Research Topics
Genomes and Genes
| Sue Goo RheeSummaryAffiliation: Ewha Womans University Country: Korea Publications
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Detail Information
Publications
Methods for detection and measurement of hydrogen peroxide inside and outside of cellsSue Goo Rhee
Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, 120 750, Korea
Mol Cells 29:539-49. 2010....
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxidesSue Goo Rhee
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
J Biol Chem 287:4403-10. 2012..The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins that are less intrinsically susceptible to H(2)O(2) also allows Prx to function as an H(2)O(2) sensor...- Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperonesSue Goo Rhee
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 15:781-94. 2011..Finally, 2-Cys Prxs interact with a variety of proteins, with such interaction having been shown to modulate the function of the binding partners in a reciprocal manner... 
Cell signaling. H2O2, a necessary evil for cell signalingSue Goo Rhee
Institute of Molecular Life Science and Technology, Ewha Women's University, Seoul 120-750, South Korea
Science 312:1882-3. 2006- Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2Hojin Kim
Department of Life Science, Division of Life and Pharmaceutical Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
J Biol Chem 285:34419-28. 2010..These results suggest that LPS-mediated Srx induction is dependent on both AP-1 and Nrf2, which is regulated by Nox2-derived reactive oxygen species... - Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complexIn Hye Lee
Department of Life Science, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Korea
J Biol Chem 283:6312-20. 2008..These data indicate that Ahnak potentiates PKC activation through inhibiting the interaction of PKC with PP2A... - Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injurySoo Han Bae
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 17:1351-61. 2012..To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress... - Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2Jin Young Baek
College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
J Biol Chem 287:81-9. 2012..These results indicate that Srx functions as a novel component to maintain the balance between H2O2 production and elimination and then protects cells from apoptosis even in the presence of low steady-state levels of H2O2... - Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin IIIYou Hyun Noh
College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Science Building C, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
J Biol Chem 284:8470-7. 2009.... - Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalphaYuyeon Jung
Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul, Korea
J Biol Chem 283:23863-71. 2008..Together, our results indicate that LC8 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK. TRP14 contributes to this inhibitory activity by maintaining LC8 in a reduced state... - Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequenceHyun Ae Woo
Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea
J Biol Chem 278:47361-4. 2003..The generation of antibodies specific for sulfonylated peptides should provide insight into protein function similar to that achieved with antibodies to peptides containing phosphoserine or phosphothreonine... - Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signalingHyun Ae Woo
Ewha Womans University, Seoul, Korea
Cell 140:517-28. 2010..In contrast, PrxII was inactivated not by phosphorylation but rather by hyperoxidation of its catalytic cysteine during sustained oxidative stress... - Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondriaIn Sup Kil
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Mol Cell 46:584-94. 2012..The coupling of CYP11B1 activity to PrxIII inactivation provides a feedback regulatory mechanism for steroidogenesis that functions independently of the hypothalamic-pituitary-adrenal axis... - Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damageSoo Han Bae
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
Cell Metab 17:73-84. 2013..Ablation of Sesn2 blocked Keap1 degradation and Nrf2 activation induced by refeeding and thereby increased the susceptibility of the liver to oxidative damage resulting from the acute stimulation of lipogenesis associated with refeeding... - Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expressionJoo Young Huh
Division of Life and Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 16:229-43. 2012..Increased oxidative stress and mitochondrial dysfunction in obese adipocytes contribute to adipokine dysregulation, inflammation, and insulin resistance... - Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liverSoo Han Bae
Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Hepatology 53:945-53. 2011..CONCLUSION: The pivotal functions of Srx and Prx I in protection of the liver in ethanol-fed mice was evident from the severe oxidative damage observed in mice lacking either Srx or Prx I... - Protective role of cytosolic 2-cys peroxiredoxin in the TNF-alpha-induced apoptotic death of human cancer cellsJoo Young Lee
Division of Life and Pharmaceutical Sciences and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, 127 750, Korea
Free Radic Biol Med 47:1162-71. 2009..Thus, this study illustrates that intracellular reactive oxygen species regulated by cytosolic 2-cysPrx is involved in the TNF-alpha-induced apoptotic cell death via controlling caspase activation... - Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2Hye Sun Park
