Young Ha Lee

Summary

Affiliation: Chungnam National University
Country: Korea

Publications

  1. pmc Inhibition of Lewis lung carcinoma growth by Toxoplasma gondii through induction of Th1 immune responses and inhibition of angiogenesis
    Ju Ock Kim
    Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea
    J Korean Med Sci 22:S38-46. 2007
  2. ncbi request reprint Immune responses of different mouse strains after challenge with equivalent lethal doses of Toxoplasma gondii
    Y H Lee
    Department of Parasitology, College of Medicine, Chungnam National University, 6 Munhwa dong, Chung gu, Daejeon 301 131, Korea
    Parasite 11:89-97. 2004
  3. pmc Seroepidemiological study of Toxoplasma gondii infection in the rural area Okcheon-gun, Korea
    Y H Lee
    Department of Parasitology, College of Medicine, Chungnam National University, Taejon 301 131, Korea
    Korean J Parasitol 38:251-6. 2000
  4. pmc Vaccination against murine toxoplasmosis using recombinant Toxoplasma gondii SAG3 antigen alone or in combination with Quil A
    Young Ha Lee
    Department of Infection Biology, College of Medicine, Chungnam National University, 6 Munwha dong, Jung Gu, Daejeon 301 131, Korea
    Yonsei Med J 48:396-404. 2007
  5. pmc T cell phenotype and intracellular IFN-gamma production in peritoneal exudate cells and gut intraepithelial lymphocytes during acute Toxoplasma gondii infection in mice
    Young Ha Lee
    Department of Parasitology, College of Medicine, Chungnam National University, Daejeon 301 131, Korea
    Korean J Parasitol 40:119-29. 2002
  6. pmc Effects of iNOS inhibitor on IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii
    Ki Man Kang
    Department of Internal Medicine, Sun General Hospital, Daejeon 301 070, Korea
    Korean J Parasitol 42:175-83. 2004
  7. doi request reprint Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis
    Juan Hua Quan
    Department of Infection Biology and Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon 301 131, South Korea
    Exp Parasitol 133:462-71. 2013
  8. pmc Antigenemia and specific IgM and IgG antibody responses in rabbits infected with Toxoplasma gondii
    Juan Hua Quan
    Department of Infection Biology, Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon 301 131, Korea
    Korean J Parasitol 47:409-12. 2009
  9. pmc Cytokine and antibody responses of reactivated murine toxoplasmosis upon administration of dexamathasone
    Ki Nam Kang
    Department of Infection Biology, College of Medicine, Chungnam National University, Daejeon, Korea
    Korean J Parasitol 44:209-19. 2006
  10. pmc Quantitative evaluation of viability- and apoptosis-related genes in Ascaris suum eggs under different culture-temperature conditions
    Yong Man Yu
    Department of Applied Biology, College of Agriculture and Life Sciences, Chungnam National University, Daejeon, Korea
    Korean J Parasitol 50:243-7. 2012

Collaborators

Detail Information

Publications39

  1. pmc Inhibition of Lewis lung carcinoma growth by Toxoplasma gondii through induction of Th1 immune responses and inhibition of angiogenesis
    Ju Ock Kim
    Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea
    J Korean Med Sci 22:S38-46. 2007
    ..Taken together, our results demonstrate that T. gondii infection inhibits tumor growth in the Lewis lung carcinoma mouse model through the induction of Th1 immune responses and antiangiogenic activity...
  2. ncbi request reprint Immune responses of different mouse strains after challenge with equivalent lethal doses of Toxoplasma gondii
    Y H Lee
    Department of Parasitology, College of Medicine, Chungnam National University, 6 Munhwa dong, Chung gu, Daejeon 301 131, Korea
    Parasite 11:89-97. 2004
    ..These observations would suggest that caution must be excersized in the planning and interpretation of data when the size of the parasite inoculum has not been adjusted for mouse strain...
