Sang Heui Seo

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. pmc H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
    Young Myong Kang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea
    Vet Res 44:92. 2013
  2. pmc Induction of inflammatory cytokines and Toll-like receptors in chickens infected with avian H9N2 influenza virus
    Nguyen Tai Nang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, 305 764, Korea
    Vet Res 42:64. 2011
  3. ncbi request reprint No apoptotic deaths and different levels of inductions of inflammatory cytokines in alveolar macrophages infected with influenza viruses
    Sang Heui Seo
    Laboratory of Immunology, Division of Preventive Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, South Korea
    Virology 329:270-9. 2004
  4. doi request reprint The severe pathogenicity of alveolar macrophage-depleted ferrets infected with 2009 pandemic H1N1 influenza virus
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea
    Virology 444:394-403. 2013
  5. doi request reprint Live attenuated H5N1 vaccine with H9N2 internal genes protects chickens from infections by both highly pathogenic H5N1 and H9N2 influenza viruses
    Nguyen Tai Nang
    Laboratory of Influenza Research Institute for Influenza Virus Laboratory of Public Health, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon, Korea
    Influenza Other Respir Viruses 7:120-31. 2013
  6. doi request reprint Transmissibility of novel H7N9 and H9N2 avian influenza viruses between chickens and ferrets
    Keun Bon Ku
    Laboratory of Influenza Research, Chungnam National University, College of Veterinary Medicine, 220 Gung Dong, Daejeon 305 764, Republic of Korea Institute for Influenza Virus, Chungnam National University, College of Veterinary Medicine, 220 Gung Dong, Daejeon 305 764, Republic of Korea
    Virology 450:316-23. 2014
  7. doi request reprint IgG antibodies mediate protective immunity of inactivated vaccine for highly pathogenic H5N1 influenza viruses in ferrets
    Jin Soo Shin
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon, Korea
    Viral Immunol 23:321-7. 2010
  8. doi request reprint Severe pathogenesis of influenza B virus in pregnant mice
    Jeong Cheol Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea Institute for Influenza Virus, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea
    Virology 448:74-81. 2014
  9. doi request reprint Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferrets
    Young Myong Kang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Gung Dong, Yuseong Gu, Daejeon, Korea
    Arch Virol 156:759-67. 2011
  10. ncbi request reprint Genetic and antigenic characterization of swine H1N2 influenza viruses isolated from Korean pigs
    Su Kyoung Jo
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Korea
    J Microbiol Biotechnol 17:868-72. 2007

Collaborators

  • Sung Hwan Cho
  • Yi Guan
  • Robert G Webster
  • Richard John Webby
  • Hyun Soo Kim
  • Heui Man Kim
  • Young Myong Kang
  • Jung Yum
  • Keun Bon Ku
  • Eun Hye Park
  • Byung Min Song
  • Joo Sub Lee
  • Seon Do Hwang
  • Jin Soo Shin
  • In Hong Lee
  • Ji An Kim
  • Jeong Cheol Kim
  • Nguyen Tai Nang
  • Jin A Kim
  • Su Kyoung Jo
  • Yun Hee Kim
  • Seung Kyoo Oh
  • Sook Jung Kang
  • Jie Yeun Park
  • Young Ki Choi
  • Tran Bac Le
  • Gil Jae Cho
  • Yoo Kyung Kang
  • Seo Yeon Jin
  • Jung Hoon Oh
  • Nico Van Rooijen
  • Ki Ja Lee
  • Young Won Lee
  • Si Yun Ryu

Detail Information

Publications37

  1. pmc H3N2 canine influenza virus causes severe morbidity in dogs with induction of genes related to inflammation and apoptosis
    Young Myong Kang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea
    Vet Res 44:92. 2013
    ....
  2. pmc Induction of inflammatory cytokines and Toll-like receptors in chickens infected with avian H9N2 influenza virus
    Nguyen Tai Nang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, 305 764, Korea
    Vet Res 42:64. 2011
    ..In the lung, TLR-15 was dominantly induced. Taken together, it seems that H9N2 infections efficiently induce inflammatory cytokines and TLRs in trachea, lung and intestine of chickens...
