Haihong Shen

Summary

Affiliation: Gwangju Institute of Science and Technology
Country: Korea

Publications

  1. ncbi request reprint UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea
    BMB Rep 42:185-8. 2009
  2. pmc The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 24:2389-94. 2010
  3. doi request reprint Chimeric RNAs as potential biomarkers for tumor diagnosis
    Jianhua Zhou
    Nantong University, Nantong, Jiangsu, P R China
    BMB Rep 45:133-40. 2012
  4. pmc Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 22:1796-803. 2008
  5. pmc Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8
    Ha Na Jang
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:25-32. 2014
  6. pmc hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene
    Hyun Kyung Oh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Apoptosis 18:825-35. 2013
  7. pmc PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:517-25. 2014
  8. doi request reprint hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:306-15. 2014
  9. doi request reprint Identification of novel splicing variants from RON proto-oncogene pre-mRNA
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 28:2217-20. 2012
  10. pmc SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:1132-40. 2014

Collaborators

  • Rui Zhao
  • Jianhua Zhou
  • Youngsoo Jun
  • Do Han Kim
  • Xiaoming Yang
  • Jang Soo Chun
  • Giuseppe Biamonti
  • Sunghee Cho
  • Heegyum Moon
  • Tiing Jen Loh
  • Xuexiu Zheng
  • Ha Na Jang
  • Michael R Green
  • Hyun Kyung Oh
  • Da Woon Jung
  • Claudia Ghigna
  • D Joshua Liao
  • Jaehoon Lee
  • Seong Eui Hong
  • Si Hwan Park
  • Darren R Williams
  • Zhi Sheng
  • Myung Geun Shin
  • Darren Reece Williams
  • Yongchao Liu
  • Takbum Ohn
  • Il Chul Kim
  • Kyung Keun Kim
  • Soon Ho Yim
  • Woong Hee Kim
  • Seung Woo Choi
  • Soohyun Eom
  • Young J Hong
  • Hyun Jung Kim
  • Yong Chul Kim
  • Ah Ra Kim
  • Nisha Tyagi
  • Soo Yeon Kim
  • Hyon E Choy
  • Hey Ran Kim
  • Darren Reese Williams
  • Minho Lee
  • Shinae Seo
  • Woo Keun Song
  • Jung Eun Lee
  • Boo Ahn Shin
  • Huyn Kyung Oh
  • Daeho Park
  • Sungchan Cho
  • Young Soo Kwon
  • Eunkyung Lee
  • Kyungjin Jo
  • Hye Ran Kim