Center for Cell Signaling Research, Division of Molecular Life Sciences, Ewha Womans University, Seoul 120-750, Korea
Mol Cell Biol 24:4384-94. 2004..These results suggest that ROS production in growth factor-stimulated cells is mediated by the sequential activation of PI3K, beta Pix, and Rac1, which then binds to Nox1 to stimulate its NADPH oxidase activity... - 2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implicationsSang Won Kang
Center for Cell Signaling Research and Division of Molecular Life Science, Ewha Womans University, Seoul 120 750, Korea
Trends Mol Med 11:571-8. 2005..Thus, the therapeutic potential of 2-Cys peroxiredoxins is clear for diseases, such as cancer and cardiovascular diseases, that involve reactive oxygen species... - Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: implication in the redox regulation of TNF-alpha signalingWoojin Jeong
Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul 120 750, Korea
Free Radic Biol Med 47:1294-303. 2009..These findings elucidate the molecular mechanism by which NF-kappaB activation is regulated through TRP14... - Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell developmentHee Yeon Won
College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 13:575-87. 2010..These data indicate that GPx1-dependent control of intracellular ROS accumulation is important not only for regulation of Th cell proliferation but for modulation of differentiation into Th1, Th2, and Th17 cells... - A fluorescence turn-on H2O2 probe exhibits lysosome-localized fluorescence signalsDayoung Song
Department of Bioinspired Science, Ewha Womans University, Seoul 120 750, Korea
Chem Commun (Camb) 48:5449-51. 2012..A new fluorescence turn-on probe that responds exclusively to H(2)O(2) exhibits subcellular localized fluorescence staining of lysosomes... - Induction of sulfiredoxin via an Nrf2-dependent pathway and hyperoxidation of peroxiredoxin III in the lungs of mice exposed to hyperoxiaSoo Han Bae
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 11:937-48. 2009..Hyperoxia induced the degradation of Prx III in Nrf2-deficient mice but not in wild-type animals, suggesting that, in the absence of a sufficient amount of Srx, sulfinic Prx III is converted to a form that is susceptible to proteolysis... - Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxinsHyun Ae Woo
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 11:739-45. 2009..These results suggest that, unlike Srx, Sesn 2 is not a sulfinic Prx reductase... - Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient miceJong Gil Park
Division of Life and Pharmaceutical Science, Ewha Womans University, Seoul, Republic of Korea
Circ Res 109:739-49. 2011..Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress... - Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formationHyun Ae Woo
Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
Science 300:653-6. 2003..The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated... - Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expressionWoojin Jeong
Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Free Radic Biol Med 53:447-56. 2012..Srx expression is also regulated at the translational level in Saccharomyces cerevisiae... - Regulation of reactive oxygen species generation in cell signalingYun Soo Bae
Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
Mol Cells 32:491-509. 2011..This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed... - AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase CIn Hye Lee
Division of Molecular Life Sciences, Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
J Biol Chem 279:26645-53. 2004..The secondary activation of PLC is likely because of the scaffolding activity of AHNAK, which is consistent with the role of 4 CRUs as a molecular linker between PLC-gamma and PKC-alpha... - Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cellsChun Seok Cho
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea
Antioxid Redox Signal 12:1235-46. 2010..In the presence of an increased H(2)O(2) flux, inhibition of catalase accelerated the accumulation of sulfinic Prx II, indicative of the protective role of catalase... - Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidaseHyun Choi
Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemoon Gu, Seoul 120 750, Korea
J Biol Chem 283:255-67. 2008..In reconstituted cells stimulated with Ang II, Nox2 exhibited a more sensitive response than Nox1 to the perturbation of protein kinase C, phosphatidylinositol 3-kinase, or the small GTPase Rac1... - Regulation of PDGF signalling and vascular remodelling by peroxiredoxin IIMin Hee Choi
Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
Nature 435:347-53. 2005..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease... - ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stressWoojin Jeong
Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul, Korea
J Biol Chem 283:25557-66. 2008..Our results suggest that ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress... - Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testisSun Hee Yim
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120 750, Korea
J Biol Chem 286:39002-12. 2011..We suggest that Prx IV-L functions as an H(2)O(2) sensor that mediates protein thiol oxidation required for the maturation of spermatozoa in placental mammals... - Blot-based detection of dehydroalanine-containing glutathione peroxidase with the use of biotin-conjugated cysteamineSue Goo Rhee
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seodaemun gu, Seoul, Korea
