Il Yup Chung

Summary

Affiliation: Hanyang University
Country: Korea

Publications

  1. pmc Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma
    Tae Gi Uhm
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Korea
    Allergy Asthma Immunol Res 4:68-79. 2012
  2. pmc CpG methylation at GATA elements in the regulatory region of CCR3 positively correlates with CCR3 transcription
    Tae Gi Uhm
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan 426 791, Korea
    Exp Mol Med 44:268-80. 2012
  3. pmc Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization
    Jeong Ah Shin
    Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, 1174, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, 420 767, Korea
    BMC Med Genet 10:106. 2009
  4. ncbi request reprint Eotaxin and monocyte chemotactic protein-3 use different modes of action
    Il Yup Chung
    Department of Biochemistry and Molecular Biology, Hanyang University, Ansan, Kyunggi Do, Republic of Korea
    Biochem Biophys Res Commun 314:646-53. 2004
  5. doi request reprint Different GATA factors dictate CCR3 transcription in allergic inflammatory cells in a cell type-specific manner
    Su Kang Kong
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Gyeonggi do 426 791, Republic of Korea
    J Immunol 190:5747-56. 2013
  6. doi request reprint Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity
    Byung Soo Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Sangrok Ku, Ansan, Gyeonggi Do, Korea
    Pharmacogenet Genomics 20:748-58. 2010
  7. doi request reprint The crucial role of GATA-1 in CCR3 gene transcription: modulated balance by multiple GATA elements in the CCR3 regulatory region
    Byung Soo Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, South Korea
    J Immunol 185:6866-75. 2010
  8. ncbi request reprint Eosinophilic differentiation is promoted by blockage of Notch signaling with a gamma-secretase inhibitor
    Jin Hyun Kang
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, South Korea
    Eur J Immunol 35:2982-90. 2005
  9. ncbi request reprint Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog
    Jung Sun Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Seoul 133 791, Korea
    Exp Mol Med 37:601-7. 2005
  10. ncbi request reprint A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypes
    Hun Soo Chang
    Division of Molecular and Life Sciences, Hanyang University, Ansan, Gyeonggi Do, Korea
    J Immunol 174:1525-31. 2005

