Yung Hyun Choi

Summary

Affiliation: Dong-Eui University
Country: Korea

Publications

  1. doi request reprint Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK
    Dong Oh Moon
    Faculty of Applied Marine Science, Cheju National University, Jeju Special Self Governing Province 690 756, South Korea
    Biochem Pharmacol 76:312-21. 2008
  2. ncbi request reprint Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells
    Young Ae Kim
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 23:1143-9. 2003
  3. ncbi request reprint Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells
    Yung Hyun Choi
    Department of Biochemistry, College of Oriental Medicine, Dong Eui University, and Research Center for Oriental Medicine, Busan 614 052, South Korea
    Cancer Lett 199:157-67. 2003
  4. ncbi request reprint beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells
    Byung Tae Choi
    Department of Anatomy, Dong Eui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan, Korea
    Anticancer Drugs 14:845-50. 2003
  5. ncbi request reprint Wikyungtang inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing cyclooxygenase-2 activity
    Dong Il Park
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 11:853-6. 2004
  6. ncbi request reprint Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells
    Yung Hyun Choi
    Department of Biochemistry, Dong Eui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 23:1657-62. 2003
  7. ncbi request reprint Suppression of human prostate cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WAF1/CIP1)
    Yung Hyun Choi
    Department of Biochemistry, College of Oriental Medicine, Dong Eui University and Research Center for Oriental Medicine, Pusan 614 052, Korea
    J Biochem Mol Biol 36:223-9. 2003
  8. ncbi request reprint Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells
    Yung Hyun Choi
    Department of Biochemistry, Dong Eui University College of Oriental Medicine and Research Center for Oriental Medicine, Pusan 614 052, Korea
    Int J Oncol 21:1293-9. 2002
  9. doi request reprint Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt
    Min Ho Han
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan 614 052, Republic of Korea
    Int J Oncol 40:2090-6. 2012
  10. doi request reprint Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill
    Jong Hwan Kim
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Food Chem Toxicol 48:807-13. 2010

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. doi request reprint Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK
    Dong Oh Moon
    Faculty of Applied Marine Science, Cheju National University, Jeju Special Self Governing Province 690 756, South Korea
    Biochem Pharmacol 76:312-21. 2008
    ..These molecular mechanisms provide that PTX-2 induces G2/M phase arrest, endoreduplication, and apoptosis through the ERK and JNK signal pathway via actin depolymerization...
  2. ncbi request reprint Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells
    Young Ae Kim
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 23:1143-9. 2003
    ..Taken together, these findings suggest that resveratrol has strong potential for development as an agent for prevention against human lung cancer...
  3. ncbi request reprint Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells
    Yung Hyun Choi
    Department of Biochemistry, College of Oriental Medicine, Dong Eui University, and Research Center for Oriental Medicine, Busan 614 052, South Korea
    Cancer Lett 199:157-67. 2003
    ..These distinctive features suggest that it is possible to create the new drugs useful for cancer therapy from the synthetic bile acid derivatives as lead compounds...
  4. ncbi request reprint beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells
    Byung Tae Choi
    Department of Anatomy, Dong Eui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan, Korea
    Anticancer Drugs 14:845-50. 2003
    ..beta-Lapachone treatment also resulted in inhibition of the transcriptional activity of NF-kappaB-luciferase reporter plasmid suggesting that beta-lapachone-induced apoptosis may be partly regulated through the inactivation of NF-kappaB...
  5. ncbi request reprint Wikyungtang inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing cyclooxygenase-2 activity
    Dong Il Park
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 11:853-6. 2004
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of WKT...
  6. ncbi request reprint Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells
    Yung Hyun Choi
    Department of Biochemistry, Dong Eui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 23:1657-62. 2003
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of beta-sitosterol...
  7. ncbi request reprint Suppression of human prostate cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WAF1/CIP1)
    Yung Hyun Choi
    Department of Biochemistry, College of Oriental Medicine, Dong Eui University and Research Center for Oriental Medicine, Pusan 614 052, Korea
    J Biochem Mol Biol 36:223-9. 2003
    ..Overall, our results demonstrate a combined mechanism that involves the inhibition of pRB phosphorylation and induction of p21 as targets for beta-lapachone. This may explain some of its anticancer effects...
  8. ncbi request reprint Phosphorylation of p53, induction of Bax and activation of caspases during beta-lapachone-mediated apoptosis in human prostate epithelial cells
    Yung Hyun Choi
    Department of Biochemistry, Dong Eui University College of Oriental Medicine and Research Center for Oriental Medicine, Pusan 614 052, Korea
    Int J Oncol 21:1293-9. 2002
    ....