Methods Enzymol 474:23-34. 2010..Our blot-based method for the detection of DHA-GPx1 will be very useful for evaluation of such stress. In addition, similar blot detection method can be devised for other proteins for which immunoprecipitating antibodies are available... - Activity assay of mammalian 2-cys peroxiredoxins using yeast thioredoxin reductase systemJu-A Kim
Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Woman's University, Seoul, Korea
Anal Biochem 338:216-23. 2005..5 microM, respectively. This modified assay method is useful for measuring 2-cys Prx activity in cell lysates and can also be adapted for a 96-well plate reader for high-throughput screening of chemical compounds that target 2-cys Prx... - A colorimetric assay for sulfiredoxin activity using inorganic phosphate measurementHojin Kim
Department of Life Science, Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu Seoul 120 750, South Korea
Anal Biochem 393:36-40. 2009..The colorimetric assay was used for high-throughput screening of 25,000 chemicals to find Srx inhibitors... - Antibodies against non-immunizing antigens derived from a large immune scFv librarySung Ah Moon
Division of Life and Pharmaceutical Sciences, The Graduate School, Ewha Womans University, Seoul, 120 750, Korea
Mol Cells 31:509-13. 2011..e., against various non-immunizing antigens to yield specific antibodies... - Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin functionWoojin Jeong
Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:3142-50. 2004..These results suggest that TRP14 and Trx1 might act on distinct substrate proteins... - Cellular regulation by hydrogen peroxideSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
J Am Soc Nephrol 14:S211-5. 2003..Furthermore, the activity of peroxiredoxin enzymes seems to be regulated via protein phosphorylation as in the case of many other intracellular messenger metabolizing enzymes... - Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expressionSatish Devadas
Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
J Exp Med 195:59-70. 2002..Thus, antigen receptor signaling induces generation of discrete species of oxidants that selectively regulate two distinct redox sensitive pathways, a proapoptotic (FasL) and a proliferative pathway (ERK)... - Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acidKap Seok Yang
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:38029-36. 2002..072% per turnover at 30 degrees C. Hyperoxidation of Prx I was also detected in HeLa cells treated with H(2)O(2)... - Peroxiredoxin II is essential for sustaining life span of erythrocytes in miceTae Hoon Lee
Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
Blood 101:5033-8. 2003..Our results suggest that Prx II-/- mice have hemolytic anemia and that Prx II plays a major role in protecting RBCs from oxidative stress in mice... - Oxidation of proteinaceous cysteine residues by dopamine-derived H2O2 in PC12 cellsJae-Ryong Kim
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
Arch Biochem Biophys 397:414-23. 2002.... - The RING-H2-finger protein APC11 as a target of hydrogen peroxideTong Shin Chang
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 37:521-30. 2004..Inhibition of APC11 function by H(2)O(2) thus likely contributes to the delay in cell cycle progression through mitosis that is characteristic of cells subjected to oxidative stress... - Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxinsHyun Ae Woo
Laboratory of Cell Signaling and Laboratory of Biophysical Chemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:3125-8. 2005..These results suggest that reduction of Cys-SO2H by Srx is specific to 2-Cys Prx isoforms. For proteins such as Prx VI and GAPDH, sulfinic acid formation might be an irreversible process that causes protein damage... - Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factorsJaeyul Kwon
Laboratories of Cell Signaling and Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8015, USA
Proc Natl Acad Sci U S A 101:16419-24. 2004..Furthermore, together with previous observations, our data indicate that peroxiredoxin likely participates in PIP3 signaling by modulating the local concentration of H2O2... - Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxinWoojin Jeong
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:14400-7. 2006..The disulfide-S-monoxide is further reduced through the oxidation of three thiol equivalents to complete the catalytic cycle and regenerate Prx-Cys-SH... - Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxinsSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Curr Opin Cell Biol 17:183-9. 2005.... - Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalingSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Free Radic Biol Med 38:1543-52. 2005..This reversible overoxidation may represent an adaptation unique to eukaryotic cells that accommodates the intracellular messenger function of H(2)O(2), but experimental validation of such speculation is yet to come... - Structural basis of cellular redox regulation by human TRP14Joo Rang Woo
Center for Cellular Switch Protein Structure and Systemic Proteomics Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Euh eun dong, Yuseong Gu, Daejeon 305 806, Korea
J Biol Chem 279:48120-5. 2004..These structural differences in the active site suggest that TRP14 has evolved to regulate cellular redox signaling by recognizing a distinctive group of substrates that would complement the group of proteins regulated by Trx1... - Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteineTong Shin Chang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:50994-1001. 2004..Finally, depletion of human Srx by RNA interference suggested that Srx is largely responsible for reduction of the Cys-SO2H of Prx in A549 human cells... - Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130Peter Varnai
