Sue Goo Rhee

Summary

Affiliation: Ewha Womans University
Country: Korea

Publications

  1. doi request reprint Methods for detection and measurement of hydrogen peroxide inside and outside of cells
    Sue Goo Rhee
    Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, 120 750, Korea
    Mol Cells 29:539-49. 2010
  2. pmc Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 287:4403-10. 2012
  3. ncbi request reprint Cell signaling. H2O2, a necessary evil for cell signaling
    Sue Goo Rhee
    Institute of Molecular Life Science and Technology, Ewha Women s University, Seoul 120 750, South Korea
    Science 312:1882-3. 2006
  4. doi request reprint Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperones
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 15:781-94. 2011
  5. pmc Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2
    Hojin Kim
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 285:34419-28. 2010
  6. doi request reprint Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    Cell Metab 17:73-84. 2013
  7. doi request reprint Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex
    In Hye Lee
    Department of Life Science, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Korea
    J Biol Chem 283:6312-20. 2008
  8. pmc Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 17:1351-61. 2012
  9. pmc Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2
    Jin Young Baek
    College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    J Biol Chem 287:81-9. 2012
  10. doi request reprint Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling
    Hyun Ae Woo
    Ewha Womans University, Seoul, Korea
    Cell 140:517-28. 2010

Collaborators

Detail Information

Publications73

  1. doi request reprint Methods for detection and measurement of hydrogen peroxide inside and outside of cells
    Sue Goo Rhee
    Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, 120 750, Korea
    Mol Cells 29:539-49. 2010
    ....
  2. pmc Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 287:4403-10. 2012
    ..The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins that are less intrinsically susceptible to H(2)O(2) also allows Prx to function as an H(2)O(2) sensor...
  3. ncbi request reprint Cell signaling. H2O2, a necessary evil for cell signaling
    Sue Goo Rhee
    Institute of Molecular Life Science and Technology, Ewha Women s University, Seoul 120 750, South Korea
    Science 312:1882-3. 2006
  4. doi request reprint Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperones
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 15:781-94. 2011
    ..Finally, 2-Cys Prxs interact with a variety of proteins, with such interaction having been shown to modulate the function of the binding partners in a reciprocal manner...
  5. pmc Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2
    Hojin Kim
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 285:34419-28. 2010
    ..These results suggest that LPS-mediated Srx induction is dependent on both AP-1 and Nrf2, which is regulated by Nox2-derived reactive oxygen species...
  6. doi request reprint Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    Cell Metab 17:73-84. 2013
    ..Ablation of Sesn2 blocked Keap1 degradation and Nrf2 activation induced by refeeding and thereby increased the susceptibility of the liver to oxidative damage resulting from the acute stimulation of lipogenesis associated with refeeding...
  7. doi request reprint Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex
    In Hye Lee
    Department of Life Science, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Korea
    J Biol Chem 283:6312-20. 2008
    ..These data indicate that Ahnak potentiates PKC activation through inhibiting the interaction of PKC with PP2A...
  8. pmc Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 17:1351-61. 2012
    ..To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress...
  9. pmc Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2
    Jin Young Baek
    College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    J Biol Chem 287:81-9. 2012
    ..These results indicate that Srx functions as a novel component to maintain the balance between H2O2 production and elimination and then protects cells from apoptosis even in the presence of low steady-state levels of H2O2...
  10. doi request reprint Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling
    Hyun Ae Woo
    Ewha Womans University, Seoul, Korea
    Cell 140:517-28. 2010
    ..In contrast, PrxII was inactivated not by phosphorylation but rather by hyperoxidation of its catalytic cysteine during sustained oxidative stress...
  11. pmc Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III
    You Hyun Noh
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Science Building C, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
    J Biol Chem 284:8470-7. 2009
    ....
  12. pmc Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha
    Yuyeon Jung
    Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul, Korea
    J Biol Chem 283:23863-71. 2008
    ..Together, our results indicate that LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state...
