Affiliation: Chungnam National University
Lee S, Kang S, Choi M, Jung S, Ryu M, Chung H, et al
. Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines. Diabetes. 2017;66:2774-2788 pubmed publisher
..Thus, beneficial effects of Th2 cytokines on systemic glucose metabolism and insulin sensitivity are mediated by GDF15. These findings open up a potential pharmacological route for reversing insulin resistance associated with obesity. ..
Jang J, Choi S, Park I, Park D, Choe K, Kim P, et al
. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med. 2017;9:750-769 pubmed publisher
..Collectively, these findings establish follicular VEGF-A-vascular VEGFR2 axis as a main regulator for thyrotropin-dependent thyroid angiofollicular remodeling and goitrogenesis. ..
Lee J, Ham S, Lee M, Kim S, Park J, Lee S, et al
. Dysregulation of Parkin-mediated mitophagy in thyroid HÃ¼rthle cell tumors. Carcinogenesis. 2015;36:1407-18 pubmed publisher
Lee J, Chang J, Kang Y, Yi S, Lee M, Joung K, et al
. Mitochondrial Energy Metabolism and Thyroid Cancers. Endocrinol Metab (Seoul). 2015;30:117-23 pubmed publisher
..Determining the molecular nature of metabolic remodeling in thyroid cancer may provide new biomarkers and therapeutic targets that may be useful in the management of refractory thyroid cancers. ..
Cho B, Yoo S, Song Y, Kim S, Lee K, Shong M, et al
. Transcriptome network analysis reveals aging-related mitochondrial and proteasomal dysfunction and immune activation in human thyroid. Thyroid. 2018;: pubmed publisher
..Our results provide clues to better understanding of aging-related decline in thyroid function and higher susceptibility to autoimmune thyroid disease. ..
Jung S, Choi M, Ryu D, Yi H, Lee S, Chang J, et al
. Reduced oxidative capacity in macrophages results in systemic insulin resistance. Nat Commun. 2018;9:1551 pubmed publisher
..Thus, reduced macrophage oxidative function controls systemic insulin resistance and adipose inflammation, which can be reversed with GDF15 and leads to improved oxidative function of macrophages. ..
Lee J, Yi S, Won M, Song Y, Yi H, Park Y, et al
. Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer. Oncogene. 2018;37:4455-4474 pubmed publisher
..However, LOF of IFT88/primary cilia did not promote thyroid cancer cell proliferation, migration, and invasion. The results suggest that IFT88/primary cilia play a role in metabolic reprogramming in thyroid cancer cells. ..
Yi H, Chang J, Shong M. The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases. J Mol Endocrinol. 2018;: pubmed publisher
Chang J, Yi H, Kim H, Shong M. Dysregulation of mitophagy in carcinogenesis and tumor progression. Biochim Biophys Acta Bioenerg. 2017;1858:633-640 pubmed publisher
..This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. ..