Research Topics
Genomes and Genes
| Aree MoonSummaryAffiliation: Duksung Women's University Country: Korea Publications
| Collaborators
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Detail Information
Publications
Chemopreventive allylthiopyridazines inhibit invasion, migration and angiogenesis in hepatocarcinoma cellsEun-Jung Lee
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea
Int J Oncol 23:1645-50. 2003..Taken in conjunction with the fact that hepatocellular carcinoma is one of the most lethal malignancies, our findings may be critical to the chemopreventive potential of these synthetic organosulfur compounds for hepatocarcinoma...
Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasionAree Moon
College of Pharmacy, Duksung Women s University, Seoul, Korea
Mol Cancer Res 6:1544-53. 2008..Our gene profile data provide useful information which may lead to the identification of additional potential targets for the prognosis and/or therapy of metastatic breast cancer...- HER2 induces expression of leptin in human breast epithelial cellsYujin Cha
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
BMB Rep 45:719-23. 2012..Taken together, the results indicate a molecular link between HER2 and leptin, providing supporting evidence that leptin represents a target for breast cancer therapy. [BMB Reports 2012; 45(12): 719-723]... - Differential functions of Ras for malignant phenotypic conversionAree Moon
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
Arch Pharm Res 29:113-22. 2006..In spite of the accumulation of information on the differential functions of Ras, much more remains to be elucidated to understand the Ras-mediated molecular events of malignant phenotypic conversion of cells in a greater detail... - H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cellsIlchung Shin
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
J Biol Chem 280:14675-83. 2005.... - The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasionEun Sook Kim
College of Pharmacy, Duksung Women s University, Seoul, Korea
Breast Cancer Res Treat 124:49-61. 2010.... - ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signalingHae Young Yong
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
Int J Oncol 36:501-7. 2010.... - p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cellsMi-Sung Kim
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea
Cancer Res 63:5454-61. 2003..This study reveals the p38 kinase as a key signaling molecule differentially regulated by H-ras and N-ras, leading to H-ras-specific cell invasive and migrative phenotypes in human breast epithelial cells... - Roles of calcium-binding proteins, S100A8 and S100A9, in invasive phenotype of human gastric cancer cellsHae Young Yong
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
Arch Pharm Res 30:75-81. 2007..Taken together, this study revealed a functional contribution of S100A8 and S100A9 proteins to processes required for malignant progression including invasion, migration and proteinase expression in SNU484 human gastric cancer cells... - Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathwaysHyun Song
College of Pharmacy, Duksung Women s University, 419 Ssangmun dong, Dobong gu, Seoul, Republic of Korea
Neurosci Res 56:29-38. 2006..Our findings revealing molecular mechanisms for the promoting effect of GDNF on glioma cell migration may provide an insight into a better understanding to the malignant progression of human gliomas... - Simvastatin and lovastatin inhibit breast cell invasion induced by H-RasSoouk Kang
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
Oncol Rep 21:1317-22. 2009.... - Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cellsHyun Song
College of Pharmacy, Duksung Women's University, Seoul National University, Seoul, Korea
Cancer Res 66:10487-96. 2006.... - H-Ras-specific upregulation of granulocyte colony-stimulating factor promotes human breast cell invasion via matrix metalloproteinase-2Sunhwa Park
College of Pharmacy, Duksung Women s University, Seoul, Republic of Korea
Cytokine 55:126-33. 2011..These data provide a molecular basis for the crucial role of G-CSF in promoting invasiveness of human breast epithelial cells... - TGF-beta-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cellsEun Sook Kim
College of Pharmacy, Duksung Women s University, Seoul 132 714, Republic of Korea
Cancer Lett 252:147-56. 2007..Taken together, this study demonstrates that ATF2 mediates the TGF-beta-induced MMP-2 transcriptional activation, elucidating a molecular mechanism for the malignant progression of human breast epithelial cells exerted by TGF-beta... - Pyrethroid insecticides, fenvalerate and permethrin, inhibit progesterone-induced alkaline phosphatase activity in T47D human breast cancer cellsIn Young Kim
Department of Toxicology, National Institute of Toxicological Research, Seoul, Korea
J Toxicol Environ Health A 68:2175-86. 2005..Our data indicate that fenvalerate and permethrin exhibit antiprogestagenic activity in T47D human breast cancer cells... - Transforming growth factor (TGF)-beta in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cellsEun Sook Kim
College of Pharmacy, Duksung Women s University, Seoul 132 714, Republic of Korea
Cytokine 29:84-91. 2005.... - Overexpression of ErbB2 induces invasion of MCF10A human breast epithelial cells via MMP-9In Young Kim
College of Pharmacy, Duksung Women s University, 419 Ssangmun dong, Tobong gu, Seoul, Republic of Korea
Cancer Lett 275:227-33. 2009..Given that ErbB2 is one of the most important oncogenes in human breast cancer and thus is an attractive therapeutic target, our findings may provide a molecular basis for the promoting role of ErbB2 in breast cancer progression... - TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cellsEun-Sook Kim
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea
Int J Oncol 25:1375-82. 2004.... - Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cellsJae In Song
College of Pharmacy, Duksung Women s University, 419 Ssangmun dong, Seoul 132 714, Republic of Korea
