In Kyoon Lyoo

Summary

Affiliation: Ewha Womans University
Country: Korea

Publications

  1. pmc Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence
    Jaeuk Hwang
    Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul, South Korea
    PLoS ONE 8:e78590. 2013
  2. pmc The role of the amygdala in the pathophysiology of panic disorder: evidence from neuroimaging studies
    Jieun E Kim
    Department of Radiology, School of Medicine, University of Washington, 1100 NE 45th St, Ste 555, WA 98105, Seattle, USA
    Biol Mood Anxiety Disord 2:20. 2012
  3. ncbi request reprint The relationship between temperament and character and psychopathology in community children with overweight
    Jun Won Hwang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    J Dev Behav Pediatr 27:18-24. 2006
  4. ncbi request reprint Altered cingulate white matter connectivity in panic disorder patients
    Doug Hyun Han
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Psychiatr Res 42:399-407. 2008
  5. pmc Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study
    Sujung J Yoon
    Department of Psychiatry, Catholic University of Korea School of Medicine, Seoul, South Korea
    Neuropsychopharmacology 35:1165-73. 2010
  6. ncbi request reprint Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder
    Seth D Friedman
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 56:340-8. 2004
  7. ncbi request reprint The relationship between the biogenetic temperament and character and psychopathology in adolescents
    Seog Ju Kim
    Department of Psychiatry, Gil Medical Center, Gachon Medical School, Incheon, South Korea
    Psychopathology 39:80-6. 2006
  8. ncbi request reprint Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
    Seog Ju Kim
    Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea
    Neuropsychobiology 54:120-5. 2006
  9. doi request reprint Laterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder
    Jieun E Kim
    Department of Psychiatry, Seoul National University, Seoul, South Korea
    Arch Gen Psychiatry 67:1187-97. 2010
  10. doi request reprint Patterns of temperament and character in a clinical sample of Korean children with attention-deficit hyperactivity disorder
    Soo Churl Cho
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 62:160-6. 2008

