Haihong Shen

Summary

Affiliation: Gwangju Institute of Science and Technology
Country: Korea

Publications

  1. ncbi request reprint UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea
    BMB Rep 42:185-8. 2009
  2. pmc The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 24:2389-94. 2010
  3. doi request reprint Chimeric RNAs as potential biomarkers for tumor diagnosis
    Jianhua Zhou
    Nantong University, Nantong, Jiangsu, P R China
    BMB Rep 45:133-40. 2012
  4. pmc Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 22:1796-803. 2008
  5. doi request reprint Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8
    Ha Na Jang
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:25-32. 2014
  6. doi request reprint hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene
    Hyun Kyung Oh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Apoptosis 18:825-35. 2013
  7. doi request reprint Identification of novel splicing variants from RON proto-oncogene pre-mRNA
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 28:2217-20. 2012
  8. ncbi request reprint hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:306-15. 2014
  9. ncbi request reprint PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:517-25. 2014
  10. doi request reprint Validation of trans-acting elements that promote exon 7 skipping of SMN2 in SMN2-GFP stable cell line
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 423:531-5. 2012

Collaborators

Detail Information

Publications14

  1. ncbi request reprint UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea
    BMB Rep 42:185-8. 2009
    ..Collective evidence indicates that UAP56 has an essential role in mRNA nuclear export. This mini-review summarizes recent evidence for the role of UAP56 in pre-mRNA splicing and nuclear export...
  2. pmc The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 24:2389-94. 2010
    ..Thus, through recognition of a common splicing element, Urp facilitates distinct steps of U2- and U12-type intron splicing...
  3. doi request reprint Chimeric RNAs as potential biomarkers for tumor diagnosis
    Jianhua Zhou
    Nantong University, Nantong, Jiangsu, P R China
    BMB Rep 45:133-40. 2012
    ....
  4. pmc Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 22:1796-803. 2008
    ..Our results indicate that hUAP56 first interacts with U2AF(65) in an ATP-dependent manner, and subsequently with U4/U6 snRNAs to facilitate stepwise assembly of the spliceosome...
  5. doi request reprint Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8
    Ha Na Jang
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:25-32. 2014
    ..Therefore we conclude that SRSF3 promotes exon 9 skipping of caspase-2 pre-mRNA by interacting with exon 8. Our results reveal a novel mechanism of caspase-2 pre-mRNA splicing. ..
  6. doi request reprint hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene
    Hyun Kyung Oh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Apoptosis 18:825-35. 2013
    ..Therefore we conclude that hnRNP A1 interacts with exon 5 to promote distal exon 6 inclusion of Fas pre-mRNA. Our study reveals a novel alternative splicing mechanism of Fas pre-mRNA...
  7. doi request reprint Identification of novel splicing variants from RON proto-oncogene pre-mRNA
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 28:2217-20. 2012
    ..In one variant intron 6 is included, but intron 6 is skipped in another variant. These two variants should be truncated but these proteins have not yet been detected...
  8. ncbi request reprint hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:306-15. 2014
    ..We conclude that hnRNP M promotes exon 7 inclusion of SMN1 and SMN2 pre-mRNA through targeting an enhancer on exon 7 through recruiting U2AF65. Our results provide a clue that hnRNP M is a potential therapeutic target for SMA. ..
  9. ncbi request reprint PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:517-25. 2014
    ..Furthermore we show that the RNA target sequences of PSF and tra2β in exon 7 are partially overlapped. These results lead us to conclude that PSF interacts with an enhancer in exon 7 to promote exon 7 splicing of SMN2 pre-mRNA. ..
  10. doi request reprint Validation of trans-acting elements that promote exon 7 skipping of SMN2 in SMN2-GFP stable cell line
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 423:531-5. 2012
    ..We conclude that we have established the stable cell lines that recapitulate alternative splicing of the SMN1 and SMN2 genes. The stable cell line can be used to identify the trans-acting elements with siRNA...
  11. pmc 3' Splice site sequences of spinal muscular atrophy related SMN2 pre-mRNA include enhancers for nearby exons
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    ScientificWorldJournal 2014:617842. 2014
    ..Our study shows that 3' splice sites of exon 7 and 8 contain enhancer for their splice site selection, in addition to providing cleavage sites. ..
  12. doi request reprint SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA
    Tiing Jen Loh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 31:273-9. 2014
    ..shRNA knockdown of SC35 showed that reduced expression of SC35 decreased expression of the V6 exon-containing isoforms. Our results reveal a novel mechanism of CD44V6 splicing. ..
  13. doi request reprint A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 31:450-5. 2014
    ....
  14. doi request reprint Identification of a novel cis-element that regulates alternative splicing of Bcl-x pre-mRNA
    Jaehoon Lee
    School of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 420:467-72. 2012
    ..This element could be potentially targeted to alter the ratio of Bcl-xL and Bcl-xS for treatment of tumors through an apoptotic pathway...