  9. doi request reprint Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt
    Min Ho Han
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan 614 052, Republic of Korea
    Int J Oncol 40:2090-6. 2012
    ....
  10. doi request reprint Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill
    Jong Hwan Kim
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Food Chem Toxicol 48:807-13. 2010
    ..We conclude that gomisin N induces the apoptosis of U937 cells through a signaling cascade of mitochondria-mediated intrinsic caspase pathways and gomisin N may be a useful chemotherapeutic agent...
  11. doi request reprint Anti-inflammatory effects of saponins derived from the roots of Platycodon grandiflorus in lipopolysaccharide‑stimulated BV2 microglial cells
    Kyung Jun Jang
    Department of Acupuncture and Moxibustion, Dongeui University College of Oriental Medicine, Busan, Republic of Korea
    Int J Mol Med 31:1357-66. 2013
    ..Therefore, these findings suggest that PGS may be useful in the treatment of neurodegenerative diseases by inhibiting inflammatory responses in activated microglial cells...
  12. ncbi request reprint Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase
    Hyun Joo Woo
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Korea
    J Med Food 9:161-8. 2006
    ..However, beta-lapachone treatment did not affect the inhibitor of apoptosis proteins family and the Fas/FasL system. Taken together, our study indicated that beta-lapachone may have potential as a chemopreventive agent for liver cancer...
  13. doi request reprint Anti-invasive activities of anthocyanins through modulation of tight junctions and suppression of matrix metalloproteinase activities in HCT-116 human colon carcinoma cells
    Dong Yeok Shin
    Department of Biochemistry, College of Oriental Medicine, and Research Institute of Oriental Medicine, Busan, Republic of Korea
    Oncol Rep 25:567-72. 2011
    ..Furthermore, the activities of MMP-2 and -9 were dose-dependently suppressed by anthocyanin treatment. These effects were related to activation of 38-MAPK and suppression of the PI3K/Akt pathway in HCT-116 human colon cancer cells...
  14. doi request reprint Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells
    Cheng Yun Jin
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Yangjung dong San 45, Busanjin Gu, Busan 614 052, South Korea
    Toxicol In Vitro 23:259-65. 2009
    ..Taken together, these observations indicate that Bcl-2 confers apoptosis resistance to naringenin by inhibiting a mitochondrial amplification step in U937 cells...
  15. ncbi request reprint Induction of apoptosis by Chan Su, a traditional Chinese medicine, in human bladder carcinoma T24 cells
    Woo Shin Ko
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine and Clinical Research Center of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 14:475-80. 2005
    ..Taken together, these findings partially provide novel insights into the possible molecular mechanisms of the anti-cancer activity of Chan Su...
  16. ncbi request reprint Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan 614 052, Korea
    Int J Oncol 35:1499-504. 2009
    ..In conclusion, this study suggests that the anthocyanins isolated from Vitis coignetiae Pulliat induce apoptosis might at least in part through activating p38-MAPK and suppressing Akt in human colon cancer HCT-116 cells...
  17. ncbi request reprint Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells
    Sung Ok Kim
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan 614 052, Korea
    BMB Rep 42:655-60. 2009
    ..Collectively, these findings indicate that the up-regulation of Egr-1 and claudin-3 are crucial steps in HDAC inhibitor-induced anti-metastasis and anti-invasion...
  18. doi request reprint Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt
    Jin Woo Jeong
    Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Int J Oncol 40:1697-704. 2012
    ..These findings suggest that cordycepin inhibits the migration and invasion of LNCaP cells by downregulating the activity of TJs and MMPs, possibly in association with suppression of Akt activation...
  19. ncbi request reprint Induction of apoptosis and inhibition of telomerase activity by aqueous extract from Platycodon grandiflorum in human lung carcinoma cells
    Dong Il Park
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan 614 052, Republic of Korea
    Pharmacol Res 51:437-43. 2005
    ..These findings suggest that the apoptotic events by AEPG were associated with the diminished telomerase activity and down-regulation of Bcl-2 expression...
  20. ncbi request reprint Suppression of U937 human monocytic leukemia cell growth by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., via induction of Cdk inhibitor p16 and down-regulation of pRB phosphorylation
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 16:171-6. 2006
    ..Overall, our results demonstrate a combined mechanism involving the inhibition of pRB phosphorylation and induction of p16 as targets for dideoxypetrosynol A, may explain some of its anti-cancer effects...