  13. ncbi request reprint Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 278:47361-4. 2003
    ..The generation of antibodies specific for sulfonylated peptides should provide insight into protein function similar to that achieved with antibodies to peptides containing phosphoserine or phosphothreonine...
  14. doi request reprint Ablation of peroxiredoxin II attenuates experimental colitis by increasing FoxO1-induced Foxp3+ regulatory T cells
    Hee Yeon Won
    College of Pharmacy and Global Top 5 Research Program, Ewha Womans University, Seoul 120 750, Korea
    J Immunol 191:4029-37. 2013
    ..These results suggest that inactivation of PrxII is important for the stability of FoxO1 protein, which subsequently mediates Foxp3(+) Treg cell development, thereby attenuating colonic inflammation. ..
  15. doi request reprint Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cells
    Joo Young Lee
    Division of Life and Pharmaceutical Sciences and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, 127 750, Korea
    Free Radic Biol Med 47:1162-71. 2009
    ..Thus, this study illustrates that intracellular reactive oxygen species regulated by cytosolic 2-cysPrx is involved in the TNF-alpha-induced apoptotic cell death via controlling caspase activation...
  16. doi request reprint Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria
    In Sup Kil
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Mol Cell 46:584-94. 2012
    ..The coupling of CYP11B1 activity to PrxIII inactivation provides a feedback regulatory mechanism for steroidogenesis that functions independently of the hypothalamic-pituitary-adrenal axis...
  17. pmc Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression
    Joo Young Huh
    Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 16:229-43. 2012
    ..Increased oxidative stress and mitochondrial dysfunction in obese adipocytes contribute to adipokine dysregulation, inflammation, and insulin resistance...
  18. doi request reprint Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver
    Soo Han Bae
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Hepatology 53:945-53. 2011
    ..The selective role of Prx I in ROS removal is thus likely attributable to the proximity of Prx I and CYP2E1...
  19. pmc Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells
    Chun Seok Cho
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 12:1235-46. 2010
    ..In the presence of an increased H(2)O(2) flux, inhibition of catalase accelerated the accumulation of sulfinic Prx II, indicative of the protective role of catalase...
  20. ncbi request reprint 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications
    Sang Won Kang
    Center for Cell Signaling Research and Division of Molecular Life Science, Ewha Womans University, Seoul 120 750, Korea
    Trends Mol Med 11:571-8. 2005
    ..Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species...
  21. pmc Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2
    Hye Sun Park
    Center for Cell Signaling Research, Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    Mol Cell Biol 24:4384-94. 2004
    ..These results suggest that ROS production in growth factor-stimulated cells is mediated by the sequential activation of PI3K, beta Pix, and Rac1, which then binds to Nox1 to stimulate its NADPH oxidase activity...
  22. doi request reprint Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: implication in the redox regulation of TNF-alpha signaling
    Woojin Jeong
    Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
    Free Radic Biol Med 47:1294-303. 2009
    ..These findings elucidate the molecular mechanism by which NF-kappaB activation is regulated through TRP14...
  23. doi request reprint Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development
    Hee Yeon Won
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 13:575-87. 2010
    ..These data indicate that GPx1-dependent control of intracellular ROS accumulation is important not only for regulation of Th cell proliferation but for modulation of differentiation into Th1, Th2, and Th17 cells...
  24. doi request reprint Study of the signaling function of sulfiredoxin and peroxiredoxin III in isolated adrenal gland: unsuitability of clonal and primary adrenocortical cells
    In Sup Kil
    Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seodaemun gu, Seoul, South Korea
    Methods Enzymol 527:169-81. 2013
    ..Organ culture system is, however, appropriate for studying the PrxIII-Srx regulatory function as the levels of hyperoxidized PrxIII and Srx in the adrenal glands maintained overnight in culture medium are not changed. ..
  25. doi request reprint A fluorescence turn-on H2O2 probe exhibits lysosome-localized fluorescence signals
    Dayoung Song
    Department of Bioinspired Science, Ewha Womans University, Seoul 120 750, Korea
    Chem Commun (Camb) 48:5449-51. 2012
    ..A new fluorescence turn-on probe that responds exclusively to H(2)O(2) exhibits subcellular localized fluorescence staining of lysosomes...
