Seong Hoon Ahn
Affiliation: Hanyang University
Ryu H, Duan R, Ahn S. Yeast symmetric arginine methyltransferase Hsl7 has a repressive role in transcription. Res Microbiol. 2019;: pubmed publisher
..Our results suggest that H4R3me2s generation by the type II PRMT Hsl7 is required for transcriptional repression, possibly in cooperation with histone deacetylation by Rpd3. ..
Srivastava R, Ahn S. Modifications of RNA polymerase II CTD: Connections to the histone code and cellular function. Biotechnol Adv. 2015;33:856-72 pubmed publisher
..This review elucidates recent findings regarding the CTD modifications of RNAPII and their coordination with the histone code, providing integrative pathways for the fine-tuned regulation of gene expression and cellular function. ..
Duan R, Rhie B, Ryu H, Ahn S. The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process. Biochem Biophys Res Commun. 2013;: pubmed publisher
Ahn S, Keogh M, Buratowski S. Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II. EMBO J. 2009;28:205-12 pubmed publisher
..Interestingly, this function of Ctk1 is independent of its kinase activity, suggesting a structural function of the protein. ..
Srivastava R, Srivastava R, Ahn S. The Epigenetic Pathways to Ribosomal DNA Silencing. Microbiol Mol Biol Rev. 2016;80:545-63 pubmed publisher
..Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases. ..
Ryu H, Ahn S. Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. BMC Biol. 2014;12:75 pubmed publisher
..These data suggest that Jhd2-mediated alleviation of excessive Csm1/Lrs4 or condensin at the NTS1 region of rDNA is required for the integrity of rDNA repeats and proper rDNA silencing during mitosis. ..