  21. doi request reprint Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells
    Shin Hyung Park
    Department of Pathology, College of Oriental Medicine, Dongeui University, Busan 614 052, Republic of Korea
    Food Chem Toxicol 56:100-9. 2013
    ..Taken together, our findings showed that luteolin triggers both endoplasmic reticulum stress-related apoptosis and non-canonical autophagy, which function as a cell death mechanism in NCI-H460 human lung cancer cells...
  22. ncbi request reprint Induction of apoptosis by (Z)-stellettic acid C, an acetylenic acid from the sponge Stelletta sp., is associated with inhibition of telomerase activity in human leukemic U937 cells
    Cheol Park
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan, Korea
    Chemotherapy 53:160-8. 2007
    ..In this study, the potential of (Z)-stellettic acid C to induce apoptosis in human leukemic U937 cells and its effects on telomerase activity were investigated...
  23. doi request reprint Inhibitory effects of diallyl disulfide on the production of inflammatory mediators and cytokines in lipopolysaccharide-activated BV2 microglia
    Hye Young Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 714, Republic of Korea
    Toxicol Appl Pharmacol 262:177-84. 2012
    ..These findings indicated that DADS is potentially a novel therapeutic candidate for the treatment of various neurodegenerative diseases...
  24. doi request reprint Anti-invasive activity of diallyl disulfide through tightening of tight junctions and inhibition of matrix metalloproteinase activities in LNCaP prostate cancer cells
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Republic of Korea
    Toxicol In Vitro 24:1569-76. 2010
    ..Although further studies are needed, the present study indicates that TJs and MMPs are critical targets of DADS-induced anti-invasiveness in human prostate cancer LNCaP cells...
  25. doi request reprint Anti-invasive activity of anthocyanins isolated from Vitis coignetiae in human hepatocarcinoma cells
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Jeju, Republic of Korea
    J Med Food 12:967-72. 2009
    ..coignetiae Pulliat have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kappaB activation...
  26. ncbi request reprint Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt
    Min Ho Han
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan, South Korea
    Anticancer Drugs 18:913-21. 2007
    ....
  27. ncbi request reprint Antiproliferative effect of resveratrol in human prostate carcinoma cells
    Young Ae Kim
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Pusan National University, Busan, Korea
    J Med Food 6:273-80. 2003
    ..These effects were found to correlate with an activation of caspase-3 and caspase-9. Taken together, our study suggests that resveratrol has a strong potential for development as an agent for the prevention of human prostate cancer...
  28. ncbi request reprint Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3
    Woo Young Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Yangjung Dong, Busanjin Gu, Busan 614 714, South Korea
    Anticancer Res 29:4457-65. 2009
    ....
  29. doi request reprint Bufalin prevents the migration and invasion of T24 bladder carcinoma cells through the inactivation of matrix metalloproteinases and modulation of tight junctions
    Su Hyun Hong
    Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan, Republic of Korea
    Int J Oncol 42:277-86. 2013
    ..These findings suggest that bufalin inhibits the migration and invasion of T24 cells by modulating the activity of TJs and MMPs, possibly in association with the activation of ERK...
  30. ncbi request reprint An aqueous extract of Platycodi radix inhibits LPS-induced NF-kappaB nuclear translocation in human cultured airway epithelial cells
    Jun Hyuk Lee
    Department of Anatomy, College of Oriental Medicine, Research Institute of Oriental Medicine, Dong Eui University, Busan 614 052, Korea
    Int J Mol Med 13:843-7. 2004
    ..These results suggest that AEPR may act as a therapeutic agent for inflammatory disease through regulating the activity of NF-kappaB and expression of inflammatory genes...
  31. ncbi request reprint Curcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Mol Med 20:365-72. 2007
    ..These results show that curcumin might help identify a new therapeutic pathway against hyperplasia of the synovial fibroblasts in RA...
  32. ncbi request reprint Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells
    Hyun Joo Woo
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Exp Mol Pathol 82:77-84. 2007
    ....
  33. doi request reprint 7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation
    Hye Young Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 714, Republic of Korea
    Oncol Rep 28:353-7. 2012
    ..Overall, our results demonstrate a combined mechanism for the anticancer effects of 7,8-DHF that involves the inhibition of pRB phosphorylation and induction of p27 as targets for 7,8-DHF...
  34. ncbi request reprint Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt in human breast cancer MDA-MB-231 Cells
    Cheng Yun Jin
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School and Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    J Microbiol Biotechnol 18:1997-2003. 2008
    ..The results indicated that AECM-induced apoptosis may relate to the activation of caspase-3 and mitochondria dysfunctions that correlate with the inactivation of Akt...