  3. ncbi request reprint No apoptotic deaths and different levels of inductions of inflammatory cytokines in alveolar macrophages infected with influenza viruses
    Sang Heui Seo
    Laboratory of Immunology, Division of Preventive Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, South Korea
    Virology 329:270-9. 2004
    ..Markedly elevated expression of tumor necrosis factor alpha may be responsible for the high mortality rate caused by H3N2 influenza virus infection in elderly patients...
  4. doi request reprint The severe pathogenicity of alveolar macrophage-depleted ferrets infected with 2009 pandemic H1N1 influenza virus
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea
    Virology 444:394-403. 2013
    ..Our study implies that alveolar macrophages are important for controlling the infections of 2009 pandemic H1N1 influenza virus. ..
  5. doi request reprint Live attenuated H5N1 vaccine with H9N2 internal genes protects chickens from infections by both highly pathogenic H5N1 and H9N2 influenza viruses
    Nguyen Tai Nang
    Laboratory of Influenza Research Institute for Influenza Virus Laboratory of Public Health, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon, Korea
    Influenza Other Respir Viruses 7:120-31. 2013
    ..Objectives  We aimed to study whether a live attenuated H5N1 vaccine comprising internal genes from a cold-adapted H9N2 influenza virus could protect chickens from infection by both H5N1 and H9N2 viruses...
  6. doi request reprint Transmissibility of novel H7N9 and H9N2 avian influenza viruses between chickens and ferrets
    Keun Bon Ku
    Laboratory of Influenza Research, Chungnam National University, College of Veterinary Medicine, 220 Gung Dong, Daejeon 305 764, Republic of Korea Institute for Influenza Virus, Chungnam National University, College of Veterinary Medicine, 220 Gung Dong, Daejeon 305 764, Republic of Korea
    Virology 450:316-23. 2014
    ..Taken together, our results suggest that chickens may be a poor agent of transmission for the H7N9 virus to other chickens and to mammals, including humans. ..
  7. doi request reprint IgG antibodies mediate protective immunity of inactivated vaccine for highly pathogenic H5N1 influenza viruses in ferrets
    Jin Soo Shin
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon, Korea
    Viral Immunol 23:321-7. 2010
    ..Our results suggest that IgG antibodies may play a major role in protecting ferrets immunized with the inactivated H5N1 vaccine from lethal challenge with H5N1 influenza viruses...
  8. doi request reprint Severe pathogenesis of influenza B virus in pregnant mice
    Jeong Cheol Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea Institute for Influenza Virus, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea
    Virology 448:74-81. 2014
    ..Taken together, our results suggest that influenza B virus can cause severe disease during pregnancy, and that preventive measures including vaccination may be important for protecting women during pregnancy...
  9. doi request reprint Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferrets
    Young Myong Kang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Gung Dong, Yuseong Gu, Daejeon, Korea
    Arch Virol 156:759-67. 2011
    ..The data support the idea that increased pathogenesis caused by the 2009 pandemic H1N1 influenza virus may have been partially mediated by a higher induction of pro-inflammatory cytokines in the lungs of affected humans or animals...
  10. ncbi request reprint Genetic and antigenic characterization of swine H1N2 influenza viruses isolated from Korean pigs
    Su Kyoung Jo
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Korea
    J Microbiol Biotechnol 17:868-72. 2007
    ..Our results suggest that swine H1N2 viruses are widespread in Korean pigs, and the development of a vaccine against H1N2 viruses may help to control their infection in pigs...
  11. doi request reprint Influenza B virus causes milder pathogenesis and weaker inflammatory responses in ferrets than influenza A virus
    Yun Hee Kim
    Laboratory of Influenza Research, Chungnam National University, Daejeon, Korea 305 764
    Viral Immunol 22:423-30. 2009
    ..Taken together, our results suggest that the lower induction of inflammatory cytokines and lower viral titers in the lungs may be responsible for the milder clinical signs seen in ferrets or humans infected with influenza B virus...
  12. doi request reprint The 2009 pandemic H1N1 influenza virus is more pathogenic in pregnant mice than seasonal H1N1 influenza virus
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea
    Viral Immunol 25:402-10. 2012
    ....
  13. pmc Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Korea
    J Virol 82:4265-74. 2008
    ..Taken together, our findings suggest that alveolar macrophages are essential for controlling H1N1 influenza viruses in pigs...
