Hyemyung Seo

Summary

Affiliation: Hanyang University
Country: Korea

Publications

  1. doi request reprint The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome
    Hyemyung Seo
    Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    J Neurochem 114:1819-26. 2010
  2. pmc Proteasome activator enhances survival of Huntington's disease neuronal model cells
    Hyemyung Seo
    Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital and Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 2:e238. 2007
  3. pmc Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients
    Hyemyung Seo
    Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital, Harvard MedicalSchool, 115 Mill Street, Belmont, MA 02478, USA
    Hum Mol Genet 17:3144-53. 2008
  4. ncbi request reprint Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner
    Kwang Soo Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 85:622-34. 2003
  5. ncbi request reprint Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice
    Hyemyung Seo
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Eur J Neurosci 15:498-506. 2002
  6. ncbi request reprint Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice
    Hyemyung Seo
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Exp Neurol 193:469-80. 2005
  7. pmc Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection
    Chee Yeun Chung
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Hum Mol Genet 14:1709-25. 2005
  8. ncbi request reprint Generalized brain and skin proteasome inhibition in Huntington's disease
    Hyemyung Seo
    Neuroregeneration Laboratories, Departments of Neurology and Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Ann Neurol 56:319-28. 2004
  9. ncbi request reprint A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination
    Hyemyung Seo
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 80:905-16. 2002
  10. ncbi request reprint Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh
    Ole Isacson
    Neuroregeneration Laboratory, McLean Hospital, Program in Neuroscience and Dept of Neurology, Harvard Medical School, Belmont, MA 02478 9106, USA
    Trends Neurosci 25:79-84. 2002

Detail Information

Publications12

  1. doi request reprint The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer's disease and Down's syndrome
    Hyemyung Seo
    Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    J Neurochem 114:1819-26. 2010
    ..Taken together, these results suggest that both the adaptive reactions in the proteostatic network and pathological changes in AD and DS need to be considered in the future potential therapeutics...
  2. pmc Proteasome activator enhances survival of Huntington's disease neuronal model cells
    Hyemyung Seo
    Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital and Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 2:e238. 2007
    ..These results demonstrate the specific functional enhancements of the UPS that can provide neuroprotection in HD cells...
  3. pmc Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients
    Hyemyung Seo
    Neuroregeneration Laboratories, Center for Neuroregeneration Research, McLean Hospital, Harvard MedicalSchool, 115 Mill Street, Belmont, MA 02478, USA
    Hum Mol Genet 17:3144-53. 2008
    ..Changes in HD patients for UPS function, BDNF expression and MCII/III activity are only partially modeled in R6/2 and YAC72 mice, with the latter at 16 months of age being most congruent with the human disease...
  4. ncbi request reprint Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner
    Kwang Soo Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 85:622-34. 2003
    ..Our results suggest that Nurr1 may play a direct role for specification of DA neurotransmitter identity by activating TH gene transcription in a cell context-dependent manner...
  5. ncbi request reprint Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice
    Hyemyung Seo
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Eur J Neurosci 15:498-506. 2002
    ....
  6. ncbi request reprint Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice
    Hyemyung Seo
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Exp Neurol 193:469-80. 2005
    ....
  7. pmc Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection
    Chee Yeun Chung
    Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Hum Mol Genet 14:1709-25. 2005
    ..These results indicate that certain differentially expressed molecules in A9 and A10 DA neurons may play key roles in their relative vulnerability to toxins and PD...
  8. ncbi request reprint Generalized brain and skin proteasome inhibition in Huntington's disease
    Hyemyung Seo
    Neuroregeneration Laboratories, Departments of Neurology and Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Ann Neurol 56:319-28. 2004
    ....
  9. ncbi request reprint A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination
    Hyemyung Seo
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurochem 80:905-16. 2002
    ..Taken together, these findings establish that Phox2a and 2b control the development of NA neurons in part by directly transactivating DBH transcription through interactions with four binding sites clustered in the proximal promoter...
  10. ncbi request reprint Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh
    Ole Isacson
    Neuroregeneration Laboratory, McLean Hospital, Program in Neuroscience and Dept of Neurology, Harvard Medical School, Belmont, MA 02478 9106, USA
    Trends Neurosci 25:79-84. 2002
    ..This eventually leads to synaptic and dendritic loss with age...
  11. pmc Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
    Oliver Cooper
    Neuroregeneration Institute, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Sci Transl Med 4:141ra90. 2012
    ....
  12. pmc miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling
    Woori Kim
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Neurobiol Aging 35:1712-21. 2014
    ..Our data imply that elevated levels of miR-126 may play a functional role in DA neurons and in PD pathogenesis by downregulating IGF-1/PI3K/AKT signaling and that its inhibition could be a mechanism of neuroprotection. ..