Collaborators

Detail Information

Publications51

  1. pmc Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence
    Jaeuk Hwang
    Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul, South Korea
    PLoS ONE 8:e78590. 2013
    ..Here we examined whether having an abnormally large cavum septum pellucidum (CSP), a putative marker of limbic structural maldevelopment, is associated with opiate dependence particularly beginning in adolescence...
  2. pmc The role of the amygdala in the pathophysiology of panic disorder: evidence from neuroimaging studies
    Jieun E Kim
    Department of Radiology, School of Medicine, University of Washington, 1100 NE 45th St, Ste 555, WA 98105, Seattle, USA
    Biol Mood Anxiety Disord 2:20. 2012
    ....
  3. ncbi request reprint The relationship between temperament and character and psychopathology in community children with overweight
    Jun Won Hwang
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea
    J Dev Behav Pediatr 27:18-24. 2006
    ..Compared to nonoverweight and children at risk of overweight, overweight children had distinct patterns of temperament and character that were related to the specific psychopathology...
  4. ncbi request reprint Altered cingulate white matter connectivity in panic disorder patients
    Doug Hyun Han
    Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    J Psychiatr Res 42:399-407. 2008
    ..Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects...
  5. pmc Neurochemical alterations in methamphetamine-dependent patients treated with cytidine-5'-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study
    Sujung J Yoon
    Department of Psychiatry, Catholic University of Korea School of Medicine, Seoul, South Korea
    Neuropsychopharmacology 35:1165-73. 2010
    ..Further studies with a larger sample size of MA-dependent patients are warranted to confirm a long-term efficacy of CDP-choline in neuroprotection and abstinence...
  6. ncbi request reprint Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder
    Seth D Friedman
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 56:340-8. 2004
    ..This study examined whether lithium (Li) and valproic acid (VPA) treatment modulated these chemicals...
  7. ncbi request reprint The relationship between the biogenetic temperament and character and psychopathology in adolescents
    Seog Ju Kim
    Department of Psychiatry, Gil Medical Center, Gachon Medical School, Incheon, South Korea
    Psychopathology 39:80-6. 2006
    ..This study was conducted to investigate the relationship between patterns of temperament and character and self-reported psychopathology in adolescents from the community...
  8. ncbi request reprint Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
    Seog Ju Kim
    Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea
    Neuropsychobiology 54:120-5. 2006
    ..7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD...
  9. doi request reprint Laterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder
    Jieun E Kim
    Department of Psychiatry, Seoul National University, Seoul, South Korea
    Arch Gen Psychiatry 67:1187-97. 2010
    ..To date, we are not aware of any in vivo reports specifically assessing subregional amygdalar abnormalities in individuals with ASD...
  10. doi request reprint Patterns of temperament and character in a clinical sample of Korean children with attention-deficit hyperactivity disorder
    Soo Churl Cho
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
    Psychiatry Clin Neurosci 62:160-6. 2008
    ....
  11. ncbi request reprint Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder
    Minue J Kim
    Department of Psychology, Seoul National University, Seoul, South Korea
    J Psychiatr Res 42:268-77. 2008
    ..The current study specifically focuses on the abnormal activity of the rostral anterior cingulate, using a paradigm which elicits an unexpected processing conflict caused by salient emotional stimuli...
  12. pmc Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy
    Seog Ju Kim
    Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea
    Sleep 31:342-7. 2008
    ..To explore absolute concentrations of brain metabolites including gamma amino-butyric acid (GABA) in the medial prefrontal cortex and basal ganglia of young adults with narcolepsy...
  13. ncbi request reprint Basal ganglia shape alterations in bipolar disorder
    Jaeuk Hwang
    Department of Psychiatry, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Am J Psychiatry 163:276-85. 2006
    ....
  14. pmc Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study
    In Kyoon Lyoo
    Department of Psychiatry, Seoul National University, Seoul, South Korea
    Neuropsychopharmacology 35:1743-50. 2010
    ..Results suggest that lithium induces sustained increases in cerebral gray matter volume in patients with BD and that these changes are related to the therapeutic efficacy of lithium...
  15. ncbi request reprint Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers
    Seog Ju Kim
    Gil Medical Center, Gachon Medical School, Department of Psychiatry, Incheon, South Korea
    Int J Neuropsychopharmacol 9:221-8. 2006
    ..01) than short-term abstinent abusers, but more than the healthy comparison subjects. We report that methamphetamine abusers have prefrontal grey-matter deficit, which may, in part, recover with long-term abstinence...
  16. pmc Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy
    Dajung J Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1182-8. 2007
    ..52, p=0.003). Our findings suggest that quetiapine's antimanic and antidepressant efficacy in patients with rapid cycling bipolar disorder may potentially be related to decreased lactate levels in frontal regions of the brain...
  17. ncbi request reprint Decreased blood flow of temporal regions of the brain in subjects with panic disorder
    Yujin S Lee
    Department of Psychiatry, Eunpyung Metropolitan Hospital, Seoul, Republic of Korea
    J Psychiatr Res 40:528-34. 2006
    ..The purpose of the current study was to investigate alterations of regional cerebral blood flow (rCBF) in subjects with panic disorder...
  18. doi request reprint Decreased glutamate/glutamine levels may mediate cytidine's efficacy in treating bipolar depression: a longitudinal proton magnetic resonance spectroscopy study
    Sujung J Yoon
    Department of Psychiatry, Catholic University College of Medicine, Seoul, South Korea
    Neuropsychopharmacology 34:1810-8. 2009
