Young Hae Chong

Summary

Affiliation: Ewha Womans University
Country: Korea

Publications

  1. ncbi request reprint Molecular mechanisms underlying cyclic AMP inhibition of macrophage dependent TNF-alpha production and neurotoxicity in response to amyloidogenic C-terminal fragment of Alzheimer's amyloid precursor protein
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Medical Research Center, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, 158 710, Seoul, South Korea
    J Neuroimmunol 133:160-74. 2002
  2. ncbi request reprint ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
  3. pmc Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury
    Hui Su Lee
    Department of Physiology, Division of Cell Biology, Ewha Medical Research Institute, Ewha Womans University College of Medicine, 911 1 Mok 6 dong, Yangcheon Ku, Seoul 158 056, Korea
    Respir Res 5:23. 2004
  4. doi request reprint Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages
    Ji Hye Yang
    Department of Microbiology, School of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University Seoul, Republic of Korea
    Exp Neurol 236:199-206. 2012
  5. doi request reprint Resveratrol reduces glutamate-mediated monocyte chemotactic protein-1 expression via inhibition of extracellular signal-regulated kinase 1/2 pathway in rat hippocampal slice cultures
    Eun Ok Lee
    Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Korea
    J Neurochem 112:1477-87. 2010
  6. pmc Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
    Eun Ok Lee
    Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul 158 710, Republic of Korea
    J Neuroinflammation 10:68. 2013
  7. doi request reprint 15-deoxy-Δ¹²,¹⁴ -prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-a
    Sang Eun Kim
    Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Republic of Korea
    J Neurosci Res 90:1732-42. 2012
  8. ncbi request reprint The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells
    Eun Ok Lee
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul 158 710, Korea
    J Biol Chem 280:7845-53. 2005
  9. ncbi request reprint Mechanisms involved in prostaglandin E2-mediated neuroprotection against TNF-alpha: possible involvement of multiple signal transduction and beta-catenin/T-cell factor
    Eun Ok Lee
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul, 158 710, South Korea
    J Neuroimmunol 155:21-31. 2004
  10. pmc S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model
    Tae Young Ha
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea
    PLoS ONE 5:e8840. 2010

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Molecular mechanisms underlying cyclic AMP inhibition of macrophage dependent TNF-alpha production and neurotoxicity in response to amyloidogenic C-terminal fragment of Alzheimer's amyloid precursor protein
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Medical Research Center, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, 158 710, Seoul, South Korea
    J Neuroimmunol 133:160-74. 2002
    ..In addition, the detailed inhibitory mechanism of cAMP action implies that an increased cAMP level could be benefit against AD progression...
  2. ncbi request reprint ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ....
  3. pmc Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury
    Hui Su Lee
    Department of Physiology, Division of Cell Biology, Ewha Medical Research Institute, Ewha Womans University College of Medicine, 911 1 Mok 6 dong, Yangcheon Ku, Seoul 158 056, Korea
    Respir Res 5:23. 2004
    ....
  4. doi request reprint Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages
    Ji Hye Yang
    Department of Microbiology, School of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University Seoul, Republic of Korea
    Exp Neurol 236:199-206. 2012
    ....
  5. doi request reprint Resveratrol reduces glutamate-mediated monocyte chemotactic protein-1 expression via inhibition of extracellular signal-regulated kinase 1/2 pathway in rat hippocampal slice cultures
    Eun Ok Lee
    Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Korea
    J Neurochem 112:1477-87. 2010
    ..Additionally, our data reveal an anti-inflammatory mechanism of resveratrol involving the inactivation of the ERK1/2 pathway in the hippocampus, which is linked principally to AD-associated cognitive dysfunction...
  6. pmc Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes
    Eun Ok Lee
    Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul 158 710, Republic of Korea
    J Neuroinflammation 10:68. 2013
    ..Evidence indicates that S100A9 contributes to Alzheimer's disease (AD) pathology, although the precise mechanisms are not clear...
  7. doi request reprint 15-deoxy-Δ¹²,¹⁴ -prostaglandin J₂ inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-a
    Sang Eun Kim
    Department of Microbiology, School of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Republic of Korea
    J Neurosci Res 90:1732-42. 2012
    ....
  8. ncbi request reprint The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells
    Eun Ok Lee
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul 158 710, Korea
    J Biol Chem 280:7845-53. 2005
    ..Collectively, these data suggest that Abeta1-42 may play an important role in the negative regulation of TGF-beta1-induced MMP-2 production via Smad7 expression...
  9. ncbi request reprint Mechanisms involved in prostaglandin E2-mediated neuroprotection against TNF-alpha: possible involvement of multiple signal transduction and beta-catenin/T-cell factor
    Eun Ok Lee
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, 911 1, Mok 6 Dong, Yangcheonku, Seoul, 158 710, South Korea
    J Neuroimmunol 155:21-31. 2004
    ....
  10. pmc S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model
    Tae Young Ha
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia and Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea
    PLoS ONE 5:e8840. 2010
    ..Thus, the inhibition of S100a9 is a possible target for AD therapy...
  11. ncbi request reprint Cyclic AMP inhibition of tumor necrosis factor alpha production induced by amyloidogenic C-terminal peptide of Alzheimer's amyloid precursor protein in macrophages: involvement of multiple intracellular pathways and cyclic AMP response element binding pro
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Medical Research Center, Ewha Womans University, Seoul, Korea
    Mol Pharmacol 63:690-8. 2003
    ..Collectively, the detailed molecular mechanisms of amyloidogenic CT-induced TNF-alpha production as negatively regulated by cAMP may advance the possibility of targeted treatment in Alzheimer's disease...
  12. doi request reprint Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury
    Ye Ji Lee
    Department of Physiology, Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, Korea
    J Leukoc Biol 91:921-32. 2012
    ..These results indicate that Mer plays as an intrinsic feedback inhibitor of the TLR4- and inflammatory mediator-driven immune responses during acute lung injury...
  13. doi request reprint Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures
    Jee Hee Lee
    Department of Microbiology, School of Medicine, Ewha Womans University, Yangcheonku, Seoul, Korea
    J Neurochem 106:1066-77. 2008
    ....
  14. doi request reprint Extracellular HIV-1 Tat upregulates TNF-α dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: inhibition by resveratrol, a polyphenolic phytostilbene
    Eun Ok Lee
    Department of Microbiology, School of Medicine, Ewha Womans University, Yangcheonku, Seoul, Republic of Korea
    Exp Neurol 229:399-408. 2011
    ..Additionally, the inhibition of Tat-induced production of MCP-1 and TNF-α via the inactivation of the ERK1/2 pathway may represent the anti-inflammatory mechanism of resveratrol in the hippocampus...
  15. ncbi request reprint C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression
    Hye Sun Kim
    Department of Pharmacology, College of Medicine, National Creative Research Initiative Center for Alzheimer s Dementia, Seoul National University, Seoul, 110 799, South Korea
    FASEB J 17:1951-3. 2003
    ....
  16. pmc Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells
    Yuyoung Joo
    Department of Pharmacology, College of Medicine, Seoul National University, Seoul, Republic of Korea
    PLoS ONE 5:e14203. 2010
    ..Collectively, these results indicate that APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells, through the interaction with APP, which is fostered by phosphorylation of threonine 668...