Oncol Rep 27:813-8. 2012.... - Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Gαq couplingEun Sook Kim
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
J Cell Sci 124:2220-30. 2011.... - Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cellsEun Sook Kim
College of Pharmacy, Duksung Women s University, Seoul, Republic of Korea
Oncol Rep 27:567-72. 2012.... - Regulation of matrix metalloproteinases and invasion by G(alpha12/13) proteins in NIH3T3 mouse fibroblast cellsEun Sook Kim
College of Pharmacy, Duksung Women s University, Seoul, Korea
Oncol Res 19:297-301. 2011..Taken together, this study elucidated the role of Galpha12/13 in regulating malignant phenotypic conversion of NIH3T3 fibroblast cells, validating the role of Galphal2/13 in tumorigenesis... - Synthesis of 3-alkylthio-6-allylthiopyridazine derivatives and their antihepatocarcinoma activitySoon Kyoung Kwon
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
Arch Pharm Res 28:391-4. 2005..Thio-K6, one of the sulfur-substituted compounds, showed better chemopreventive activity toward hepatocarcinoma cells... - Capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells is Rac-dependent via ROS generationSeonhoe Kim
College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea
Arch Pharm Res 27:845-9. 2004.... - Type I collagen-induced pro-MMP-2 activation is differentially regulated by H-Ras and N-Ras in human breast epithelial cellsIn Young Kim
College of Pharmacy, Duksung Women s University, Seoul 132 714, Korea
J Biochem Mol Biol 40:825-31. 2007.... - Hemin, an iron-binding porphyrin, inhibits HIF-1α induction through its binding with heat shock protein 90Jung Min Lee
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
Int J Cancer 130:716-27. 2012.... 
Identification of H-Ras-specific motif for the activation of invasive signaling program in human breast epithelial cellsHae Young Yong
College of Pharmacy, Duksung Women s University, Seoul, South Korea
Neoplasia 13:98-107. 2011....- G alpha 12/13 basally regulates p53 through Mdm4 expressionMi Sung Kim
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
Mol Cancer Res 5:473-84. 2007..Our results indicate that G alpha(12/13) regulate basal p53 levels via mdm4, which constitutes a cell signaling pathway distinct from p53 phosphorylations elicited by genotoxic stress... - Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cellsMin Soo Koh
College of Pharmacy, Duksung Women s University, Seoul 132 714, Republic of Korea
Biochem Biophys Res Commun 406:25-9. 2011.... - The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancerHae Young Yong
Duksung Women s University, College of Pharmacy, Seoul, Korea
Expert Opin Investig Drugs 18:1893-905. 2009.... - Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assaysIn Young Kim
Endocrine Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
J Reprod Dev 50:245-55. 2004..These results suggest that certain pyrethroid insecticides may be considered to be estrogen-like chemicals that act through pathways other than direct ER binding, and may function as endocrine modulators in both wildlife and humans... - Phthalates inhibit tamoxifen-induced apoptosis in MCF-7 human breast cancer cellsIn Young Kim
College of Pharmacy, Duksung Women's University, Seoul, Korea
J Toxicol Environ Health A 67:2025-35. 2004..Given that the phthalates are widely used in cosmetics mainly for women, our findings that revealed the promoting effect of BBP, DBP, and DEHP on chemotherapeutic drug resistance to TAM in breast cancer may be of biological relevance... - Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cellsHye Jung Kang
College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
Int J Cancer 103:475-82. 2003.... - In vitro evaluation of biomarkers for cisplatin-induced nephrotoxicity using HK-2 human kidney epithelial cellsSo Jung Sohn
College of Pharmacy, Duksung Women s University, Seoul 132 714, Republic of Korea
Toxicol Lett 217:235-42. 2013.... - Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cellsHyun Song
College of Pharmacy, Duksung Women's University, Seoul, Korea
Biol Pharm Bull 26:1428-30. 2003..Our findings may be critical for developing a strategy to protect nerve cells from apoptosis, suggesting the potential development of sauchinone as a neuroprotective agent... - In vitro bioassay for transforming growth factor-beta using XTT methodMi-Sung Kim
College of Pharmacy, Duksung Womens University, Seoul 132-714, Korea
Arch Pharm Res 25:903-9. 2002..Our results may contribute to the establishment of an in vitro bioassay system, which could be used for the satisfactory quantitation of TGF-beta... - Synthesis and mechanistic studies of a mitomycin dimer containing an eight-membered cyclic disulfideHyun Jung Park
College of Pharmacy, Duksung Women s University, Seoul, Republic of Korea
Bioorg Med Chem 19:4004-13. 2011.... - Retroviral delivery of TIMP-2 inhibits H-ras-induced migration and invasion in MCF10A human breast epithelial cellsSeong-Min Ahn
College of Pharmacy, Duksung Women's University, Seoul 132-714, South Korea
Cancer Lett 207:49-57. 2004.... - Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cellsJung Hwan Kim
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
Chem Biol Interact 171:133-41. 2008..These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA-stimulated human mammary epithelial cells... - H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cellsKi Won Lee
Department of Food Biotechnology, School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
Int J Cancer 119:1767-75. 2006.... - A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: implication for a potential anti-inflammatory effectYoungju Choi
College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, Republic of Korea
Int Immunopharmacol 8:548-55. 2008..Taken together, this study demonstrates that 15-MPA inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB, suggesting a potential anti-inflammatory effect of the compound on microglial cells...