  35. doi request reprint Beta-sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Acta Pharmacol Sin 29:341-8. 2008
    ..To investigate whether subtoxic concentration of beta-sitosterol (SITO) combined with TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-resistant MDA-MB-231 breast cancer cells...
  36. doi request reprint Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells
    Jin Woo Jeong
    Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Toxicol In Vitro 25:817-24. 2011
    ..These results support a mechanism whereby cordycepin induces apoptosis of human leukemia cells through a signaling cascade involving a ROS-mediated caspase pathway...
  37. doi request reprint Induction of G2/M arrest and apoptosis by water extract of Strychni Semen in human gastric carcinoma AGS cells
    Sang Man Lee
    Department of Pathology, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Phytother Res 22:752-8. 2008
    ..Taken together, the results of this study suggest the involvement of multiple signaling pathways targeted by ESS in mediating G2/M cell cycle arrest and apoptosis in AGS cells, and warrant further investigation...
  38. ncbi request reprint Streptochlorin isolated from Streptomyces sp. Induces apoptosis in human hepatocarcinoma cells through a reactive oxygen species-mediated mitochondrial pathway
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control BK21Program, Dongeui University Graduate School, Busan 614 052, Korea
    J Microbiol Biotechnol 18:1862-8. 2008
    ..Taken together, our data imply that streptochlorin-induced ROS is a key mediator of MMP collapse, which leads to the caspase-3 activation, culminating in apoptosis...
  39. ncbi request reprint Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis
    Cheol Park
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Biomedical Research Center of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 13:1211-6. 2005
    ....
  40. doi request reprint Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species
    Shin Hyung Park
    Department of Pathology and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Toxicol Lett 212:252-61. 2012
    ..The data suggest that regulation of ROS generation and autophagy can be a potential strategy for treating lung cancer that is resistant to pro-apoptotic therapeutics...
  41. doi request reprint Induction of apoptosis by streptochlorin isolated from Streptomyces sp. in human leukemic U937 cells
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Yangjung dong San 45, Busanjin Gu, Busan, South Korea
    Toxicol In Vitro 22:1573-81. 2008
    ..Taken together, these findings demonstrate that the pro-apoptotic effect of streptochlorin is mediated through activation of caspases and mitochondria in U937 cells...
  42. ncbi request reprint Induction of apoptosis and inhibition of cyclooxygenase-2 expression by N-methyl-N'-nitro-N-nitrosoguanidine in human leukemia cells
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Dongeui University Graduate School, Busan 614 052, South Korea
    Anticancer Drugs 16:507-13. 2005
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of MNNG...
  43. ncbi request reprint Ircinin-1 induces cell cycle arrest and apoptosis in SK-MEL-2 human melanoma cells
    Hye Joung Choi
    Department of Pharmacy and Pusan Cancer Research Center, Pusan National University, Busan, South Korea
    Mol Carcinog 44:162-73. 2005
    ..Taken together, these findings suggest that ircinin-1 has strong potential for development as an agent for prevention against skin cancer...
  44. ncbi request reprint Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells
    Young Ae Kim
    Department of Oriental Medicine, Dongeui University and Research Institute of Oriental Medicine, San 45 1, Yangjung Dong, Pusanjin gu, Busan 614 052, Korea
    Oncol Rep 11:441-6. 2004
    ..In addition, the apoptotic process involves activation of caspase-9, a decrease of Bcl-2 as well as Bcl-XL levels, and an increase of Bax levels...
  45. doi request reprint Induction of apoptosis and inhibition of invasion in human hepatoma cells by anthocyanins from meoru
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Korea
    Ann N Y Acad Sci 1171:137-48. 2009
    ..This study provides evidence that the anthocyanins isolated from meoru might be useful in the treatment of human hepatitis B-associated hepatoma...
  46. doi request reprint 7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells
    Hye Young Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Republic of Korea
    Int J Mol Med 29:1146-52. 2012
    ..7 cells. Thus, 7,8-DHF may be a novel therapeutic agent for the prevention of various inflammatory diseases...
  47. doi request reprint Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells
    Jae Im Kwon
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Republic of Korea
    J Med Food 11:1-8. 2008
    ..The present results indicate that the Fas/Fas ligand pathway might be involved in LA-induced apoptosis of AGS cells...
  48. ncbi request reprint Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3
    Soung Young Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Oncol Rep 18:181-7. 2007
    ..z-DEVD-fmk, a caspase-3 specific inhibitor, blocked the activation of caspase-3 and increased the survival of the SFN-treated HeLa and HepG3 cells, suggesting that caspase-3 activation is essential for SFN-induced apoptosis...