  26. doi request reprint Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxia
    Soo Han Bae
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 11:937-48. 2009
    ..Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx, sulfinic Prx III is converted to a form that is susceptible to proteolysis...
  27. doi request reprint Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins
    Hyun Ae Woo
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Antioxid Redox Signal 11:739-45. 2009
    ..These results suggest that, unlike Srx, Sesn 2 is not a sulfinic Prx reductase...
  28. doi request reprint Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice
    Jong Gil Park
    Division of Life and Pharmaceutical Science, Ewha Womans University, Seoul, Republic of Korea
    Circ Res 109:739-49. 2011
    ..Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress...
  29. ncbi request reprint Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    Science 300:653-6. 2003
    ..The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated...
  30. doi request reprint Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression
    Woojin Jeong
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
    Free Radic Biol Med 53:447-56. 2012
    ..Srx expression is also regulated at the translational level in Saccharomyces cerevisiae...
  31. doi request reprint Regulation of reactive oxygen species generation in cell signaling
    Yun Soo Bae
    Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    Mol Cells 32:491-509. 2011
    ..This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed...
  32. ncbi request reprint AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C
    In Hye Lee
    Division of Molecular Life Sciences, Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 279:26645-53. 2004
    ..The secondary activation of PLC is likely because of the scaffolding activity of AHNAK, which is consistent with the role of 4 CRUs as a molecular linker between PLC-gamma and PKC-alpha...
  33. ncbi request reprint Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase
    Hyun Choi
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Korea
    J Biol Chem 283:255-67. 2008
    ..In reconstituted cells stimulated with Ang II, Nox2 exhibited a more sensitive response than Nox1 to the perturbation of protein kinase C, phosphatidylinositol 3-kinase, or the small GTPase Rac1...
  34. pmc ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress
    Woojin Jeong
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul, Korea
    J Biol Chem 283:25557-66. 2008
    ..Our results suggest that ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress...
  35. ncbi request reprint Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease...
  36. pmc Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis
    Sun Hee Yim
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
    J Biol Chem 286:39002-12. 2011
    ..We suggest that Prx IV-L functions as an H(2)O(2) sensor that mediates protein thiol oxidation required for the maturation of spermatozoa in placental mammals...
  37. doi request reprint Blot-based detection of dehydroalanine-containing glutathione peroxidase with the use of biotin-conjugated cysteamine
    Sue Goo Rhee
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seodaemun gu, Seoul, Korea
    Methods Enzymol 474:23-34. 2010
    ..Our blot-based method for the detection of DHA-GPx1 will be very useful for evaluation of such stress. In addition, similar blot detection method can be devised for other proteins for which immunoprecipitating antibodies are available...
  38. doi request reprint A colorimetric assay for sulfiredoxin activity using inorganic phosphate measurement
    Hojin Kim
    Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu Seoul 120 750, South Korea
    Anal Biochem 393:36-40. 2009
    ..The colorimetric assay was used for high-throughput screening of 25,000 chemicals to find Srx inhibitors...
  39. doi request reprint Antibodies against non-immunizing antigens derived from a large immune scFv library
    Sung Ah Moon
    Division of Life and Pharmaceutical Sciences, The Graduate School, Ewha Womans University, Seoul, 120 750, Korea
    Mol Cells 31:509-13. 2011
    ..e., against various non-immunizing antigens to yield specific antibodies...
  40. ncbi request reprint Activity assay of mammalian 2-cys peroxiredoxins using yeast thioredoxin reductase system
    Ju A Kim
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Woman s University, Seoul, Korea
    Anal Biochem 338:216-23. 2005
    ..5 microM, respectively. This modified assay method is useful for measuring 2-cys Prx activity in cell lysates and can also be adapted for a 96-well plate reader for high-throughput screening of chemical compounds that target 2-cys Prx...
  41. pmc Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia
    Chun Seok Cho
    Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seodaemun gu, Seoul, Korea
    Antioxid Redox Signal 13:1-11. 2010
    ..GPx1 expression represents a previously unrecognized potential benefit of hydroxyurea treatment in SCD patients...