Collaborators

Detail Information

Publications24

  1. pmc Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma
    Tae Gi Uhm
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Korea
    Allergy Asthma Immunol Res 4:68-79. 2012
    ....
  2. pmc CpG methylation at GATA elements in the regulatory region of CCR3 positively correlates with CCR3 transcription
    Tae Gi Uhm
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan 426 791, Korea
    Exp Mol Med 44:268-80. 2012
    ..These results suggest that methylation of CpG sites at the GATA elements in the regulatory regions fine-tunes CCR3 transcription...
  3. pmc Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization
    Jeong Ah Shin
    Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, 1174, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, 420 767, Korea
    BMC Med Genet 10:106. 2009
    ..We investigated the genetic effects of the SNPs and haplotypes on the expression of the CysLTR2 gene...
  4. ncbi request reprint Eotaxin and monocyte chemotactic protein-3 use different modes of action
    Il Yup Chung
    Department of Biochemistry and Molecular Biology, Hanyang University, Ansan, Kyunggi Do, Republic of Korea
    Biochem Biophys Res Commun 314:646-53. 2004
    ..These results suggest that the two N-terminal motifs of eotaxin must cooperate with other regions to successfully bind and activate CCR3...
  5. doi request reprint Different GATA factors dictate CCR3 transcription in allergic inflammatory cells in a cell type-specific manner
    Su Kang Kong
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Gyeonggi do 426 791, Republic of Korea
    J Immunol 190:5747-56. 2013
    ..These results highlight a mechanistic role of GATA factors in which cell type-specific expression is the primary determinant of transcription of the CCR3 gene in major allergic inflammatory cells...
  6. doi request reprint Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity
    Byung Soo Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Sangrok Ku, Ansan, Gyeonggi Do, Korea
    Pharmacogenet Genomics 20:748-58. 2010
    ..The objective of the study was to examine the influence of single nucleotide polymorphisms (SNPs) in IL-4 gene on aspirin hypersensitivity in asthmatics at the genetic and molecular levels...
  7. doi request reprint The crucial role of GATA-1 in CCR3 gene transcription: modulated balance by multiple GATA elements in the CCR3 regulatory region
    Byung Soo Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, South Korea
    J Immunol 185:6866-75. 2010
    ..These data suggest that GATA-1 controls CCR3 transcription by interacting dynamically with the multiple GATA sites in the regulatory region of the CCR3 gene...
  8. ncbi request reprint Eosinophilic differentiation is promoted by blockage of Notch signaling with a gamma-secretase inhibitor
    Jin Hyun Kang
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, South Korea
    Eur J Immunol 35:2982-90. 2005
    ..Our data suggest that Notch signaling may modulate eosinophil migration at the mature stage as well as inhibit eosinophil differentiation...
  9. ncbi request reprint Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog
    Jung Sun Kim
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Seoul 133 791, Korea
    Exp Mol Med 37:601-7. 2005
    ..We conclude that, despite the difference in primary structure and expression pattern in various stem cells, the alternatively-spliced variant of Nanog has similar activity to that of the full length version...
  10. ncbi request reprint A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypes
    Hun Soo Chang
    Division of Molecular and Life Sciences, Hanyang University, Ansan, Gyeonggi Do, Korea
    J Immunol 174:1525-31. 2005
    ..Our data suggest that the EOT-384A>G SNP participates in the regulation of eotaxin1 expression by providing a potential binding site for a repressor, and that the ANOVA of EOT-384A>G may predict asthma phenotypes...
  11. ncbi request reprint Regulation of functional phenotypes of cord blood derived eosinophils by gamma-secretase inhibitor
    Jin Hyun Kang
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, South Korea
    Am J Respir Cell Mol Biol 37:571-7. 2007
    ..GSI has therapeutic potential for eosinophilic inflammatory diseases, such as asthma...
  12. ncbi request reprint The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells
    Jung Sun Kim
    Hanyang University, Ansan, Korea
    Arch Pharm Res 33:1117-25. 2010
    ..Thus, Nanog expression appears to be differently regulated by the PI3K/Akt pathway depending on differentiation stage...
  13. doi request reprint Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses
    Jin Hyun Kang
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Seoul, South Korea
    Am J Respir Crit Care Med 179:875-82. 2009
    ..In asthma, a subset of CD4(+) T cells is believed to initiate and perpetuate the disease...
  14. doi request reprint Epithelial-to-mesenchymal transition of human lung alveolar epithelial cells in a microfluidic gradient device
    Su Hwan Kim
    Department of Bionano Engineering, Hanyang University, Ansan, Korea
    Electrophoresis 34:441-7. 2013
    ..Therefore, this microfluidic device could be a powerful tool to monitor EMT induced by a variety of environmental stresses including cigarette smoke with high sensitivity...
  15. pmc Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras
    Soon Young Shin
    Division of Molecular and Life Science, College of Science and Technology, Hanyang University, Ansan, Korea
    EMBO J 25:1093-103. 2006
    ..Our findings suggest a novel signaling mechanism by which prolonged activation of oncogenic H-Ras can trigger the loss of tumor suppressor Egr-1 through the PI3K pathway in NIH3T3 fibroblast model cell lines...
  16. pmc A parallel signal-transduction pathway for eotaxin- and interleukin-5-induced eosinophil shape change
    Eun Nam Choi
    Department of Biochemistry and Molecular Biology, Hanyang University, Ansan, South Korea
    Immunology 108:245-56. 2003
    ..Collectively, two eosinophil-selective cytokines/chemokines probably regulate eosinophil shape change via a largely overlapping signalling pathway, with involvement of PKC restricted to the IL-5 signal alone...
  17. ncbi request reprint Use of surface-enhanced Raman scattering to quantify EGFR markers uninhibited by cetuximab antibodies
    Eunsu Chung
    Department of BioNano Technology, Hanyang University, Ansan 426 791, South Korea
    Biosens Bioelectron 60:358-65. 2014
    ..Our experimental data demonstrate the feasibility of SERS imaging to improve the prognostic efficacy of cetuximab treatment. ..
  18. doi request reprint MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways
    Jin Hyun Kang
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Gyeonggi do 426 791, South Korea
    J Immunol 187:222-9. 2011
    ..Collectively, these results suggest that MUC5AC expression is regulated by a bidirectional circuit between Notch and EGFR signaling pathways...
  19. doi request reprint Mucin (MUC5AC) expression by lung epithelial cells cultured in a microfluidic gradient device
    Su Hwan Kim
    Department of Bionano Engineering, Hanyang University, Ansan, Korea
    Electrophoresis 32:254-60. 2011
    ..Therefore, this microfluidic gradient device could be a potentially useful tool for regulating the mucin expression of lung epithelial cells exposed to chemokine gradient profiles...
  20. ncbi request reprint The purification and characterization of a Bacillus stearothermophilus methionine aminopeptidase (MetAP)
    Jae Min Chung
    Department of Biochemistry and Molecular Biology, Hanyang University, Sa 1 dong 1271, Ansan, Kyunggi Do, 425 791, Korea
    J Biochem Mol Biol 35:228-35. 2002
    ..0 mM and 1.7 mmol/min/mg, respectively. The B. stearothermophilus MetAP was completely inactivated by EDTA and required Co(2+) ion(s) for activation, suggesting the metal dependence of this enzyme..
  21. ncbi request reprint Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients
    June Hyuk Lee
    Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Gyeonggi Do, Korea
    J Allergy Clin Immunol 120:1110-7. 2007
    ..Eosinophilic infiltration and peripheral blood eosinophilia in asthma require the cooperation of eosinophil-specific cytokines and chemokines and their receptors...
  22. ncbi request reprint Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5
    Choon Sik Park
    Genome Research Center for Asthma and Allergic Diseases, Division of Allergy and Respiratory Medicine, Soonchunhyang University Hospital, Seoul and Bucheon, Korea
    Int Arch Allergy Immunol 136:295-302. 2005
    ..Th2 cytokines play pivotal roles in allergic inflammation, including eosinophilia, and their actions are antagonized by Th1 cytokines, conferring them therapeutic potential...
  23. ncbi request reprint Association of interleukin-5 and eotaxin with acute exacerbation of asthma
    Sung Woo Park
    Asthma and Allergy Research Group, Soonchunhyang University Hospital, Bucheon, Korea
    Int Arch Allergy Immunol 131:283-90. 2003
    ..Interrelation between these cytokines is expected to occur in acute exacerbation of asthma. Thus, we evaluated the relevance of interaction between eotaxin and IL-5 in the airway inflammation of acute exacerbation...
  24. ncbi request reprint Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway
    Chang Hoon Woo
    Graduate School of Biotechnology, Korea University, 5 1 Anam dong, Sungbuk Gu, Seoul 136 701, South Korea
    Biochem Biophys Res Commun 298:392-7. 2002
    ..It thus appears that Rac1 acts upstream of ERK to signal chemotaxis in these cells, and that a Rac-ERK-dependent cascade mediates the eotaxin-induced chemotactic motility of RBL-2H3 mast cells...