Minho Shong

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. doi request reprint Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines.
    Seong Eun Lee
    Diabetes 66:2774-2788. 2017
  2. pmc Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice
    Min Jeong Ryu
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Korea
    PLoS Genet 9:e1003356. 2013
  3. pmc Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma
    Seong Jin Lee
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea
    PLoS ONE 6:e16180. 2011
  4. pmc Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice
    Jung Hwan Hwang
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
    Diabetes 58:965-74. 2009
  5. pmc Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, 640 Daesa dong, Jung Gu, Daejeon, Korea
    J Korean Med Sci 23:262-9. 2008
  6. pmc Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC
    Young Rae Kim
    Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, 301 131, South Korea
    BMC Cancer 8:144. 2008
  7. ncbi request reprint Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: involvement of STAT3 and suppressor of cytokine signaling
    Ho Kim
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejon, Korea
    J Immunol 171:616-27. 2003
  8. ncbi request reprint RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1
    Dong Wook Kim
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Daejon, Korea
    Mol Endocrinol 17:1382-94. 2003
  9. ncbi request reprint Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases
    Hye Sook Jung
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Chungnam National University School of Medicine, 640 Daesadong Chungku, Daejeon 301 721, Korea
    Mol Endocrinol 19:2748-59. 2005
  10. doi request reprint Mitochondrial localization and regulation of BRAFV600E in thyroid cancer: a clinically used RAF inhibitor is unable to block the mitochondrial activities of BRAFV600E
    Min Hee Lee
    Department of Internal Medicine, Division of Endocrinology, Chungnam National University School of Medicine, Jung Gu, Daejeon, Korea
    J Clin Endocrinol Metab 96:E19-30. 2011

