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Species | Ji Young ParkSummaryAffiliation: Gachon Medical School Country: Korea Publications
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Publications
Effect of ketoconazole on the pharmacokinetics of rosiglitazone in healthy subjectsJi Young Park
Department of Pharmacology, Gachon Medical School and Clinical Trial Centre, Gil Medical Centre, Incheon, Korea
Br J Clin Pharmacol 58:397-402. 2004..Rosiglitazone is a novel thiazolidinedione antidiabetic drug, mainly metabolized by CYP2C8 and to a lesser extent CYP2C9. We investigated the possible effect of ketoconazole on the pharmacokinetics of rosiglitazone in humans...
Relative bioavailability and pharmacokinetics of a new sibutramine formulation in healthy male subjects: a randomized, open-label, two-period, comparative crossover studyJi Young Park
Department of Pharmacology, Gachon Medical School, Gil Medical Center, 1198 Kuwol dong, Namdong gu, Incheon 405 760, Korea
Clin Ther 26:2092-101. 2004..Drugs formed from different salts may differ in their solubility profiles and dissolution rates, which may affect their rate of absorption and thus their onset, duration, and intensity of effect...- Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjectsJi Young Park
Departmernts of Pharmacology and Endocrinology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon 405 760, South Korea
Clin Pharmacol Ther 75:157-62. 2004..Our objective was to investigate the effect of rifampin on the pharmacokinetics of rosiglitazone in humans... - Quantification of gliclazide by semi-micro high-performance liquid chromatography: application to a bioequivalence study of two formulations in healthy subjectsJi Young Park
Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon 405 760, Republic of Korea
J Pharm Biomed Anal 35:943-9. 2004..80-1.25. This result suggests that two formulations are bioequivalent when administered orally at a dose of 80 mg gliclazide... - Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomesJi Young Park
Department of Pharmacology, Gachon Medical School, Incheon, Korea
Antimicrob Agents Chemother 47:3464-9. 2003..In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol... - Inhibitory effect of 5-fluorouracil on human cytochrome P(450) isoforms in human liver microsomesJi Young Park
Department of Pharmacology, Gachon Medical School, 1198 Kuwol dong, Namdong gu, 405 760 Incheon, Korea
Eur J Clin Pharmacol 59:407-9. 2003..The aim of the present study was to elucidate the inhibitory effect of 5-FU on CYP isoforms using human liver microsomes... - Randomized, open-label, two-period crossover comparison of the pharmacokinetic and pharmacodynamic properties of two amlodipine formulations in healthy adult male Korean subjectsJi Young Park
Department of Pharmacology, Clinical Trial Center, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon 405 760, Korea
Clin Ther 26:715-23. 2004.... - Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjectsJi Young Park
Department of Pharmacology, Korea University College of Medicine, Seoul, South Korea
Clin Pharmacol Ther 79:590-9. 2006..Our objective was to evaluate the effect of the CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy volunteers... - Genetic polymorphisms and linkage disequilibrium of sulfotransferase SULT1A1 and SULT1A2 in a Korean population: comparison of other ethnic groupsKyoung Ah Kim
Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon, 405 760, Korea
Eur J Clin Pharmacol 61:743-7. 2005..To determine the allele frequencies of sulfotransferases (SULTs) 1A1 and 1A2 and their linkage disequilibrium in a Korean population and compare them with those of other ethnic groups... - Inhibitory effects of tricyclic antidepressants (TCAs) on human cytochrome P450 enzymes in vitro: mechanism of drug interaction between TCAs and phenytoinJae Gook Shin
Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Busan Paik Hospital, Busan, Seoul, Korea
Drug Metab Dispos 30:1102-7. 2002..These results suggest that TCAs inhibit both CYP2D6 and CYP2C19 and that the interaction between TCAs and phenytoin involves inhibition of CYP2C19-catalyzed phenytoin p-hydroxylation... - Effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazideJi-Young Park
Department of Pharmacology, Ghil Medical Center, Gachon Medical School, Incheon, South Korea
Clin Pharmacol Ther 74:334-40. 2003..Concomitant use of rifampin with gliclazide can considerably reduce the glucose-lowering effects of gliclazide... - Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjectsKyoung-Ah Kim
Department of Pharmacology and Gil Medical Center, Gachon Medical School and Clinical Trial Center, 1198 Kuwol-dong, Namdong-gu, Incheon, 405-760, Korea
Eur J Clin Pharmacol 61:275-80. 2005..These results demonstrate that glucuronide conjugation plays a minor role in the metabolism of CBZ and CBZ-E in humans, and that probenecid has an inducing effect on the disposition of CBZ... - Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomesKyoung Ah Kim
Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwol dong, 405 760, Incheon, Namdong gu, Korea
