Minkyun Na


Affiliation: Chungnam National University
Country: Korea


  1. Park H, Jo E, Han J, Jung S, Lee D, Park I, et al. Hepatoprotective effects of an Acer tegmentosum Maxim extract through antioxidant activity and the regulation of autophagy. J Ethnopharmacol. 2019;:111912 pubmed publisher
    ..Therefore, these results indicate that the AT extract has a hepatoprotective effect by increasing antioxidant activity and inducing autophagy. ..
  2. Son H, Noh K, Park I, Na M, Oh S, Shin B, et al. Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats. Mar Drugs. 2019;17: pubmed publisher
    ..The stereo-specific behavior of the isomers appears to originate from differences in both their tissue distribution and gastrointestinal permeability. ..
  3. Park S, Yun E, Hwang I, Yoon S, Kim D, Kim J, et al. Ilimaquinone and ethylsmenoquinone, marine sponge metabolites, suppress the proliferation of multiple myeloma cells by down-regulating the level of β-catenin. Mar Drugs. 2014;12:3231-44 pubmed publisher
    ..These findings suggest that ilimaquinone and ethylsmenoquinone exert their anti-cancer activity by blocking the Wnt/β-catenin pathway and have significant potential as therapies for multiple myeloma. ..
  4. Byun H, Zhou W, Park I, Kang K, Lee S, Piao X, et al. C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells. Biochem Pharmacol. 2018;158:243-260 pubmed publisher
  5. Choi Y, Quan K, Park I, Lee S, Kang K, Na M, et al. Discovery of rubiarbonone C as a selective inhibitor of cytochrome P450 4F enzymes. Arch Toxicol. 2018;92:3325-3336 pubmed publisher
    ..Thus, rubiarbonone C is a selective inhibitor of CYP4F and can be used to discriminate among CYP4 family enzymes and evaluate their roles in physiological and pathophysiological conditions. ..
  6. Bajpai V, Park I, Lee J, Shukla S, Nile S, Chun H, et al. Antioxidant and antimicrobial efficacy of a biflavonoid, amentoflavone from Nandina domestica in vitro and in minced chicken meat and apple juice food models. Food Chem. 2019;271:239-247 pubmed publisher
    ..aureus and E. coli in minced chicken and apple juice at 4 °C, thus suggesting its nutritional enhancing efficacy as a natural antioxidant and antimicrobial agent. ..
  7. Park H, Tuan N, Oh J, Son Y, Hamann M, Stone R, et al. Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells. Mar Drugs. 2018;16: pubmed publisher
  8. Bajpai V, Alam M, Quan K, Choi H, An H, Ju M, et al. Cytotoxic properties of the anthraquinone derivatives isolated from the roots of Rubia philippinensis. BMC Complement Altern Med. 2018;18:200 pubmed publisher
  9. Bajpai V, Alam M, Quan K, Ju M, Majumder R, Shukla S, et al. Attenuation of inflammatory responses by (+)-syringaresinol via MAP-Kinase-mediated suppression of NF-κB signaling in vitro and in vivo. Sci Rep. 2018;8:9216 pubmed publisher
    ..Interestingly, SGRS (30 mg/kg) suppressed carrageenan-induced elevation of iNOS, COX-2, TNF-α, IL-1β, and IL-6 mRNA levels as well as COX-2 and NF-κB protein levels, suggesting SGRS may possess anti-inflammatory activities. ..

More Information


  1. Kulkarni R, Lee W, Jang T, Lee J, Kwak S, Park M, et al. Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses. Bioorg Med Chem Lett. 2015;25:5367-71 pubmed publisher
  2. Park S, Kim J, Kim J, Song G, Zhou W, Goh S, et al. Cytotoxic activity of aeroplysinin-1 against colon cancer cells by promoting ?-catenin degradation. Food Chem Toxicol. 2016;93:66-72 pubmed publisher
    ..These findings indicate that aeroplysinin-1 exerts its antiproliferative activity by attenuating Wnt/?-catenin signaling and may have potential as a chemopreventive agent for human colon cancer. ..
  3. Lee J, Hwang I, Kim J, Kim M, Hwang J, Kim Y, et al. Quinoxaline-, dopamine-, and amino acid-derived metabolites from the edible insect Protaetia brevitarsis seulensis. Arch Pharm Res. 2017;40:1064-1070 pubmed publisher
    ..The structures of all the isolated compounds were established mainly by analysis of HRESIMS, NMR, and electronic circular dichroism data. Compound 5 exhibited inhibition of tyrosinase with IC50 value of 44.8 µM. ..
  4. Lee W, Kim M, Park I, Hwang J, Na M, Bae J. Novel direct factor Xa inhibitory compounds from Tenebrio molitor with anti-platelet aggregation activity. Food Chem Toxicol. 2017;109:19-27 pubmed publisher
    ..Therefore, 1-2 could serve as candidates and provide scaffolds for the development of new anti-FXa and anti-platelet drugs. ..
  5. Lee W, Lee H, Kim M, Choi J, Kim K, Hwang J, et al. Evaluation of novel factor Xa inhibitors from Oxya chinensis sinuosa with anti-platelet aggregation activity. Sci Rep. 2017;7:7934 pubmed publisher
    ..Collectively, these results suggest that compounds 1-4 could serve as candidates and provide scaffolds for development of new antithrombotic drugs. ..
  6. Park S, Hwang I, Kim J, Chung Y, Song G, Na M, et al. Smenospongidine suppresses the proliferation of multiple myeloma cells by promoting CCAAT/enhancer-binding protein homologous protein-mediated ?-catenin degradation. Arch Pharm Res. 2017;40:592-600 pubmed publisher
    ..These findings indicate that smenospongidine exerts its anti-proliferative activity by blocking the Wnt/?-catenin signaling pathway and may be a potential chemotherapeutic agent against multiple myeloma. ..
  7. Kang H, Ku S, Kim J, Chung J, Kim S, Zhou W, et al. Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo. Chem Biol Interact. 2017;261:127-138 pubmed publisher
    ..Therefore, these compounds can be considered as a potential therapy for vascular inflammatory diseases. ..
  8. Tuan N, Oh J, Park H, Ferreira D, Choe S, Lee J, et al. A grayanotox-9(11)-ene derivative from Rhododendron brachycarpum and its structural assignment via a protocol combining NMR and DP4 plus application. Phytochemistry. 2017;133:45-50 pubmed publisher
    ..This work exemplifies how NMR analysis, combined with quantum mechanics calculations, is a viable approach to accomplish structural assignment of minor abundance molecules in lieu of X-ray crystallography or chiroptical approaches. ..
  9. Oh J, Liu H, Park H, Ferreira D, Jeong G, Hamann M, et al. In silico investigation of lavandulyl flavonoids for the development of potent fatty acid synthase-inhibitory prototypes. Biochim Biophys Acta Gen Subj. 2017;1861:3180-3188 pubmed publisher
    ..In silico technologies with available FAS crystal structures may be of significant use in optimizing preliminary leads. ..
  10. Bajpai V, Park Y, Na M, Kang S. α-Glucosidase and tyrosinase inhibitory effects of an abietane type diterpenoid taxoquinone from Metasequoia glyptostroboides. BMC Complement Altern Med. 2015;15:84 pubmed publisher
    ..glyptostroboides with a possibility for using it as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent. ..
  11. Jung B, Chung J, Zhou W, Lee T, Na M, Bae J. Inhibitory effects of pentacyclic triterpenoids from Astilbe rivularis on TGFBIp-induced inflammatory responses in vitro and in vivo. Chem Biol Interact. 2016;254:179-90 pubmed publisher
  12. Nguyen T, Thuong P, Hwang I, Hoang T, Nguyen M, Nguyen H, et al. Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content. BMC Complement Altern Med. 2017;17:191 pubmed publisher
    ..orientalis is related to XO inhibitory effect of the phenolic components. Our findings support the use of this plant as the treatment of gout and other inflammatory diseases. ..