Collaborators

Detail Information

Publications35

  1. doi request reprint Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines.
    Seong Eun Lee
    Diabetes 66:2774-2788. 2017
    ..Thus, beneficial effects of Th2 cytokines on systemic glucose metabolism and insulin sensitivity are mediated by GDF15. These findings open up a potential pharmacological route for reversing insulin resistance associated with obesity...
  2. pmc Crif1 deficiency reduces adipose OXPHOS capacity and triggers inflammation and insulin resistance in mice
    Min Jeong Ryu
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Korea
    PLoS Genet 9:e1003356. 2013
    ..These findings indicate that the OXPHOS status of adipose tissue determines its metabolic and inflammatory responses, and may cause systemic inflammation and insulin resistance...
  3. pmc Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma
    Seong Jin Lee
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea
    PLoS ONE 6:e16180. 2011
    ....
  4. pmc Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice
    Jung Hwan Hwang
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
    Diabetes 58:965-74. 2009
    ..We tried to determine whether pharmacological stimulation of NADH oxidation provides therapeutic effects in rodent models of metabolic syndrome...
  5. pmc Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, 640 Daesa dong, Jung Gu, Daejeon, Korea
    J Korean Med Sci 23:262-9. 2008
    ..Thus, in summary, we found that TSH regulates Id2 expression, but that Id2 does not alter the expression of thyroid-specific genes, such as Tg, in FRTL-5 thyroid cells...
  6. pmc Modulatory role of phospholipase D in the activation of signal transducer and activator of transcription (STAT)-3 by thyroid oncogenic kinase RET/PTC
    Young Rae Kim
    Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, 301 131, South Korea
    BMC Cancer 8:144. 2008
    ..Based on the observation of high levels of PLD expression in human papillary thyroid cancer tissues, we investigated whether PLD plays a role in the regulating the RET/PTC-induced STAT3 activation...
  7. ncbi request reprint Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: involvement of STAT3 and suppressor of cytokine signaling
    Ho Kim
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejon, Korea
    J Immunol 171:616-27. 2003
    ..This report suggests that TSH is also engaged in immunomodulation through signal cross-talk with the cytokines in thyroid cells...
  8. ncbi request reprint RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1
    Dong Wook Kim
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Daejon, Korea
    Mol Endocrinol 17:1382-94. 2003
    ..In conclusion, RET/PTC-induced tyrosine phosphorylation of PDK1 may be one of the mechanisms by which it acts as an oncogenic tyrosine kinase in thyroid carcinogenesis...
  9. ncbi request reprint Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases
    Hye Sook Jung
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Chungnam National University School of Medicine, 640 Daesadong Chungku, Daejeon 301 721, Korea
    Mol Endocrinol 19:2748-59. 2005
    ..In summary, these observations suggest that RET/PTC is able to phosphorylate the Y315 residue of PKB, an event that results in maximal activation of PKB for RET/PTC-induced thyroid tumorigenesis...
  10. doi request reprint Mitochondrial localization and regulation of BRAFV600E in thyroid cancer: a clinically used RAF inhibitor is unable to block the mitochondrial activities of BRAFV600E
    Min Hee Lee
    Department of Internal Medicine, Division of Endocrinology, Chungnam National University School of Medicine, Jung Gu, Daejeon, Korea
    J Clin Endocrinol Metab 96:E19-30. 2011
    ..The oncogenic BRAF(V600E) mutation results in an active structural conformation characterized by greatly elevated ERK activity. However, additional cellular effects caused by subcellular action of BRAF(V600E) remain to be identified...
  11. ncbi request reprint Significance of the expression of major histocompatibility complex class II antigen, HLA-DR and -DQ, with recurrence of papillary thyroid cancer
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea
    Int J Cancer 122:785-90. 2008
    ..59 and 6.07, p = 0.03 and 0.01, respectively). In conclusion, PTC frequently expresses MHC Class II antigen, and the expression of MHC Class II antigen correlated inversely with the risk of recurrence of PTC...
  12. ncbi request reprint Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC)
    Dong Wook Kim
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Department of Pathology, Chungnam National University School of Medicine, Daejeon 301 721, Korea
    Mol Endocrinol 21:3039-49. 2007
    ..Thus, this study suggests that LKB1 suppresses tumor growth by inhibiting RET/PTC-dependent activation of oncogenic STAT3...
  13. ncbi request reprint Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland
    Jae Mi Suh
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University School of Medicine, 640 Daesadong Chungku, Taejon 301 040, Korea
    J Biol Chem 278:21960-71. 2003
    ..This pathway may play a role in the TSH/stimulating type TSH receptor antibody-mediated thyrocyte proliferation in vitro and in the response to TSH in vivo...
  14. ncbi request reprint CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation
    Ki Cheol Park
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University College of Medicine, 640 Daesadong Chungku Daejeon 301 721, Korea
    Mol Endocrinol 19:12-24. 2005
    ..These results suggest that CRIF1 acts as a repressor of the orphan nuclear receptor Nur77 by inhibiting AB domain-mediated transcriptional activity...
  15. ncbi request reprint An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases
    Dong Wook Kim
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University School of Medicine, 640 Daesadong Chungku, Daejon 301 721, Korea
    J Clin Endocrinol Metab 91:4070-6. 2006
    ..The oncogenic RET/PTC tyrosine kinase causes papillary thyroid cancer (PTC). The use of inhibitors specific for RET/PTC may be useful for targeted therapy of PTC...
  16. ncbi request reprint Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation
    Jung Hwan Hwang
    Laboratory of Endocrine Cell Biology, Department of Internal Medicine, Chungnam National University College of Medicine, 640 Daesadong Chungku, Daejeon 301 721, Korea
    Mol Endocrinol 17:1155-66. 2003
    ....
  17. doi request reprint CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane
    Soung Jung Kim
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301 721, Korea
    Cell Metab 16:274-83. 2012
    ..g., Tid1. Taken together, these results suggest that CRIF1 plays a critical role in the integration of OXPHOS polypeptides into the mitochondrial membrane in mammals...