  3. pmc Seroepidemiological study of Toxoplasma gondii infection in the rural area Okcheon-gun, Korea
    Y H Lee
    Department of Parasitology, College of Medicine, Chungnam National University, Taejon 301 131, Korea
    Korean J Parasitol 38:251-6. 2000
    ..3). These results revealed that the seroprevalence of toxoplasmosis in rural inhabitants is similar to previous reports in Korea; however we need further investigation to clarify the prevalence of toxoplasmosis in the general population...
  4. pmc Vaccination against murine toxoplasmosis using recombinant Toxoplasma gondii SAG3 antigen alone or in combination with Quil A
    Young Ha Lee
    Department of Infection Biology, College of Medicine, Chungnam National University, 6 Munwha dong, Jung Gu, Daejeon 301 131, Korea
    Yonsei Med J 48:396-404. 2007
    ..Although numerous studies have supported the importance of SAG1 in protection against T. gondii infection, few reports exist on SAG3...
  5. pmc T cell phenotype and intracellular IFN-gamma production in peritoneal exudate cells and gut intraepithelial lymphocytes during acute Toxoplasma gondii infection in mice
    Young Ha Lee
    Department of Parasitology, College of Medicine, Chungnam National University, Daejeon 301 131, Korea
    Korean J Parasitol 40:119-29. 2002
    ..These results suggest that PEC and IEL comprise different cell differentials and T cell responses, and according to infection route these factors may contribute to the different cellular immune responses...
  6. pmc Effects of iNOS inhibitor on IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii
    Ki Man Kang
    Department of Internal Medicine, Sun General Hospital, Daejeon 301 070, Korea
    Korean J Parasitol 42:175-83. 2004
    ..gondii-infected C57BL/6 mice, and that NO is involved in mediating a protective response in toxoplasmosis susceptible, but not resistant, mice strain during acute infection...
  7. doi request reprint Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis
    Juan Hua Quan
    Department of Infection Biology and Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon 301 131, South Korea
    Exp Parasitol 133:462-71. 2013
    ..These data demonstrate that the PI3K-PKB/Akt pathway may be one of the major route for T. gondii in the prevention of host cell apoptosis and T. gondii phosphorylates the pro-apoptotic Bad protein to prevent apoptosis...
  8. pmc Antigenemia and specific IgM and IgG antibody responses in rabbits infected with Toxoplasma gondii
    Juan Hua Quan
    Department of Infection Biology, Research Institute for Medical Sciences, School of Medicine, Chungnam National University, Daejeon 301 131, Korea
    Korean J Parasitol 47:409-12. 2009
    ..Therefore, co-detection of circulating antigens with IgM antibodies may improve the reliability of the diagnosis of acute toxoplasmosis...
  9. pmc Cytokine and antibody responses of reactivated murine toxoplasmosis upon administration of dexamathasone
    Ki Nam Kang
    Department of Infection Biology, College of Medicine, Chungnam National University, Daejeon, Korea
    Korean J Parasitol 44:209-19. 2006
    ....
  10. pmc Quantitative evaluation of viability- and apoptosis-related genes in Ascaris suum eggs under different culture-temperature conditions
    Yong Man Yu
    Department of Applied Biology, College of Agriculture and Life Sciences, Chungnam National University, Daejeon, Korea
    Korean J Parasitol 50:243-7. 2012
    ..suum eggs were associated with survival of the eggs under temperature stress...
  11. pmc Gene expression profiles in genetically different mice infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU
    Hassan Ahmed Hassan Ahmed Ismail
    Department of Infection Biology, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon 301 131, Korea
    Korean J Parasitol 50:7-13. 2012
    ..Thus, these demonstrate that host genetic factors exert a strong impact on the expression of these 5 genes and their expression patterns were varied depending on the gene or tissue...
