Sin Hyeog Im

Summary

Affiliation: Gwangju Institute of Science and Technology
Country: Korea

Publications

  1. ncbi request reprint Suppression of myasthenia gravis by antigen-specific mucosal tolerance and modulation of cytokines and costimulatory factors
    Miriam C Souroujon
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 998:533-6. 2003
  2. ncbi request reprint Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Vigo Heissmeyer
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 5:255-65. 2004
  3. pmc Molecular Mechanisms Governing IL-24 Gene Expression
    Anupama Sahoo
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Korea
    Immune Netw 12:1-7. 2012
  4. pmc Immune disorders and its correlation with gut microbiome
    Ji Sun Hwang
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Korea
    Immune Netw 12:129-38. 2012
  5. pmc Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis
    Chang Suk Chae
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Buk Gu, Gwangju, Korea
    PLoS ONE 7:e52119. 2012
  6. pmc Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells
    Jun Seock Son
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    PLoS ONE 6:e22042. 2011
  7. pmc Looping mediated interaction between the promoter and 3' UTR regulates type II collagen expression in chondrocytes
    Arijita Jash
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju, Korea
    PLoS ONE 7:e40828. 2012
  8. ncbi request reprint Chromatin-level regulation of the IL10 gene in T cells
    Sin Hyeog Im
    Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
    J Biol Chem 279:46818-25. 2004
  9. ncbi request reprint Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling
    Sin Hyeog Im
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Mol Cells 18:1-9. 2004
  10. doi request reprint Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:2690-9. 2008

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Suppression of myasthenia gravis by antigen-specific mucosal tolerance and modulation of cytokines and costimulatory factors
    Miriam C Souroujon
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Ann N Y Acad Sci 998:533-6. 2003
    ..We suggest that antagonists to key cytokines and/or costimulatory factors be used to augment antigen-specific treatments of myasthenia such as mucosal administration of AChR recombinant fragments...
  2. ncbi request reprint Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
    Vigo Heissmeyer
    Center for Blood Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 5:255-65. 2004
    ..Our results define a complex molecular program that links gene transcription induced by calcium and calcineurin to a paradoxical impairment of signal transduction in anergic T cells...
  3. pmc Molecular Mechanisms Governing IL-24 Gene Expression
    Anupama Sahoo
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Korea
    Immune Netw 12:1-7. 2012
    ..Herein, we briefly review the signaling pathways and transcription factors that facilitate, induce, or repress production of this cytokine along with the cellular sources and functions of IL-24...
  4. pmc Immune disorders and its correlation with gut microbiome
    Ji Sun Hwang
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Korea
    Immune Netw 12:129-38. 2012
    ..Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in diverse disorders...
  5. pmc Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis
    Chang Suk Chae
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Buk Gu, Gwangju, Korea
    PLoS ONE 7:e52119. 2012
    ..Our data suggest that IRT5 probiotics could be applicable to modulate antibody mediated autoimmune diseases including myasthenia gravis...
  6. pmc Enhanced chromatin accessibility and recruitment of JUNB mediate the sustained IL-4 expression in NFAT1 deficient T helper 2 cells
    Jun Seock Son
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    PLoS ONE 6:e22042. 2011
    ..Our results suggest that the prolonged IL-4 expression in NFAT1 deficient Th2 cells is mediated by preferential binding of JUNB/SATB1 to the IL-4 promoter with permissive chromatin architecture...
  7. pmc Looping mediated interaction between the promoter and 3' UTR regulates type II collagen expression in chondrocytes
    Arijita Jash
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju, Korea
    PLoS ONE 7:e40828. 2012
    ..Our results indicate that Lef1 mediated looping between promoter and 3' UTR under the permissive chromatin architecture upregulates Col2a1 expression in primary chondrocytes...
  8. ncbi request reprint Chromatin-level regulation of the IL10 gene in T cells
    Sin Hyeog Im
    Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
    J Biol Chem 279:46818-25. 2004
    ....
  9. ncbi request reprint Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling
    Sin Hyeog Im
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Mol Cells 18:1-9. 2004
    ..In this review we focus on the dual function, activator or deactivator, of NFAT and the binding partners that determine the role of NFAT in gene expression...
  10. doi request reprint Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:2690-9. 2008
    ..Our results suggest that oral administration of L. casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation...
  11. doi request reprint Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis
    Jae Seon So
    School of Life Sciences, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Life Sci 88:358-66. 2011
    ..The major purpose of this study was to evaluate therapeutic effects of L. casei on pathological responses in experimental rodent model of osteoarthritis (OA)...
