Duk Hee Kang

Summary

Affiliation: Ewha Womans University
Country: Korea

Publications

  1. ncbi request reprint Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Curr Opin Nephrol Hypertens 12:43-9. 2003
  2. doi request reprint Uric acid and chronic kidney disease: new understanding of an old problem
    Duk Hee Kang
    Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Center, Seoul, Korea
    Semin Nephrol 31:447-52. 2011
  3. ncbi request reprint Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul 110 126, Korea
    Semin Nephrol 25:43-9. 2005
  4. pmc The impact of gender on progression of renal disease: potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Am J Pathol 164:679-88. 2004
  5. ncbi request reprint A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
  6. ncbi request reprint Renoprotective effect of erythropoietin (EPO): possibly via an amelioration of renal hypoxia with stimulation of angiogenesis in the kidney
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul, Korea
    Kidney Int 67:1683. 2005
  7. pmc Nitric oxide modulates vascular disease in the remnant kidney model
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 161:239-48. 2002
  8. ncbi request reprint Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul, Korea
    J Hypertens 22:229-35. 2004
  9. ncbi request reprint Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
  10. ncbi request reprint Role of the microvascular endothelium in progressive renal disease
    Duk Hee Kang
    Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:806-16. 2002

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Curr Opin Nephrol Hypertens 12:43-9. 2003
    ....
  2. doi request reprint Uric acid and chronic kidney disease: new understanding of an old problem
    Duk Hee Kang
    Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Center, Seoul, Korea
    Semin Nephrol 31:447-52. 2011
    ....
  3. ncbi request reprint Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul 110 126, Korea
    Semin Nephrol 25:43-9. 2005
    ....
  4. pmc The impact of gender on progression of renal disease: potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Am J Pathol 164:679-88. 2004
    ..Estrogen stimulated basal VEGF expression in renal tubular cells. We propose that estrogen may protect female rats in progressive renal disease by stimulating VEGF expression and maintaining a healthy intrarenal vasculature...
  5. ncbi request reprint A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
    ..These studies provide direct evidence that uric acid may be a true mediator of renal disease and progression...
  6. ncbi request reprint Renoprotective effect of erythropoietin (EPO): possibly via an amelioration of renal hypoxia with stimulation of angiogenesis in the kidney
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul, Korea
    Kidney Int 67:1683. 2005
  7. pmc Nitric oxide modulates vascular disease in the remnant kidney model
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 161:239-48. 2002
    ..Interestingly, inhibition of NO synthesis did not lead to a loss of the preglomerular endothelium, which may relate to the effect of NO blockade to stimulate VEGF synthesis in the adjacent vascular smooth muscle cell...
  8. ncbi request reprint Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul, Korea
    J Hypertens 22:229-35. 2004
    ....
  9. ncbi request reprint Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
    ..The observation that UA alters the proliferation/migration and NO release of human vascular cells, mediated by the expression of CRP, calls for careful reconsideration of the role of UA in hypertension and vascular disease...
  10. ncbi request reprint Role of the microvascular endothelium in progressive renal disease
    Duk Hee Kang
    Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:806-16. 2002
    ..Therefore, angiogenic agents may represent a novel therapeutic approach for slowing the progression of renal disease...
  11. ncbi request reprint Transplant graft vasculopathy: an emerging target for prevention and treatment of renal allograft dysfunction
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Yonsei Med J 45:1053-8. 2004
    ..We also discuss the potential for therapies targeting endothelial dysfunction and transplant graft vasculopathy...
  12. ncbi request reprint Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
    Susumu Watanabe
    Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 40:355-60. 2002
    ..Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic...
  13. ncbi request reprint TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
    Takahiko Nakagawa
    Division of Nephrology Medicine, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:605-13. 2004
    ..Recent studies have shown that VEGF-A as well as TSP-1 is regulated by transforming growth factor-beta1 (TGF-beta1), but the mechanism remains unclear...
  14. ncbi request reprint Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 282:F991-7. 2002
    ..Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system...
  15. ncbi request reprint Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 287:F658-64. 2004
    ..Thus TGF-beta and hypoxia act via additive/synergistic but distinct pathways to stimulate VEGF in proximal tubular cells, a finding that may be important in understanding how VEGF is stimulated in renal disease...
  16. ncbi request reprint Hyperuricemia causes glomerular hypertrophy in the rat
    Takahiko Nakagawa
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Am J Nephrol 23:2-7. 2003
    ..Am J Physiol 2002;6:F991-F997]. We hypothesized that hyperuricemia might also induce glomerular changes...
  17. doi request reprint Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease
    Eun Sun Ryu
    Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, 911 Mok dong Yangcheon Ku, Seoul 158 710, Korea
    Am J Physiol Renal Physiol 304:F471-80. 2013
    ..In conclusion, uric acid induces EMT of renal tubular cells decreasing E-cadherin synthesis via an activation of Snail and Slug as well as increasing the degradation of E-cadherin...
  18. ncbi request reprint Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  19. ncbi request reprint Uric acid--a uremic toxin?
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Blood Purif 24:67-70. 2006
    ..In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease...
  20. ncbi request reprint Serum uric acid: a risk factor and a target for treatment?
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Soc Nephrol 17:S69-73. 2006
    ..Although the investigations are still preliminary, serum uric acid represents a possible new and intriguing target for the reduction of morbidity and mortality associated with hypertension and CV disease...
  21. ncbi request reprint Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
    Richard J Johnson
    University of Florida, Division of Nephrology, Hypertension, and Transplantation, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:1909-19. 2005
    ..Understanding the pathogenetic pathways mediating renal progression in hypertensive subjects should help identify those subjects at highest risk and may provide insights into new therapeutic maneuvers to slow or prevent progression...
  22. pmc Non-dipper status and left ventricular hypertrophy as predictors of incident chronic kidney disease
    Hye Rim An
    Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea
    J Korean Med Sci 26:1185-90. 2011
    ..These findings suggest that non-dipper status and LVH may be the therapeutic targets for preventing the development of CKD in non-diabetic hypertensive patients...
  23. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease...
  24. ncbi request reprint Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Seoul, Korea
    Am J Nephrol 25:425-33. 2005
    ..The mechanism by which uric acid enters the VSMC is not known. We hypothesized that uric acid enters via transporters similar to that observed in the kidney...
  25. ncbi request reprint Tubulointerstitial disease: role of ischemia and microvascular disease
    Takahiko Nakagawa
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Nephrol Hypertens 12:233-41. 2003
    ..Here we summarize recent studies on the pathogenesis and consequences of tubulointerstitial disease, emphasizing the role of ischemia and the microvasculature...
  26. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  27. ncbi request reprint Combined effects of losartan and pravastatin on interstitial inflammation and fibrosis in chronic cyclosporine-induced nephropathy
    Can Li
    Department of Internal Medicine, Kangnam St Mary s Hospital, The Catholic University of Korea, Seoul 137 040, Korea
    Transplantation 79:1522-9. 2005
    ..We evaluated whether combined treatment with losartan (LSRT) and pravastatin (PRVT) affords superior protection compared with their respective monotherapies in treating chronic cyclosporine (CsA)-induced nephropathy in rats...
  28. ncbi request reprint Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction
    Min A Yu
    Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Center, Seoul, South Korea
    J Hypertens 28:1234-42. 2010
    ..We also examined whether uric acid-induced changes in redox status were related to aging and death of endothelial cells or an activation of local renin-angiotensin system, another mediator of endothelial dysfunction...
  29. ncbi request reprint Uric acid and hypertension
    Daniel I Feig
    Department of Pediatrics, Renal Section, MC3 2482, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030, USA
    Curr Hypertens Rep 8:111-5. 2006
    ..Ongoing clinical trials will elucidate the role of uric acid in human hypertension and will determine whether control of uric acid may be a new way to prevent or treat essential hypertension...
  30. ncbi request reprint Angiotensin II type 1 receptor blockade ameliorates tubulointerstitial injury induced by chronic potassium deficiency
    Shin Ichi Suga
    Division of Nephrology, University of Washington Medical Center, Seattle, Washington, USA
    Kidney Int 61:951-8. 2002
    ..We tested the hypothesis that K+-deficiency-induced renal tubulointerstitial injury could be mediated by Ang II or a reduction in nitric oxide...
  31. ncbi request reprint Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension
    Daniel I Feig
    Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:281-7. 2004
    ..Genetic, physiologic, and epidemiologic studies provide clues to its origins, but a clear understanding has been elusive. Recent experimental and clinical studies have implicated uric acid in the onset of essential hypertension...
  32. doi request reprint Effects of dexamethasone on the TGF-β1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells
    Yang Hee Jang
    Division of Nephrology, Department of Internal Medicine, Ewha Medical Research Center, Ewha Womans University School of Medicine, Seoul, Korea
    Lab Invest 93:194-206. 2013
    ..In conclusion, this is the first study demonstrating the protective effect of DEXA on the EMT in TGF-β1-stimulated HPMCs by inhibiting MAPK activation, GSK-3β phosphorylation and Snail upregulation...
  33. ncbi request reprint Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston TX 77030
    Hypertension 41:1287-93. 2003
    ..Uric acid regulates critical proinflammatory pathways in VSMCs, suggesting it may have a role in the vascular changes associated with hypertension and vascular disease...