  14. ncbi request reprint Pathogenesis and inflammatory responses of swine H1N2 influenza viruses in pigs
    Su Kyoung Jo
    Laboratory of Influenza Research, Institute of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon 305 764, South Korea
    Virus Res 129:64-70. 2007
    ..These results suggest that the pathogenesis induced in pigs by H1N2 influenza viruses may be induced by pro-inflammatory cytokines instead of anti-inflammatory cytokines...
  15. doi request reprint Single dose of oil-adjuvanted inactivated vaccine protects chickens from lethal infections of highly pathogenic H5N1 influenza virus
    Seon Do Hwang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon 305 764, Republic of Korea
    Vaccine 29:2178-86. 2011
    ..Taken together, our results suggest that one dose of oil-adjuvanted inactivated H5N1 vaccine could provide chickens with sterile immunity against the homologous highly pathogenic H5N1 influenza virus...
  16. doi request reprint Phylogenic analysis of reassorted avian influenza viruses isolated from Korean domestic ducks from 2005 to 2007
    Sook Jung Kang
    Laboratory of Influenza Research, Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, South Korea
    Virus Genes 38:80-4. 2009
    ..NP genes of two H3N2 isolates, A/Duck/Korea/S71/07, and A/Duck/Korea/S72/07 belonged to North American lineage. Our results suggest that the genetic reassortment among avian influenza viruses can occur in domestic ducks...
  17. doi request reprint Protection of pregnant mice, fetuses and neonates from lethality of H5N1 influenza viruses by maternal vaccination
    Seon Do Hwang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon 305 764, Republic of Korea
    Vaccine 28:2957-64. 2010
    ..Our results suggest that maternal vaccination may be critical for protecting pregnant animals, their fetuses, and their infant mice from lethal infections of H5N1 influenza viruses...
  18. doi request reprint Protection of ferrets from infection by swine-origin 2009 A (H1N1) influenza virus by the inactivated vaccine
    Jin Soo Shin
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon, Korea
    Viral Immunol 23:395-402. 2010
    ..IgG subtype of antibody was dominantly detected in tissues of immunized ferrets. Our study suggests that pandemic H1N1 vaccine may not elicit the antibody cross-reactive to the seasonal H1N1 influenza virus...
  19. pmc Protective efficacy of a single dose of baculovirus hemagglutinin-based vaccine in chickens and ducks against homologous and heterologous H5N1 virus infections
    Eun Hye Park
    1 Laboratory of Influenza Research, Chungnam National University, Daejeon, Republic of Korea
    Viral Immunol 27:449-62. 2014
    ..Also, baculovirus HA-vaccinated poultry can be differentiated from infected poultry by NA inhibition assay...
  20. doi request reprint Low infectivity of a novel avian-origin H7N9 influenza virus in pigs
    Jung Yum
    Laboratory of Influenza Research, College of Veterinary Medicine, Institute for Influenza Virus, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Republic of Korea
    Arch Virol 159:2745-9. 2014
    ..Taken together, our results suggest that pigs may not play an active role in transmitting H7N9 influenza virus to mammals...
  21. ncbi request reprint H9N2 influenza viruses isolated from poultry in Korean live bird markets continuously evolve and cause the severe clinical signs in layers
    Jin A Kim
    College of Veterinary Medicine, Chungnam National University, Yuseong Gu, Daejeon, South Korea
    Vet Microbiol 118:169-76. 2006
    ..Considering that H9N2 influenza virus is one of potential pandemic candidates, the continuous surveillance is needed to monitor avian H9N2 influenza viruses for the poultry industry and humans...
  22. doi request reprint Induction of inflammatory cytokines and toll-like receptors in human normal respiratory epithelial cells infected with seasonal H1N1, 2009 pandemic H1N1, seasonal H3N2, and highly pathogenic H5N1 influenza virus
    Byung Min Song
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea
    Viral Immunol 24:179-87. 2011
    ....
  23. doi request reprint Greater virulence of highly pathogenic H5N1 influenza virus in cats than in dogs
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Republic of Korea
    Arch Virol 160:305-13. 2015
    ..Our results suggest that the intensive monitoring of dogs is necessary to prevent human infection by H5N1 influenza virus, since infected dogs may not show clear clinical signs, in contrast to infected cats...
  24. doi request reprint Genetic characterization of avian influenza viruses isolated from waterfowl in southern part of South Korea in 2006
    Heui Man Kim
    Laboratory of Influenza Research, Institute of Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, South Korea
    Virus Genes 37:49-51. 2008
    ..Results suggest that the interregional transmission of genes of avian influenza viruses may occur in the migratory birds...