  12. ncbi request reprint Differential regulation of the IL-10 gene in Th1 and Th2 T cells
    Kyu Ho Kang
    Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
    Ann N Y Acad Sci 1050:97-107. 2005
    ..Our results suggest that the combination of HS site and comparative genomic approaches allows identification of regulatory elements involved in differential IL-10 gene expression between Th1 and Th2 cells during T cell differentiation...
  13. doi request reprint Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis
    Jae Seon So
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Mol Immunol 46:172-80. 2008
    ..Our study provides evidence that L. casei could potentiate antigen-specific oral tolerance and suppress Th1-type immune responses of arthritic inflammation...
  14. pmc Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation
    Arijita Jash
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, 123 Cheomdan gwagiro, Buk Gu, Gwangju 500 712, Korea
    J Biol Chem 287:15445-57. 2012
    ..In summary, our data suggest that functional cooperation of NFAT1 and NF-κB synergistically enhances IL-9 transcription in CD4(+) T cells...
  15. pmc Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1
    Ho Keun Kwon
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Republic of Korea
    BMC Cancer 10:392. 2010
    ..In this study, we further identified that anti-tumor effect of cinnamon extracts is also link with enhanced pro-apoptotic activity by inhibiting the activities NFkappaB and AP1 in mouse melanoma model...
  16. doi request reprint Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression
    Anupama Sahoo
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Immunol 186:4098-109. 2011
    ..In summary, TCR stimulation induces IL-24 expression in Th2 cells by the coordinate action of Stat6 and c-Jun transcription factors at the transcriptional level...
  17. pmc Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
    Ho Keun Kwon
    Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Proc Natl Acad Sci U S A 107:2159-64. 2010
    ..Collectively, the administration of probiotics that enhance the generation of rDCs and Tregs represents an applicable treatment of inflammatory immune disorders...
  18. pmc Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells
    Ho Keun Kwon
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, South Korea
    World J Gastroenterol 17:976-86. 2011
    ..To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells...
  19. doi request reprint IRF4 regulates IL-10 gene expression in CD4(+) T cells through differential nuclear translocation
    Choong Gu Lee
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Cell Immunol 268:97-104. 2011
    ..Collectively, our results suggest that stimulation driven quantitative differences of IRF4 in the nucleus and its binding to IL-10 regulatory elements are crucial mechanisms to induce IL-10(high) gene expression in Th2 cells...
  20. doi request reprint A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells
    Choong Gu Lee
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 46:613-21. 2009
    ..Collectively, our results establish crucial roles for enhancer element CNS-9, and NFAT1 and IRF4 that bind to it, for IL-10 expression in differential T helper subsets...
  21. doi request reprint Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway
    Ramesh P Thylur
    Department of Life Science, Cell Dynamics Research Center, BioImaging Research Center, and Research Center for Biomolecular Nanotechnology, GIST, Gwangju 500 712, South Korea
    J Cell Biochem 108:705-15. 2009
    ..Collectively, these results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway...
  22. doi request reprint Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells
    Choong Gu Lee
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, The Republic of Korea
    J Immunol 188:2244-53. 2012
    ..Coexpression of Ets-1 with HDAC1 synergistically repressed IL-10 transcription activity. In summary, our data suggest that an interaction of Ets-1 with HDAC1 represses the Il10 gene expression in Th1 cells...
  23. doi request reprint Defect in TCR-CD3zeta signaling mediates T cell hypo-responsiveness in mesenteric lymph node
    Hwa Jung Yi
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:3748-55. 2008
    ..Collectively, we suggest that reduced CD3zeta expression and defects in TCR signaling mediate the anergy state of MLN CD4(+) T cells, which play a critical role in maintenance of mucosal tolerance in gut-associated lymphoid tissue...
  24. doi request reprint Foxp3 induces IL-4 gene silencing by affecting nuclear translocation of NFkappaB and chromatin structure
    Ho Keun Kwon
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Republic of Korea
    Mol Immunol 45:3205-12. 2008
    ..Our results suggest that Foxp3 could induce gene silencing by inhibiting NFkappaB activity and by causing its target loci to adopt an inactive chromatin configuration...
  25. doi request reprint JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation
    Jun Seock Son
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 407:141-7. 2011
    ....
  26. ncbi request reprint NF-kappaB regulates Lef1 gene expression in chondrocytes
    Kangsun Yun
    Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 357:589-95. 2007
    ..Lef1 expression was synergistically upregulated by interactions of NF-kappaB with Lef1/beta-catenin in chondrocytes. Our results suggest a pivotal role of NF-kappaB in Lef1 expression in arthritic chondrocytes or cartilage degeneration...
  27. doi request reprint Amelioration of experimental autoimmune encephalomyelitis by probiotic mixture is mediated by a shift in T helper cell immune response
    Ho Keun Kwon
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, 261 Cheomdan gwagiro, Buk Gu, Gwangju, 500 712, Republic of Korea
    Clin Immunol 146:217-27. 2013
    ..Collectively, our data suggest that IRT5 probiotics could be applicable to modulate T cell mediated neuronal autoimmune diseases, including multiple sclerosis...