  42. ncbi request reprint Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice
    Tae Hoon Lee
    Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Blood 101:5033-8. 2003
    ..Our results suggest that Prx II-/- mice have hemolytic anemia and that Prx II plays a major role in protecting RBCs from oxidative stress in mice...
  43. ncbi request reprint Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function
    Woojin Jeong
    Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:3142-50. 2004
    ..These results suggest that TRP14 and Trx1 might act on distinct substrate proteins...
  44. ncbi request reprint Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid
    Kap Seok Yang
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:38029-36. 2002
    ..072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2)...
  45. ncbi request reprint Cellular regulation by hydrogen peroxide
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 14:S211-5. 2003
    ..Furthermore, the activity of peroxiredoxin enzymes seems to be regulated via protein phosphorylation as in the case of many other intracellular messenger metabolizing enzymes...
  46. ncbi request reprint Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cells
    Jae Ryong Kim
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Arch Biochem Biophys 397:414-23. 2002
    ....
  47. ncbi request reprint The RING-H2-finger protein APC11 as a target of hydrogen peroxide
    Tong Shin Chang
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 37:521-30. 2004
    ..Inhibition of APC11 function by H(2)O(2) thus likely contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress...
  48. pmc Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
    Satish Devadas
    Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Exp Med 195:59-70. 2002
    ..Thus, antigen receptor signaling induces generation of discrete species of oxidants that selectively regulate two distinct redox sensitive pathways, a proapoptotic (FasL) and a proliferative pathway (ERK)...
  49. pmc Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
    Jaeyul Kwon
    Laboratories of Cell Signaling and Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8015, USA
    Proc Natl Acad Sci U S A 101:16419-24. 2004
    ..Furthermore, together with previous observations, our data indicate that peroxiredoxin likely participates in PIP3 signaling by modulating the local concentration of H2O2...
  50. ncbi request reprint Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 38:1543-52. 2005
    ..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come...
  51. ncbi request reprint Structural basis of cellular redox regulation by human TRP14
    Joo Rang Woo
    Center for Cellular Switch Protein Structure and Systemic Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Euh eun dong, Yuseong Gu, Daejeon 305 806, Korea
    J Biol Chem 279:48120-5. 2004
    ..These structural differences in the active site suggest that TRP14 has evolved to regulate cellular redox signaling by recognizing a distinctive group of substrates that would complement the group of proteins regulated by Trx1...
  52. ncbi request reprint Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Cell Biol 17:183-9. 2005
    ....
  53. ncbi request reprint Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin
    Woojin Jeong
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:14400-7. 2006
    ..The disulfide-S-monoxide is further reduced through the oxidation of three thiol equivalents to complete the catalytic cycle and regenerate Prx-Cys-SH...
  54. ncbi request reprint Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine
    Tong Shin Chang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:50994-1001. 2004
    ..Finally, depletion of human Srx by RNA interference suggested that Srx is largely responsible for reduction of the Cys-SO2H of Prx in A549 human cells...
  55. ncbi request reprint Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins
    Hyun Ae Woo
    Laboratory of Cell Signaling and Laboratory of Biophysical Chemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:3125-8. 2005
    ..These results suggest that reduction of Cys-SO2H by Srx is specific to 2-Cys Prx isoforms. For proteins such as Prx VI and GAPDH, sulfinic acid formation might be an irreversible process that causes protein damage...
  56. ncbi request reprint Membrane targeting of C2 domains of phospholipase C-delta isoforms
    Bharath Ananthanarayanan
    Department of Chemistry, University of Illinois, Chicago 60607, USA
    J Biol Chem 277:3568-75. 2002
    ..Together, these results establish the C2 domains of PLC-delta isoforms as Ca(2+)-dependent membrane targeting domains that have distinct membrane binding properties that control their subcellular localization behaviors...
