Affiliation: Hanyang University
Seo H, Isacson O. The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome. J Neurochem. 2010;114:1819-26 pubmed publisher
..Taken together, these results suggest that both the adaptive reactions in the proteostatic network and pathological changes in AD and DS need to be considered in the future potential therapeutics. ..
Das A, Chai J, Jung K, Das N, Kang S, Lee Y, et al
. JMJD2A attenuation affects cell cycle and tumourigenic inflammatory gene regulation in lipopolysaccharide stimulated neuroectodermal stem cells. Exp Cell Res. 2014;328:361-78 pubmed publisher
Seo H, Sonntag K, Kim W, Cattaneo E, Isacson O. Proteasome activator enhances survival of Huntington's disease neuronal model cells. PLoS ONE. 2007;2:e238 pubmed
..These results demonstrate the specific functional enhancements of the UPS that can provide neuroprotection in HD cells. ..
Kim W, Seo H. Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice. Biochem Biophys Res Commun. 2014;443:706-11 pubmed publisher
..These data indicate that stimulation of GABAergic neurons with the GABAB receptor agonist, baclofen, enhances ubiquitin-proteasome system (UPS) function and cell survival in in vitro and in vivo models of HD. ..
Jeon J, Kim W, Jang J, Isacson O, Seo H. Gene therapy by proteasome activator, PA28Î³, improves motor coordination and proteasome function in Huntington's disease YAC128 mice. Neuroscience. 2016;324:20-8 pubmed publisher
..These data demonstrate that the gene therapy with PA, PA28Î³ can improve UPS function as well as behavioral abnormalities in HD model mice. ..
Park J, Lee Y, Kim J, Seo H, Kim H. ?-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes. Free Radic Biol Med. 2016;97:168-178 pubmed publisher
..Collectively, the results suggest that ?-LAP increases antioxidant enzyme gene expression in astrocytes by modulating NQO1-AMPK/PI3K-Nrf2/ARE signaling. ..
Kim J, Jeong Y, Lee E, Park J, Seo H, Kim H. Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. Biochem Biophys Res Commun. 2017;493:879-886 pubmed publisher
..Collectively, the data suggested that M8I has a therapeutic potential in treating neurodegenerative diseases that are aggravated by systemic inflammation. ..
Noh H, Jeon J, Seo H. Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain. Neurochem Int. 2014;69:35-40 pubmed publisher
..The region-specific inflammatory response to LPS in the brain may serve to create a model for studies of neurodegenerative disease. ..