  18. pmc Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPARγ agonist-induced adipogenesis
    Min Jeong Ryu
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, Korea
    Mol Cells 35:134-41. 2013
    ..Rosiglitazone treatment did not induce adipogenesis or mitochondria biogenesis in Crif1 knockout ADSCs. These results show that mitochondrial OXPHOS and Crif1 are required for rosiglitazone- and hormone-induced adipogenesis...
  19. doi request reprint Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity
    Yong Hoon Kim
    Animal Model Center, Korea Research Institute of Bioscience and Biotechnology, 111 Gwahangno, Yuseong Gu, Daejeon, Republic of Korea
    Cardiovasc Res 91:519-27. 2011
    ..In this study, we evaluated whether βL-induced activation of NQO1 modulates BP in an animal model of hypertension...
  20. ncbi request reprint Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells
    Hyo Kyun Chung
    Department of Internal Medicine, School of Medicine, Chungnam National University, Daejon 301 721, Korea
    Exp Mol Med 34:451-61. 2002
    ..TNF-alpha does not induce phosphorylation of ERK1/ERK2 and S727 in ECV304 and smooth muscle cells. The results provide the evidences that statins may have beneficial effects by inhibiting IFN-gamma action in atherosclerotic process..
  21. doi request reprint Aberrant l1 cell adhesion molecule affects tumor behavior and chemosensitivity in anaplastic thyroid carcinoma
    Koon Soon Kim
    Research Center for Endocrinology and Metabolic Diseases, Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea
    Clin Cancer Res 18:3071-8. 2012
    ..Molecular targets of ATC that determine its highly aggressive nature remain unidentified. This study investigated L1 cell adhesion molecule (L1CAM) expression and its role in tumorigenesis of ATCs...
  22. ncbi request reprint Predictive value of the preablation serum thyroglobulin level after thyroidectomy is combined with postablation 131I whole body scintigraphy for successful ablation in patients with differentiated thyroid carcinoma
    Hyo Jin Lee
    Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea
    Am J Clin Oncol 30:63-8. 2007
    ....
  23. doi request reprint Diagnostic value of pyrosequencing for the BRAF V600E mutation in ultrasound-guided fine-needle aspiration biopsy samples of thyroid incidentalomas
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Eulji University, College of Medicine, Daejeon, Korea
    Clin Endocrinol (Oxf) 70:139-44. 2009
    ..Pyrosequencing, which measures the incorporation of each of the four nucleotides at each template position and indicates the amounts of mutant template present, may be more useful in such situations...
  24. doi request reprint Pyrosequencing cut-off value identifying BRAFV600E mutation in fine needle aspiration samples of thyroid nodules
    Min Kyung Yeo
    Department of Pathology, Chungnam National University School of Medicine, Daejeon, South Korea
    Clin Endocrinol (Oxf) 75:555-60. 2011
    ..However, newly developed quantitative and semi-quantitative methods, such as dual-priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR), have the potential to generate false-positive (FP) results...
  25. pmc An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice
    Ji Hoon Park
    Department of Biochemistry, School of Medicine, Chungnam National University, Daejeon, Korea
    Antioxid Redox Signal 18:1713-22. 2013
    ..Here, we show that the indole-derived synthetic compound has a protective effect against APAP-induced liver injury in C57Bl/6 mice model...
  26. pmc DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly
    Jun Young Heo
    Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, Korea
    PLoS ONE 7:e32629. 2012
    ..These mitochondrial defects induced by DJ-1mutation may be a pathological mechanism for the degeneration of dopaminergic neurons in Parkinson's disease...
  27. ncbi request reprint CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells
    Jung Hwan Hwang
    Laboratory of Endocrine Cell Biology, National Research Laboratory Program, Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea
    J Clin Endocrinol Metab 88:408-16. 2003
    ..These findings suggest that a subset of ATC cells expresses functional CXCR4, which may be important in tumor cell migration and local tumor invasion...
  28. pmc Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes
    Hye Mi Lee
    Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, South Korea
    Diabetes 62:194-204. 2013
    ....
  29. ncbi request reprint Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer
    Young Suk Jo
    Division of Endocrinology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 301 721, Korea
    J Clin Endocrinol Metab 91:3667-70. 2006
    ..The BRAF mutation may influence the expression patterns of molecular markers that are related to the development and progression of thyroid cancer...
  30. doi request reprint DJ-1 mediates paraquat-induced dopaminergic neuronal cell death
    Hyun Joo Kwon
    Department of Biochemistry, School of Medicine, Chungnam National University, Daejeon, South Korea
    Toxicol Lett 202:85-92. 2011
    ..In summary, our results suggest that DJ-1 is critical to maintain mitochondrial complex I and complex I could be a key target in interaction of paraquat toxicity and DJ-1 for giving rise to PD...
  31. pmc Bone mineral density in prediabetic men
    Ju Hee Lee
    Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
    Korean Diabetes J 34:294-302. 2010
    ..There are many studies regarding the effects of insulin on bone metabolism and changes in bone mineral density (BMD) in the setting of diabetes. The effect of prediabetes on BMD is not known...
  32. doi request reprint IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter
    Sangmi Ock
    2Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung Ang University, 224 1 Heuk Seok dong, Dongjak ku Seoul 156 755, Korea
    FASEB J 27:4899-908. 2013
    ..0 and 5.4-fold, respectively), but in TIGF1RKO mice, goiter development was completely abrogated. These data reveal an essential role for IGF-1 receptor signaling in the regulation of thyroid function and TSH-stimulated goitrogenesis...
  33. pmc Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data
    Won Gu Kim
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Korean J Intern Med 29:325-33. 2014
    ..In this study we evaluated the clinical behavior, prognostic factors and treatment outcomes of FTC and HCC in Korea...
  34. pmc CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation
    Harsha Nagar
    Department of Physiology, School of Medicine, Chungnam National University, Daejeon, Republic of Korea
    PLoS ONE 9:e98670. 2014
    ..Taken together, these results suggest that CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc. ..