    ..Furthermore, cytidine's efficacy in bipolar depression may be mediated by decreased levels of cerebral glutamate and/or glutamine, consistent with alterations in excitatory neurotransmission...
  19. ncbi request reprint Decreased N-acetyl-aspartate levels in anterior cingulate and hippocampus in subjects with post-traumatic stress disorder: a proton magnetic resonance spectroscopy study
    Byung Joo Ham
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Eur J Neurosci 25:324-9. 2007
    ....
  20. ncbi request reprint Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
    Jaeuk Hwang
    Department of Psychiatry, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Drug Alcohol Depend 82:177-81. 2006
    ..The aim of the current study was to explore changes of relative regional cerebral blood flow (rCBF) in short-term and long-term abstinent methamphetamine (MA) users...
  21. ncbi request reprint The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder
    Byeong Taek Lee
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1487-92. 2007
    ..Also, these findings suggest that the bilateral inferior orbitofrontal cortices and left amygdala may be preferentially recruited in MDD patients, but not in healthy individuals...
  22. pmc Network-level structural abnormalities of cerebral cortex in type 1 diabetes mellitus
    In Kyoon Lyoo
    Ewha Brain Institute and College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha W University, Seoul, South Korea
    PLoS ONE 8:e71304. 2013
    ..The current results provide structural evidence for T1DM-related dysfunctional cortical organization, which specifically underlie the top-down cognitive control of language, memory, and emotion. ..
  23. ncbi request reprint Decreased GABA levels in anterior cingulate and basal ganglia in medicated subjects with panic disorder: a proton magnetic resonance spectroscopy (1H-MRS) study
    Byung Joo Ham
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:403-11. 2007
    ..Our data suggested in part that alterations of the GABA function and the energy metabolism in ACC and basal ganglia may play an important role in the pathophysiology of panic disorder...
  24. doi request reprint Associations between anterior cingulate cortex glutamate and gamma-aminobutyric acid concentrations and the harm avoidance temperament
    Hengjun J Kim
    Interdisciplinary Program in Brain Science, Seoul National University College of Natural Sciences, Seoul, South Korea
    Neurosci Lett 464:103-7. 2009
    ..48, df=30, P=0.005). These findings suggest that glutamate and GABA concentrations in ACC are closely related to levels of the HA temperament in healthy subjects...
  25. ncbi request reprint Biogenetic temperament and character and attention deficit hyperactivity disorder in Korean children
    Hee Jeong Yoo
    Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, South Korea
    Psychopathology 39:25-31. 2006
    ....
  26. ncbi request reprint Putaminal gray matter volume decrease in panic disorder: an optimized voxel-based morphometry study
    Hanik K Yoo
    Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Eur J Neurosci 22:2089-94. 2005
    ..The current study reports a putaminal gray matter volume decrease in panic subjects, which may be related to the clinical severity of panic disorder...
  27. ncbi request reprint Posterior cerebellar vermal deficits in bipolar disorder
    Dajung Kim
    Interdisciplinary Program in Neuroscience, Seoul National University, Seoul, South Korea
    J Affect Disord 150:499-506. 2013
    ..Based on growing evidence of the crucial role of the cerebellum in emotional regulation, we sought to identify cerebellar structural deficits in a large sample of patients with bipolar disorder (BD)...
  28. ncbi request reprint Shape changes of the corpus callosum in abstinent methamphetamine users
    Jungsu S Oh
    Interdisciplinary Program in Medical and Biological Engineering, Seoul National University, 28 Yongun Dong Chongno Gu, Seoul, South Korea
    Neurosci Lett 384:76-81. 2005
    ....
  29. pmc Brain activity and desire for Internet video game play
    Doug Hyun Han
    Department of Psychiatry, Chung Ang University, College of Medicine, Seoul 104 757, South Korea
    Compr Psychiatry 52:88-95. 2011
    ..We hypothesized that desire for Internet video games during cue presentation would activate similar brain regions to those that have been linked with craving for drugs or pathologic gambling...
  30. ncbi request reprint Frontal glucose hypometabolism in abstinent methamphetamine users
    Seog Ju Kim
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, Seoul, Korea
    Neuropsychopharmacology 30:1383-91. 2005
    ..Our findings also suggest that the neurotoxic effect of MA on frontal lobes of the brain might be more prominent in men than in women...
  31. doi request reprint Altered cortical gyrification patterns in panic disorder: deficits and potential compensation
    Sujung Yoon
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    J Psychiatr Res 47:1446-54. 2013
    ..Our findings suggest not only substantial perturbation in cortical gyrification patterns in panic disorder but also potential contribution of integrated cortical folding pattern of the default mode network to alleviated panic severity. ..
  32. ncbi request reprint A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder
    In Kyoon Lyoo
    Department of Psychiatry and the Interdisciplinary Program in Neuroscience, Seoul National University College of Medicine, Seoul, South Korea
    Am J Psychiatry 169:937-45. 2012
    ..Such augmentation may lead to a more rapid onset of antidepressant effects and a greater treatment response, potentially by restoring brain bioenergetics at the cellular level...
  33. ncbi request reprint Advances in magnetic resonance imaging methods for the evaluation of bipolar disorder
    In Kyoon Lyoo
    Department of Psychiatry, Seoul National University, South Korea, Seoul, South Korea
    CNS Spectr 11:269-80. 2006
    ..Integrative issues and future directions in this relatively young field, including multi-modal approaches enabling us to produce more comprehensive results, are discussed...
  34. ncbi request reprint Increased white matter hyperintensities in male methamphetamine abusers
    Soojeong C Bae
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongon Dong, Chongno Gu, Seoul 110 744, South Korea
    Drug Alcohol Depend 81:83-8. 2006
    ..The current study was conducted to compare the prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance (MR) imaging in methamphetamine (MA) abusers...