  28. doi request reprint Lymphoid enhancer binding factor 1 regulates transcription through gene looping
    Kangsun Yun
    Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    J Immunol 183:5129-37. 2009
    ..Our results indicate a novel function of Lef1, as a mediator of gene looping between 5' and 3' regions. Gene looping may serve to delineate the transcription unit in the inducible gene transcription of mammalian cells...
  29. pmc IGSF4 is a novel TCR ζ-chain-interacting protein that enhances TCR-mediated signaling
    Hye Ran Kim
    Immune Synapse Research Center, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    J Exp Med 208:2545-60. 2011
    ..Collectively, the results indicate that IGSF4 plays a central role in T cell functioning by dual independent mechanisms, control of TCR signaling and control of T cell-APC interaction...
  30. doi request reprint Topical application of porcine placenta extract inhibits the progression of experimental contact hypersensitivity
    Arijita Jash
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Republic of Korea
    J Ethnopharmacol 133:654-62. 2011
    ..In this study, we intended to test the effect of topical application of porcine placenta extract in mouse model of contact hypersensitivity and elucidate its mechanism of action...
  31. ncbi request reprint Lef1 regulates COX-2 transcription in chondrocytes
    Kangsun Yun
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, 1 Oryong dong, Puk ku, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 364:270-5. 2007
    ..Moreover, binding of Lef1 and beta-catenin to the Lef1-binding site transactivates COX-2 promoter activity. Our results indicate a pivotal role of Lef1 in the regulation of COX-2 transcription in arthritic chondrocytes...
  32. doi request reprint Suppression of experimental myasthenia gravis by a B-cell epitope-free recombinant acetylcholine receptor
    Hwa Jung Yi
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, 1 Oryong dong, Buk Gu, Gwangju 500 712, Republic of Korea
    Mol Immunol 46:192-201. 2008
    ..Collectively, careful consideration of the immunogenicity of a tolerogen is necessary to induce successful oral tolerance in autoimmune disorders...
  33. pmc A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis
    Anupama Sahoo
    Department of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 283:28860-72. 2008
    ..Our results suggest that the novel splicing variant FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo...
  34. ncbi request reprint Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1
    Eun Young Choi
    Department of Life Science, Gwangju Institute of Science and Technology GIST, Gwangju, Korea
    J Cell Biochem 102:1442-57. 2007
    ..A possible link between iron status and two additional transcription factors, that is, CREB and Egr-1, rather than NF-kappaB, was also suggested...
  35. doi request reprint Topical application of Taglisodog-eum inhibits the development of experimental atopic dermatitis
    Ji Sun Hwang
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    J Ethnopharmacol 145:536-46. 2013
    ..In this study, we examined the effect of topical application of TSE on experimental atopic dermatitis (AD) and elucidated its action mechanism...
  36. pmc Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis
    Ji Sun Hwang
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, 261 Cheomdan gwagiro, Gwangju 500 712, Korea
    BMC Complement Altern Med 12:159. 2012
    ..In this study, we examined the immunomodulatory effects of P. linteus on experimental atopic dermatitis (AD) and elucidated its action mechanism...
  37. doi request reprint Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency
    Woong Hee Kim
    New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Buk Gu, Republic of Korea
    ACS Chem Biol 7:732-43. 2012
    ..This method induces dedifferentiation in a simple, stepwise approach and has therapeutic potential to enhance tissue regeneration in mammals...
  38. doi request reprint Interleukin and interleukin receptor diversity: role of alternative splicing
    Anupama Sahoo
    Department of Life Sciences, Gwangju Institute of Science and Technology GIST, Gwangju, Republic of Korea
    Int Rev Immunol 29:77-109. 2010
    ....
  39. doi request reprint Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells
    Ho Keun Kwon
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju, Republic of Korea
    Cancer Lett 278:174-82. 2009
    ..In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment...
  40. doi request reprint A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90
    Da Woon Jung
    New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Chem Biol 18:1581-90. 2011
    ..Furthermore, S06 represents a new class of Hsp90 inhibitor and is an attractive candidate for anticancer drug development...
  41. ncbi request reprint Transcriptional regulation of MMP13 by Lef1 in chondrocytes
    Kangsun Yun
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Republic of Korea
    Biochem Biophys Res Commun 364:1009-14. 2007
    ..Our results suggest a pivotal role of Lef1/beta-catenin in MMP13 regulation in chondrocytes, which might be associated with matrix loss of degenerated arthritic cartilage...