Endocrinology and Reproduction Research Branch, NICHD National Institutes of Health, 49 Convent Drive, Bldg 49, Bethesda, MD 20892, USA
J Biol Chem 277:27412-22. 2002.... - Annexin A2-S100A10 heterotetramer, a novel substrate of thioredoxinMijung Kwon
Cancer Biology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Biol Chem 280:23584-92. 2005..Therefore, we identify AIIt as a substrate of the thioredoxin system and propose a new model for the role of AIIt in the redox-dependent processing of plasminogen and generation of an angiostatin at the cell surface... - Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylationTong Shin Chang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:25370-6. 2002..These results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H(2)O(2) might be important for progression of the cell cycle... - Reversible inactivation of the tumor suppressor PTEN by H2O2Seung Rock Lee
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8015, USA
J Biol Chem 277:20336-42. 2002.... - Intramolecular interaction between phosphorylated tyrosine-783 and the C-terminal Src homology 2 domain activates phospholipase C-gamma1Benoit Poulin
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8015, USA
Proc Natl Acad Sci U S A 102:4276-81. 2005..Our results thus clarify the molecular mechanism of PLC-gamma1 activation, revealing the specific function of pY783 and the distinct roles of the two SH2 domains in this process... - Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2Yeun Ju Kim
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
Mol Cell Biol 24:9986-99. 2004..Finally, phosphorylation of Y1217 and that of Y753 and Y759 occurred on different PLC-gamma2 molecules... - Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modificationSue Goo Rhee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Antioxid Redox Signal 7:619-26. 2005..Similarily, GPx1 is activated by c-Abl- and Arg-mediated phosphorylation. The tyrosine phosphorylation is critical for ubiquitination-dependent degradation of catalase... - Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysisDuck Yeon Lee
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 0301, USA
Biochemistry 45:15301-9. 2006..The modeling and mutagenesis analyses strongly implicate Asp187 of Prx I as the catalytic residue responsible for ATP hydrolysis in the cysteinesulfinic acid reduction of Prx by hSrx... - Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone functionHo Hee Jang
Division of Applied Life Sciences, Gyeonsang National University, Chinju, 660-701, South Korea
Cell 117:625-35. 2004..The chaperone function of these proteins enhances yeast resistance to heat shock... - Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondriaTong Shin Chang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:41975-84. 2004..Our results suggest that Prx III is a critical regulator of the abundance of mitochondrial H(2)O(2), which itself promotes apoptosis in cooperation with other mediators of apoptotic signaling... - Membrane targeting of C2 domains of phospholipase C-delta isoformsBharath Ananthanarayanan
Department of Chemistry, University of Illinois, Chicago 60607, USA
J Biol Chem 277:3568-75. 2002..Together, these results establish the C2 domains of PLC-delta isoforms as Ca(2+)-dependent membrane targeting domains that have distinct membrane binding properties that control their subcellular localization behaviors... - Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidantAmy L Mowbray
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
J Biol Chem 283:1622-7. 2008..However, PRX 5 depletion did not. Together, these results suggest that PRX 1 is a novel mechanosensitive antioxidant, playing an important role in shear-dependent regulation of endothelial biology and atherosclerosis... - Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sitesKatsue Suzuki-Inoue
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Biochem J 378:1023-9. 2004..Our results demonstrate fundamental differences between GPVI and GPIb-IX-V in the regulation of tyrosine phosphorylation of Syk and PLCg2 consistent with the functional impairment of phospholipase in signalling by GPIb-IX-V... - Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activationFujio Sekiya
Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:32181-90. 2004..Finally, concurrent production of phosphatidylinositol 3,4,5-trisphosphate was found to contribute to the activation of phosphorylated PLC-gamma 1... - Measuring H2O2 produced in response to cell surface receptor activationSue Goo Rhee
Nat Chem Biol 3:244-6. 2007 - Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathwaysWoojin Jeong
Laboratory of Cell Signaling, National Heart, Lung and Bllod Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:3151-9. 2004..The complex was detected in HeLa cells treated with H(2)O(2) or TNF-alpha but not in untreated cells, suggesting that LC8 cytoplasmic dynein light chain is a possible substrate of TRP14... - Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor necrosis factor-alphaSang Won Kang
Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:2535-43. 2004..Our results also suggest that cytosolic peroxiredoxins are important regulators of TNF signaling pathways... - Identification of phospholipase C-gamma1 as a mitogen-activated protein kinase substrateColin T Buckley
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
J Biol Chem 279:41807-14. 2004..These studies have uncovered a previously unidentified mechanism for the integration of PLC-gamma1- and ERK2-dependent signaling...