Hyun Ae Woo
Affiliation: Ewha Womans University
Woo H, Yim S, Shin D, Kang D, Yu D, Rhee S. Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. Cell. 2010;140:517-28 pubmed publisher
..In contrast, PrxII was inactivated not by phosphorylation but rather by hyperoxidation of its catalytic cysteine during sustained oxidative stress. ..
Ji Y, Chae S, Lee H, Park I, Kim C, Ismail T, et al
. Peroxiredoxin5 controls vertebrate ciliogenesis by modulating mitochondrial ROS. Antioxid Redox Signal. 2018;: pubmed publisher
..The loss of Prdx5 is associated with excessive production of ROS resulting in mitochondrial dysfunction and aberrant ciliogenesis. ..
Kil Y, Park J, Han A, Woo H, Seo E. A new 9,10-dihydrophenanthrene and cell proliferative 3,4-δ-dehydrotocopherols from Stemona tuberosa. Molecules. 2015;20:5965-74 pubmed publisher
..4% increase of δ-tocopherol. Moreover, none of them induced cancer cell proliferation. Therefore, 3,4-δ-dehydrotocopherols, especially pure isomers 2 and 3 can be suggested as potential wound healing agents. ..
Kim M, Park S, Kim J, Seong J, Kim K, Woo H, et al
. Peroxiredoxin 5 regulates adipogenesis-attenuating oxidative stress in obese mouse models induced by a high-fat diet. Free Radic Biol Med. 2018;: pubmed publisher
..In conclusion, we suggest that Prx5 inhibits adipogenesis by modulating ROS generation and adipogenic gene expression, implying that Prx5 may serve as a potential strategy to prevent and treat obesity. ..
Jung J, Ryu S, Ki I, Woo H, Lee K. Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP). Int J Mol Sci. 2018;19: pubmed publisher
..This review attempts to collate the biological effects of Na,K-ATPase and TCTP interaction and suggests that this interaction has the potential to serve as a possible therapeutic target for selected diseases. ..
Kil Y, Park J, Jafari M, Woo H, Seo E. Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells. Bioorg Med Chem Lett. 2017;27:3065-3070 pubmed publisher
..Cytoprotective effects against oxidative stress induced by glucose oxidase were also examined on Hep3B cells and mouse fibroblast NIH3T3 cells and all compounds showed significant dose-dependent protection against oxidative stress. ..
Kang U, Park J, Han A, Woo M, Lee J, Lee S, et al
. Identification of cytoprotective constituents of the flower buds of Tussilago farfara against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells. Arch Pharm Res. 2016;39:474-480 pubmed publisher
..The structure of 1 was determined by spectroscopic data analysis including 1D- and 2D-NMR experiments, and its absolute configuration was elucidated by a circular dichroism. ..