Young Hae Chong
Affiliation: Ewha Womans University
Jhang K, Park J, Kim H, Chong Y. Sulforaphane rescues amyloid-Î² peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages. J Neuroinflammation. 2018;15:75 pubmed publisher
..These findings implicate that targeting of MerTK with phytochemical sulforaphane as a mechanism for preventing AÎ²1-42-induced neuroinflammation has potential to be applied in AD therapeutics. ..
An Y, Jhang K, Woo S, Kang J, Chong Y. Sulforaphane exerts its anti-inflammatory effect against amyloid-Î² peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages. Neurobiol Aging. 2016;38:1-10 pubmed publisher
..These findings suggest that the phytochemical sulforaphane has a potential application in AD therapeutics. ..
Jhang K, Lee E, Kim H, Chang K, Suh Y, Chong Y. S100A9 Exacerbates the A?1-42-mediated Innate Immunity in Human THP-1 Monocytes. CNS Neurol Disord Drug Targets. 2016;15:910-917 pubmed
..Our findings clearly suggest that excess S100A9 protein may play an important role in the pathological processes of Alzheimer's disease by exacerbating the A?1-42-induced innate immune response. ..
Chong Y, Shin Y, Lee E, Kayed R, Glabe C, Tenner A. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem. 2006;281:20315-25 pubmed