Won Sik Shim

Summary

Affiliation: College of Medicine
Country: Korea

Publications

  1. pmc Histamine-induced itch and its relationship with pain
    Won Sik Shim
    National Research Laboratory of Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Mol Pain 4:29. 2008
  2. doi request reprint An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction
    Won Sik Shim
    National Research Laboratory for Transporters Targeted Drug Design and Research Institute of Pharmaceutical Sciences and Department of Pharmaceutics, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Ethnopharmacol 132:328-33. 2010
  3. ncbi request reprint TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    Won Sik Shim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 27:2331-7. 2007
  4. doi request reprint Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure
    Han Joo Maeng
    College of Pharmacy, Inje University, Gyeongnam, 621 749, Korea
    Arch Pharm Res 35:1441-8. 2012
  5. doi request reprint Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
    Eun Young Kwak
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 42:603-13. 2012
  6. ncbi request reprint TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1
    Sangsung Kim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 26:2403-12. 2006
  7. doi request reprint Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug
    Hyo Eon Jin
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 43:355-67. 2013
  8. doi request reprint TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
  9. doi request reprint Liver cancer targeting of Doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats
    Ji Eun Chang
    National Research Laboratory for Transporters Targeted Drug Design Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, 151 742, South Korea
    Pharm Res 29:795-805. 2012
  10. doi request reprint Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation
    Ju Hwan Park
    National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Int J Pharm 441:562-9. 2013

Collaborators

  • Saeho Chong
  • Hong Li
  • Su Geun Yang
  • Sun Wook Hwang
  • Dae Duk Kim
  • Chang Koo Shim
  • Suk Jae Chung
  • Uhtaek Oh
  • Hyo Eon Jin
  • Eun Young Kwak
  • Ji Eun Chang
  • Byung Moon Kim
  • Young Duk Yang
  • Yongwoo Jang
  • Ju Hwan Park
  • Han Joo Maeng
  • Hawon Cho
  • Sangsung Kim
  • Jungeun Oh
  • Sang Bum Kim
  • Su Won Kim
  • Boran Song
  • Gyu Sang Hong
  • Eun Kyoung Seo
  • Sang Soo Yu
  • Sun Joo Ahn
  • Young Ki Shin
  • Seung Pyo Park
  • Jae Yeon Koo
  • Byeongjun Lee
  • Min Ho Tak
  • Ramin Raouf
  • Jesun Lee
  • Yeongyo Cho
  • Min Young Park
  • Chan Young Shin
  • Youngki Shin
  • Misook Kim
  • Eunhee Kim
  • Changjoong Kang
  • Sang Hee Lee

