Hyun Ae Woo

Summary

Affiliation: Ewha Womans University
Country: Korea

Publications

  1. doi request reprint Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling
    Hyun Ae Woo
    Ewha Womans University, Seoul, Korea
    Cell 140:517-28. 2010
  2. ncbi request reprint Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 278:47361-4. 2003
  3. doi request reprint Ablation of peroxiredoxin II attenuates experimental colitis by increasing FoxO1-induced Foxp3+ regulatory T cells
    Hee Yeon Won
    College of Pharmacy and Global Top 5 Research Program, Ewha Womans University, Seoul 120 750, Korea
    J Immunol 191:4029-37. 2013
  4. doi request reprint Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria
    In Sup Kil
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Mol Cell 46:584-94. 2012
  5. doi request reprint Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver
    Soo Han Bae
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Hepatology 53:945-53. 2011
  6. pmc Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 17:1351-61. 2012
  7. pmc Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 287:4403-10. 2012
  8. pmc Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression
    Joo Young Huh
    Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 16:229-43. 2012
  9. doi request reprint Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperones
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 15:781-94. 2011
  10. pmc Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody
    Mi Young Koo
    Division of Life and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, and Global Top 5 Research Program, Ewha Womans University, 52 Ewhayeodae gil, Seodaemun gu, Seoul 120 750, Korea
    Proc Natl Acad Sci U S A 111:6269-74. 2014

Collaborators

Detail Information

Publications15

  1. doi request reprint Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling
    Hyun Ae Woo
    Ewha Womans University, Seoul, Korea
    Cell 140:517-28. 2010
    ..In contrast, PrxII was inactivated not by phosphorylation but rather by hyperoxidation of its catalytic cysteine during sustained oxidative stress...
  2. ncbi request reprint Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 278:47361-4. 2003
    ..The generation of antibodies specific for sulfonylated peptides should provide insight into protein function similar to that achieved with antibodies to peptides containing phosphoserine or phosphothreonine...
  3. doi request reprint Ablation of peroxiredoxin II attenuates experimental colitis by increasing FoxO1-induced Foxp3+ regulatory T cells
    Hee Yeon Won
    College of Pharmacy and Global Top 5 Research Program, Ewha Womans University, Seoul 120 750, Korea
    J Immunol 191:4029-37. 2013
    ..These results suggest that inactivation of PrxII is important for the stability of FoxO1 protein, which subsequently mediates Foxp3(+) Treg cell development, thereby attenuating colonic inflammation. ..
  4. doi request reprint Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria
    In Sup Kil
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Mol Cell 46:584-94. 2012
    ..The coupling of CYP11B1 activity to PrxIII inactivation provides a feedback regulatory mechanism for steroidogenesis that functions independently of the hypothalamic-pituitary-adrenal axis...
  5. doi request reprint Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver
    Soo Han Bae
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Hepatology 53:945-53. 2011
    ..The selective role of Prx I in ROS removal is thus likely attributable to the proximity of Prx I and CYP2E1...
  6. pmc Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 17:1351-61. 2012
    ..To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress...
  7. pmc Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 287:4403-10. 2012
    ..The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins that are less intrinsically susceptible to H(2)O(2) also allows Prx to function as an H(2)O(2) sensor...
  8. pmc Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression
    Joo Young Huh
    Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 16:229-43. 2012
    ..Increased oxidative stress and mitochondrial dysfunction in obese adipocytes contribute to adipokine dysregulation, inflammation, and insulin resistance...
  9. doi request reprint Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperones
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 15:781-94. 2011
    ..Finally, 2-Cys Prxs interact with a variety of proteins, with such interaction having been shown to modulate the function of the binding partners in a reciprocal manner...
  10. pmc Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody
    Mi Young Koo
    Division of Life and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, and Global Top 5 Research Program, Ewha Womans University, 52 Ewhayeodae gil, Seodaemun gu, Seoul 120 750, Korea
    Proc Natl Acad Sci U S A 111:6269-74. 2014
    ....
  11. doi request reprint Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development
    Hee Yeon Won
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 13:575-87. 2010
    ..These data indicate that GPx1-dependent control of intracellular ROS accumulation is important not only for regulation of Th cell proliferation but for modulation of differentiation into Th1, Th2, and Th17 cells...
  12. pmc Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells
    Chun Seok Cho
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 12:1235-46. 2010
    ..In the presence of an increased H(2)O(2) flux, inhibition of catalase accelerated the accumulation of sulfinic Prx II, indicative of the protective role of catalase...
  13. doi request reprint Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins
    Hyun Ae Woo
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 11:739-45. 2009
    ..These results suggest that, unlike Srx, Sesn 2 is not a sulfinic Prx reductase...
  14. doi request reprint Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 11:937-48. 2009
    ..Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx, sulfinic Prx III is converted to a form that is susceptible to proteolysis...
  15. ncbi request reprint Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    Science 300:653-6. 2003
    ..The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated...