Kyu Lim

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. doi request reprint Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids
    Kyu Lim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 68:553-60. 2008
  2. pmc Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells
    Soyeon Jeong
    Department of Biochemistry, School of Medicine, Chungnam National University, Daejeon 301 747, Korea
    BMC Cancer 14:481. 2014
  3. pmc PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells
    Kang Sik Seo
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea
    BMC Cancer 14:36. 2014
  4. pmc Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2
    Kyu Lim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Cancer Ther 8:3046-55. 2009
  5. ncbi request reprint Association of castration-dependent early induction of c-myc expression with a cell proliferation of the ventral prostate gland in rat
    K Lim
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea
    Exp Mol Med 32:216-21. 2000
  6. ncbi request reprint Phosphorylation of octamer-binding transcriptional factor may be correlated with H2B histone gene repression during 12-O-tetradecanoylphorbol 13-acetate-dependent differentiation of HL-60 cells
    Kyu Lim
    Department of Biochemistry, College of Medicine, Chungnam National University, Jungu, Daejeon 301 747, Korea
    Oncol Rep 14:727-31. 2005
  7. ncbi request reprint Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells
    Lihong Xu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 66:11859-68. 2006
  8. ncbi request reprint Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells
    Meizi Zheng
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Oncol Rep 14:713-7. 2005
  9. pmc Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cell Biochem 105:534-45. 2008
  10. ncbi request reprint Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Autophagy 6:46-60. 2010

Collaborators

Detail Information

Publications44

  1. doi request reprint Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids
    Kyu Lim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 68:553-60. 2008
    ..Thus, utilization of omega 3-PUFAs may represent an effective and safe therapeutic approach for the chemoprevention and treatment of human cholangiocarcinoma...
  2. pmc Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells
    Soyeon Jeong
    Department of Biochemistry, School of Medicine, Chungnam National University, Daejeon 301 747, Korea
    BMC Cancer 14:481. 2014
    ....
  3. pmc PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells
    Kang Sik Seo
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea
    BMC Cancer 14:36. 2014
    ..Apicularen A induces cytotoxicity in tumor cells through disrupting microtubule networks by tubulin down-regulation. In this study, we examined whether PMA increases apicularen A-induced cytotoxicity in HeLa cells...
  4. pmc Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2
    Kyu Lim
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Cancer Ther 8:3046-55. 2009
    ..These findings provide important preclinical evidence and molecular insight for utilization of omega-3 PUFAs for the chemoprevention and treatment of human HCC...
  5. ncbi request reprint Association of castration-dependent early induction of c-myc expression with a cell proliferation of the ventral prostate gland in rat
    K Lim
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea
    Exp Mol Med 32:216-21. 2000
    ..These results suggest that an early induction of c-myc mRNA in ventral prostate gland after castration is closely associated with cell proliferation of the gland...
  6. ncbi request reprint Phosphorylation of octamer-binding transcriptional factor may be correlated with H2B histone gene repression during 12-O-tetradecanoylphorbol 13-acetate-dependent differentiation of HL-60 cells
    Kyu Lim
    Department of Biochemistry, College of Medicine, Chungnam National University, Jungu, Daejeon 301 747, Korea
    Oncol Rep 14:727-31. 2005
    ....
  7. ncbi request reprint Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells
    Lihong Xu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 66:11859-68. 2006
    ..Thus, PPARdelta induces COX-2 expression and the COX-2-derived PGE(2) further activates PPARdelta via cPLA(2)alpha. Such an interaction forms a novel feed-forward growth-promoting signaling that may play a role in hepatocarcinogenesis...
  8. ncbi request reprint Transcriptional repression of vimentin gene expression by pyrroline dithiocarbamate during 12-O-tetradecanoylphorbol-13-acetate-dependent differentiation of HL-60 cells
    Meizi Zheng
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Oncol Rep 14:713-7. 2005
    ..Taken together, these results suggest that NF-kappaB may be an essential transacting factor for transcriptional repression of the vimentin gene by PDTC during TPA-dependent differentiation of HL-60 cells...
  9. pmc Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cell Biochem 105:534-45. 2008
    ..These results depict a novel interaction linking cPLA(2)alpha, PPARdelta and Wnt/beta-catenin signaling pathways and provide insight for further understanding the roles of these key molecules in human cells and diseases...
  10. ncbi request reprint Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy
    Jae Min Yuk
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea
    Autophagy 6:46-60. 2010
    ..Our data suggest that BCG/CWS in combination with IR is a promising therapeutic strategy for enhancing radiation therapy in colon cancer cells through the induction of autophagy...
  11. pmc The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53
    Soyeon Shin
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea
    Biomed Res Int 2013:568671. 2013
    ..Collectively, these findings present a novel mechanism of ROS-regulated apoptosis and autophagy that involves Akt-mTOR signaling in prostate cancer cells with mutant p53 exposed to DHA. ..
  12. ncbi request reprint Apicularen A induces cell death through Fas ligand up-regulation and microtubule disruption by tubulin down-regulation in HM7 human colon cancer cells
    Jong Seok Kim
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
    Clin Cancer Res 13:6509-17. 2007
    ..In this study, we investigated the molecular mechanisms of apicularen A-induced cell death in HM7 human colon cancer cells in vitro and anticancer activity in vivo...
  13. doi request reprint Radiation-induced thymidine phosphorylase upregulation in rectal cancer is mediated by tumor-associated macrophages by monocyte chemoattractant protein-1 from cancer cells
    Tae Dong Kim
    Department of Biochemistry, Chungnam National University College of Medicine, Daejon, Korea
    Int J Radiat Oncol Biol Phys 73:853-60. 2009
    ..The mechanisms of thymidine phosphorylase (TP) regulation induced by radiation therapy (XRT) in various tumors are poorly understood. We investigated the effect and mechanisms of preoperative XRT on TP expression in rectal cancer tissues...
  14. pmc Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells
    Kyoung Sub Song
    Department of Biochemistry, College of Medicine, Chungnam National University, Joong Gu, Daejeon, Korea
    BMC Cancer 11:307. 2011
    ..However, the molecular mechanisms responsible for the anti-tumor properties of PL remain to be explored. Experiments were carried out to unravel the anticancer effects of PL...
  15. pmc Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition
    Nayeong Kim
    Department of Biochemistry, School of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea Infection Signaling Network Research Center, School of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea
    Biomed Res Int 2015:239764. 2015
    ....
  16. doi request reprint Apicularen A acetate induces cell death via AIF translocation and disrupts the microtubule network by down-regulating tubulin in HM7 human colon cancer cells
    Kang Sik Seo
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
    Biochem Biophys Res Commun 434:634-40. 2013
    ..Taken together, these results indicate that the mechanism of apicularen A acetate involves caspase-independent apoptotic cell death and disruption of microtubule architecture...
  17. doi request reprint Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling
    Kyoung Sub Song
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea
    Pancreatology 11:574-84. 2011
    ..However, the relationship between ω3-PUFAs and β-catenin, one of the key components of the Wnt signaling pathway, in human pancreatic cancer remains poorly characterized...
  18. doi request reprint Expression regulation and function of Pref-1 during adipogenesis of human mesenchymal stem cells (MSCs)
    Kaipeng Jing
    Department of Biochemistry, Medical School of Chungnam National University, Daejeon, Republic of Korea
    Biochim Biophys Acta 1791:816-26. 2009
    ..Taken together, our study demonstrates that IBMX accelerates accumulation of lipid in MSCs only under the circumstance that the negative effect of Pref-1 induced by IBMX on the adipogenesis is overcome by dexamethasone...
  19. doi request reprint Downregulation of APE1/Ref-1 is involved in the senescence of mesenchymal stem cells
    Jun Young Heo
    Department of Biochemistry, College of Medicine, Chungnam National University, Teajeon, South Korea
    Stem Cells 27:1455-62. 2009
    ..Maintaining characteristics of hBMSCs by regulating intracellular reactive oxygen species production can contribute to tissue regeneration and to improved cell therapy...
  20. pmc Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53
    Kaipeng Jing
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Korea
    Autophagy 7:1348-58. 2011
    ..Overall, our results demonstrate that autophagy contributes to the cytotoxicity of DHA in cancer cells harboring wild-type p53...
  21. ncbi request reprint Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis
    Kyoung Sub Song
    Department of Biochemistry, Chungnam National University, Munhwa dong, Joong Gu, Daejeon, Korea
    Autophagy 4:650-8. 2008
    ....
  22. pmc Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 181:8027-35. 2008
    ..Therefore, blocking COX-2-EP(1) pathway may represent a potential approach for amelioration of LPS-induced liver injury...
  23. pmc DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly
    Jun Young Heo
    Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, Korea
    PLoS ONE 7:e32629. 2012
    ..These mitochondrial defects induced by DJ-1mutation may be a pathological mechanism for the degeneration of dopaminergic neurons in Parkinson's disease...
  24. pmc Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor
    Guiying Li
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Hepatology 50:834-43. 2009
    ..Pretreatment with a COX-2 inhibitor (NS-398) or an EGFR inhibitor (AG1478) exacerbated Jo2-mediated liver injury and hepatocyte apoptosis...
  25. ncbi request reprint Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2
    Lihong Xu
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 283:3077-87. 2008
    ..Therefore, therapy aimed at disrupting this interplay may represent a promising strategy to effectively inhibit PGE(2) production and prevent inflammation and carcinogenesis...
  26. doi request reprint The tumorigenic, invasive and metastatic potential of epithelial and round subpopulations of the SW480 human colon cancer cell line
    Wan Hee Yoon
    Department of Surgery, Chungnam National University College of Medicine, Daejeon 301 747, Korea
    Mol Med Rep 1:763-8. 2008
    ..These findings suggest that E- and R-type cells may have different biological properties in terms of colon cancer progression, regression, invasion and nodal metastasis, and might serve as a useful model for these studies...
  27. pmc Docosahexaenoic acid suppresses breast cancer cell metastasis by targeting matrix-metalloproteinases
    Eun Jin Yun
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejon 301 747, Republic of Korea
    Oncotarget . 2016
    ..In conclusion, DHA attenuated breast cancer progression and lung metastasis in part through suppressing MMPs, and these findings suggest chemoprevention and potential therapeutic strategy to overcome malignant breast cancer...
  28. doi request reprint Docosahexaenoic acid prevents paraquat-induced reactive oxygen species production in dopaminergic neurons via enhancement of glutathione homeostasis
    Hyoung Jun Lee
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, Republic of Korea
    Biochem Biophys Res Commun 457:95-100. 2015
    ..These findings indicate that DHA prevents PQ-induced neuronal cell loss by enhancing Nrf2-regulated GSH homeostasis. ..
  29. ncbi request reprint Omega-3 polyunsaturated fatty acids and cancer
    Kaipeng Jing
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, 301 747, Korea
    Anticancer Agents Med Chem 13:1162-77. 2013
    ....
  30. ncbi request reprint ATF is important to late S phase-dependent regulation of DNA topoisomerase IIalpha gene expression in HeLa cells
    Mee Young Son
    Department of Biochemistry, Chungnam National University, Moonhwa dong, Jungu, Daejeon 301 747, South Korea
    Cancer Lett 184:81-8. 2002
    ..Taken together, these results suggest that ATF may be essential transacting factor for maximal expression of Topo IIalpha gene during late S phase in HeLa cells...
  31. ncbi request reprint Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway
    Chang Han
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 281:24831-46. 2006
    ..DNA binding complex and that activation of EP(1) receptor in the nuclei enhances Stat3 activation depicts a previously undescribed G protein-coupled receptor in the nucleus for Stat3 activation and tumor cell growth...
  32. pmc Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation
    Yunseon Jang
    Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, Republic of Korea, 301 747
    Oncotarget 6:38127-38. 2015
    ..We suggest that blockade HIF-1a and reforming energy metabolism with auraptene is an effective approach for suspension RCC progression. ..
  33. ncbi request reprint Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis
    Wan Hee Yoon
    Department of Surgery, Cancer Research Institute, Chungnam National University College of Medicine, Daejon, Korea
    Clin Cancer Res 10:4517-26. 2004
    ..These results suggest that GM is a novel inhibitor of MMPs and that it may inhibit the invasion and metastasis of human colon cancer cells by blocking MMPs and neoangiogenesis...
  34. ncbi request reprint Differential regulation of vimentin mRNA by 12-O-tetradecanoylphorbol 13-acetate and all-trans-retinoic acid correlates with motility of Hep 3B human hepatocellular carcinoma cells
    Wan Hee Yoon
    Department of Surgery, College of Medicine, Cancer Research Institute, Chungnam National University and Hospital, 640 Daesa dong, Joong ku, 301 721 Daejon, South Korea
    Cancer Lett 203:99-105. 2004
    ..These findings suggest that TPA and RA could modulate the invasive potential of Hep 3B cells by altering cellular motility related to differential regulation of vimentin mRNA...
  35. ncbi request reprint Characterization of mutations, including a novel regulatory defect in the first intron, in Bruton's tyrosine kinase gene from seven Korean X-linked agammaglobulinemia families
    E K Jo
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Chung Ku, Taejon 301 131, Korea
    J Immunol 167:4038-45. 2001
    ..Precise definition of the regulatory defect in the Btk intron 1 may provide valuable clues toward elucidating the pathogenesis of X-linked agammaglobulinemia...
  36. pmc Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer
    Tae Dong Kim
    Department of Surgery, College of Medicine, Chungnam National University and Hospital, Daejeon, 301 721, Korea
    BMC Cancer 6:211. 2006
    ..We designed this study to determine any differences in the expression of MMP-2, MMP-9 and uPA system between colon and rectal cancer tissues...
  37. pmc Dexamethasone Induces FcγRIIb Expression in RBL-2H3 Cells
    Prashanta Silwal
    Research Institute for Medical Sciences and Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Korean J Physiol Pharmacol 16:393-8. 2012
    ..Our data showed, for the first time, that Dex regulates Fc receptor expressions resulting in augmentation of the inhibitory receptor FcγRIIb...
  38. doi request reprint Adenine suppresses IgE-mediated mast cell activation
    Prashanta Silwal
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 747, Republic of Korea
    Mol Immunol 65:242-9. 2015
    ..Therefore, adenine may be useful for the treatment of mast cell-mediated allergic diseases. Also, the upregulation of adenine production may provide another mechanism for suppressing mast cell activity especially at inflammatory sites...
  39. ncbi request reprint Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation
    Young Rae Kim
    Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon 301 130, Korea
    Exp Mol Med 35:118-24. 2003
    ..Thus, these results suggest that pervanadate-induced PLD activation is coupled to the transactivation of EGFR by pervanadate resulting in the activation of p38 MAP kinase...
  40. ncbi request reprint Role of mitogen-activated protein kinase pathways in the production of tumor necrosis factor-alpha, interleukin-10, and monocyte chemotactic protein-1 by Mycobacterium tuberculosis H37Rv-infected human monocytes
    Chang Hwa Song
    Department of Microbiology, College of Medicine, Chungnam National University, 6 Munhwa dong, Jung ku, Daejeon 301 747, Korea
    J Clin Immunol 23:194-201. 2003
    ..Collectively, these results suggest that induction of the MAPK pathway is required for the expression of TNF-alpha, IL-10, and MCP-1 by human monocytes during M. tuberculosis H37Rv infection...
  41. pmc Why is autophagy important in human diseases?
    Kaipeng Jing
    Department of Biochemistry College of Medicine, Chungnam National University, Daejeon 301 747, Korea
    Exp Mol Med 44:69-72. 2012
    ..The machinery and regulation of autophagy were outlined with special attention to its role in diabetes, neurodegenerative disorders, infectious diseases and cancer...
  42. ncbi request reprint Modification of octamer binding transcriptional factor is related to H2B histone gene repression during dimethyl sulfoxide-dependent differentiation of HL-60 cells
    M S Lee
    Department of Food and Nutrition, Chungnam National University, 305-764, Daejeon, South Korea
    Cancer Lett 172:165-70. 2001
    ..These results suggest that the posttranslational modification of OTF may be responsible for the repression of H2B histone gene during DMSO-dependent differentiation of HL-60 cells...
  43. ncbi request reprint Reduced level of ATF is correlated with transcriptional repression of DNA topoisomerase II alpha gene during TPA-induced differentiation of HL-60 cells
    K Lim
    Department of Biochemistry and Surgery, College of Medicine, Chungnam National University, Daejeon, Korea
    Biochem Mol Biol Int 46:35-42. 1998
    ..These results suggest that the reduced level of ATF may be important to the transcriptional repression of Topo II alpha gene during TPA-induced differentiation in HL-60 cells and related to protein kinase C signal pathway...
  44. ncbi request reprint Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells
    Ge Li
    Department of Surgery, College of Medicine, Cancer Research Institute, Chungnam National University and Hospital, 640 Daesa dong, Joong ku, Daejon 301 721, South Korea
    Cancer Lett 216:175-81. 2004
    ..These results suggest that PL has a direct antitumor effect through apoptosis and cell cycle blockade in certain cancer cells...