  12. doi request reprint Toxoplasma gondii protects against H(2)O(2) -induced apoptosis in ARPE-19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway
    Si Hwan Choi
    Department of Ophthalmology, Chungnam National University School of Medicine, Daejeon, Korea
    Acta Ophthalmol 89:e350-6. 2011
    ..T. gondii inhibits or delays programmed cell death caused by various apoptotic triggers; however, the mechanisms involved in the T. gondii-induced suppression of apoptosis in retinal cells have not been analysed in detail...
  13. pmc Epidemiological study of clonorchiasis and metagonimiasis along the Geum-gang (River) in Okcheon-gun (county), Korea
    Gye Sung Lee
    Department of Internal Medicine, Sun General Hospital, Daejeon 301 131, Korea
    Korean J Parasitol 40:9-16. 2002
    ..However, there is still a high prevalence of infection with C. sinensis and Metagonimus sp. in this region, especially in the riverside area...
  14. doi request reprint Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of pregnant women in Korea
    Kyun Han
    Department of Infection Biology, Research Institute for Medical Science, Chungnam National University, Daejeon, Korea
    J Parasitol 94:963-5. 2008
    ..The consumption of raw or undercooked meat may, therefore, be the main route of T. gondii infection in Korea...
  15. pmc Seroprevalence of Toxoplasma gondii infection and characteristics of seropositive patients in general hospitals in Daejeon, Korea
    Dae Whan Shin
    Department of Infection Biology, Research Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon, Korea
    Korean J Parasitol 47:125-30. 2009
    ..gondii seropositivity may be associated with neoplasms, diabetes, and other chronic infections...
  16. pmc Prevalence, risk factors, and clinical manifestations of schistosomiasis among school children in the White Nile River basin, Sudan
    Hassan Ahmed Hassan Ahmed Ismail
    Departments of Infection Biology, Chungnam National University School of Medicine, Daejeon, 301 131, Korea
    Parasit Vectors 7:478. 2014
    ..We investigated the prevalence, risk factors, and clinical manifestations of schistosomiasis in White Nile State, Sudan, to determine the local characteristics of schistosomiasis in the White Nile River basin...
  17. pmc Kinetics of IL-23 and IL-12 secretion in response to Toxoplasma gondii antigens from THP-1 monocytic cells
    Juan Hua Quan
    Department of Infection Biology and Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon 301 131, Korea
    Korean J Parasitol 51:85-92. 2013
    ..The detailed kinetics induced by each T. gondii antigen were different from each other...
  18. pmc Proteomic analysis of Toxoplasma gondii KI-1 tachyzoites
    Si Hwan Choi
    Department of Ophthalmology, Chungnam National University School of Medicine, Daejeon 301 747, Korea
    Korean J Parasitol 48:195-201. 2010
    ..These observations demonstrate that the protein compositions of KI-1 and RH tachyzoites are similar but differential protein expression is involved in virulence...
  19. pmc Induction of protective immune responses by a multiantigenic DNA vaccine encoding GRA7 and ROP1 of Toxoplasma gondii
    Juan Hua Quan
    Department of Infection Biology, Research Institute for Medical Sciences, Chungnam National University School of Medicine, Daejeon, South Korea
    Clin Vaccine Immunol 19:666-74. 2012
    ..Our data suggest that the multiantigenic DNA antigen pGRA7-ROP1 was more effective in stimulating host protective immune responses than separately injected single antigens, and that IL-12 serves as a good DNA adjuvant...
  20. doi request reprint Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70
    Il Young Hwang
    Department of Infection Biology, Research Institute for Medical Science, Chungnam National University School of Medicine, 6 Munhwa dong, Jung Gu, Daejeon, 301 131, South Korea
    Parasitol Res 107:1313-21. 2010
    ..Taken together, these data demonstrate that T. gondii infection inhibits mitochondrial apoptosis through overproduction of anti-apoptotic Bcl-2 as well as HSP70, which are increased parasite loads dependently...
  21. ncbi request reprint 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder
    I S Chee
    Department of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, Jung ku, Taejon, Korea
    Psychiatr Genet 11:111-4. 2001
    ..Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder...
  22. pmc Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis
    Jung Bo Yang
    Department of Obstetrics and Gynecology, Chungnam National University School of Medicine, Daejeon 301 131, Korea
    Korean J Parasitol 53:371-7. 2015
    ..However, activation patterns of each pathway were different from the types of PI3K/MAPK pathways. ..
  23. pmc Genotyping of a Korean isolate of Toxoplasma gondii by multilocus PCR-RFLP and microsatellite analysis
    Juan Hua Quan
    Department of Infection Biology, College of Medicine, Reseach Institute for Medical Science, Chungnam National University, Daejeon 301 747, Korea
    Korean J Parasitol 46:105-8. 2008
    ..These results provide strong genetic evidence that KI-1 is a type I lineage of T. gondii...
  24. pmc Effects of some pesticides on development of Ascaris suum eggs
    Yong Man Yu
    Department of Applied Biology, College of Agriculture and Life Sciences, Chungnam National University, Daejeon 305 764, Korea
    Korean J Parasitol 52:111-5. 2014
    ..Thus, pesticides tested at levels similar to those used in agricultural practices exhibited low-level ovicidal activity and delayed embryogenesis of A. suum eggs, although some differences were evident among the tested pesticides. ..
  25. pmc Sequential analysis of cell differentials and IFN-gamma production of splenocytes from mice infected with Toxoplasma gondii
    Y H Lee
    Department of Parasitology, College of Medicine, Chungnam National University, Taejon, Korea
    Korean J Parasitol 38:85-90. 2000
    ..gondii in the susceptible murine hosts, and lymphocytes were the major cellular components and the important source of IFN-gamma...
  26. pmc Monitoring of Fasciola Species Contamination in Water Dropwort by cox1 Mitochondrial and ITS-2 rDNA Sequencing Analysis
    In Wook Choi
    Department of Infection Biology, Chungnam National University School of Medicine, Daejeon 35015, Korea
    Korean J Parasitol 53:641-5. 2015
    ..Collectively, in this survey of the water dropwort contamination with Fasciola species, very low prevalence of F. hepatica contamination was detected in the samples. ..
  27. doi request reprint Innate signaling mechanisms controlling Mycobacterium chelonae-mediated CCL2 and CCL5 expression in macrophages
    Yi Sak Kim
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, 34134, Republic of Korea
    J Microbiol 53:864-74. 2015
    ..Taken together, the present data indicate that the TLR2, MyD88, and NF-κB pathways, Dectin-1 signaling, and intracellular ROS generation contribute to the Mch-mediated expression of chemokine genes in BMDMs...
  28. pmc Intestinal parasite infections in pigs and beef cattle in rural areas of Chungcheongnam-do, Korea
    Hassan Ahmed Hassan Ahmed Ismail
    Department of Infection Biology, Chungnam National University School of Medicine, Daejeon 301 131, Korea
    Korean J Parasitol 48:347-9. 2010
    ....
  29. pmc The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development
    Oky Maeng
    Department of Infection Biology, College of Medicine and Brain Korea 21 Program for Medical Science, Chungnam National University, Daejeon 301 131, Korea
    Mol Cells 33:457-63. 2012
    ..These results indicate that dPLZF is a transcription factor controlled by the Ras/ERK signaling pathway, which is a prominent regulator of vein cell formation during wing development in Drosophila...
  30. ncbi request reprint The functional p53 codon 72 polymorphism is associated with systemic lupus erythematosus
    Y H Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, College of Medicine, Korea University, Anam Dong, Seongbuk Ku, Seoul, Korea
    Lupus 14:842-5. 2005
    ..Further studies for replications are needed to confirm that the p53 polymorphism contributes to SLE...