  25. doi request reprint H7N9 Influenza Virus Is More Virulent in Ferrets than 2009 Pandemic H1N1 Influenza Virus
    Jung Yum
    1 Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, Korea
    Viral Immunol 28:590-9. 2015
    ..This study suggests that close monitoring is needed to prevent human infection by the lethal H7N9 influenza virus. ..
  26. doi request reprint Genetic characterization and protective immunity of cold-adapted attenuated avian H9N2 influenza vaccine
    Joo Sub Lee
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon 305 764, Republic of Korea
    Vaccine 26:6569-76. 2008
    ..Our results suggest that cold-adapted attenuated H9N2 vaccine can be used for controlling the infection of H9N2 influenza viruses in chickens...
  27. doi request reprint Porcine mast cells infected with H1N1 influenza virus release histamine and inflammatory cytokines and chemokines
    In Hong Lee
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 99 Dae Hak Ro, Yuseong Gu, Daejeon, 305 764, Republic of Korea
    Arch Virol . 2017
    ..Our results suggest that mast cells could be involved in enhancing influenza-virus-mediated disease in infected animals...
  28. ncbi request reprint Cells in the respiratory and intestinal tracts of chickens have different proportions of both human and avian influenza virus receptors
    Jin A Kim
    College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea
    J Microbiol 43:366-9. 2005
    ..We have also determined that primarily cultured chicken lung cells can support the replication of both avian and human influenza viruses...
  29. ncbi request reprint Characterization of interaction between porcine reproductive and respiratory syndrome virus and porcine dendritic cells
    Jie Yeun Park
    Division of Preventive Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Korea
    J Microbiol Biotechnol 18:1709-16. 2008
    ..Therefore, these results suggest that PRRSV would appear to modulate the immune stimulatory function of porcine dendritic cells...
  30. doi request reprint Inactivated Antigen of the H7N9 Influenza Virus Protects Mice from Its Lethal Infection
    Sang Heui Seo
    1 Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Daejeon, Korea
    Viral Immunol 29:235-43. 2016
    ..Therefore, our results suggest that the inactivated whole antigen of the H7N9 influenza virus might protect animals and humans from its lethal infection. ..
  31. doi request reprint Isolation of a novel H3N2 influenza virus containing a gene of H9N2 avian influenza in a dog in South Korea in 2015
    In Hong Lee
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 99 Dae Hak Ro, Yuseong Gu, Daejeon, Republic of Korea
    Virus Genes 52:142-5. 2016
    ..These findings suggest that the continued surveillance of the influenza virus in dogs is warranted because humans have close contact with dogs, which may promote viral transmission. ..
  32. ncbi request reprint Lethal H5N1 influenza viruses escape host anti-viral cytokine responses
    Sang Heui Seo
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Med 8:950-4. 2002
    ..These effects required the presence of glutamic acid at position 92 of the NS1 molecule. These findings may explain the mechanism of the high virulence of H5N1 influenza viruses in humans...
  33. ncbi request reprint The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses
    Sang Heui Seo
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Virus Res 103:107-13. 2004
    ..These findings may explain the mechanism of the high virulence of H5N1 influenza viruses in humans and provide insight into the virulence of 1918 Spanish influenza...
  34. pmc Tumor necrosis factor alpha exerts powerful anti-influenza virus effects in lung epithelial cells
    Sang Heui Seo
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 76:1071-6. 2002
    ..These findings suggest that TNF-alpha serves as the first line of defense against influenza virus infection in the natural host...
  35. pmc Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8(+) T cells expressing gamma interferon
    Sang Heui Seo
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Virol 76:4886-90. 2002
    ..Our findings indicate that pulmonary cellular immunity may be very important in protecting naïve natural hosts against lethal influenza viruses...
  36. ncbi request reprint Avian influenza viruses in Korean live poultry markets and their pathogenic potential
    Young Ki Choi
    Division of Virology, Department of Infectious Diseases, Mail Stop 330, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis TN 38105 2794, USA
    Virology 332:529-37. 2005
    ..The H3N2 viruses replicated in chickens and mice without preadaptation, but the H6N1 virus did not. Our results show an increasingly diverse pool of avian influenza viruses in Korea that are potential pandemic influenza agents...