Detail Information

Publications15

  1. pmc Histamine-induced itch and its relationship with pain
    Won Sik Shim
    National Research Laboratory of Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Mol Pain 4:29. 2008
    ..In this review, we discuss the molecular mechanism and the pharmacological aspects of histamine-induced itch. Especially, the underlying mechanism of TRPV1 (an anti-pruritus target) has been determined to some extent...
  2. doi request reprint An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction
    Won Sik Shim
    National Research Laboratory for Transporters Targeted Drug Design and Research Institute of Pharmaceutical Sciences and Department of Pharmaceutics, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Ethnopharmacol 132:328-33. 2010
    ..An aqueous extract of PF (PF-W) has particularly potent gastroprokinetic effects, but its molecular mechanism was not well understood. Identification of the underlying prokinetic mechanism of PF-W was pursued in the present study...
  3. ncbi request reprint TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase
    Won Sik Shim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 27:2331-7. 2007
    ..Together, these results indicate that TRPV1 plays a key role in mediating the pruritogenic action of histamine via the PLA2/LO pathway...
  4. doi request reprint Differential changes in functional activity of organic cation transporters in rats with uranyl nitrate-induced acute renal failure
    Han Joo Maeng
    College of Pharmacy, Inje University, Gyeongnam, 621 749, Korea
    Arch Pharm Res 35:1441-8. 2012
    ....
  5. doi request reprint Enhanced intracellular accumulation of a non-nucleoside anti-cancer agent via increased uptake of its valine ester prodrug through amino acid transporters
    Eun Young Kwak
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 42:603-13. 2012
    ..The results of the present study make a compelling argument in favour of a prodrug concept that can improve intracellular accumulation and take advantage of amino acid transporters without significantly inducing multiple-drug resistance...
  6. ncbi request reprint TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1
    Sangsung Kim
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Neurosci 26:2403-12. 2006
    ..We therefore conclude that FAF1 forms an integral component of the vanilloid receptor complex and that it constitutively modulates the sensitivity of TRPV1 to various noxious stimuli in sensory neurons...
  7. doi request reprint Transport of gemifloxacin, a 4th generation quinolone antibiotic, in the Caco-2 and engineered MDCKII cells, and potential involvement of efflux transporters in the intestinal absorption of the drug
    Hyo Eon Jin
    National Research Laboratory for Transporters Targeted Drug Design, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
    Xenobiotica 43:355-67. 2013
    ..6. Efflux transporters appeared to significantly limit the bioavailability of gemifloxacin in rats, suggesting their possible contribution to the low bioavailability of the drug in the human (70%)...
  8. doi request reprint TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Young Duk Yang
    Sensory Research Center, CRI, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Nature 455:1210-5. 2008
    ..We conclude that ANO1 is a candidate Ca(2+)-activated chloride channel that mediates receptor-activated chloride currents in diverse physiological processes...
  9. doi request reprint Liver cancer targeting of Doxorubicin with reduced distribution to the heart using hematoporphyrin-modified albumin nanoparticles in rats
    Ji Eun Chang
    National Research Laboratory for Transporters Targeted Drug Design Research Institute of Pharmaceutical Sciences College of Pharmacy, Seoul National University, Seoul, 151 742, South Korea
    Pharm Res 29:795-805. 2012
    ..To evaluate the usefulness of hematoporphyrin (HP)-modification of the surface of doxorubicin (DOX)-loaded bovine serum albumin (BSA) nanoparticles (NPs) in the liver cancer-selective delivery of DOX...
  10. doi request reprint Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation
    Ju Hwan Park
    National Research Laboratory of Transporters Targeted Drug Design, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Int J Pharm 441:562-9. 2013
    ....
  11. doi request reprint Ghrelin receptor is activated by naringin and naringenin, constituents of a prokinetic agent Poncirus fructus
    Yongwoo Jang
    College of Pharmacy, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Ethnopharmacol 148:459-65. 2013
    ..Poncirus fructus (PF), also known as a dried immature fruit of Poncirus trifoliata (L.) Raf. (Rutaceae), has long been traditionally used for the various gastrointestinal disorders in Eastern Asia...
  12. doi request reprint An improved prediction of the human in vivo intestinal permeability and BCS class of drugs using the in vitro permeability ratio obtained for rat intestine using an Ussing chamber system
    Hong Li
    College of Pharmacy, Seoul National University, Seoul, Korea
    Drug Dev Ind Pharm 39:1515-22. 2013
    ..The results indicate that PR is a reliable factor with high correlation to human in vivo intestinal permeability, which can further be used to accurately predict the BCS classification. ..
  13. doi request reprint Long-term administration of an aqueous extract of dried, immature fruit of Poncirus trifoliata (L.) Raf. suppresses body weight gain in rats
    Won Sik Shim
    National Research Laboratory for Transporters Targeted Drug Design and Research Institute of Pharmaceutical Sciences, Department of Pharmaceutics, College of Pharmacy, Seoul National University, Gwanak Gu, Seoul 151 742, Republic of Korea
    J Ethnopharmacol 126:294-9. 2009
    ..The purpose of the present study was to examine the effects of daily administration of an aqueous extract of the dried, immature fruit of Poncirus trifoliata Raf. (Rutaceae) (PF-W) on body weight in rats...
  14. doi request reprint Decreased secretory transport of a quarternary ammonium, TBuMA, across LLC-PK1 cells by the anionic kidney extract
    Won Sik Shim
    Department of Pharmaceutics, College of Pharmacy, Seoul National University, Seoul, 151 742, Korea
    Arch Pharm Res 31:671-7. 2008
    ..Regardless of underlying mechanisms, it is notable that OA components of liver and kidney extracts influence the APC and secretory transport of QAs with Mw >200...
  15. ncbi request reprint Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons
    Byung Moon Kim
    Sensory Research Center, National Creative Research Initiatives, College of Pharmacy, Seoul National University, San 56 1, Shinlim, Kwanak gu, Seoul 151 742, South Korea
    Neurosci Lett 361:159-62. 2004
    ..We thus conclude that histamine activates TRPV1 after stimulating the PLA(2)/LO pathway, leading to the excitation of sensory neurons. These results further provide an idea for potential use of TRPV1 antagonists as anti-itch drugs...