M C Gye


Affiliation: Hanyang University
Country: Korea


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    Gye M. Expression of occludin in canine testis and epididymis. Reprod Domest Anim. 2004;39:43-7 pubmed
    ..In the epididymis weak immunoreactivity was found in the apical sides and cytoplasm of epithelial cells. ..
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    Gye M, Choi J, Ahn H, Kim Y. Expression of p50 C-terminal Src kinase (Csk) in mouse testis. Arch Androl. 2004;50:287-93 pubmed
    ..Csk immunoreactivity was also found in the Leydig cells, suggesting the possible regulation of Leydig cell function. Src-Csk loop may participate in the differentiation of the seminiferous epithelia and Leydig cells in mouse testis. ..
  3. Xu Y, Park S, Yoon K, Park S, Gye M. Effects of citrate ester plasticizers and bis (2-ethylhexyl) phthalate in the OECD 28-day repeated-dose toxicity test (OECD TG 407). Environ Res. 2019;172:675-683 pubmed publisher
    ..The results of the OECD TG407 subacute repeated dosing toxicity test indicate ATEC is less toxic compared to ATHC or DEHP and could be recommended as an alternative to phthalate plasticizers. ..
  4. Kim H, Choi M, Ji Y, Kim I, Kim G, Bae I, et al. Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient. Pharmaceutics. 2018;10: pubmed publisher
    ..These pharmacokinetic data would be useful in studies investigating the safety and toxicity of ATBC. ..
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    Gye M, Choi J, Ahn H, Kim Y. Postnatal changes in the expression of p60c-Src in mouse testes. Dev Growth Differ. 2005;47:233-42 pubmed
    ..Taken together, it is suggested that c-Src may participate in the remodeling of the seminiferous epithelia and functional differentiation of Leydig cells during the postnatal development of mouse testes. ..
  6. Park C, Gye M. Sensitization of vitellogenin gene expression by low doses of octylphenol is mediated by estrogen receptor autoregulation in the Bombina orientalis (Boulenger) male liver. Aquat Toxicol. 2014;156:191-200 pubmed publisher
    ..Thus, chronic exposure to alkylphenols, even at their NOECs, could still disrupt endocrine function in B. orientalis. ..
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    Gye M, Kim S. Expression of cathepsin L in human testis under diverse infertility conditions. Arch Androl. 2004;50:187-91 pubmed
    ..The absence of expression of cathepsin L in germ cell cancer emphasizes that cathepsin L expression in Sertoli cells is regulated by functional germ cells in human testis. ..
  8. Park C, Ha C, Lee J, Gye M. Claudin 11 inter-sertoli tight junctions in the testis of the korean soft-shelled turtle (Pelodiscus maackii). Biol Reprod. 2015;92:96 pubmed publisher
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    Gye M. Changes in the expression of claudins and transepithelial electrical resistance of mouse Sertoli cells by Leydig cell coculture. Int J Androl. 2003;26:271-8 pubmed
    ..Interactions between Leydig and Sertoli cells might be involved in the development of functional blood testis barrier in mouse testis. ..

More Information


  1. Son S, Nam K, Kim H, Gye M, Shin I. Cytotoxicity measurement of Bisphenol A (BPA) and its substitutes using human keratinocytes. Environ Res. 2018;164:655-659 pubmed publisher
    ..In conclusion, this study suggests that cytotoxicity of BPA induces apoptosis of human keratinocytes, and that CHDM and TPA are the most suitable substitutes for BPA. ..
  2. Nguyen D, Kim H, Kim D, Lee J, Gye M, Kim Y. Detection of Matrix Metalloproteinase Activity by Bioluminescence via Intein-Mediated Biotinylation of Luciferase. Sensors (Basel). 2018;18: pubmed publisher
    ..Our approach is anticipated to be useful for generating biotinylated proteins and for their applications in diagnosing MMP activity in human diseases. ..
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    Gye M, Kang H, Kang H. Expression of cannabinoid receptor 1 in mouse testes. Arch Androl. 2005;51:247-55 pubmed
    ..Ubiquitous, but spatiotemporal difference in expression of CB1 in soma and germ line during postnatal development of testis suggests functional involvement of CB1 signaling in steroidogenesis, spermatogenesis and fertilization. ..
  4. Xu Y, Gye M. Developmental toxicity of dibutyl phthalate and citrate ester plasticizers in Xenopus laevis embryos. Chemosphere. 2018;204:523-534 pubmed publisher
    ..In conclusion, ATEC was recommended as the alternative to phthalate plasticizer having the lowest developmental toxicity in amphibian embryos. ..
  5. Choi H, Choi B, Seo J, Lee K, Gye M, Kim Y. Rapid Detection of Glycogen Synthase Kinase-3 Activity in Mouse Sperm Using Fluorescent Gel Shift Electrophoresis. Sensors (Basel). 2016;16: pubmed publisher
    ..We suggest that our assay can be used for reliable and rapid detection of GSK3 activity in cells and tissue extracts. ..
  6. Park C, Song S, Kim D, Gye M. Developmental and acute toxicity of cetylpyridinium chloride in Bombina orientalis (Amphibia: Anura). Aquat Toxicol. 2016;177:446-53 pubmed publisher
    ..At 2.0?M CPC, pro-apoptotic Bax and Bak mRNA levels were significantly increased together with DNA fragmentation, indicative of apoptotic cell death. CPC in freshwater system may threaten the normal development of amphibian embryos. ..
  7. Oh Y, Jo N, Park J, Gye M. Changes in Inflammatory Cytokines Accompany Deregulation of Claudin-11, Resulting in Inter-Sertoli Tight Junctions in Varicocele Rat Testes. J Urol. 2016;196:1303-12 pubmed publisher
  8. Park C, Song S, Kim D, Gye M. Nickel affects gill and muscle development in oriental fire-bellied toad (Bombina orientalis) embryos. Aquat Toxicol. 2017;182:67-78 pubmed publisher
    ..Expression was restored by exogenous calcium. Our results indicate that nickel affects muscle development by disrupting calcium-dependent myogenesis in developing B. orientalis embryos. ..
  9. Oh Y, Nah W, Choi B, Kim S, Gye M. Coxsackievirus and Adenovirus Receptor, a Tight Junction Protein, in Peri-Implantation Mouse Embryos. Biol Reprod. 2016;95:5 pubmed publisher
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    Gye M. Changes in sperm phosphotyrosine proteins by human follicular fluid in mice. Arch Androl. 2003;49:417-22 pubmed
    ..hFF increased tyrosine phosphorylation of Mr 56 kDa protein with genistein sensitive manner, suggesting that 56 kDa phosphotyrosine protein might be involved in capacitation and AR by follicular fluid. ..
  11. Lee J, Park S, Han H, Gye M, Moon E. Di-(2-ethylhexyl) phthalate enhances melanoma tumor growth via differential effect on M1-and M2-polarized macrophages in mouse model. Environ Pollut. 2018;233:833-843 pubmed publisher
    ..This suggests that individuals at high risk for tumor incidence should avoid long-term exposure to various kind of phthalate including DEHP. ..