Young Ho Ahn
Affiliation: Ewha Womans University
Kim J, Kim E, Lee S, Tan X, Liu X, Park S, et al
. MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas. Exp Mol Med. 2019;51:9 pubmed publisher
..Similarly, lung adenocarcinoma patients with higher miR-34a/b/c levels had better survival rates than did those with lower levels. In summary, we suggest that miR-34b and miR-34c are more effective tumor suppressors than miR-34a. ..
Choi K, Cho Y, Kim J, Ahn Y, Hong S. SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment. Biochem Biophys Res Commun. 2015;463:673-8 pubmed publisher
..On the basis of these findings, we conclude that SHC1 functions as a sensor during the 8-Cl-cAMP-induced growth inhibition in SHC1-overexpressing cancer cells. ..
Kim J, Kurie J, Ahn Y. BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells. Mol Cancer. 2015;14:173 pubmed publisher
..Thus, we propose that BMP4 and its antagonists may be suitable therapeutic targets for the treatment of lung cancer. ..
Jung J, Ahn Y, Moon B, Kim H. Exogenous C2 Ceramide Suppresses Matrix Metalloproteinase Gene Expression by Inhibiting ROS Production and MAPK Signaling Pathways in PMA-Stimulated Human Astroglioma Cells. Int J Mol Sci. 2016;17:477 pubmed publisher
..The results suggest C2 ceramide inhibits MMP expression and glioma invasion, at least partly, by modulating ROS-p38 MAPK signaling axis and other MAPK signaling pathways. ..
Kim J, Kim E, Kim H, Kurie J, Ahn Y. MKK4 activates non-canonical NF?B signaling by promoting NF?B2-p100 processing. Biochem Biophys Res Commun. 2017;491:337-342 pubmed publisher
..These results suggest that the MKK4/JNK-dependent pathway regulates NF?B2 processing/activation and, through this mechanism, MKK4 and NF?B2 control cellular growth and senescence. ..