Cheol Whee Park
Affiliation: College of Medicine
Hwang S, Song J, Kim Y, Lim J, Kim M, Kim E, et al
. Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice. Cell Death Dis. 2019;10:219 pubmed publisher
Chung S, Kim S, Son M, Kim M, Koh E, Shin S, et al
. Inhibition of p300/CBP-Associated Factor Attenuates Renal Tubulointerstitial Fibrosis through Modulation of NF-kB and Nrf2. Int J Mol Sci. 2019;20: pubmed publisher
..These results suggest that the inhibition of inordinately enhanced PCAF could mitigate renal fibrosis by redressing aberrant balance between inflammatory signaling and antioxidant response through the modulation of NF-κB and Nrf2. ..
Kim Y, Park C. Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease. Int J Mol Sci. 2019;20: pubmed publisher
..Its renoprotective role against lipotoxicity and oxidative stress by enhancing the AMPK/PPARα pathway and ceramidase activity through AdipoRs is revealed here. ..
Kim Y, Hwang S, Lim J, Kim M, Kim E, Choi B, et al
. Attenuated Lymphatic Proliferation Ameliorates Diabetic Nephropathy and High-Fat Diet-Induced Renal Lipotoxicity. Sci Rep. 2019;9:1994 pubmed publisher
Chung Y, Lim J, Oh H, Kim H, Kim M, Kim E, et al
. Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy. Cell Death Dis. 2018;9:1163 pubmed publisher
..Therefore, cinacalcet may play an important role in the restoration and amelioration of DPN by ameliorating apoptosis and improving autophagy. ..
Koh E, Lim J, Kim M, Chung S, Shin S, Choi B, et al
. Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice. J Transl Med. 2015;13:203 pubmed publisher
Park H, Lim J, Kim M, Kim Y, Hong Y, Choi S, et al
. Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy. J Transl Med. 2016;14:176 pubmed publisher
..These results suggest that resveratrol prevents diabetic nephropathy by ameliorating lipotoxicity, oxidative stress, apoptosis and endothelial dysfunction via increasing AdipoR1 and AdipoR2 expression. ..
Kim Y, Lim J, Kim M, Kim E, Yoon H, Shin S, et al
. The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes. J Am Soc Nephrol. 2018;29:1108-1127 pubmed publisher
..Our results show that AdipoRon ameliorates GEC and podocyte injury by activating the intracellular Ca2+/LKB1-AMPK/PPARα pathway, suggesting its efficacy for treating type 2 diabetes-associated DN. ..
Lim J, Kim H, Kim M, Kim T, Kim E, Kim Y, et al
. Cinacalcet-mediated activation of the CaMKKÎ²-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy. Cell Death Dis. 2018;9:270 pubmed publisher