Eun Sook Hwang
Affiliation: Ewha Womans University
Hwang J, Kim A, Kim K, Il Park J, Oh H, Moon S, et al
. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun. 2019;10:421 pubmed publisher
..These results suggest that TAZ is a novel insulin signalling activator that increases insulin sensitivity and couples Hippo/Wnt signalling and insulin sensitivity. ..
Hwang E. Transcriptional regulation of T helper 17 cell differentiation. Yonsei Med J. 2010;51:484-91 pubmed publisher
..This review focuses on the functions and regulatory mechanisms of several transcription factors in the control of Th17 cell differentiation. ..
Oh S, Shin J, Jang E, Won H, Kim H, Jeong M, et al
. Anti-inflammatory activity of chloroquine and amodiaquine through p21-mediated suppression of T cell proliferation and Th1 cell differentiation. Biochem Biophys Res Commun. 2016;474:345-350 pubmed publisher
Won H, Hwang E. Transcriptional modulation of regulatory T cell development by novel regulators NR4As. Arch Pharm Res. 2016;39:1530-1536 pubmed
..This review summarizes the function and regulatory mechanisms of Treg cells and also implicates current advances in immunomodulatory functions of NR4As and their therapeutic potentials in inflammation and cancer. ..
Kim A, Kim K, Byun M, Hwang J, Park J, Oh H, et al
. (-)-Epigallocatechin-3-gallate stimulates myogenic differentiation through TAZ activation. Biochem Biophys Res Commun. 2017;486:378-384 pubmed publisher
..Together, these results suggest that EGCG induces myogenic differentiation through TAZ, suggesting that TAZ plays an important role in EGCG induced muscle regeneration. ..
Bae S, Min Y, Hwang E. Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP. Biochem Biophys Res Commun. 2017;487:409-414 pubmed publisher
..Collectively, IBIP may have beneficial effects on bone loss through potentiation of bone formation. ..
Bae S, Kim H, Won H, Min Y, Hwang E. Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways. Sci Rep. 2017;7:8455 pubmed publisher
..These results suggest that DMP-PYT may have beneficial effects for preventing and for treating osteoporosis. ..
Kim T, Kim H, Hwang E. Novel anti-adipogenic activity of anti-malarial amodiaquine through suppression of PPAR? activity. Arch Pharm Res. 2017;40:1336-1343 pubmed publisher
..AQ is recommended as a safe and effective anti-obesity drug for controlling overweight and obesity. ..
Won H, Shin J, Oh S, Jeong H, Hwang E. Enhanced CD25+Foxp3+ regulatory T cell development by amodiaquine through activation of nuclear receptor 4A. Sci Rep. 2017;7:16946 pubmed publisher
..The ability of anti-malarial AQ to potentiate iTreg cell development makes it a promising drug for preventing and treating inflammatory and autoimmune diseases. ..