Affiliation: College of Medicine
Yeo S, Lee K, Shin D, An S, Cho K, Kim S. A positive feedback loop bi-stably activates fibroblasts. Nat Commun. 2018;9:3016 pubmed publisher
..Considering that this PFL is specific to activated fibroblasts, Twist1-Prrx1-TNC PFL may be a fibroblast-specific therapeutic target to deprogram perpetually activated fibroblasts. ..
Song I, Kim K, Lim S, Kim S, Sung C. Expression and prognostic significance of epithelial-mesenchymal transition-related markers and phenotype in serous ovarian cancer. Pathol Res Pract. 2018;214:1564-1571 pubmed publisher
..EMT related transition factor expression like SLUG is more important in association with clinical outcome than EMT phenotype itself in HGSC. ..
Lee K, Yeo S, Sung C, Kim S. Twist1 is a key regulator of cancer-associated fibroblasts. Cancer Res. 2015;75:73-85 pubmed publisher
..Our findings define Twist1 as a compelling target to deprogram the tumor-supporting features of the cancer microenvironment. ..
Lee H, Lee E, Yeo S, Shin S, Park H, Nam D, et al
. Drug repurposing screening identifies bortezomib and panobinostat as drugs targeting cancer associated fibroblasts (CAFs) by synergistic induction of apoptosis. Invest New Drugs. 2018;36:545-560 pubmed publisher
..Therefore, a combination therapy with BTZ/PST and anticancer drugs might be considered as a new rational for the development of anticancer therapy. ..
Lee K, Lee N, Ham S, Roh T, Kim S. Twist1 is essential in maintaining mesenchymal state and tumor-initiating properties in synovial sarcoma. Cancer Lett. 2014;343:62-73 pubmed publisher
..Hence, our results suggest that Twist1 is an essential transcription factor for the maintenance of mesenchymal characters and tumor initiating properties of synovial sarcoma. ..
Yang Z, Cui Y, Ni W, Kim S, Xuan Y. Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma. J Cancer Res Clin Oncol. 2017;143:243-254 pubmed publisher
..Targeting Gli1, a potential diagnostic marker of ESCC stem cells, will have a profound therapeutic and prognostic value. ..