  49. doi request reprint Induction of apoptosis by ethanol extract of Prunus mume in U937 human leukemia cells through activation of caspases
    Cheol Park
    Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Oncol Rep 26:987-93. 2011
    ..Taken together, these findings suggest that EEPM may be a potential chemotherapeutic agent for use in the control of human leukemia U937 cells and that further studies are needed for the identification of the active compounds...
  50. doi request reprint Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Chem Biol Interact 179:185-91. 2009
    ..Furthermore, the activities of MMP-2 and -9 in MDA-MB-231 cells were dose-dependently inhibited by treatment with sanguinarine, and this was also correlated with a decrease in the expression of their mRNA and proteins...
  51. doi request reprint Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB-231 human breast carcinoma cells through a reactive oxygen species-mediated mitochondrial pathway
    Woo Young Choi
    Department of Biology, College of Natural Sciences, Dongeui University College of Oriental Medicine, Busan, South Korea
    Chemotherapy 54:279-87. 2008
    ..In this study, we examined the effects of this compound on reactive oxygen species (ROS) production and the association of these effects with apoptotic tumor cell death using a human breast carcinoma MDA-MB-231 cell line...
  52. ncbi request reprint Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells
    Young Ae Kim
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Korea
    Int J Mol Med 17:1069-75. 2006
    ..Collectively, the present results indicate that modulation of nuclear factor-kappaB (NF-kappaB) activity is involved in the neuroprotective action of resveratrol against beta-amyloid-induced toxicity...
  53. ncbi request reprint Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt
    Seung Chan Park
    Department of East West Cancer Center, College of Oriental Medicine, Daejeon University, Daejeon 301 724, Korea
    Int J Oncol 35:121-7. 2009
    ....
  54. ncbi request reprint Induction of apoptotic cell death by mycelium extracts of Phellinus linteus in human neuroblastoma cells
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Mol Med 14:227-32. 2004
    ..Taken together, the present results suggest that apoptotic signals evoked by MEPL in human neuroblastoma SK-N-MC cells may converge caspase-3 activation through an up-regulation of Bax rather than a down-regulation of Bcl-2...
  55. doi request reprint Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells
    Cheng Yun Jin
    Department of Biomaterial Control, Dongeui University Graduate School, Dongeui University College of Oriental Medicine, Busan, Republic of Korea
    Chem Biol Interact 180:143-50. 2009
    ....
  56. ncbi request reprint Inhibition of cyclooxygenase-2 and telomerase activities in human leukemia cells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 30:291-8. 2007
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of dideoxypetrosynol A...
  57. ncbi request reprint Anti-inflammatory effects of aqueous extract from Dichroa febrifuga root in rat liver
    Byung Tae Choi
    Department of Oriental Medicine, College of Oriental Medicine, Research Institute of Oriental Medicine, Dong Eui University, Busan 614 052, Korea
    Acta Pharmacol Sin 24:127-32. 2003
    ..To study the anti-inflammatory effects of aqueous extract from Dichroa febrifuga root (AEDF) for suppression in the process of lipopolysaccharide (LPS)-induced sepsis in the rat liver...
  58. ncbi request reprint Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells
    Jun Hyuk Lee
    Department of Oriental Medicine, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 21:1239-44. 2002
    ..These results suggest that tetrandrine merits further investigation as a cell cycle blocker as well as a cancer chemopreventive agent...
  59. ncbi request reprint Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio
    Cheol Park
    Department of Biochemistry, Dongeui University, College of Oriental Medicine, Busan, South Korea
    Biol Pharm Bull 30:1317-23. 2007
    ..These results show that beta-sitosterol potently induces apoptosis in U937 cells and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio...
  60. ncbi request reprint Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells
    Cheol Park
    Blue Bio Industry Regional Innovation Center, Dongeui University, Busan 614 052, Korea
    Int J Mol Med 24:495-502. 2009
    ..In summary, growth inhibition by schisandrin C is related to cell cycle arrest at G1 and induction of caspase-3-dependent apoptosis in U937 cells; these findings suggest that schisandrin C may be a useful chemotherapeutic agent...
  61. doi request reprint Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells
    Eun Young Jang
    Department of Physiology, College of Oriental Medicine, Daegu Haany University, Daegu 706 828, South Korea
    Int Immunopharmacol 14:188-94. 2012
    ..Therefore, sauchinone may be a useful treatment for neurodegenerative disease by inhibiting inflammatory responses in activated microglia...
