Genomes and Genes


Gun Il Im


Affiliation: Dongguk University International Hospital
Country: Korea


  1. Im G, Kim H. Electroporation-mediated gene transfer of SOX trio to enhance chondrogenesis in adipose stem cells. Osteoarthritis Cartilage. 2011;19:449-57 pubmed publisher
    ..The electroporation-mediated transfection of SOX trio greatly enhances chondrogenesis from ASCs, while decreasing hypertrophy. ..
  2. Im G, Kim H, Lee J. Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes. Biomaterials. 2011;32:4385-92 pubmed publisher
    ..Gross and histological findings from the in vivo study showed enhanced cartilage regeneration in ASCs/SOX trio pDNA-incorporated PLGA scaffolds. ..
  3. Im G, Lim M. Proximal hip geometry and hip fracture risk assessment in a Korean population. Osteoporos Int. 2011;22:803-7 pubmed publisher
    ..Our study showed that some PFG parameters as well as BMD values predict hip fractures in a Korean population, and their evaluation may be useful in the understanding of the biomechanics of hip fractures. ..
  4. Im G, Lee J, Kim H. Wnt inhibitors enhance chondrogenesis of human mesenchymal stem cells in a long-term pellet culture. Biotechnol Lett. 2011;33:1061-8 pubmed publisher
    ..05) while SOX-9 and type X collagen protein expression was unaffected. These findings suggest that Wnt inhibitors promote the chondrogenic differentiation of hMSCs when treated for three weeks. ..
  5. Kang M, Ko J, Kim J, Im G. Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration. Biomaterials. 2014;35:9984-9994 pubmed publisher
    ..In conclusion, CHI-KGN NPs or CHI-KGN MPs can be useful polymer-drug conjugates as an IA drug delivery system to treat OA. ..
  6. Im G, Shin K. Epigenetic approaches to regeneration of bone and cartilage from stem cells. Expert Opin Biol Ther. 2015;15:181-93 pubmed publisher
    ..Inhibition of PcG protein enhancer of zeste (Ezh2) a chromatin modifier, could be a promising candidate to improve MSC differentiation by decreasing Ezh2-mediated H3K27me3. ..
  7. Ko J, Im G. Chondrogenic and Osteogenic Induction from iPS Cells. Methods Mol Biol. 2016;1357:441-50 pubmed publisher
    ..The authors developed protocol to examine the in vitro chondrogenesis and osteogenesis from hiPSCs and in vivo cartilage and bone regeneration using animal models. ..
  8. Im G. Tissue Engineering in Osteoarthritis: Current Status and Prospect of Mesenchymal Stem Cell Therapy. BioDrugs. 2018;32:183-192 pubmed publisher
    ..Further radiological and histological data will be needed, with a larger pool of patients, before this question can be answered. ..
  9. Kang M, Im G. Drug delivery systems for intra-articular treatment of osteoarthritis. Expert Opin Drug Deliv. 2014;11:269-82 pubmed publisher
    ..Future innovations in this field should be directed toward the development of adapted delivery systems that can induce tissue regeneration in OA patients. ..

More Information


  1. Lee J, Ryu J, Kim E, Jo S, Kim B, Lee H, et al. Adhesive barrier/directional controlled release for cartilage repair by endogenous progenitor cell recruitment. Biomaterials. 2015;39:173-81 pubmed publisher
    ..This CHI-C barrier is expected to make a significant contribution in cartilage tissue engineering without cell transplantation as well as application for other tissue engineering. ..
  2. Im G, Kim M. The relationship between osteoarthritis and osteoporosis. J Bone Miner Metab. 2014;32:101-9 pubmed publisher
    ..Low BMD at the lumbar spine is associated with a lower incidence of knee OA although it does not arrest the progression of knee OA. ..
  3. Kang M, Kim J, Im G. Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis. Acta Biomater. 2016;39:65-78 pubmed publisher
    ..We think that this study will add a new concept to current body of knowledge in the field of drug delivery and treatment of osteoarthritis. ..
  4. request reprint
    Ko J, Im G. Concave microwell plate facilitates chondrogenesis from mesenchymal stem cells. Biotechnol Lett. 2016;38:1967-1974 pubmed
    ..Concave microwell plates provide a convenient and effective tool for the study of in vitro chondrogenesis and may replace the use of propylene culture tube. ..
  5. Im G, Quan Z. The effects of Wnt inhibitors on the chondrogenesis of human mesenchymal stem cells. Tissue Eng Part A. 2010;16:2405-13 pubmed publisher
    ..The overall results of this study suggest that although the inhibitors of Wnt pathway promote early chondrogenesis of MSCs, they do not provide an ultimately enhancing role in the cartilage tissue engineering of MSCs. ..