  57. ncbi request reprint Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification
    Sue Goo Rhee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Antioxid Redox Signal 7:619-26. 2005
    ..Similarily, GPx1 is activated by c-Abl- and Arg-mediated phosphorylation. The tyrosine phosphorylation is critical for ubiquitination-dependent degradation of catalase...
  58. ncbi request reprint Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130
    Peter Varnai
    Endocrinology and Reproduction Research Branch, NICHD National Institutes of Health, 49 Convent Drive, Bldg 49, Bethesda, MD 20892, USA
    J Biol Chem 277:27412-22. 2002
    ....
  59. pmc Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1
    Benoit Poulin
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8015, USA
    Proc Natl Acad Sci U S A 102:4276-81. 2005
    ..Our results thus clarify the molecular mechanism of PLC-gamma1 activation, revealing the specific function of pY783 and the distinct roles of the two SH2 domains in this process...
  60. ncbi request reprint Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxin
    Mijung Kwon
    Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 280:23584-92. 2005
    ..Therefore, we identify AIIt as a substrate of the thioredoxin system and propose a new model for the role of AIIt in the redox-dependent processing of plasminogen and generation of an angiostatin at the cell surface...
  61. ncbi request reprint Reversible inactivation of the tumor suppressor PTEN by H2O2
    Seung Rock Lee
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8015, USA
    J Biol Chem 277:20336-42. 2002
    ....
  62. ncbi request reprint Identification of phospholipase C-gamma1 as a mitogen-activated protein kinase substrate
    Colin T Buckley
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Biol Chem 279:41807-14. 2004
    ..These studies have uncovered a previously unidentified mechanism for the integration of PLC-gamma1- and ERK2-dependent signaling...
  63. ncbi request reprint Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis
    Duck Yeon Lee
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 0301, USA
    Biochemistry 45:15301-9. 2006
    ..The modeling and mutagenesis analyses strongly implicate Asp187 of Prx I as the catalytic residue responsible for ATP hydrolysis in the cysteinesulfinic acid reduction of Prx by hSrx...
  64. ncbi request reprint Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
    Tong Shin Chang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:41975-84. 2004
    ..Our results suggest that Prx III is a critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling...
  65. ncbi request reprint Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function
    Ho Hee Jang
    Division of Applied Life Sciences, Gyeonsang National University, Chinju, 660 701, South Korea
    Cell 117:625-35. 2004
    ..The chaperone function of these proteins enhances yeast resistance to heat shock...
  66. ncbi request reprint Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
    Fujio Sekiya
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:32181-90. 2004
    ..Finally, concurrent production of phosphatidylinositol 3,4,5-trisphosphate was found to contribute to the activation of phosphorylated PLC-gamma 1...
  67. pmc Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:1023-9. 2004
    ..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V...
  68. pmc Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2
    Yeun Ju Kim
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 24:9986-99. 2004
    ..Finally, phosphorylation of Y1217 and that of Y753 and Y759 occurred on different PLC-gamma2 molecules...
  69. ncbi request reprint Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidant
    Amy L Mowbray
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    J Biol Chem 283:1622-7. 2008
    ..However, PRX 5 depletion did not. Together, these results suggest that PRX 1 is a novel mechanosensitive antioxidant, playing an important role in shear-dependent regulation of endothelial biology and atherosclerosis...
  70. ncbi request reprint Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways
    Woojin Jeong
    Laboratory of Cell Signaling, National Heart, Lung and Bllod Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:3151-9. 2004
    ..The complex was detected in HeLa cells treated with H(2)O(2) or TNF-alpha but not in untreated cells, suggesting that LC8 cytoplasmic dynein light chain is a possible substrate of TRP14...
  71. ncbi request reprint Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alpha
    Sang Won Kang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:2535-43. 2004
    ..Our results also suggest that cytosolic peroxiredoxins are important regulators of TNF signaling pathways...
  72. ncbi request reprint Measuring H2O2 produced in response to cell surface receptor activation
    Sue Goo Rhee
    Nat Chem Biol 3:244-6. 2007
  73. ncbi request reprint Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation
    Tong Shin Chang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:25370-6. 2002
    ..These results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H(2)O(2) might be important for progression of the cell cycle...