  62. doi request reprint Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Oncol Rep 28:1043-50. 2012
    ..In conclusion, this study suggests that TJs and MMPs are critical targets of decitabine-induced inhibition of invasiveness in AGS human gastric cancer cells...
  63. ncbi request reprint Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells
    Cheol Park
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 15:1225-31. 2006
    ..These observations suggest that curcumin may have therapeutic potential for bladder cancer patients...
  64. doi request reprint Apoptosis induction of human lung carcinoma cells by Chan Su (Venenum Bufonis) through activation of caspases
    Hye Ri Yun
    Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea
    J Acupunct Meridian Stud 2:210-7. 2009
    ..Data from this study indicates that SVB induces the apoptosis of A549 cells through a signaling cascade of death receptor-mediated extrinsic and mitochondria-mediated intrinsic caspase pathways...
  65. ncbi request reprint Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Oncol Rep 19:517-26. 2008
    ....
  66. ncbi request reprint Electroacupuncture inhibits inflammatory edema and hyperalgesia through regulation of cyclooxygenase synthesis in both peripheral and central nociceptive sites
    Jun Hyuk Lee
    Department of Anatomy, College of Oriental Medicine, Dong Eui University, Busan 614 052, Korea
    Am J Chin Med 34:981-8. 2006
    ..In conclusion, EA treatment might be a useful therapy for mitigation of inflammatory edema and hyperalgesia through regulation of COX-2 expression in both peripheral and central nociceptive sites...
  67. ncbi request reprint Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia
    Young Ae Kim
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Republic of Korea
    J Med Food 10:218-24. 2007
    ....
  68. doi request reprint J7, a methyl jasmonate derivative, enhances TRAIL-mediated apoptosis through up-regulation of reactive oxygen species generation in human hepatoma HepG2 cells
    Cheol Park
    Department of Biochemistry and Research Institute of Oriental Medicine, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Toxicol In Vitro 26:86-93. 2012
    ..These results support a mechanism whereby J7 plus TRAIL induces apoptosis of HepG2 human hepatoma cells through a signaling cascade involving a ROS-mediated caspase pathway...
  69. doi request reprint Anti-invasive activity of ethanol extracts of Ganoderma lucidum through tightening of tight junctions and inhibition of matrix metalloproteinase activities in human gastric carcinoma cells
    Kyung Jun Jang
    Departments of Acupuncture and Moxibustion, Dongeui University College of Oriental Medicine, Busan, South Korea
    J Acupunct Meridian Stud 4:225-35. 2011
    ..Although further studies are needed, the present study indicates that TJs and MMPs are crucial targets of EGL-induced anti-invasiveness in human gastric cancer AGS cells...
  70. ncbi request reprint Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation
    Kyeong Jin Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Korea
    J Leukoc Biol 82:1332-9. 2007
    ..Taken together, these results indicate that SDF-1alpha is involved in granulocyte differentiation in response to ATRA, mediated by the activation of the transcription factor C/EBPbeta...
  71. ncbi request reprint Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells
    Sung Ok Kim
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Biosci Biotechnol Biochem 71:2169-76. 2007
    ....
  72. ncbi request reprint Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Int J Oncol 27:473-9. 2005
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of TSA...
  73. ncbi request reprint Apoptosis of U937 human leukemic cells by sodium butyrate is associated with inhibition of telomerase activity
    Yung Hyun Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 29:1207-13. 2006
    ....
  74. doi request reprint Implication of intracellular ROS formation, caspase-3 activation and Egr-1 induction in platycodon D-induced apoptosis of U937 human leukemia cells
    Dong Yeok Shin
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, South Korea
    Biomed Pharmacother 63:86-94. 2009
    ....
  75. doi request reprint Dichloromethane fraction of Cimicifuga heracleifolia decreases the level of melanin synthesis by activating the ERK or AKT signaling pathway in B16F10 cells
    Ji Yeon Jang
    Department of Oriental Medicine, College of Oriental Medicine, Dongeui University, Busan, South Korea
    Exp Dermatol 18:232-7. 2009
    ..Therefore, C. heracleifolia would be a useful therapeutic agent for treating hyperpigmentation and an effective component in whitening and/or lightening cosmetics...
  76. pmc Tetraarsenic Hexoxide Induces Beclin-1-Induced Autophagic Cell Death as well as Caspase-Dependent Apoptosis in U937 Human Leukemic Cells
    Min Ho Han
    Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control BK21 program, Dongeui University Graduate School, 42 San, Yangjung don, Busan 614 052, Republic of Korea
    Evid Based Complement Alternat Med 2012:201414. 2012
    ..This study suggests that As(4)O(6) should induce Beclin-1-induced autophagic cell death as well as caspase-dependent apoptosis and that it might be a promising agent for the treatment of leukemia...