  34. ncbi request reprint Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610, USA
    Hypertension 45:326-30. 2005
  35. doi request reprint Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease
    Su Hyun Kim
    Division of Nephrology, Department of Internal Medicine, Chung Ang University, Seoul, Korea
    Lab Invest 92:488-98. 2012
    ..These findings suggested phenotypic transition and apoptosis as potential mechanisms of IS-induced renal damage and the differential role of MAPK activation in IS-induced EMT and apoptosis of renal tubular cells...
  36. pmc Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress
    Mina Yu
    Division of Nephrology, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea
    Clin J Am Soc Nephrol 6:30-9. 2011
    ..The role of IS in endothelial dysfunction in CKD and potential mechanisms of IS-induced endothelial dysfunction were investigated...
  37. ncbi request reprint Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
    Katsuyuki Matsui
    Institute of Clinical Pathology, University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
    J Am Soc Nephrol 14:1981-9. 2003
    ..As lymphatic endothelial cells secrete chemokines that attract dendritic cells, it is possible that the increase in lymphatic vascularization could enhance the immunologic surveillance of remnant kidneys...
  38. ncbi request reprint A unifying pathway for essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Hypertens 18:431-40. 2005
    ..This pathway unites many of the previous hypotheses on the etiology of hypertension, and offers insights into ways to prevent, ameliorate, or cure the underlying process...
  39. ncbi request reprint Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease
    John Kanellis
    Department of Nephrology and Medicine, University of Melbourne, Austin Hospital, Australia
    Semin Nephrol 25:39-42. 2005
    ..Experimental evidence suggests a complex but potentially direct causal role for uric acid in the pathogenesis of hypertension and atherosclerosis...
  40. ncbi request reprint Uric acid and preeclampsia
    Chun Lam
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Semin Nephrol 25:56-60. 2005
    ..This article reviews our current understanding of hyperuricemia in the setting of preeclampsia, and highlights the hypothesis that hyperuricemia may contribute to vascular damage in preeclampsia...
  41. ncbi request reprint Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells
    Myoung Soo Kim
    Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea
    Yonsei Med J 45:1121-6. 2004
    ....
  42. ncbi request reprint Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
    ..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury...
  43. doi request reprint A case report of crescentic glomerulonephritis associated with Hantaan virus infection
    Soi Kim
    Department of Internal Medicine, Ewha Womans University, Seoul, Korea
    Nephrol Dial Transplant 25:2790-2. 2010
    ..Herein, we report a case of immune complex-mediated crescentic glomerulonephritis in a 70-year-old man with Hantaan virus infection...
  44. pmc A more appropriate cardiac troponin T level that can predict outcomes in end-stage renal disease patients with acute coronary syndrome
    Dong Ryeol Ryu
    Department of Internal Medicine, School of Medicine, Ewha Womans University, 911 1 Mok Dong, Yangcheon Gu, Seoul 158 710, Korea
    Yonsei Med J 52:595-602. 2011
    ..The aim of this study was to evaluate the clinical usefulness of cTnT in ESRD patients with acute coronary syndrome (ACS)...
  45. doi request reprint Clinical implication of metabolic syndrome on chronic kidney disease depends on gender and menopausal status: results from the Korean National Health and Nutrition Examination Survey
    Mina Yu
    Division of Nephrology, Department of Internal Medicine, School of Medicine, Ewha Medical Research Center, Ewha Womans University, Seoul, Korea
    Nephrol Dial Transplant 25:469-77. 2010
    ..However, both renal and metabolic diseases are experienced differently in men and women, and clinical implication of MS on CKD may be different according to gender...
  46. ncbi request reprint Resurrection of uric acid as a causal risk factor in essential hypertension
    Richard J Johnson
    Hypertension 45:18-20. 2005
  47. ncbi request reprint Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model
    Christian Hugo
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Germany
    Nephron 90:460-70. 2002
    ..We studied the expression of TSP-1 mRNA and protein during the development of glomerular and tubulointerstitial nephrosclerosis in the renal ablation model particularly in relation to TGF-beta1 expression...
  48. ncbi request reprint Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
    ..Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis...
  49. ncbi request reprint Hormonal and cytokine effects of uric acid
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Curr Opin Nephrol Hypertens 15:30-3. 2006
    ..In the present review, we summarize recent studies on the mechanisms involved in the uric acid deleterious effects...
  50. doi request reprint Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequence
    Duk Hee Kang
    Division of Nephrology Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul 158 710, South Korea
    Gene 501:33-8. 2012
    ..This study demonstrates for the first time that PCBP3 can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences...
  51. ncbi request reprint Diuretic-induced hyperuricemia does not decrease cardiovascular risk
    Titte R Srinivas
    J Hypertens 22:1415-7; author reply 1417-9. 2004