  31. ncbi request reprint Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis
    Y H Lee
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    Lupus 13:188-91. 2004
    ..In conclusion, our data show that the eNOS ab genotypes may be associated with the development of lupus nephritis, suggesting individuals who carry the 'a' allele are more susceptible to lupus nephritis than those with the 'b' allele...
  32. pmc Reduction of urogenital schistosomiasis with an integrated control project in Sudan
    Young Ha Lee
    Department of Infection Biology, Chungnam National University School of Medicine, Daejeon, Korea
    PLoS Negl Trop Dis 9:e3423. 2015
    ..This study presents the disease-reduction outcomes of an integrated control program for schistosomiasis in Al Jabalain locality of White Nile State, Sudan from 2009 through 2011...
  33. ncbi request reprint Functional polymorphisms in matrix metalloproteinase-1 and monocyte chemoattractant protein-1 and rheumatoid arthritis
    Y H Lee
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    Scand J Rheumatol 32:235-9. 2003
    ..Our data show that the functional promoter polymorphism in the MMP-1 promoter may not play an important role in the susceptibility of RA, but the polymorphism may be related to clinical phenotypes...
  34. ncbi request reprint Congenital curly toe of the fetus
    J Y Cho
    Department of Radiology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Jung Gu, Seoul, Korea
    Ultrasound Obstet Gynecol 24:417-20. 2004
    ..To assess the prevalence, prenatal detection rate, and associated anomalies of congenital curly toe in an unselected obstetric population...
  35. ncbi request reprint Preliminary results of a new covered biliary metal stent for malignant biliary obstruction
    C S Shim
    Division of Gastroenterology, College of Medicine, Soon Chun Hyang University, Seoul, Korea
    Endoscopy 30:345-50. 1998
    ..To evaluate the success and the effectiveness of the new membrane-covered self-expandable metal stent (covered modified Gianturco biliary stent), we studied patients with biliary obstruction caused by biliopancreatic carcinoma...
  36. doi request reprint Triple negative breast cancer in Korea-distinct biology with different impact of prognostic factors on survival
    Jung Ah Lee
    Department of General Surgery, Anam Hospital, Korea University, College of Medicine, 126, Anam Dong 5 Ga, Seongbuk gu, Seoul 136 705, Korea
    Breast Cancer Res Treat 123:177-87. 2010
    ..However, younger age is not related to prognosis, and mortality risk decreases to that of the luminal A subtype, which is known to have the best prognosis after a few years...
  37. doi request reprint Diagnosis of vivax malaria using an IgM capture ELISA is a sensitive method, even for low levels of parasitemia
    Jae Won Park
    Department of Microbiology, Gachon Medical School, Incheon, South Korea
    Parasitol Res 103:625-31. 2008
    ..Therefore, the use of IgM ELISA for the detection of specific IgM that was not involved in memorial immune activity could be an alternative tool for the diagnosis of malaria and blood screening, even in areas in which malaria is endemic...
  38. ncbi request reprint Humoral responses against the C-terminal region of merozoite surface protein 1 can be remembered for more than 30 years in persons exposed to Plasmodium vivax
    Kook Jin Lim
    Protein Network Research Center, Department of Biochemistry, College of Science, Yonsei University, 120 749 Seoul, Korea
    Parasitol Res 92:384-9. 2004
    ..This long-term memory of humoral immunity supports the C-terminal region of merozoite surface protein 1 as an effective malaria vaccine, in addition to the neutralizing activity reported previously...
  39. pmc Influence of calcium ion on host cell invasion and intracellular replication by Toxoplasma gondii
    Hyun Ouk Song
    Department of Parasitology and Institute of Biomedical Science, Hanyang University College of Medicine, Seoul 133 791, Korea
    Korean J Parasitol 42:185-93. 2004
    ..These results suggest that host cell invasion and the intracellular replication of T. gondii tachyzoites are inhibited by the calcium ionophore, A23187, and by the extracellular calcium chelator, EGTA...