  77. ncbi request reprint Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity
    Hyun Joo Woo
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Korea
    Int J Oncol 26:1017-23. 2005
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of beta-lapachone...
  78. ncbi request reprint Induction of apoptosis and G2/M arrest by N-methyl-N'-nitro-N-nitrosoguanidine in human prostate carcinoma cells
    Cheol Park
    Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614 052, Republic of Korea
    Mutat Res 563:139-49. 2004
    ..Present results indicate that the up-regulation of p21 by MNNG is likely responsible for the inhibition of Cdks kinase activity rather than the down-regulation of cyclins and Cdks expression...
  79. doi request reprint Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells
    Kyung Jun Jang
    Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongeui University, Busan, Korea
    J Acupunct Meridian Stud 3:24-31. 2010
    ....
  80. ncbi request reprint Induction of apoptosis by dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., in human skin melanoma cells
    Hye Joung Choi
    Department of Biochemistry, Dongeui University College of Oriental Medicineand Biomedical Research Center of Oriental Medicine, Busan 614 052, Korea
    Int J Mol Med 14:1091-6. 2004
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of dideoxypetrosynol A...
  81. ncbi request reprint Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells
    Cheung Yun Jin
    Department of Microbiology, Pusan National University, Busan 614 052, South Korea
    Carcinogenesis 28:1058-66. 2007
    ..These results indicate that caspase-3 is a key regulator of apoptosis in response to combined SFN and TRAIL in human lung adenocarcinoma A549 cells through downregulation of ERK and Akt...
  82. ncbi request reprint Trichostatin A increases the thermosensitivity of human glioblastoma A172 cells
    Sun Yong Baek
    Department of Anatomy, College of Medicine, Pusan National University, Busan 602 739, South Korea
    Neurosci Lett 396:230-4. 2006
    ..Collectively, our results show the role of TSA as a chemical thermosensitizer, suggesting the possible therapeutic application of combined treatment of TSA/hyperthermia on STAT3-dependent tumors...
  83. ncbi request reprint Down-regulation of cyclooxygenase-2 and telomerase activity by beta-lapachone in human prostate carcinoma cells
    Jae Hun Lee
    Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614 052, Republic of Korea
    Pharmacol Res 51:553-60. 2005
    ..Taken together, these findings provide important new insights into the possible molecular mechanisms of the anti-cancer activity of beta-lapachone...
  84. doi request reprint Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation
    Min Ho Han
    Department of Biomaterial Control BK21 program, Dongeui University Graduate School, Busan, South Korea
    Chemotherapy 54:157-65. 2008
    ..We investigated the mechanisms of sanguinarine on the induction of apoptosis using U937 leukemia cells...
  85. ncbi request reprint Siegesbeckia glabrescens induces apoptosis with different pathways in human MCF-7 and MDA-MB-231 breast carcinoma cells
    Soo Young Jun
    Department of Physiology, College of Oriental Medicine, Dongguk University, Kyongju 780 714, South Korea
    Oncol Rep 15:1461-7. 2006
    ..Therefore, regardless of the ER status, SG might be a promising pro-apoptotic agent for treating breast cancer...
  86. ncbi request reprint Effects of mycelial culture of Phellinus linteus on ethanol-induced gastric ulcer in rats
    Jun Hyuk Lee
    Department of Anatomy, College of Oriental Medicine, Dong Eui University, Busan, Republic of Korea
    Phytother Res 20:396-402. 2006
    ..These results indicate that pretreatment with MCPL provided protection of the gastric mucosa from ethanol-induced injury by maintaining the mucus barrier in rats...
  87. ncbi request reprint Phosphorylation of the large subunit of replication factor C is associated with adipocyte differentiation
    Min Jung Park
    Department of Molecular Biology, Pusan National University, Jang Jeon Dong, Keum Jeong Gu, Busan 607 935, Korea
    FEBS J 274:1235-45. 2007
    ....
  88. ncbi request reprint Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway
    Mi Nam Lee
    Department of Microbiology, College of Natural Sciences, Pusan National University, Pusan 609 735, Korea
    J Gen Virol 83:2145-51. 2002
    ....
  89. ncbi request reprint Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia
    Dong Oh Moon
    Faculty of Applied Marine Science, Cheju National University, Jeju Si, Jeju Special Self Governing Province 690 756, South Korea
    Int Immunopharmacol 7:1092-101. 2007
    ....
