Hee Sun Kim


Affiliation: Ewha Womans University
Country: Korea


  1. Lee E, Han J, Woo M, Shin J, Park E, Kang J, et al. Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-? activation. J Immunol. 2014;193:2384-93 pubmed publisher
    ..These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-? activity, which may explain neuroinflammation in septic mouse brain...
  2. Leem Y, Park J, Chang H, Park J, Kim H. Exercise Prevents Memory Consolidation Defects Via Enhancing Prolactin Responsiveness of CA1 Neurons in Mice Under Chronic Stress. Mol Neurobiol. 2019;: pubmed publisher
    ..The above findings suggest a protective role for exercise against chronic stress-evoked defects in memory consolidation via PRL-modulated incorporation of CP-AMPARs into hippocampal CA1 synapses. ..
  3. Lee G, Park J, Lee E, Ahn J, Kim H. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019;55:50-57 pubmed publisher
    ..The strong anti-inflammatory and antioxidant effects of urolithin B may provide therapeutic potential for neuroinflammatory disorders that are associated with oxidative stress and microglial activation. ..
  4. Han T, Leem Y, Kim H. Treadmill exercise restores high fat diet-induced disturbance of hippocampal neurogenesis through β2-adrenergic receptor-dependent induction of thioredoxin-1 and brain-derived neurotrophic factor. Brain Res. 2019;1707:154-163 pubmed publisher
    ..Therefore, our data collectively suggests that regular exercise may be a promising approach to preventing HFD-induced memory impairments via anti-inflammatory, antioxidant and neuroprotective mechanisms in the hippocampal DG region. ..
  5. Lee E, Park J, Lee Y, Kim D, Kang J, Kim H. Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways. J Neuroinflammation. 2018;15:326 pubmed publisher
    ..The data collectively suggest the therapeutic potential of an MMP-8 inhibitor in neuroinflammatory disorders that are associated with astrocyte reactivity. ..
  6. Lee E, Ko H, Jeong Y, Park E, Kim H. β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. J Neuroinflammation. 2015;12:133 pubmed publisher
    ..The strong anti-inflammatory/anti-oxidant effects of β-LAP may provide preventive therapeutic potential for various neuroinflammatory disorders. ..
  7. Jung J, Choi M, Ko H, Kim H. Short-chain C2 ceramide induces heme oxygenase-1 expression by upregulating AMPK and MAPK signaling pathways in rat primary astrocytes. Neurochem Int. 2016;94:39-47 pubmed publisher
    ..Therefore, the upregulation of antioxidant enzymes by C2 ceramide may be a potential therapeutic modality for neurodegenerative diseases that are accompanied by oxidative stress. ..
  8. Lee Y, Lee E, Park J, Jang S, Kim D, Kim H. Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia. J Neuroimmune Pharmacol. 2016;11:294-305 pubmed publisher
    ..Taken together, the results of the present study demonstrate that tangeretin possesses a potent anti-inflammatory and antioxidant effect in microglia. ..
  9. Jhang K, Park J, Kim H, Chong Y. Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages. J Neuroinflammation. 2018;15:75 pubmed publisher
    ..These findings implicate that targeting of MerTK with phytochemical sulforaphane as a mechanism for preventing Aβ1-42-induced neuroinflammation has potential to be applied in AD therapeutics. ..

More Information


  1. Lee E, Kim H. The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia. J Neuroinflammation. 2014;11:116 pubmed publisher
    ..Finally, we demonstrated that TIMP-2 exerts a neuroprotective effect via the inhibition of microglial activation. Enhancement of TIMP-2 expression may be a potential therapeutic target for neuroinflammatory disorders...
  2. Han J, Lee E, Moon E, Ryu J, Choi J, Kim H. Matrix Metalloproteinase-8 is a Novel Pathogenetic Factor in Focal Cerebral Ischemia. Mol Neurobiol. 2016;53:231-239 pubmed publisher
    ..These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia. ..
  3. Jung J, Ahn Y, Moon B, Kim H. Exogenous C2 Ceramide Suppresses Matrix Metalloproteinase Gene Expression by Inhibiting ROS Production and MAPK Signaling Pathways in PMA-Stimulated Human Astroglioma Cells. Int J Mol Sci. 2016;17:477 pubmed publisher
    ..The results suggest C2 ceramide inhibits MMP expression and glioma invasion, at least partly, by modulating ROS-p38 MAPK signaling axis and other MAPK signaling pathways. ..
  4. Park J, Lee Y, Kim J, Seo H, Kim H. ?-Lapachone increases phase II antioxidant enzyme expression via NQO1-AMPK/PI3K-Nrf2/ARE signaling in rat primary astrocytes. Free Radic Biol Med. 2016;97:168-178 pubmed publisher
    ..Collectively, the results suggest that ?-LAP increases antioxidant enzyme gene expression in astrocytes by modulating NQO1-AMPK/PI3K-Nrf2/ARE signaling. ..
  5. Jeong Y, Park J, Kim D, Kang J, Kim H. Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation. Pharmacol Res. 2017;119:431-442 pubmed publisher
    ..Its strong anti-inflammatory effects may make lonchocarpine an effective preventative drug for neuroinflammatory disorders that are associated with systemic inflammation. ..
  6. Choi M, Lee E, Park J, Kim S, Park E, Kim H. Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: Critical role of PPAR-? signaling pathway. Biochem Pharmacol. 2017;144:120-131 pubmed publisher
    ..Altogether, our data suggest that PPAR-? plays a key role in mediating the anti-inflammatory effects of galangin by modulating the NF-?B and Nrf2/CREB signaling pathways. ..
  7. Kim J, Jeong Y, Lee E, Park J, Seo H, Kim H. Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide. Biochem Biophys Res Commun. 2017;493:879-886 pubmed publisher
    ..Collectively, the data suggested that M8I has a therapeutic potential in treating neurodegenerative diseases that are aggravated by systemic inflammation. ..