Eur J Clin Pharmacol 60:575-81. 2004..The purpose of the present study was to elucidate the cytochrome P450 (P450) isoform(s) involved in the metabolism of loperamide (LOP) to N-demethylated LOP (DLOP) in human liver microsomes... - Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjectsKyoung-Ah Kim
Department of Pharmacology, Gil Medical Center, Gachon Medical School, 1198 Kuwoldong, Namdong-gu, Incheon 405-760, Korea
J Clin Pharmacol 45:941-6. 2005.... - Effect of ABCB1 (MDR1) haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjectsKyoung Ah Kim
Department of Pharmacology, Korea University College of Medicine, Seoul, Korea
Br J Clin Pharmacol 63:53-8. 2007..We aimed to investigate the effect of the ABCB1 gene on the pharmacokinetics of amlodipine... - Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humansJi-Hong Shon
Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Pusan, South Korea
Pharmacogenetics 12:111-9. 2002..The in-vivo contribution of CYP2C19 to tolbutamide 4-methylhydroxylation appears to be minor in humans. This suggests that, at least in vivo, tolbutamide remains a selective probe for measuring CYP2C9 activity in humans... - Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19Kyoung-Ah Kim
Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, and the Department of Chemistry, Pusan National University, Pusan, South Korea
Clin Pharmacol Ther 72:90-9. 2002..The disposition of lansoprazole enantiomers appears to be influenced by enantioselective protein binding and by enantioselective metabolism of lansoprazole... - Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patientsSun Min Jung
Departments of Pharmacology and Laboratory Medicine, Gil Medical Center, Gachon Medical School, 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, Korea
Clin Pharmacol Ther 78:520-8. 2005..In addition to CYP2D6, treatment with CYP3A inhibitor(s) including itraconazole may influence clinical symptoms and risperidone side effects... - Simple and extractionless high-performance liquid chromatographic determination of rosiglitazone in human plasma and application to pharmacokinetics in humansKyoung-Ah Kim
Department of Pharmacology, Gachon Medical School, Incheon 405-760, Korea
Biomed Chromatogr 18:613-5. 2004..This method is simple, specific, sensitive and requires only a small plasma volume with short analytical time, and is suitable for the determination of plasma rosiglitazone in routine measurements for pharmacokinetic studies... 
Functional implication of BAFF synthesis and release in gangliosides-stimulated microgliaKwang Soo Kim
Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea
J Leukoc Biol 86:349-59. 2009..These findings imply that BAFF secreted by microglia may play important roles in CNS inflammation by regulating microglia as well as infiltrated B cells...- 4-Hydroxynonenal induces vascular smooth muscle cell apoptosis through mitochondrial generation of reactive oxygen speciesJi Young Lee
Department of Pharmacology, College of Medicine, Pusan National University, 10 Ami-Dong 1-Ga, Seo-gu, Busan, Republic of Korea
Toxicol Lett 166:212-21. 2006..Taken together, these results suggest that mitochondrial dysfunction plays a key role in mediating HNE-induced VSMC apoptosis through an increased mitochondrial production of ROS... - Gomisin A induces Ca2+-dependent activation of eNOS in human coronary artery endothelial cellsJi Young Park
Department of Pharmacology, School of Medicine, and MRC for Ischemic Tissue Regeneration and Medical Research Institute, Pusan National University, Yangsan, Gyeongnam 626 770, Republic of Korea
J Ethnopharmacol 125:291-6. 2009..In this study, we examined whether GA could actually induce nitric oxide (NO) production and clarified the mechanism in cultured human coronary artery endothelial cells (HCAEC)... - Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probeJi-Young Park
Department of Pharmacology, Gachon Medical School, 1198 Kuwol-dong, Namdong-gu, Incheon 405-760, Korea
J Clin Pharmacol 46:109-14. 2006..24). The AUC ratio and plasma concentration ratios of 6-hydroxychlorzoxazone/chlorzoxazone were not changed significantly by high-dose aspirin. High-dose aspirin at a therapeutic dose does not affect CYP2E1 activity in humans... - Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidoneKyoung Ah Kim
Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, 126 1, Anam Dong 5 Ga, Sungbuk Gu, Seoul 136 705, Korea
J Clin Pharmacol 48:66-72. 2008..Thus, rifampin reduced the exposure to risperidone, probably because of a decrease in its bioavailability through the induction of CYP3A and probably P-glycoprotein... - Pharmacokinetic and pharmacodynamic characteristics of a new S-amlodipine formulation in healthy Korean male subjects: a randomized, open-label, two-period, comparative, crossover studyJi Young Park
Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, Seoul, Korea
Clin Ther 28:1837-47. 2006..It is used therapeutically as a racemic mixture, composed of S- and R-enantiomers, but its calcium channel-blocking effect is confined to S-amlodipine; R-amlodipine has 1000-fold less activity than its S-enantiomer... - Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjectsKyoung Ah Kim
Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, 126 1, Anam Dong 5 Ga, Sungbuk Gu, Seoul 136 705, Korea
J Clin Pharmacol 47:87-93. 2007..These findings suggest that the polymorphic CYP3A5 gene affects the disposition of simvastatin and provides a plausible explanation for interindividual variability of simvastatin disposition... - Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjectsKyoung Ah Kim
Department of Clinical Pharmacology, Anam Hospital, Korea University College of Medicine, Sungbuk Gu, Seoul, South Korea
Clin Pharmacol Ther 80:646-56. 2006..We investigated the effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean male subjects... - Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humansKyoung Ah Kim
Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, Seoul, Korea
Br J Clin Pharmacol 63:339-45. 2007..To investigate the effect of multiple dosing with montelukast, a selective leukotriene-receptor antagonist, on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans... - Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomesKyoung-Ah Kim
Research Group of Pain and Neuroscience, East-West Medical Research Institute, Kyung Hee University, Seoul, Korea
Arch Pharm Res 26:631-7. 2003..900). In conclusion, the results of the present study demonstrated that CYP2C8 and CYP3A4/5 are the major enzymes responsible for the chloroquine N-deethylation to DCQ in human liver microsomes... - Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharmacodynamics of haloperidol in healthy subjectsJi Young Park
Department of Pharmacology and Pharmacogenetics Research Center, Inje University College of Medicine, Busan, Korea
J Clin Psychopharmacol 26:135-42. 2006..The moderate effect of CYP2D6*10 genotype on the pharmacokinetics and pharmacodynamics of haloperidol seems to be augmented by the presence of itraconazole pretreatment... - Inhibitory effect of glyburide on human cytochrome p450 isoforms in human liver microsomesKyoung Ah Kim
East West Medical Research Institute, Kyunghee University, Seoul, Korea
Drug Metab Dispos 31:1090-2. 2003..It is anticipated that clinically significant drug-drug interactions will ensue when glyburide is coadministered with agents that are cleared primarily by the CYP2C9-mediated pathway and those with narrow therapeutic ranges... - Stereoselective metabolism of lansoprazole by human liver cytochrome P450 enzymesKyoung-Ah Kim
Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine Clinical Pharmacology Center, Busan Paik Hospital Busan, Korea
Drug Metab Dispos 31:1227-34. 2003.... - An overexpression of chalcone reductase of Pueraria montana var. lobata alters biosynthesis of anthocyanin and 5'-deoxyflavonoids in transgenic tobaccoJae-youl Joung
Plant Cell Biotechnology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon 305-333, Republic of Korea
Biochem Biophys Res Commun 303:326-31. 2003..The introduction of pl-chr gene provides a method to redirect the flavonoid pathway into 5'-deoxyflavonoid production in non-legume crops, in order to manipulate the phenylpropanoid pathway for isoflavonoid production... - RNAi-mediated suppression of p-coumaroyl-CoA 3'-hydroxylase in hybrid poplar impacts lignin deposition and soluble secondary metabolismHeather D Coleman
Department of Wood Science, University of British Columbia, 4030 2424 Main Mall, Vancouver, BC, Canada V6T 1Z4
Proc Natl Acad Sci U S A 105:4501-6. 2008..The data presented indicate that when down-regulated, C3'H becomes a rate-limiting step in lignin biosynthesis and further support the involvement of hydroxycinnamic acid shikimate esters in the lignin biosynthetic pathway... - Aortoduodenal fistula and aortic aneurysm secondary to biliary stent-induced retroperitoneal perforationTae Hoon Lee
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Songpagu, Seoul 138 736, South Korea
World J Gastroenterol 14:3095-7. 2008..To our knowledge, this is the first report describing a lethal complication of a bleeding, aortoduodenal fistula and caused by biliary metallic stent-induced perforation... - Cavum septum pellucidum in subjects at ultra-high risk for psychosis: compared with first-degree relatives of patients with schizophrenia and healthy volunteersJung Seok Choi
Department of Psychiatry, Seoul National University College of Medicine and Clinical Cognitive Neuroscience Center, SNU MRC, Seoul, Republic of Korea
Prog Neuropsychopharmacol Biol Psychiatry 32:1326-30. 2008..We examined whether CSP was present more frequently in subjects at ultra-high risk (UHR) for psychosis compared to first-degree relatives of patients with schizophrenia (genetic high risk, GHR) and healthy controls (HC)... - Ligand-binding domain of farnesoid X receptor (FXR) had the highest sensitivity and activity among FXR variants in a fluorescence-based assayKyung-Hyun Cho
Lipid Metabolism and Atherosclerosis Research Unit, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon, South Korea, 305-333
Lipids 38:1149-56. 2003....