  90. ncbi request reprint Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt
    Cheng Yun Jin
    Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 614 052, Republic of Korea
    Biol Pharm Bull 30:1432-7. 2007
    ..The results indicated that major regulators of ABE-induced apoptosis in human leukemic U937 cells are Bcl-2 and caspase-3, which are associated with dephosphorylation of the Akt signal pathway...
  91. ncbi request reprint Activating transcription factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic acid
    Min Young Lee
    Hormone Research Center, Chonnam National University, Kwangju, Korea
    Diabetes 51:3400-7. 2002
    ..Taken together, the data suggest that RA activates the p38beta kinase pathway leading to phosphorylation and activation of ATF-2, thereby enhancing PEPCK gene transcription and glucose production...
  92. ncbi request reprint Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei
    Cheng Yun Jin
    Department of Microbiology, College of Natural Sciences, Pusan National University, Pusan 614 714, Korea
    Oncol Rep 16:1349-55. 2006
    ..In summary, the growth inhibition of ABE is highly related to cell cycle arrest at the G2/M phase and the induction of caspase-3-dependent apoptosis in human gastric epithelial AGS cells...
  93. ncbi request reprint Genome-scale analysis of resveratrol-induced gene expression profile in human ovarian cancer cells using a cDNA microarray
    Sang Hwa Yang
    Microarray Division, GenomicTree, Inc, Daejon 305 390, Korea
    Int J Oncol 22:741-50. 2003
    ....
  94. ncbi request reprint Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells
    Jong Wook Park
    Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, 194 DingSan Dong Jung Gu, Taegu 700 712, South Korea
    Oncol Rep 18:1269-73. 2007
    ..Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis...
  95. ncbi request reprint The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis
    Youl Nam Lee
    Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong A University, Busan 602 714, South Korea
    Cancer Lett 222:227-35. 2005
    ..The results of our study suggest that m-3M3FBS can be developed as a novel anti-leukemic agent...
  96. doi request reprint Bcl-2 overexpression attenuates SP600125-induced apoptosis in human leukemia U937 cells
    Dong Oh Moon
    Faculty of Applied Marine Science, Cheju National University, Jeju Special Self Governing Province 690 756, South Korea
    Cancer Lett 264:316-25. 2008
    ..These data provide important mechanistic insights related to Bcl-2-mediated resistance to SP600125-induced apoptosis, and induction of G2/M phase arrest and endoreduplication...
  97. doi request reprint Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells
    Mun Ock Kim
    Department of Microbiology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea
    Int J Cancer 122:2674-81. 2008
    ..We conclude that the primary antileukemia activity of PD is induction of endoreduplication and mitotic arrest, as a consequence of suppressing spindle MT dynamics and in promoting apoptosis in human leukemia cells...
  98. ncbi request reprint Induction of apoptosis by piceatannol in human leukemic U937 cells through down-regulation of Bcl-2 and activation of caspases
    Yeong Hoon Kim
    Division of Applied Life Science, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660 701, Korea
    Oncol Rep 19:961-7. 2008
    ..z-DEVD-fmk, a caspase-3-specific inhibitor, blocked the activation of caspase-3 and increased the survival of the piceatannol-treated U937 cells, suggesting that caspase-3 activation is essential for piceatannol-induced apoptosis...
  99. ncbi request reprint Methanol extract of the seaweed Gloiopeltis furcata induces G2/M arrest and inhibits cyclooxygenase-2 activity in human hepatocarcinoma HepG2 cells
    Song Ja Bae
    Department of Food Science and Nutrition, Silla University and Marine Biotechnology center for Bio Functional Material Industries, Busan 617 736, Korea
    Phytother Res 21:52-7. 2007
    ..These findings indicate that MEGF may have a possible therapeutic potential in hepatoma cancer patients...
  100. ncbi request reprint Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells
    Dong Oh Moon
    Faculty of Applied Marine Science, Cheju National University, Jeju Si, Jeju Special Self Governing Province 690 756, South Korea
    Int Immunopharmacol 7:1044-53. 2007
    ..Therefore, SITO has a strong potential as a therapeutic agent for preventing cancers such as fibrosarcoma...
  101. ncbi request reprint Piceatannol attenuates lipopolysaccharide-induced NF-kappaB activation and NF-kappaB-related proinflammatory mediators in BV2 microglia
    Cheng Yun Jin
    Department of Microbiology, College of Natural Sciences, Pusan National University, Busan 609 735, South Korea
    Pharmacol Res 54:461-7. 2006
    ..The anti-inflammatory properties of PIC may be useful for attenuating inflammatory diseases and LPS-stimulated microglial activation...