Detail Information

Publications19

  1. ncbi request reprint UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea
    BMB Rep 42:185-8. 2009
    ..Collective evidence indicates that UAP56 has an essential role in mRNA nuclear export. This mini-review summarizes recent evidence for the role of UAP56 in pre-mRNA splicing and nuclear export...
  2. pmc The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 24:2389-94. 2010
    ..Thus, through recognition of a common splicing element, Urp facilitates distinct steps of U2- and U12-type intron splicing...
  3. doi request reprint Chimeric RNAs as potential biomarkers for tumor diagnosis
    Jianhua Zhou
    Nantong University, Nantong, Jiangsu, P R China
    BMB Rep 45:133-40. 2012
    ....
  4. pmc Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome
    Haihong Shen
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Genes Dev 22:1796-803. 2008
    ..Our results indicate that hUAP56 first interacts with U2AF(65) in an ATP-dependent manner, and subsequently with U4/U6 snRNAs to facilitate stepwise assembly of the spliceosome...
  5. pmc Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8
    Ha Na Jang
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:25-32. 2014
    ..Therefore we conclude that SRSF3 promotes exon 9 skipping of caspase-2 pre-mRNA by interacting with exon 8. Our results reveal a novel mechanism of caspase-2 pre-mRNA splicing. ..
  6. pmc hnRNP A1 contacts exon 5 to promote exon 6 inclusion of apoptotic Fas gene
    Hyun Kyung Oh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Apoptosis 18:825-35. 2013
    ..Therefore we conclude that hnRNP A1 interacts with exon 5 to promote distal exon 6 inclusion of Fas pre-mRNA. Our study reveals a novel alternative splicing mechanism of Fas pre-mRNA...
  7. pmc PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:517-25. 2014
    ..Furthermore we show that the RNA target sequences of PSF and tra2β in exon 7 are partially overlapped. These results lead us to conclude that PSF interacts with an enhancer in exon 7 to promote exon 7 splicing of SMN2 pre-mRNA. ..
  8. doi request reprint hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:306-15. 2014
    ..We conclude that hnRNP M promotes exon 7 inclusion of SMN1 and SMN2 pre-mRNA through targeting an enhancer on exon 7 through recruiting U2AF65. Our results provide a clue that hnRNP M is a potential therapeutic target for SMA. ..
  9. doi request reprint Identification of novel splicing variants from RON proto-oncogene pre-mRNA
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 28:2217-20. 2012
    ..In one variant intron 6 is included, but intron 6 is skipped in another variant. These two variants should be truncated but these proteins have not yet been detected...
  10. pmc SRSF2 promotes splicing and transcription of exon 11 included isoform in Ron proto-oncogene
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1839:1132-40. 2014
    ..Our results indicate that SRSF2 promotes exon 11 inclusion of Ron proto-oncogene through targeting exon 11. Our study provides a novel mechanism by which Ron is expressed. ..
  11. doi request reprint hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron
    Tiing Jen Loh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1849:743-50. 2015
    ..Importantly, we provide evidences that hnRNP L inhibits U2AF65 binding on the upstream Py tract of V10 exon. Our results reveal that hnRNP L is a new regulator for CD44 V10 exon splicing...
  12. doi request reprint Validation of trans-acting elements that promote exon 7 skipping of SMN2 in SMN2-GFP stable cell line
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 423:531-5. 2012
    ..We conclude that we have established the stable cell lines that recapitulate alternative splicing of the SMN1 and SMN2 genes. The stable cell line can be used to identify the trans-acting elements with siRNA...
  13. pmc A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene
    Heegyum Moon
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 31:450-5. 2014
    ....
  14. pmc 3' Splice site sequences of spinal muscular atrophy related SMN2 pre-mRNA include enhancers for nearby exons
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    ScientificWorldJournal 2014:617842. 2014
    ..Our study shows that 3' splice sites of exon 7 and 8 contain enhancer for their splice site selection, in addition to providing cleavage sites. ..
  15. pmc Splicing inhibition of U2AF65 leads to alternative exon skipping
    Sunghee Cho
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Proc Natl Acad Sci U S A 112:9926-31. 2015
    ..Thus, we conclude that U2AF(65) possesses a splicing Inhibitory function that leads to alternative exon skipping. ..
  16. pmc SC35 promotes splicing of the C5-V6-C6 isoform of CD44 pre-mRNA
    Tiing Jen Loh
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Oncol Rep 31:273-9. 2014
    ..shRNA knockdown of SC35 showed that reduced expression of SC35 decreased expression of the V6 exon-containing isoforms. Our results reveal a novel mechanism of CD44V6 splicing. ..
  17. doi request reprint Delineation of the role of glycosylation in the cytotoxic properties of quercetin using novel assays in living vertebrates
    Si Hwan Park
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    J Nat Prod 77:2389-96. 2014
    ..Importantly, the development of a novel and convenient fluorescence-based assay for monitoring deglycosylation in living vertebrates provides a valuable platform for determining the metabolic fate of naturally occurring glycosides. ..
  18. doi request reprint Identification of a novel cis-element that regulates alternative splicing of Bcl-x pre-mRNA
    Jaehoon Lee
    School of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 420:467-72. 2012
    ..This element could be potentially targeted to alter the ratio of Bcl-xL and Bcl-xS for treatment of tumors through an apoptotic pathway...
  19. doi request reprint 5-Nitro-5'hydroxy-indirubin-3'oxime is a novel inducer of somatic cell transdifferentiation
    Da Woon Jung
    New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Arch Pharm (Weinheim) 347:806-18. 2014
    ..Thus, our results demonstrate that 5'-HNIO is an attractive molecular tool for cell transdifferentiation and cell fate research...