  35. ncbi request reprint Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects
    Minyoung E Sim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul 110 744, South Korea
    Neuropsychopharmacology 32:2229-37. 2007
    ....
  36. ncbi request reprint Depression and Internet addiction in adolescents
    Jee Hyun Ha
    Department of Psychiatry, School of Medicine, Konkuk University, Seoul, South Korea
    Psychopathology 40:424-30. 2007
    ..Third, the relationship between Internet addiction and biogenetic temperament as assessed by the Temperament and Character Inventory was evaluated...
  37. doi request reprint The neural substrates of affective face recognition in patients with Hwa-Byung and healthy individuals in Korea
    Byeong Taek Lee
    Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    World J Biol Psychiatry 10:552-9. 2009
    ..The current study indicates that the suppression of affect results in aberrant function of the brain regions of the visual pathway, and functional impairment in the ACC may contribute to the pathophysiology of HB...
  38. doi request reprint Amygdalar shape analysis method using surface contour aligning, spherical mapping, and probabilistic subregional segmentation
    Namkug Kim
    Department of Radiology, Ulsan University College of Medicine, Seoul, South Korea
    Neurosci Lett 488:65-9. 2011
    ..This is generally in agreement with previous findings from animal studies. The current method may be used for measuring subtle local shape changes of the amygdala in various psychiatric or neurologic disorders...
  39. doi request reprint Differential regional gray matter volumes in patients with on-line game addiction and professional gamers
    Doug Hyun Han
    Department of Psychiatry, Chung Ang University, College of Medicine, Seoul, South Korea
    J Psychiatr Res 46:507-15. 2012
    ..The current study suggests that increased gray matter volumes of the left cingulate gyrus in pro-gamers and of the left thalamus in POGA may contribute to the different clinical characteristics of pro-gamers and POGA...
  40. pmc Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats
    Perry F Renshaw
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 92:88-92. 2009
    ..Altered cholesterol levels can affect serotonergic neurotransmission, which might be involved in the clinical efficacy of standard antidepressants...
  41. ncbi request reprint Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students
    Byung Joo Ham
    Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, South Korea
    Neuropsychobiology 53:203-9. 2006
    ....
  42. ncbi request reprint Intellect declines in healthy elderly subjects and cerebellum
    Jun Young Lee
    Department of Psychiatry, Clinical Research Institute, Seoul National University College of Medicine and Hospital, Seoul, Korea
    Psychiatry Clin Neurosci 59:45-51. 2005
    ..The current study suggests that the cerebellum may play an important role in changes of intellectual capacity in old age...
  43. ncbi request reprint Attention deficit hyperactivity symptoms and internet addiction
    Hee Jeong Yoo
    Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, South Korea
    Psychiatry Clin Neurosci 58:487-94. 2004
    ..In addition, current findings suggest that the presence of ADHD symptoms, both in inattention and hyperactivity-impulsivity domains, may be one of the important risk factors for Internet addiction...
  44. pmc Morphometric changes in lateral ventricles of patients with recent-onset type 2 diabetes mellitus
    Junghyun H Lee
    Department of Pharmacy, Ewha University College of Pharmacy, Seoul, South Korea
    PLoS ONE 8:e60515. 2013
    ..The current findings suggest that atrophic changes particularly of the anterior frontal lobe can occur as early as the first year after the clinical diagnosis of type 2 diabetes mellitus...
  45. ncbi request reprint Dopamine genes and reward dependence in adolescents with excessive internet video game play
    Doug Hyun Han
    From McLean Hospital Brain Imaging Center and Department of Psychiatry DHH, KCY, IKL, PFR, Harvard Medical School, Belmont, MA the Department of Psychiatry YSL, EYK, Chung Ang University Medical School, Seoul, South Korea and the Department of Psychiatry IKL, Seoul National University College of Medicine, Seoul, South Korea
    J Addict Med 1:133-8. 2007
    ..In particular, the DRD2 Taq1A1 allele seems to be associated with reward dependence in EIGP adolescents...
  46. ncbi request reprint Psychosis of Alzheimer's disease: Gender differences in regional perfusion
    E K Moran
    Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Tilton 201, Boston, MA 02114, USA
    Neurobiol Aging 29:1218-25. 2008
    ....
  47. ncbi request reprint Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part I)
    Dan V Iosifescu
    Massachusetts General Hospital, Department of Psychiatry, Depression Clinical and Research Program, Harvard Medical School, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    Psychiatry Res 140:291-9. 2005
    ..In light of the adverse impact of WMHs on a number of health-related outcomes later in life, hypofolatemia and hypertension may represent modifiable risk factors to prevent the occurrence of such adverse outcomes...
  48. ncbi request reprint Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    ..Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings...
  49. ncbi request reprint Trait and state aspects of harm avoidance and its implication for treatment in major depressive disorder, dysthymic disorder, and depressive personality disorder
    Kelley Yost Abrams
    Department of Psychiatry, Seoul National University College of Medicine and Hospital, South Korea
    Psychiatry Clin Neurosci 58:240-8. 2004
    ....
  50. ncbi request reprint Effects of catechol-O-methyltransferase Val158Met polymorphism on the cognitive stability and aggression in the first-onset schizophrenic patients
    Doug Hyun Han
    Department of Psychiatry, Seoul National University Hospital College of Medicine, South Korea
    Neuroreport 17:95-9. 2006
    ..Our results support the theory that COMTL allele was related with increased tonic dopamine activity and cognitive 'stability', which may induce cognitive inflexibility in schizophrenia...
  51. ncbi request reprint Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study
    Ronald L Cowan
    Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 72:225-35. 2003
    ....