kim
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Brain Res 1027:1-10. 2004
    ..Taken these in vitro and in vivo results together, it is concluded that glucocorticoid receptor activation blocks only proliferation, but not differentiation, in hippocampal neurogenesis...
  14. ncbi request reprint Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells
    Jae Yeol Joo
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Korea
    J Cell Sci 120:1358-70. 2007
    ..In addition, our results are the first to show that stimulation of NPCs may lead to either proliferation or neuronal differentiation, depending on the level of NMDA receptor activation...
  15. ncbi request reprint Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth
    Ju Hee Kim
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul, Korea
    FASEB J 20:109-11. 2006
    ..Together, these findings establish the novel calbindin-regulated function of CaMKII and NeuroD in control of neuronal differentiation and neurite outgrowth...
  16. ncbi request reprint Ascorbate-induced differentiation of embryonic cortical precursors into neurons and astrocytes
    Ji Yeon Lee
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea
    J Neurosci Res 73:156-65. 2003
    ..These data suggest that AA may act in the developing brain to stimulate the generation of CNS neurons and glia, thereby assisting in the formation of neural circuits by promoting the acquisition of neuronal synaptic functions...
  17. ncbi request reprint Chronic lithium enhances hippocampal long-term potentiation, but not neurogenesis, in the aged rat dentate gyrus
    In Tag Yu
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Biochem Biophys Res Commun 303:1193-8. 2003
    ..Lithium might has a beneficial effects through other signaling pathways in the aged brain...
  18. pmc Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors
    Jeong Sik Lee
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, 133 791 Seoul, Korea
    J Neurosci 29:8493-505. 2009
    ..These findings reveal a molecular interaction between the cAMP cascade and VEGF expression, and the pronounced behavioral consequences of this interaction shed light on the mechanism underlying neuronal VEGF functions in antidepression...
  19. ncbi request reprint Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300
    Miyeon Choi
    Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Biochem Biophys Res Commun 446:79-84. 2014
    ..These findings have important medical implications because cEPO is of interest in the development of therapeutic agents against neuropsychiatric disorders. ..
  20. pmc Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
    Hyo Jung Kang
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Nat Med 18:1413-7. 2012
    ....
  21. ncbi request reprint Neural cell adhesion molecule (NCAM) induces neuronal phenotype acquisition in dominant negative MEK1-expressing hippocampal neural progenitor cells
    Byung Woo Kim
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul 133 791, Korea
    Exp Mol Med 38:732-8. 2006
    ..These results suggest that the activation of MEK1 is required for obtaining neuronal phenotype in NPCs...
  22. ncbi request reprint Differential effects of corticosterone and dexamethasone on hippocampal neurogenesis in vitro
    In Tag Yu
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Republic of Korea
    Biochem Biophys Res Commun 317:484-90. 2004
    ..It is concluded that corticosterone elicits its effects on neurogenesis including proliferation and differentiation whereas stimulation of the glucocorticoid receptor is sufficient to decrease only proliferation...
  23. ncbi request reprint Neurons and astrocytes secrete factors that cause stem cells to differentiate into neurons and astrocytes, respectively
    Mi Yoon Chang
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, South Korea
    Mol Cell Neurosci 23:414-26. 2003
    ..These findings demonstrate the importance of soluble signals in lineage-specific differentiation and provide evidence for the roles of neurons and astrocytes in stem cell differentiation...
  24. ncbi request reprint Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression
    Ju Yeon Kim
    Department of Biochemistry, and Institute of Mental Health, Hanyang University, Seoul, Korea
    J Neurochem 85:1443-54. 2003
    ..However, additional factors will be required to achieve in vivo function and to unravel the full potential of neural precursors for cell therapy in Parkinson's disease...
  25. ncbi request reprint Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
    Min Hwa Shin
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, Korea
    Exp Mol Med 34:401-10. 2002
    ....
  26. pmc Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 69:754-61. 2011
    ....
  27. pmc A critical time window for the survival of neural progenitor cells by HDAC inhibitors in the hippocampus
    Byung Woo Kim
    Department of Biochemistry and Molecular Biology, Hanyang University, Seoul, Korea
    Mol Cells 31:159-64. 2011
    ..This suggests that epigenetic modification within a specific time window is critical for the survival of newborn hippocampal neurons by inhibiting the apoptotic pathway...
  28. ncbi request reprint Phosphorylation of ERK and CREB in cultured hippocampal neurons after haloperidol and risperidone administration
    Byung Hwan Yang
    Department of Neuropsychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul, Korea
    Psychiatry Clin Neurosci 58:262-7. 2004
    ..Furthermore, these results demonstrate that different antipsychotic drugs could lead to different profiles of ERK and CREB phosphorylation in neurons...
  29. ncbi request reprint Reciprocal actions of NCAM and tPA via a Ras-dependent MAPK activation in rat hippocampal neurons
    Hyeon Son
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, South Korea
    Biochem Biophys Res Commun 298:262-8. 2002
    ..In turn, MAPK activation may cause tPA degradation or a decrease in expression to promote synaptic plasticity...
  30. ncbi request reprint Enhancement of rat hippocampal long-term potentiation by 17 beta-estradiol involves mitogen-activated protein kinase-dependent and -independent components
    Jin Seuk Kim
    Department of Biochemistry, Hanyang University College of Medicine, 17 Haengdang dong, Sungdong gu, Seoul 133 791, South Korea
    Neurosci Lett 332:65-9. 2002
    ..These results indicate that 17beta-estradiol might affect hippocampal synaptic plasticity in a way involving two separate pathways, which are MAPK-dependent and MAPK-independent...
  31. doi request reprint Neuropathological abnormalities of astrocytes, GABAergic neurons, and pyramidal neurons in the dorsolateral prefrontal cortices of patients with major depressive disorder
    Dong Hoon Oh
    Department of Neuropsychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul, Republic of Korea
    Eur Neuropsychopharmacol 22:330-8. 2012
    ..05). These findings yield some insight into the mechanism by which increased glutamatergic neurotransmission leads to excitotoxic damage both in neurons and glial cells in the dlPFC of MDD patients...
  32. ncbi request reprint Adult hippocampal neurogenesis and related neurotrophic factors
    Eugene Lee
    Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul 133 731, Korea
    BMB Rep 42:239-44. 2009
    ..Elucidation of the roles of such neurotropic factors should provide insight into how adult hippocampal neurogenesis is related to psychiatric disease and synaptic plasticity...
  33. ncbi request reprint Co-transfection with cDNA encoding the Bcl family of anti-apoptotic proteins improves the efficiency of transfection in primary fetal neural stem cells
    You Chan Kim
    Department of Biochemistry, College of Medicine, Hanyang University, 133 791, Seoul, South Korea
    J Neurosci Methods 117:153-8. 2002
    ....
  34. ncbi request reprint An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway
    Dong Hoon Oh
    Department of Psychiatry, College of Medicine and Institute of Mental Health, Hanyang University, 222 Wangsimni ro, Seongdong Gu, Seoul, 133 791, Republic of Korea
    J Neural Transm 121:783-92. 2014
    ..The integration of the existing archival data may shed light on one important aspect of the pathophysiology of MDD. ..
  35. ncbi request reprint The functional domains of dopamine transporter for cocaine analog, CFT binding
    Sang Hun Lee
    Department of Biochemistry, College of Medicine, Hanyang University
    Exp Mol Med 34:90-4. 2002
    ....
  36. pmc A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6220-30. 2008
    ....