Won Sik Shim

Summary

Affiliation: College of Medicine
Country: Korea

Publications

  1. ncbi Histamine-induced itch and its relationship with pain
    Won Sik Shim
    National Research Laboratory of Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Mol Pain 4:29. 2008
  2. ncbi TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    Won Sik Shim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 27:2331-7. 2007
  3. ncbi Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure
    Han Joo Maeng
    College of Pharmacy, Inje University, Gyeongnam, 621 749, Korea
    Arch Pharm Res 35:1441-8. 2012
  4. ncbi Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
    Eun Young Kwak
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 42:603-13. 2012
  5. ncbi Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug
    Hyo Eon Jin
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 43:355-67. 2013
  6. ncbi TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
  7. ncbi TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1
    Sangsung Kim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 26:2403-12. 2006
  8. ncbi Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation
    Ju Hwan Park
    National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Int J Pharm 441:562-9. 2013
  9. ncbi An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction
    Won Sik Shim
    National Research Laboratory for Transporters Targeted Drug Design and Research Institute of Pharmaceutical Sciences and Department of Pharmaceutics, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Ethnopharmacol 132:328-33. 2010
  10. ncbi Liver cancer targeting of Doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats
    Ji Eun Chang
    National Research Laboratory for Transporters Targeted Drug Design Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, 151 742, South Korea
    Pharm Res 29:795-805. 2012

Collaborators

  • Saeho Chong
  • Su Geun Yang
  • Sun Wook Hwang
  • Chang Koo Shim
  • Suk Jae Chung
  • Dae Duk Kim
  • Hyo Eon Jin
  • Ji Eun Chang
  • Eun Young Kwak
  • Byung Moon Kim
  • Young Duk Yang
  • Uhtaek Oh
  • Ju Hwan Park
  • Han Joo Maeng
  • Hawon Cho
  • Sangsung Kim
  • Boran Song
  • Sang Bum Kim
  • Sun Joo Ahn
  • Sang Soo Yu
  • Jae Yeon Koo
  • Jesun Lee
  • Byeongjun Lee
  • Young Ki Shin
  • Min Ho Tak
  • Seung Pyo Park
  • Yeongyo Cho
  • Ramin Raouf
  • Changjoong Kang
  • Min Young Park
  • Byung-Moon Kim
  • Eunhee Kim
  • Chan Young Shin
  • Youngki Shin
  • Misook Kim
  • Min-Young Park
  • Sang Hee Lee

Detail Information

Publications12

  1. ncbi Histamine-induced itch and its relationship with pain
    Won Sik Shim
    National Research Laboratory of Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Mol Pain 4:29. 2008
    ..In this review, we discuss the molecular mechanism and the pharmacological aspects of histamine-induced itch. Especially, the underlying mechanism of TRPV1 (an anti-pruritus target) has been determined to some extent...
  2. ncbi TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    Won Sik Shim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 27:2331-7. 2007
    ..Together, these results indicate that TRPV1 plays a key role in mediating the pruritogenic action of histamine via the PLA2/LO pathway...
  3. ncbi Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure
    Han Joo Maeng
    College of Pharmacy, Inje University, Gyeongnam, 621 749, Korea
    Arch Pharm Res 35:1441-8. 2012
    ....
  4. ncbi Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
    Eun Young Kwak
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 42:603-13. 2012
    ..The results of the present study make a compelling argument in favour of a prodrug concept that can improve intracellular accumulation and take advantage of amino acid transporters without significantly inducing multiple-drug resistance...
  5. ncbi Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug
    Hyo Eon Jin
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 43:355-67. 2013
    ..6. Efflux transporters appeared to significantly limit the bioavailability of gemifloxacin in rats, suggesting their possible contribution to the low bioavailability of the drug in the human (70%)...
  6. ncbi TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
    ..We conclude that ANO1 is a candidate Ca(2+)-activated chloride channel that mediates receptor-activated chloride currents in diverse physiological processes...
  7. ncbi TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1
    Sangsung Kim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 26:2403-12. 2006
    ..We therefore conclude that FAF1 forms an integral component of the vanilloid receptor complex and that it constitutively modulates the sensitivity of TRPV1 to various noxious stimuli in sensory neurons...
  8. ncbi Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation
    Ju Hwan Park
    National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Int J Pharm 441:562-9. 2013
    ....
  9. ncbi An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction
    Won Sik Shim
    National Research Laboratory for Transporters Targeted Drug Design and Research Institute of Pharmaceutical Sciences and Department of Pharmaceutics, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Ethnopharmacol 132:328-33. 2010
    ..An aqueous extract of PF (PF-W) has particularly potent gastroprokinetic effects, but its molecular mechanism was not well understood. Identification of the underlying prokinetic mechanism of PF-W was pursued in the present study...
  10. ncbi Liver cancer targeting of Doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats
    Ji Eun Chang
    National Research Laboratory for Transporters Targeted Drug Design Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, 151 742, South Korea
    Pharm Res 29:795-805. 2012
    ..To evaluate the usefulness of hematoporphyrin (HP)-modification of the surface of doxorubicin (DOX)-loaded bovine serum albumin (BSA) nanoparticles (NPs) in the liver cancer-selective delivery of DOX...
  11. ncbi Decreased secretory transport of a quarternary ammonium, TBuMA, across LLC-PK1 cells by the anionic kidney extract
    Won Sik Shim
    Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Arch Pharm Res 31:671-7. 2008
    ..Regardless of underlying mechanisms, it is notable that OA components of liver and kidney extracts influence the APC and secretory transport of QAs with Mw >200...
  12. ncbi Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons
    Byung Moon Kim
    Sensory Research Center, National Creative Research Initiatives, College of Pharmacy, Seoul National University, San 56 1, Shinlim, Kwanak gu, Seoul 151 742, South Korea
    Neurosci Lett 361:159-62. 2004
    ..We thus conclude that histamine activates TRPV1 after stimulating the PLA(2)/LO pathway, leading to the excitation of sensory neurons. These results further provide an idea for potential use of TRPV1 antagonists as anti-itch drugs...