  42. pmc Epigenetic regulation of cytokine gene expression in T lymphocytes
    Choong Gu Lee
    Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong dong, Buk Gu, Gwangju 500 712, Korea
    Yonsei Med J 50:322-30. 2009
    ..This review discusses the basic epigenetic mechanisms and the role of transcription factors for the differential cytokine gene regulation in the T helper lymphocyte subsets...
  43. pmc Abalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity
    Choong Gu Lee
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    BMC Complement Altern Med 10:60. 2010
    ..The aim of the present study is to examine anti-tumor efficacy of abalone visceral extract and to elucidate its working mechanism...
  44. pmc Modulation of experimental atopic dermatitis by topical application of Gami-Cheongyeul-Sodok-Eum
    Ji Sun Hwang
    School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology GIST, Gwangju 500 712, Republic of Korea
    BMC Complement Altern Med 13:312. 2013
    ..GCSE has various biological activities such as anti-inflammatory, anti-bacterial and anti-viral activities. However, it is still unclear whether GCSE has any immunomodulatory effect on atopic dermatitis (AD)...
  45. doi request reprint Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates
    In Hyun Lee
    Cell Dynamics Research Center, School of Life Sciences, Gwang ju Institute of Science and Technology, Buk Gu, Gwang Ju, Republic of Korea
    J Control Release 155:435-41. 2011
    ..Employing these vehicles, we demonstrate the promising possibility of this chemoimmuno therapeutic system against prostate cancer in in vivo and in vitro models...
  46. pmc Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis
    Je Hwang Ryu
    Cell Dynamics Research Center and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea Research Center for Biomineralization Disorders and Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea
    PLoS Biol 12:e1001881. 2014
    ..Thus, our results collectively suggest that HIF-2α plays a pivotal role in the pathogenesis of RA by regulating FLS functions, independent of HIF-1α...
  47. ncbi request reprint Structural analysis of immunotherapeutic peptides for autoimmune Myasthenia gravis
    Hyun Ho Jung
    Department of Life Sciences, Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Biochemistry 46:14987-95. 2007
    ..1. Furthermore, our results suggest that cyclic extended peptides could be utilized generally as useful tools to optimize the affinity of phage library-derived peptide antigens...
  48. doi request reprint Handheld mechanical cell lysis chip with ultra-sharp silicon nano-blade arrays for rapid intracellular protein extraction
    Sung Sik Yun
    Department of Nanobio Materials and Electronics, Gwangju Institute of Science and Technology GIST, 261 Cheomdan gwagiro Oryong dong, Buk Gu, Gwangju, Republic of Korea 500 712
    Lab Chip 10:1442-6. 2010
    ..The protein concentration in the cell lysate obtained by the proposed lysis chip is quantitatively comparable to the one prepared by a conventional chemical lysis method...
  49. ncbi request reprint Transcriptional mechanisms underlying lymphocyte tolerance
    Fernando Macian
    Center for Blood Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 109:719-31. 2002
    ..Thus, in the absence of AP-1, NFAT imposes a genetic program of lymphocyte anergy that counters the program of productive activation mediated by the cooperative NFAT:AP-1 complex...
  50. ncbi request reprint Immunosuppression of rat myasthenia gravis by oral administration of a syngeneic acetylcholine receptor fragment
    Prasanta K Maiti
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Neuroimmunol 152:112-20. 2004
    ..The ability to suppress EAMG by a non-immunogenic syngeneic fragment of AChR is encouraging and may in the future be applied for the treatment of myasthenia gravis in humans...
  51. ncbi request reprint A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling
    Vigo Heissmeyer
    Department of Pathology, Harvard Medical School, CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Novartis Found Symp 267:165-74; discussion 174-9. 2005
    ..Thus Ca(2+)-calcineurin-NFAT signalling links gene transcription to a multi-step programme that leads to impaired signal transduction in anergic T cells...
  52. ncbi request reprint Breakage of tolerance to hidden cytoplasmic epitopes of the acetylcholine receptor in experimental autoimmune myasthenia gravis
    Tali Feferman
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neuroimmunol 140:153-8. 2003
    ..The presence of autoantibodies to intracellular epitopes seems to be correlated with development of clinical signs of disease. We propose that a similar process of epitope spreading may take place in the natural course of myasthenia...
  53. ncbi request reprint Experimental autoimmune myasthenia gravis in mice expressing human immunoglobulin loci
    Maurice H W Stassen
    Department of Neurology, Brain and Behaviour Institute Uns 50, Box 38, University of Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Neuroimmunol 135:56-61. 2003
    ..These experiments show that the HuMAb-Mouse represents a suitable model to generate and study the effects of human anti-AChR Abs in vivo...
  54. ncbi request reprint T-cell anergy
    Fernando Macian
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Opin Immunol 16:209-16. 2004
    ..These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state...